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The annual conference of National Cancer Institute - Cairo University "Bridging Gaps in Oncology" : InterContinental Citystars Cairo hotel. 3 - 5 November, 2021.

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… P4 Effect of nutritional status on survival of Egyptian patients with gastrointestinal malignancies Dalia A Mohammed 1 , Iman A Abdelgawad 2 , Mohamed Hassany 3 , Manar M Moneer 1 , Inas A Elattar 1 , Rasha M Allam 1 1 Department of Cancer Epidemiology and Biostatistics, National Cancer Institute, … Data were collected from the biostatistics and cancer epidemiology department. Results Out of 232 patients; 156 (67.2%) were male and 76 (32.8%) were female; the median age of the study population was 49 years (range 19_80years). …

Is there a subgroup of long-term evolution among patients with advanced lung cancer?: hints from the analysis of survival curves from cancer registry data.

BackgroundRecently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected population with advanced lung cancer to look for evidence of multimodality in survival distribution, and estimate the proportion of long-term survivors.MethodsWe used survival data of 4944 patients with non-small-cell lung cancer (NSCLC) stages IIIb-IV at diagnostic, registered in the National Cancer Registry of Cuba (NCRC) between January 1998 and December 2006. We fitted one-compon

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… Biostatistics. 2007;8(3):576–594. doi: 10.1093/biostatistics/kxl030. 14. Galan Y, Fernandez L, Torres P, Garcia M. Trends in Cuba's Cancer Incidence (1990 to 2003) and mortality (1990 to 2007) MEDICC Rev. 2009;11(3):19–26. doi: 10.37757/MR2009V11.N3.6. 15. Nagode M, Fajdiga M. …

The effect of drug holiday before tooth extraction on the development of medication-related osteonecrosis of the jaw in cancer patients receiving intravenous bisphosphonates.

OBJECTIVES: Drug holidays are suggested to reduce the formation of osteonecrosis in patients under intravenous (IV) bisphosphonates (BPs) therapy. The objectives of this study are to evaluate the incidence of medication-related osteonecrosis of the jaw (MRONJ) following tooth extraction in cancer patients using IV BP, and to assess the effect of drug holiday on the development of MRONJ. Patients and. METHODS: A manuel search of the patient folders of Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hacettepe University was undertaken to identify cancer patients who used IV

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… The statistical analysis was accomplished using IBM SPSS Statistics (ver. 24.0; IBM) in the Department of Biostatistics at Hacettepe University. Descriptive statistics were used to express the medians, the minimum and maximum values and percentage distributions in the groups. … Yağmur Zengin, Department of Biostatistics, Faculty of Medicine, Hacettepe University for statistical analysis of the study. Footnotes Authors’ Contributions G.T.Y., S.A., and E.U. participated in data collection. Ç.K. and G.T.Y. participated in the study design. Ç.K. wrote the manuscript. …

Isatuximab, Lenalidomide, Bortezomib и Dexametason Incublishing Therapy for Transplat-Eltled Newly Dignosed Myeloma: заключительная часть 1 Анализ GMMG-HD7 Судебный процесс.

Ранее, добавление изатуксимаба (Иса) в стандарт медицинского обслуживания lenalidomide-bortezomib-dexametasone (RV) для пациентов, имеющих право на трансплантацию, с недавно диагностированным множественным миелом в GMMG-HD7 судебное разбирательство (индивидуальный идентификатор Клинического производства.gov: NCT03617731) привело к значительному увеличению минимального коэффициента остаточной негативности (MRD-) после вводного лечения. Всего 662 пациентам было поручено пройти вводный курс лечения с помощью Isa-RV (n = 331) или RVd (n = 329), за которым следуют однократная или тандемная аутометр

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… Biostatistics 14 : 299 - 312 , 2013 23178734 10.1093/biostatistics/kxs042 7. Guo X , Tsiatis A : A weighted risk set estimator for survival distributions in two-stage randomization designs with censored survival data . Int J Biostatistics 1 : 1 - 15 , 2005 8. …

Диагностическая задержка и неправильное диагностирование симптомов, сообщенных пациентами с множественным склерозом, участвующими в исследовательской работе.

РУКОВОДЯЩИЕ ПРИНЦИПЫ: Данные групп исследований свидетельствуют о том, что задержка с диагностикой множественных склерозов (MS) уменьшилась параллельно с пересмотром диагностических критериев MS, однако в других исследованиях этот вывод не был повторен. Последние данные свидетельствуют о неправильной диагностике первоначальных симптомов НР, что часто приводит к задержкам в диагностике. ЦЕЛИ: В ходе этого обследования была проведена оценка задержки с диагностикой и неправильной диагностики в реестре пациентов с НР. МЕТОДЫ: Участники завершили исследование в период с 12 ноября 2021 года по 22 де

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… Sarah M Weinstein, Department of Epidemiology and Biostatistics, College of Public Health, Temple University, Philadelphia, PA, USA. … Russell T Shinohara, Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. …

Short-term assessment of functional outcomes and quality of life after thoracic and lumbar spinal metastasis surgery.

