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Cost-effectiveness analysis of nab-paclitaxel with or without relacorilant for platinum-resistant ovarian cancer.

BACKGROUND: Platinum-resistant ovarian cancer (PROC) has a poor prognosis and limited treatments. Relacorilant plus nab-paclitaxel (RnP) shows clinical efficacy in Phase III trials, but its cost-effectiveness has not yet been evaluated. This study evaluated RnP versus nab-paclitaxel (nP) for PROC from the U.S. payers’ perspective. METHODS: A partitioned survival model (1-month cycle, 5-year time horizon) was utilized to assess the cost-effectiveness of the RnP regimen for PROC, and appropriate parametric functions were applied to fit survival curves and extrapolate 5 years of treatment. Critic

Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis.

Nonmyeloablative-related haploidentical allogeneic stem cell transplantation (NMAC-HID allo-HSCT) has emerged as an additional treatment to … tion and the absence of cost-effectiveness data comparing NMAC-HID allo-HSCT and GT, we conducted a cost-effectiveness analysis of NMAC-HID allo-HSCT vs GT vs SOC for adults and children living with SCD. The primary outcomes were the incremental cost-effectiveness ratio and the net monetary benefits across these 3 strategies. The secondary outcome was the maximum cost-effect …

Integrating clinical and economic outcomes in the elderly myeloma management: a comparative cost-effectiveness analysis.

INTRODUCTION: Multiple myeloma (MM) is a hematologic malignancy that predominantly affects older adults and poses substantial therapeutic challenges due to the high prevalence of comorbidities and limited treatment tolerability. This study evaluates the cost-effectiveness of four first-line treatment regimens for elderly MM patients, ineligible for autologous stem cell transplantation (ASCT): bortezomib, melphalan, and prednisone (VMP); daratumumab in combination with VMP (D-VMP); lenalidomide and dexamethasone (Rd); and daratumumab combined with Rd (DARA-Rd). METHODS: A state-transition Marko

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… Cost - effectiveness analysis, extended dominance, and ethics: A quantitative assessment . Med Decis Making . ( 1994 ) 14 : 259–65 . doi: 10.1177/0272989X9401400308 7934713 39 Russo P Zanuzzi M Carletto A Sammarco A Romano F Manca A . … Cost-effectiveness analysis of daratumumab plus bortezomib, melphalan and prednisone versus bortezomib, melphalan and prednisone in patients with newly diagnosed multiple myeloma ineligible for stem cell transplantation . …

Threshold Price of Belantamab for Relapsed/Refractory Multiple Myeloma in China: A Cost-Effectiveness Analysis.

BACKGROUND: Multiple myeloma is a life-threatening hematologic malignancy with a rising incidence and significant economic burden, driven largely by costly novel therapies. This study estimated the value-based price of belantamab, a novel agent for relapsed or refractory multiple myeloma, from the perspective of the Chinese healthcare system. METHODS: A three-state partitioned survival model was constructed to compare belantamab plus bortezomib and dexamethasone (BVd) versus daratumumab plus bortezomib and dexamethasone (DVd) for the treatment of relapsed or refractory multiple myeloma over a

Sugemalimab plus chemotherapy versus chemotherapy for advanced gastric cancer in China: a cost-effectiveness analysis.

This study aimed to evaluate the cost-effectiveness of sugemalimab plus chemotherapy compared to chemotherapy in the treatment of advanced gastric cancer in China. A Markov model of partitioned survival was developed based on the GEMSTONE-303 Phase III clinical trial evaluating sugemalimab in combination with chemotherapy for advanced gastric cancer. The model incorporates three distinct health states: progression-free survival, disease progression, and death.The transition probabilities between these states and drug treatment and adverse reaction datas were derived from the clinical trial.Dir

Predictive validity and cost-effectiveness analysis of two caries risk assessment tools for preschool children.

BACKGROUND: This study compared the predictive validity and cost-effectiveness of Cariostat and a reduced Cariogram model for caries risk screening in preschoolers, to guide community-based prevention programs. METHODS: A longitudinal study was conducted among 156 children (aged 3-4 years) recruited from two randomly selected kindergartens. Baseline assessments included oral examinations, caregiver questionnaires, and caries-risk stratification using Cariostat and the reduced Cariogram. After 12 months, follow-up examinations recorded caries incidence. Predictive performance was analyzed usin

Cost-effectiveness Analysis of COVID-19 mRNA XBB.1.5 Fall 2023 Vaccination in the Netherlands.

