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Mucormycosis during Imatinib treatment: case report.

UnlabelledPhiladelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor. Most times, intensive chemotherapy regimens are associated with prolonged and profound pancytopenia when the risk of invasive fungal infection increases. After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a redu

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… Fig. 4 Cerebral MRI A) Mucosal thickening of the posterior wall of the right frontal sinus, ethmoidal cells of right maxillary and bilateral sphenoid sinuses; B) Symmetrical mucosal thickening of paranasal sinuses, moderate right periorbital edema, minor right intraorbital adipose tissue edema, secondary …

Diffuse large B cell lymphoma originating from the maxillary sinus with skin metastases: A case report and review of literature.

BackgroundDiffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma (ML), accounting for 30%-40% of cases of non-Hodgkin's lymphoma (NHL) in adults. Primary paranasal sinus lymphoma is a rare presentation of extranodal NHL that accounts for only 0.17% of all lymphomas. ML from the maxillary sinus (MS) is a particularly rare presentation, and is thus often difficult to diagnose. We have reported the first known case of DLBCL originating from the MS with rapidly occurrent multiple skin metastasis.Case summaryAn 81-year-old Japanese man visited our hospital due to contin

Диагностика множественных склерозов: из материалов Конференции Национального общества по проблемам множественных склерозов.

28-летняя чернокожая женщина имела как типичные, так и нетипичные особенности множественного склероза в условиях многоженства, включая психиатрическую историю, осложняющие диагностику и лечение. Этот случай иллюстрирует важность дифференциального диагноза и продольного контроля, прежде чем брать на себя обязательство по профилактике заболеваний. Особое внимание уделяется принятию решений в отношении индивидуального лечения.

A Case of Syphilis with High Bone Arsenic Concentration from Early Modern Cemetery (Wroclaw, Poland).

Venereal syphilis is a sexually transmitted disease caused by Treponema pallidum - Gram-negative, slowly growing bacteria. The spread of the disease in the Old World was due to increased birth rate, urban population growth, migration and lack of knowledge concerning the epidemiology. In the past, the treatment was mainly symptomatic and included application of mercury compounds. The goal of the study was to present the case of advanced venereal syphilis found in early modern (16th-18thc) graveyard localized in Wroclaw, Poland. The object of the study is a cranium of a male whose age at death h

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… The lesions were configured as wide irregular bone defects extending to the anterior part of the frontal sinus on the left side of the frontal bone. The frontal bone in this region was markedly thinner as a result of extensive bone loss. … On the right side of the basal part of the frontal bone, there was a regular round lesion (1.0 cm in diameter) penetrating towards the interior of the frontal sinus. …

Hairy cell leukemia with isolated bone lesions.

Key clinical message18F-FDG PET/CT has clinical relevance in HCL at diagnosis and for the follow-up of patients treated, especially in case of atypical presentations such as bone involvements (which are probably underestimated) and poor bone marrow infiltration.AbstractBone lesions are rarely reported in Hairy Cell Leukemia (HCL). We report two BRAFV600E mutated HCL patients presented bone lesions at foreground, poor bone marrow involvement, and the important role 18F-FDG PET/CT played in their management. We discuss the crucial role that 18F-FDG PET/CT could play in HCL routine practice.

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… The scan showed a frontal anterior right tissue process up to the external part of the right frontal sinus and a lytic bone lesion beginning at the right orbit roof. …

Osteitis Fibrosa Cystica: The Hideous Face of Hyperparathyroidism.

Osteitis fibrosa cystica (OFC), the skeletal scourge of advanced hyperparathyroidism, unveils itself as a relentless destroyer of bone architecture, leaving behind a landscape of fragility and deformity. In the shadow of chronic kidney disease, where mineral imbalances reign, this rare but devastating entity emerges as a silent tormentor. We present the case of a hemodialysis patient who fell victim to this sinister complication, manifesting with excruciating bone pain, pathological fractures, and radiographic and histological evidence of cystic osteolytic lesions. Biological assessments revea

An unusual case of aggressive endometrial adenocarcinoma metastasis to the clivus: illustrative case.

BackgroundThough endometrial carcinomas are a relatively common cancer of the female genitourinary tract, they rarely metastasize. Similarly, clival metastases make up a tiny fraction of all brain metastases. To the authors' knowledge, an endometrial carcinoma clival metastasis has never been described in the literature; therefore, the authors present the following unusual case of a 69-year-old female with a history of an initially grade 2 endometrial adenocarcinoma that metastasized to her clivus.ObservationsEndometrial carcinoma has the potential to metastasize to the clivus.LessonsEndometri

Представление результатов анализа диабетических осложнений с головы до ног: всеобъемлющий радиологический обзор.

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ИАНКОН 2023 Выдержки из плаката

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Abstracts - IANCON 2024

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Молекулярная и клеточная основа физиологических изменений беременности и ее последствий для нейрологовых и офтальмических патологий.

Беременность олицетворяет глубокие неврологические, гормональные и анатомические преобразования в материнском мозге, подготавливая их к уходу и сближению младенцев. Нейроимация свидетельствует о таких структурных изменениях, как сокращение содержания серых веществ и реорганизация белых веществ во время беременности, за которыми следует частичное послеродовое выздоровление. Эти адаптации модернизируются изменяющимися уровнями эстрадиола, прогестерона, пролактина и окситоцина, которые координируют нейропластичность и поведенческий уровень готовности. На молекулярном и клеточном уровнях гормоны б

Leptomeningeal carcinomatosis in gastric cancer: A Review.