BackgroundBecause of improvements in initial tumor identification and treatment, as well as longer life expectancies, more people are receiving diagnoses for spinal metastases.ObjectiveThe aim of this study was to assess early functional outcomes and quality of life (QOL) after surgical management of patients with spinal metastases.Patients and methodsIn this prospective cohort study, a total of 33 patients with thoracic and lumbar spine metastases who underwent surgical management between November 2021 and August 2023 were followed up for 1 year or until death. Oswestry Disability Index and t

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… version of the Oswestry index in Saudi Arabia Ann Phys Rehabil Med 2014 57 653 63 25262247 10.1016/j.rehab.2014.06.006 13 Al Shabasy SA Abbassi MM Finch AP Baines D Farid SF The EQ-5D-5L valuation study in Egypt Pharmacoeconomics 2021 39 549 61 33709283 10.1007/s40273-021-01002-z PMC7952144 14 Chan YH Biostatistics … 102: Quantitative data –Parametric and non-parametric tests Singapore Med J 2003 44 391 6 14700417 15 Chan YH Biostatistics 103: Qualitative data –Tests of independence Singapore Med J 2003 44 498 503 15024452 16 Westermann L Eysel P Luge H Olivier A Oikonomidis S Baschera D Quality of life and functional …

A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies.

Chemotherapy-induced thrombocytopenia (CIT) frequently complicates cancer treatment causing chemotherapy delays, dose reductions, and discontinuation. There is no FDA-approved agent available to manage CIT. This study retrospectively evaluated patients with CIT treated on institutional romiplostim treatment pathways at 4 U.S. centers. The primary outcome was achievement of a romiplostim response [median on-romiplostim platelet count (Plt) ≥75x109/L and ≥30x109/L above baseline]. Secondary outcomes included time to Plt≥100x109/L and rates of the following: Plt<100x109/L, Plt<75x109/L, Plt<50x10

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… We also acknowledge the Harvard Catalyst Biostatistics Team, and in particular Dr. Douglas Hayden, for biostatistical support in this study. References 1. Kuter DJ. Managing thrombocytopenia associated with cancer chemotherapy. Oncology (Williston Park). 2015;29(4):282-294. 2. …

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

Efficacy and Safety of Thalidomide for Chemotherapy-induced Nausea and Vomiting.

Purpose: A substantial number of cancer patients discontinue chemotherapy due to severe chemotherapy-induced nausea and vomiting (CINV). This study aimed to evaluate the efficacy and safety of thalidomide (THD) in CINV. Methods: We searched different databases to identify related studies that investigated the efficacy and safety of THD in CINV. The primary outcomes were CINV in the acute (0-24 h), delayed (24-120 h), and overall (0-120 h) phases, respectively. The secondary outcomes were the safety of THD and the patients' quality of life (QOL). Results: Fourteen randomized control trials (RCT

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… Macaskill P Irwig L The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed J Clin Epidemiol 2005 58 882 93 16085191 10.1016/j.jclinepi.2005.01.016 33 Copas J Shi JQ Meta-analysis, funnel plots and sensitivity analysis Biostatistics … 2000 1 247 62 12933507 10.1093/biostatistics/1.3.247 34 Duval S Tweedie R Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis Biometrics 2000 56 455 63 10877304 10.1111/j.0006-341x.2000.00455.x 35 Rosenthal R The file drawer problem and tolerance …

Анализ биологических возрастных показателей в ходе клинических испытаний на ремимилинацию.

Улучшение ремонта миелина CNS (восстановление) является перспективной стратегией предотвращения нейродегенерации и связанной с этим постепенной инвалидности при множественном склерозе. Ремиэлизация становится неэффективной в более старшем хронологическом возрасте, но связь между показателями биологического возраста и воспоминанием ранее не описывалась в клинической когорте. Здесь, мы расследовали two - показатели биологического возраста среди участников Кембриджского центра миелинового ремонта One bexarotone: МРТ (BAMRI) и основанный на крови биологический возраст (BABlood). У людей с радиолог

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… Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0AH, UK; Department of Neuroinflammation, NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Queen Square Institute of Neurology, London, WC1B 5EH, UK; Department of Medical Epidemiology and Biostatistics … Sara Hägg, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden. …

HealthTree Cure Hub: A Patient-Derived, Patient-Driven Clinical Cancer Information Platform Used to Overcome Hurdles and Accelerate Research in Multiple Myeloma.