INTRODUCTION: This study aims to assess the cost-effectiveness of the fall 2023 COVID-19 mRNA XBB.1.5 vaccination campaign in the Netherland … ld (WTP) of 20,000 or 50,000 euro per QALY gained. CONCLUSION: This study provides a comprehensive cost-effectiveness analysis supporting the adoption of the mRNA-1273 vaccine in the national immunization program in the Netherlands, provided that the Dutch government negotiates a vaccine price that is at most €34.32 per dose higher than BNT162b2. Despite limitations, the fi …

Cost-Effectiveness Analysis Methods Used in Evaluations of Treatment for Cystic Fibrosis: A Scoping Review.

BACKGROUND: Cystic fibrosis (CF) is a rare genetic condition requiring extensive medical care, which has a significant impact on people with CF. Advances in treatment have extended life expectancy, yet there remains a significant economic burden to manage CF. Cost-effectiveness analysis (CEA) is crucial for evaluating the economic value of treatments and screening for CF. This scoping review seeks to highlight the best practices and gaps in the current evidence base, contributing to robust and comparable CEAs in CF research. METHODS: A scoping review was conducted using PubMed and Embase. Stu…

Redefining ventilator-associated pneumonia treatment: a novel economic analysis of tobramycin and colistin's cost-effectiveness.

BACKGROUND: Ventilator-associated pneumonia (VAP) is a significant clinical challenge due to its morbidity, mortality, and economic burden, especially in low- and middle-income countries. This study evaluates the cost-utility of tobramycin and colistin as nebulized adjunct therapies to systemic antibiotics for managing VAP in Colombia. METHODS: A decision tree model was constructed comparing three interventions: tobramycin + systemic antibiotics, colistin + systemic antibiotics, and systemic antibiotics alone. The model used a one-year time horizon from a third-payer perspective. Clinical pro

CT Colonography versus Multitarget Stool DNA Test for Colorectal Cancer Screening: A Cost-Effectiveness Analysis.

Background Colorectal cancer (CRC) is largely preventable or curable with effective screening. Purpose To compare both the clinical efficacy and cost effectiveness of CRC screening with CT colonography (CTC) with those of multitarget stool DNA (mt-sDNA) testing. Materials and Methods A state-transition Markov model was constructed using updated natural history evidence for colorectal polyps applied to a hypothetical 10 000-person cohort representative of the 45-year-old U.S. population. Three screening strategies were modeled with these data: mt-sDNA testing every 3 years, the conventional CTC

Cost-effectiveness analysis of robotic-arm assisted versus manual total knee arthroplasty in the UK.

AIMS: The aim of this study was to estimate the additional cost per quality-adjusted life-year (QALY) of robotic-assisted total knee arthroplasty (rTKA) compared to manually performed total knee arthroplasty (mTKA). METHODS: An economic evaluation was undertaken from the UK NHS and personal social services perspective, alongside a randomized controlled trial comparing rTKA and mTKA. Costs were estimated individually using a top-down approach and included all healthcare resources incurred during the trial. Costs were presented in 2021 GBP sterling (£). Responses to the EuroQol five-dimension t

Pre-Hospital Pulse-Oximetry and Supplemental Oxygen Utilization in Malawi: An Exploratory Cost-Effectiveness Analysis.

BACKGROUND: Pneumonia is the leading cause of death globally in children aged 0-5 years. Early access to pulse-oximetry and supplemental oxygen in low-resource, pre-hospital settings may result in improved pediatric pneumonia outcomes. However, few data exist regarding their application in such settings. METHODS: We performed an exploratory cost-effectiveness analysis using a decision analytic model to examine use of pulse-oximetry and supplemental oxygen in pre-hospital environments of Malawi. RESULTS: Our model yielded an Incremental Cost-Effectiveness Ratio (ICER) for pre-hospital pulse-o…

12 versus 24 hours of postpartum magnesium sulfate for seizure prophylaxis: A cost-effectiveness analysis.

BACKGROUND: The approach to prevent eclampsia in the postpartum period utilizes magnesium sulfate but there is no evidence-based standard to guide duration. OBJECTIVES: To assess the cost-effectiveness of an abbreviated 12-hour postpartum magnesium sulfate regimen compared with a standard 24-hour regimen. STUDY DESIGN: A decision-analytic model was constructed to compare a 12-hour regimen with a 24-hour regimen in a theoretical cohort of 45,800 patients with preeclampsia with severe features. Probabilities, costs, and utilities were derived from the literature. Primary outcomes included incr

Cost-effectiveness analysis of HPV vaccination of men who have sex with men in Germany.

