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Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome.

Skeletal muscle adapts its mass as consequence of physical activity, metabolism and hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the process of muscle loss. Muscle atrophy in adult tissue occurs when protein degradation rates exceed protein synthesis. Two major protein degradation pathways, the ubiquitin-proteasome and the autophagy-lysosome systems, are activated during muscle atrophy and variably contribute to the loss of muscle mass. These degradation systems are controlled by a transcription dependent program that modulates the expression of rate-lim

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… Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases Cell 143 2010 35 45 20887891 10.1016/j.cell.2010.09.004 PMC2982779 Nagpal P. Plant P.J. Correa J. Bain A. Takeda M. Kawabe H. …

Decreased miR-497-5p Suppresses IL-6 Induced Atrophy in Muscle Cells.

Interleukin-6 (IL-6) is a pro-inflammatory cytokine associated with skeletal muscle wasting in cancer cachexia. The control of gene expression by microRNAs (miRNAs) in muscle wasting involves the regulation of thousands of target transcripts. However, the miRNA-target networks associated with IL6-induced muscle atrophy remain to be characterized. Here, we show that IL-6 promotes the atrophy of C2C12 myotubes and changes the expression of 20 miRNAs (5 up-regulated and 15 down-regulated). Gene Ontology analysis of predicted miRNAs targets revealed post-transcriptional regulation of genes involve

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… Myogenin ( Myog ) expression was increased in myotubes overexpressing miR-497-5p, but no differences were observed in myotubes transfected with miR-497-5p inhibitors ( Suppl. Figure S4 ). Furthermore, we investigated the expression of the Myh7 , Hmga1 , and Id3 genes. …

Skeletal organoids.

The skeletal system, composed of bones, muscles, joints, ligaments, and tendons, serves as the foundation for maintaining human posture, mobility, and overall biomechanical functionality. However, with ageing, chronic overuse, and acute injuries, conditions such as osteoarthritis, intervertebral disc degeneration, muscle atrophy, and ligament or tendon tears have become increasingly prevalent and pose serious clinical challenges. These disorders not only result in pain, functional loss, and a marked reduction in patients' quality of life but also impose substantial social and economic burdens.

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… Techniques such as real-time polymerase chain reaction and RNA sequencing enable researchers to examine the expression of muscle-specific genes, such as Pax genes 7 and myogenin, to evaluate the differentiation and maturation status of muscle organoids. 57 Overall, the construction of muscle organoids …

The Role of Exercise in Cancer-Related Sarcopenia and Sarcopenic Obesity.

One of the most common adverse effects of cancer and its therapeutic strategies is sarcopenia, a condition which is characterised by excess muscle wasting and muscle strength loss due to the disrupted muscle homeostasis. Moreover, cancer-related sarcopenia may be combined with the increased deposition of fat mass, a syndrome called cancer-associated sarcopenic obesity. Both clinical conditions have significant clinical importance and can predict disease progression and survival. A growing body of evidence supports the claim that physical exercise is a safe and effective complementary therapy f

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… Moreover, in the same mouse cancer model, resistance exercise resulted in the increased mRNA expression of insulin-like growth factor-1 (IGF-1) Ea isoform and myogenin in mouse muscles [ 112 ], which are both implicated in skeletal muscle regeneration and hypertrophy processes [ 113 , 114 , 115 , 116 …

Cardiac Cachexia: Unaddressed Aspect in Cancer Patients.

Tumor-derived cachectic factors such as proinflammatory cytokines and neuromodulators not only affect skeletal muscle but also affect other organs, including the heart, in the form of cardiac muscle atrophy, fibrosis, and eventual cardiac dysfunction, resulting in poor quality of life and reduced survival. This article reviews the holistic approaches of existing diagnostic, pathophysiological, and multimodal therapeutic interventions targeting the molecular mechanisms that are responsible for cancer-induced cardiac cachexia. The major drivers of cardiac muscle wasting in cancer patients are au

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… Protein synthesis is affected by the down regulation of insulin-like growth factor 1 (IGF1) and myogenin expression. The IGF1-mediated activation of Akt/mTOR inhibits proteolysis. …

Резюме научных материалов, представленных ГКОМ 2019 : Берлин, Германия. 27 - 30 Март 2019

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… Terminal myogenic differentiation was evaluated by myogenin expression, an essential transcription factor of myogenic differentiation. Cell fusion was quantified as the number of nuclei incorporated into myotubes. …

Семья гистона деацетилазы в здравии и болезни.

Классические деацетилазы, включая классы I, II и IV, в зависимости от цинка, повсеместно присутствуют у млекопитающих и играют жизненно важную роль в многочисленных биологических процессах. На сегодняшний день eleven Были выявлены члены < < хисттон деацетилаза > > , а именно < < хиттон деацетилаза > > . 1 через гистонную деацетилазу 11. Растущий объем данных подчеркивает важнейшую роль этих гистоновых деацетилазов как в физиологических, так и патологических условиях. В частности, эти гистонные деацетилазы участвуют в различных клеточных процессах, включая воспаление, ме

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… Activated muscle-specific biomarkers myogenin/Cav3, causing potent differentiation into myotubes. (PMID:38060537) | In vitro | Preclinical | 1. 0.5 μM, 1.0 μM, 2.0 μM, 4.0 μM (PMID:38060537) A452 | HDAC6 | 1. …

Crosstalk of the Wnt/β-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells.

The Wnt/β-catenin signaling pathway plays a major role in cell survival and proliferation, as well as in angiogenesis, migration, invasion, metastasis, and stem cell renewal in various cancer types. However, the modulation (either up- or downregulation) of this pathway can inhibit cell proliferation and apoptosis both through β-catenin-dependent and independent mechanisms, and by crosstalk with other signaling pathways in a wide range of malignant tumors. Existing studies have reported conflicting results, indicating that the Wnt signaling can have both oncogenic and tumor-suppressing roles, d

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… Additionally, treating human alveolar rhabdomyosarcoma ARMS cell lines with WNT 3A induced the stabilization of β-catenin and its nuclear location and activation, leading to a marked decrease in proliferation levels and in the induction of the myogenic differentiation markers myf5, myogenin, and MyoD …

34th Европейский конгресс патологии - резюме.

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BREAST

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… Tumor cells were focally positive for desmin and ALK (diffuse cytoplasmic staining) while negative for CK, SALL4, MUC4, SMA, CD30, CD45, CD3, CD20, SOX10, SMMHC, CD21, CD35, cathepsin K, myogenin, ERG, MPO, DOG1 and ROS1. BRG and INI1 expression was retained. …

Обязательный экзамен по патологии: лишний или необходимый?

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33rd Европейский конгресс патологии - резюме.

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Резюме: 32 Второй Конгресс ЭСП и Международный конгресс XXXIII МПД.

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Резюме: 31 Европейский конгресс патологии.

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Устные бесплатные бумажные сессии.

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42nd International Symposium on Intensive Care & Emergency Medicine

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Резюме ЭСП 2013.

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Резюме

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ISEV2025 Резюме книги.

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