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The causal relationship between multiple cardiovascular diseases and glioblastoma: A Mendelian randomization study.

Observational studies suggest an association between glioblastoma (GBM) and cardiovascular diseases (CVDs), but a causal relationship remains unestablished. This study aimed to investigate the causal link between multiple CVDs and GBM risk. The inverse variance weighted method indicated that all 18 CVDs had significant causal associations with GBM (P < .05). Genetically predicted CVDs were uniformly associated with a lower risk of GBM (odds ratio < 1), identifying them as potential protective factors. Sensitivity analyses confirmed the absence of significant heterogeneity or horizontal pleiotr

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… Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism. Blood. 2017;129:1831–9. [17] Sol N, In ‘t Veld S, Vancura A, et al. Tumor-educated platelet RNA for the detection and (pseudo)progression monitoring of glioblastoma. …

Molecular Impact of the Tumor Microenvironment on Multiple Myeloma Dissemination and Extramedullary Disease.

Multiple myeloma (MM) is the most common malignant monoclonal disease of plasma cells. Aside from classical chemotherapy and glucocorticoids, proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are used in the current treatment scheme of MM. The tumor microenvironment (TME) plays a fundamental role in the development and progression of numerous solid and non-solid cancer entities. In MM, the survival and expansion of malignant plasma cell clones heavily depends on various direct and indirect signaling pathways provided by the surrounding bone marrow (BM) niche. In a number

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… The Impact of Aggrus/podoplanin on Platelet Aggregation and Tumour Metastasis. J Biochem (2012) 152(5):407–13. doi: 10.1093/jb/mvs108 40. Labelle M, Begum S, Hynes RO. Platelets Guide the Formation of Early Metastatic Niches. …

Galectins in the Pathogenesis of Common Retinal Disease.

Diseases of the retina are major causes of visual impairment and blindness in developed countries and, due to an ageing population, their prevalence is continually rising. The lack of effective therapies and the limitations of those currently in use highlight the importance of continued research into the pathogenesis of these diseases. Vascular endothelial growth factor (VEGF) plays a major role in driving vascular dysfunction in retinal disease and has therefore become a key therapeutic target. Recent evidence also points to a potentially similarly important role of galectins, a family of β-g

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… Gal-8 has also been shown to act specifically on human lymphatic endothelial cells and promotes lymphangiogenesis in a pathway involving integrin VEGF-C and podoplanin ( Chen et al., 2016 ). Neovessels formed by pathological angiogenesis are frequently leakier than their healthy equivalents. … Pathological Lymphangiogenesis Is Modulated by Galectin-8-dependent Crosstalk between Podoplanin and Integrin-Associated VEGFR-3. Nat. Commun. 7, 11302. 10.1038/ncomms11302 Cheng Y.-L., Wu Y.-W., Kuo C.-F., Lu S.-L., Liu F.-T., Anderson R., et al. (2017). …

CXCL13 как биомаркер: фон и полезность в многоразовом склерозе.

CXCL13 — хемокин, регулируемый в рамках CNS в множестве склерозов, нейроборлиозе Лайма и других подстрекательских болезнях, который все чаще используется в качестве биомаркера. Этот обзор служит основой для понимания его функций в иммунной системе и его связи с эктическими лимфоидными фолликулами. Кроме того, был рассмотрен вопрос о его полезности в случае множественного склероза и нейроборлиоза Лайма, а также потенциальные проблемы в его измерении. CXCL13 может быть исключительно полезным биомаркером для целого ряда подстрекательских заболеваний.

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… Peferoen et al. [ 43 ] found prominent B-cell infiltrates but did not identify B-cell follicles as defined by the presence of CXCL13 or podoplanin. Torkildsen et al. [ 44 ] found B cells in the meninges but no follicle-like structures. …

Current Trends and Future Prospects of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma.

In recent years, advances in drug therapy for head and neck squamous cell carcinoma (HNSCC) have progressed rapidly. In addition to cytotoxic anti-cancer agents such as platinum-based drug (cisplatin and carboplatin) and taxane-based drugs (docetaxel and paclitaxel), epidermal growth factor receptor-tyrosine kinase inhibitors (cetuximab) and immune checkpoint inhibitors such as anti-programmed cell death-1 (PD-1) antibodies (nivolumab and pembrolizumab) have come to be used. The importance of anti-cancer drug therapy is increasing year by year. Therefore, we summarize clinical trials of molecu

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… Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin. Cells. 2020;9:1019. doi: 10.3390/cells9041019. 64. Kobayashi H. Near infrared photoimmunotherapy for cancer. Jpn. J. Chemother. Gan To Kagaku Ryoho. 2019;46:28–33. 65. …

Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer.