INTRODUCTION: Men who have sex with men (MSM) have a high risk of human papillomavirus (HPV) infection and HPV-related diseases. While gender neutral HPV vaccination between the ages of 9-14 years (with the option for catch-up between 15- and 17-years-of-age) has been recommended in Germany since 2018, adult MSM are currently not included and thus do not benefit from its advantages. This analysis aims to quantify the reduction in public health and health economic burden of including 18-26-year-old or 18-45-year-old MSM in the national HPV vaccination recommendation, compared to the status quo

Automated Feedback After Internet-Based Depression Screening: Cost-Effectiveness Analysis of a Randomized Controlled Trial.

BACKGROUND: The clinical and cost-related consequences of internet-based depression screening, in combination with automated feedback, have been rarely investigated. We aimed to conduct a cost-effectiveness analysis of DISCOVER, a 3-armed, observer-masked, randomized controlled trial that focused on 2 versions of automated feedback interventions after internet-based depression screening. OBJECTIVE: This study aimed to evaluate the cost-effectiveness of automated nontailored and tailored feedback interventions after internet-based depression screening from a societal perspective. METHODS: Par…

Cost-effectiveness analysis of Chinese patent medicines for the treatment of postmenopausal osteoporosis in China.

INTRODUCTION: Evidence indicates that Chinese patent medicines can significantly increase bone mass in patients with osteoporosis and alleviate symptoms associated with low bone density. Although the therapeutic effects of these two drugs have been compared both directly and indirectly, no economic-related studies currently exist. Therefore, this study aims to assess the cost-effectiveness of Xianling Gubao Capsules compared to Jintiange Capsules and non-treatment for postmenopausal osteoporosis from the perspective of Chinese healthcare providers. METHODS: A Markov microsimulation model was

Cost-Effectiveness of Medial Patellofemoral Ligament Reconstruction for First-Time Patellar Dislocations: A Markov Analysis.

BACKGROUND: Nonoperative management versus medial patellofemoral ligament reconstruction (MPFLR) for first-time patellar dislocations remains controversial, and it is unclear whether the increased up-front costs from MPFLR are justified. PURPOSE: To compare the cost-effectiveness of an initial trial of physical therapy alone to that of early MPFLR to determine the preferred cost-effective treatment strategy for first-time patellar dislocations. STUDY DESIGN: Economic and decision analysis; Level of evidence, 3. METHODS: A Markov chain Monte Carlo probabilistic model was developed to evaluat

Cost-Effectiveness Analysis of Non-Surgical Interventions for Oral Submucous Fibrosis: A Novel Economic Framework.

BACKGROUND: Oral submucous fibrosis (OSF) is a chronic, progressive disorder characterised by reduced mouth opening (MO) and a risk of malignant transformation. Despite numerous non-surgical interventions, sustained functional improvement remains elusive. This study introduces a cost-effectiveness analysis framework to compare various OSF treatments, addressing a critical knowledge gap. MATERIALS AND METHODS: Data from a previously published network meta-analysis (NMA) comprising 72 studies ( N = 5268 patients) were analysed. Cost/millimeter of MO improvement (cost/mm) and cost/millimeter/wee…

Cost-effectiveness analysis of herpes zoster vaccination for adults aged 50 years in Zhejiang province, China.

OBJECTIVE: Live-attenuated zoster vaccine (LZV) and adjuvanted recombinant zoster vaccine (RZV) have been approved for use in China. This study aimed to evaluate and compare the cost-effectiveness of these two herpes zoster (HZ) vaccination strategies in a birth cohort of individuals aged 50 years. METHODS: The cost-effectiveness of RZV and LZV was compared to no vaccination strategy using a lifetime Markov model from a societal perspective. Model parameters were obtained from up-to-date published literature and statistical data. The costs associated with vaccination and medical treatment, qu

Cost-effectiveness of dengue control strategies in Bangladesh: An optimal control and ACER-ICER analysis.

The prevalence of the dengue virus in Bangladesh is extensive, significantly contributing to both illness and death. Managing outbreaks of dengue fever poses a challenge in tropical regions like Bangladesh, where consistently warm temperatures allow mosquitoes to breed and the virus to proliferate. This study introduces a deterministic model with four compartments to represent the transmission of the dengue virus, with parameters estimated using the 2023 outbreak data in Bangladesh. Utilizing the next generation method, we calculate the basic reproduction number (Rb) and conduct sensitivity an