PurposeThe study of rare diseases, such as multiple myeloma (MM), often experiences unique research hurdles that can delay or prevent lifesaving discoveries. HealthTree Cure Hub is a first-in-class software program designed to overcome these potential research hurdles.MethodsWe assessed whether HealthTree Cure Hub improved four commonly experienced research hurdles such as (1) small numbers of patient accrual to clinical trials and research studies, (2) shallow and isolated data sets, (3) high costs to answer research questions, and (4) lack of long-term follow-up patient data.ResultsAs of Jun

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… Other Ownership Interests: Doximity Consulting or Advisory Role: Celgene, VIA Oncology, Takeda, GlaxoSmithKline, Syapse, Adaptive Biotechnologies, AbbVie, GRAIL, Epizyme, Janssen Oncology, Sanofi Research Funding: Takeda (Inst), Bristol Myers Squibb (Inst), TG Therapeutics (Inst), Cancer Research and Biostatistics … Other Ownership Interests: Doximity Consulting or Advisory Role: Celgene, VIA Oncology, Takeda, GlaxoSmithKline, Syapse, Adaptive Biotechnologies, AbbVie, GRAIL, Epizyme, Janssen Oncology, Sanofi Research Funding: Takeda (Inst), Bristol Myers Squibb (Inst), TG Therapeutics (Inst), Cancer Research and Biostatistics …

Phase-Specific and Lifetime Costs of Multiple Myeloma Among Older Adults in the US.

ImportanceHealth care costs associated with diagnosis and care among older adults with multiple myeloma (MM) are substantial, with cost of care and the factors involved differing across various phases of the disease care continuum, yet little is known about cost of care attributable to MM from a Medicare perspective.ObjectiveTo estimate incremental phase-specific and lifetime costs and cost drivers among older adults with MM enrolled in fee-for-service Medicare.Design, setting, and participantsA retrospective cohort study was conducted using population-based registry data from the 2007-2015 Su

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… Biostatistics. 2005;6(1):93-109. doi: 10.1093/biostatistics/kxh020 30. Basu A, Polsky D, Manning WG. Estimating treatment effects on healthcare costs under exogeneity: is there a “magic bullet”? Health Serv Outcomes Res Methodol. 2011;11(1-2):1-26. doi: 10.1007/s10742-011-0072-8 31. …

Quality of life for patients on oncology treatments in the Kingdom of Saudi Arabia: a systematic review.

BackgroundCancer cases in the Kingdom of Saudi Arabia (KSA) have tripled in recent years. Quality of Life (QoL) measurements are crucial for healthcare professionals because they reveal important information about how patients respond to drugs and their general health. This study aimed to collect and summarise articles exploring the QoL of patients undergoing oncology treatments in KSA.MethodsThis systematic review captured articles on the Quality of Life of patients undergoing oncology treatments living in the KSA from 2000-2023. A query was established by adapting (PICOS) guidelines for syst

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… Biostatistics (Oxford, England) , 20(2), 273–286. 10.1093/biostatistics/kxx069 Yancik, R. (1997). Cancer burden in the aged: An epidemiologic and demographic overview. Cancer: Interdisciplinary International Journal of the American Cancer Society , 80(7), 1273–1283. …

Послеаварийное продолжение COVID-19 Инфекция у людей с множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Множество распространенных симптомов в послеакуумных сиквелах после острого острого дыхательного синдрома коронавируса 2 (В тыс.SARS-CoV-2) инфекция (PASC) дублирует инфекцию с множественным склерозом (MS). Мы изучили симптомы и показатели ПАСС, разработанные для населения в целом, в MS на основе истории инфекции. Мы опросили участников Североамериканского научно-исследовательского комитета по множественным склерозам (NARCOMS) по вопросам регистрации инфекций и их классификации на основе истории инфекции. Симптомы до, во время и после инфицирования использовались для выя

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… She is supported (in part) by a Biostatistics/Informatics Junior Faculty Award (BI-2105-37656) from the National Multiple Sclerosis Society. She holds the Kenney Marie Dixon-Pickens Distinguished Professorship in Multiple Sclerosis Research. Samantha Lancia has nothing to disclose. … Gary R Cutter, Department of Biostatistics, The University of Alabama at Birmingham, Birmingham, AL, USA. Robert J Fox, Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. …

Differences in the relative importance of predictors of short- and long-term mortality among critically ill patients with cancer.