BACKGROUND: International guidelines suggest prophylactic anticoagulation for patients with cancer at high risk of venous thromboembolism (VTE). Here, we evaluated whether tumor whole-genome sequencing data may improve the selection of high-risk patients. METHODS: In a pan-cancer cohort of 3087 patients, associations of candidate clinical predictors, the germline extended 297-single nucleotide polymorphism polygenic risk score, tumor mutational characteristics, and somatic tumor mutations with VTE were estimated by calculating hazard ratios (HRs). RESULTS: During 12-month follow-up, 237 (7.7

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… Two previous studies showed that CDKN2A mutations are related to VTE in cancer patients, possibly due to a positive effect on the expression of the prothrombotic proteins podoplanin and tissue factor. 18 , 44 The ELANE gene is known to be associated with VTE via neutrophil extracellular traps, which …

Tumor buster - where will the CAR-T cell therapy 'missile' go?

Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing technology represents a significant breakthrough in personalized immunotherapy for human cancer. This strategy uses genetic modification to enable T cells to target tumor-specific antigens, attack specific cancer cells, and bypass tumor cell apoptosis avoidance mechanisms to some extent. This method has been extensively used to treat hematologic diseases, but the therapeutic effect in solid tumors is not ideal. Tumor antigen escape, treatment-related toxicity, and the immunosuppressive tumor microenvironment (TME

CAR T cells: engineered immune cells to treat brain cancers and beyond.

Malignant brain tumors rank among the most challenging type of malignancies to manage. The current treatment protocol commonly entails surgery followed by radiotherapy and/or chemotherapy, however, the median patient survival rate is poor. Recent developments in immunotherapy for a variety of tumor types spark optimism that immunological strategies may help patients with brain cancer. Chimeric antigen receptor (CAR) T cells exploit the tumor-targeting specificity of antibodies or receptor ligands to direct the cytolytic capacity of T cells. Several molecules have been discovered as potential t

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… A combination of anti-podoplanin CAR T cells with oncolytic herpes virus G47D successfully reduced ‘on-target off tumor’ toxicity acting against patient-derived glioma stem cells while sparing normal cells [ 188 ]. …

Oncolytic Virus Therapy in a New Era of Immunotherapy, Enhanced by Combination with Existing Anticancer Therapies: Turn up the Heat!

Oncolytic viral therapy is a promising treatment for cancer, where 'cold' tumour cells can become 'hot' to the host immune system. However, with few FDA approved therapies, development of new strategies for more cancer types has been slow and relatively unsuccessful in recent years, Combination therapy has been successful for other types of cancer treatment, therefore, may be a viable alternative to improve the efficacy of oncolytic viral therapy which may reduce some of the adverse events of currently used monotherapies, oncolytic virus therapy and chemotherapy being mutually complimentary wi

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… Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma. Mol Ther Oncolytics. 2022;26:265–74. doi: 10.1016/j.omto.2022.07.006. 58. Astellas Pharma Global Development Inc. …

Nuances in the treatment of malignant tumors of the clival and petroclival region.

Introduction Malignancies of the clivus and petroclival region are mainly chordomas and chondrosarcomas. Although a spectrum of malignancies may present in this area, a finite group of commonly encountered malignant pathologies will be the focus of this review, as they are recognized to be formidable pathologies due to adjacent critical neurovascular structures and challenging surgical approaches. Objectives The objective is to review the literature regarding medical and surgical management of malignant tumors of the clival and petroclival region with a focus on clinical presentation, diagnost

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… implications Cancer 1993 72 10 2943 2949 7693324 10.1002/1097-0142(19931115)72:10<2943::aid-cncr2820721014>3.0.co;2-6 21 Abenoza P Sibley R K Chordoma: an immunohistologic study Hum Pathol 1986 17 7 744 747 2424820 10.1016/s0046-8177(86)80185-x 22 Oakley G J Fuhrer K Seethala R R Brachyury, SOX-9, and podoplanin …

Резюме ЭСП 2013.

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Update on Occupational Cancer for Better Cancer Prevention and Control.

Occupational cancer remains an ongoing and emerging issue in cancer prevention and control and is more easily preventable in practice than other causes. As of 2024, changes in various aspects, such as methods for estimating the burden of cancer, evidence on novel carcinogens and classification systems, modernization of working conditions, job characteristics, occupational exposure, and societal changes have played a significant role. Furthermore, advances in technology, including wearable devices, exposome, and biomedical technology, offer more precise methods for identifying the associations

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… For instance, commonly used markers that differentiate between pleural mesothelioma and lung adenocarcinoma include markers positive for mesothelioma, such as WT1, calretinin, D2-40 (podoplanin), and cytokeratin 5/6, whereas markers positive for lung adenocarcinoma include MOC-31, BG8, CEA, B72.3, Ber-EP4 …

Association Between Interleukin-6 and Head and Neck Squamous Cell Carcinoma: A Systematic Review.