Gastric cancer is the fifth most common cancer worldwide and leptomeningeal carcinomatosis (LM) occurs in 0.06% of gastric cancers. As such, trials are difficult to power and quantitative analyses difficult to standardize. We composed a review and analysis of 47 recent cases to be used as a comprehensive resource for an oncologist faced with managing this highly morbid, rapidly fatal disease. Gold-standard of diagnosis of LM is through cerebral spinal fluid (CSF) cytology; MRI is the preferred imaging modality to identify LM. However, repeated lumbar punctures and imaging studies are often req

The unusual first sign of presentation of hepatocellular carcinoma: a rare case report.

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, characterized by aggressive biological behavior and a high propensity for extrahepatic spread. The most common sites of metastasis are the lungs, regional lymph nodes, bones, adrenal glands, and peritoneum. In contrast, the paranasal sinuses are an unusual site for metastatic HCC, and involvement of the sphenoid sinus represents an even rarer event. CASE DESCRIPTION: We report the case of a 67-year-old male patient who presented with transient diplopia, left eyelid ptosis, and refractory epistaxis as the i

Metastatic lung adenocarcinoma causes extensive destruction of the hip and pelvis.

BackgroundLung cancer is the most prevalent tumor and frequently present with distant metastases, with the bone being one of the most common affected sites. However, bone metastases leading to complete resorption of the hip joint and pelvis are extremely rare. This case aimed to report an extensive destruction of the hip and pelvis in metastatic lung adenocarcinoma, and conduct a literature review to explore the factors influencing the diagnosis and treatment decisions of bone metastasis.Case presentationA 56-year-old woman presented with progressive pain in her left hip joint and pelvis accom

Canine laryngotracheal plasma cell tumors: Ten cases and literature review.

Canine extramedullary plasma cell tumors (EMPs) most commonly arise in the skin, oral cavity, rectum, and colon. This retrospective study describes the histopathological and immunohistochemical characteristics and associated clinical signs and outcomes of laryngeal and tracheal EMPs in dogs. Five tracheal and 5 laryngeal EMPs were diagnosed at the Penn Vet Diagnostic Laboratory. Clinical information was obtained via submission forms and follow-up questionnaires. All dogs were male (9 castrated), 7 to 15 years old, and of different breeds. Neoplasms were composed of well-differentiated (n = 6)

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… An autopsy revealed EMP at the initial site with no evidence of metastasis. 22 In cats, 2 reports described EMPs involving components of the respiratory tract. 13 , 18 One case report documented an invasive EMP with involvement of the frontal sinus, nasal cavity, soft palate, larynx, trachea, lungs, … In the other case, an EMP was present within the right nasal cavity and frontal sinus without involvement of other tissues. 13 In both instances, the EMP caused severe respiratory signs and resulted in the euthanasia of the animal. 13 , 18 In humans, EMP most commonly arise in the upper respiratory …

Osteomyelitis of the Jaw in COVID-19 Patients: A Rare Condition With a High Risk for Severe Complications.

Osteomyelitis of the jaw is an uncommon infection that arises from the flora of the oral cavity or sinuses and affects immunocompromised and polymorbid patients. Treatment includes surgical debridement and long regiments of broad-spectrum antibiotics. We present three cases of complicated jaw osteomyelitis presented with concurrent COVID-19 infection, including only two reported cases of odontogenic COVID-related osteomyelitis. The two mandibular cases were patients in their 30s with no comorbidities. The first case was an asymptomatic COVID-19-positive patient who developed an odontogenic inf

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… Inflammatory thickening of the mucosal lining of the left frontal sinus, ethmoid cells, and maxillary sinus. He was discharged after 29 days of hospital stay with an acrylic obturator plate that served to close the defect left in the hard palate. …

Изучение цереброваскулярных проявлений нейроборлиоза: обзор.

Заболевание Lyme - это зоонотическая инфекция, передающаяся Боррелией Бурдорфери, и, если ее не диагностировать, она может появиться на более поздних этапах с неврологическими проявлениями. Цель этого обзора заключается в обобщении данных о инсультовом или аналогичном цереброваскулярном исходе нейроборрелиоза Лайма (НБ) для содействия раннему распознаванию и лечению. 90 - пациенты, отвечающие критериям Европейской федерации неврологических обществ/Американской академии неврологических заболеваний/Американской школы ревматологии (EFNS/IDSA/AAN/ACR) для ЛНБ с радиологически или серологически под

Posterior reversible encephalopathy syndrome after CD19 chimeric antigen receptor therapy for B-acute lymphoblastic leukemia: case report.

Posterior reversible encephalopathy syndrome (PRES) is a neurologic condition characterized by distinctive radiologic findings and altered mental status, often associated with chemotherapy or systemic endothelial dysfunction. To date, there have been no documented cases of PRES occurring after chimeric antigen receptor T cell therapy (CAR-T) for B-cell acute lymphoblastic leukemia (B-ALL). We describe the case of a 30-year-old female patient with relapsed B-ALL who received brexucabtagene autoleucel and subsequently developed a progressively worsening cytokine release syndrome and immune effec

Соотношение интенсивности краниального сигнала с множественным склерозным клиническим курсом и продвижением.

Цели Множественный склероз (MS), как правило, рецидивы, примерно половина из которых становится прогрессивной с течением времени, мало что происходит с самого начала. Лептомингелезные лимфоидные фолликулы с клеточным потоком из краниального костного мозга могут быть связаны с продвижением. Цель этого ретроспективного исследования заключалась в том, чтобы определить прогнозируемое значение краниальной интенсивности сигнала и увязать его с другими клиническими характеристиками. 96 Психиатрические пациенты16 первичный прогрессивный множественный склероз, 80 многократного склероза (RRMS) и 60 Были

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present