ObjectiveTo identify the relative importance of several clinical variables present at intensive care unit admission on the short- and long-term mortality of critically ill patients with cancer after unplanned intensive care unit admission.MethodsThis was a retrospective cohort study of patients with cancer with unplanned intensive care unit admission from January 2017 to December 2018. We developed models to analyze the relative importance of well-known predictors of mortality in patients with cancer admitted to the intensive care unit compared with mortality at 28, 90, and 360 days after inte

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… Cham Springer International Publishing 2015 (Springer Series in Statistics) 21 Wolbers M Blanche P Koller MT Witteman JC Gerds TA Concordance for prognostic models with competing risks Biostatistics 2014 15 3 526 539 24493091 10.1093/biostatistics/kxt059 PMC4059461 22 Van Calster B McLernon DJ van …

Joint AI-driven event prediction and longitudinal modeling in newly diagnosed and relapsed multiple myeloma.

Multiple myeloma management requires a balance between maximizing survival, minimizing adverse events to therapy, and monitoring disease progression. While previous work has proposed data-driven models for individual tasks, these approaches fail to provide a holistic view of a patient's disease state, limiting their utility to assist physician decision-making. To address this limitation, we developed a transformer-based machine learning model that jointly (1) predicts progression-free survival (PFS), overall survival (OS), and adverse events (AE), (2) forecasts key disease biomarkers, and (3)

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… Joint modeling of time to event and longitudinal data has a long history in the biostatistics literature, where it has been used to improve the efficiency of estimators 25 . … Biostatistics 10 , 535–549 (2009). 10.1093/biostatistics/kxp009 29. Liu, S. et al. Pyraformer: low-complexity pyramidal attention for long-range time series modeling and forecasting. In Proc. International Conference on Learning Representations (2021). 30. Zhou, T. et al. …

Missed Opportunities in Geriatric Oncology Research.

The field of geriatric oncology has made significant progress in recent decades, but there are still missed opportunities in important areas of research. One issue is the underrepresentation of older patients, especially those aged 75 years and older, in clinical trials. This has resulted in a lack of high-quality data for the care of this population, and the American Society of Clinical Oncology has called for an increase in the evidence base for older patients with cancer. The second missed opportunity is the chance to gather important knowledge from older patients participating in clinical

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… Cores for geriatric oncology infrastructure in the Cancer and Aging Research Group: biostatistics, epidemiology, and research design (the analytics core). J Geriatr Oncol. 2020;11(2):355-358. 10.1016/j.jgo.2019.07.013. 8. Soto-Perez-De-Celis E, Lichtman SM.. …

Association Between Survival Benefits of Anticancer Drugs and Probability of US Food and Drug Administration Approval: A Systematic Review.

BACKGROUND AND OBJECTIVES: Survival benefit constitutes the primary pillar of therapeutic efficacy in oncology. However, the survival benefits observed in registrational trials broadly range from significant to marginal, even for US Food and Drug Administration (FDA)-approved drugs. This study explores the association between survival benefits and the likelihood of FDA approval and estimates the boundary effect size that distinguishes FDA-approved from non-approved drugs.MethodsWe screened 3463 phase 3 trials initiated between 1990 and 2021 on ClinicalTrials.gov. Eligibility was restricted to

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… Biostatistics. 2019;20(2):273–86. 10.1093/biostatistics/kxx069. 25. Hay M, Thomas DW, Craighead JL, et al. Clinical development success rates for investigational drugs. Nat Biotechnol. 2014;32(1):40–51. 10.1038/nbt.2786. 26. Thomas DW, Burns J, Audette J, et al. …

Gene Expression Profiling and Pathway Network Analysis Predicts a Novel Antitumor Function for a Botanical-Derived Drug, PG2.

PG2 is a botanical drug that is mostly composed of Astragalus polysaccharides (APS). Its role in hematopoiesis and relieving cancer-related fatigue has recently been clinically investigated in cancer patients. However, systematic analyses of its functions are still limited. The aim of this study was to use microarray-based expression profiling to evaluate the quality and consistency of PG2 from three different product batches and to study biological mechanisms of PG2. An integrative molecular analysis approach has been designed to examine significant PG2-induced signatures in HL-60 leukemia ce

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… Adjusting batch effects in microarray expression data using empirical Bayes methods Biostatistics 2007 8 1 118 127 10.1093/biostatistics/kxj037 2-s2.0-33845432928 16632515 49 Boyman O. Sprent J. …

Виром ДНК связан с аутоиммунными заболеваниями и COVID-19.

Аберрантная иммунная реакция на вирусные патогены способствует патогенезу, но наше понимание патологических иммунных реакций, вызванных вирусами в вироме человека, особенно в масштабе населения, остается ограниченным. Мы проанализировали наборы данных о последовательности целых генов 6,321 Японцы, включая пациентов с аутоиммунными заболеваниями (псориаз вульгарис, ревматоидный артрит (RA), системный волшебный эритематос (SLE), легочный альвеолярный протеиноз (PAP) или множественный склероз) и коронавирусное заболевание 2019 (В тыс.COVID-19) или здоровый контроль. Систематическая количественная