Interleukin-6 (IL-6) is a proinflammatory cytokine which plays an important role in several regulatory mechanisms of cancer. Moreover, experimental and clinical studies have reported that IL-6 targeted therapies might provide significant benefits for cancer treatment. The purpose of this systematic review is to evaluate IL-6 activity in patients with head and neck squamous cell carcinoma (HNSCC). A systematic review of the association between serum, saliva and tumor IL-6 and HNSCC was developed on PubMed/Medline in the publication range from January 1995 to January 2019. Our literature analysi

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… ME IL-6 Inhibition with MEDI5117 decreases the fraction of head and neck cancer stem cells and prevents tumor recurrence Neoplasia 2016 5 18 5 273 81 27237319 10.1016/j.neo.2016.03.004 PMC4887598 106 Hwang YS Ahn SY Moon S Zheng Z Cha IH Kim J Insulinlike growth factor-II mRNA binding protein-3 and podoplanin …

Development and validation of a novel modified cancer cachexia index in patients with locally advanced gastric cancer undergoing neoadjuvant chemotherapy: a multicenter cohort study.

BACKGROUND: Although the cachexia index (CXI) is a well-established prognostic predictor in gastric cancer (GC) patients, its effectiveness in patients with locally advanced gastric cancer (LAGC) who have undergone neoadjuvant chemotherapy (NACT) remains unclear. METHODS: This multicenter study included 600 LAGC patients treated with NACT from January 2010 to June 2022. A modified CXI was constructed based on Random Forest model, calculated as (post-NACT subcutaneous adipose tissue area at L3) × (post-NACT serum albumin)/(post-NACT platelet count) . Patients were categorized into mCXI-low and

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… Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin . Blood 2019 ; 134 : 1912 – 18 . 31778548 10.1182/blood.2019001388 [27] Liang XW Wen J Liu B Wang SZ Wu JC Pan T . …

Cardiogenic shock among cancer patients.

Sophisticated cancer treatments, cardiovascular risk factors, and aging trigger acute cardiovascular diseases in an increasing number of cancer patients. Among acute cardiovascular diseases, cancer treatment, as well as the cancer disease itself, may induce a cardiogenic shock. Although increasing, these cardiogenic shocks are still relatively limited, and their management is a matter of debate in cancer patients. Etiologies that cause cardiogenic shock are slightly different from those of non-cancer patients, and management has some specific features always requiring a multidisciplinary appro

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… In addition to the usual risk factors, the hypercoagulable state of cancer is driven by activation of the coagulation cascade and platelet aggregation caused by tumor expression of procoagulant proteins released into the circulation such as tissue factor, plasminogen activator inhibitor-1, and podoplanin …

The Deadly Duo of COVID-19 and Cancer!

As of September 19, 2020, about 30 million people have been infected with the novel corona virus disease 2019 (COVID-19) globally, and the numbers are increasing at an alarming rate. The disease has a tremendous impact on every aspect of life, but one of the biggest, related to human health and medical sciences, is its effect on cancer. Nearly 2% of the total COVID-19 patients prior to May 2020 had cancer, and the statistics are quite frightening as the patient can be referred to as "doubly unfortunate" to suffer from cancer with the added misery of infection with COVID-19. Data regarding the

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… Tumoral factors such as tissue factor (TF), podoplanin, plasminogen activator factor (PAI-1), cytokines, NET, and mucins trigger the risk for thrombosis ( Thålin et al., 2019 ). …

The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances.

Platelet dysfunction plays a critical role in the pathogenesis of various disorders affecting the hemostatic-coagulant system. This review aims to explore the mechanisms by which platelet dysfunctions contribute to the disruption of hemostasis, leading to an increased risk of both thrombosis and bleeding. Platelets, traditionally known for their role in clot formation, can exhibit altered functionality under pathological conditions such as cardiovascular diseases, metabolic disorders, and autoimmune diseases, impacting their interaction with coagulation factors and vascular endothelium. The re

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… Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2 PLoS ONE 2013 8 e73609 10.1371/journal.pone.0073609 23991201 PMC3749157 13. Godfrey A.L. Green A.C. Harrison C.N. …

Targeting the Kynurenine Pathway: A Novel Approach in Tumor Therapy.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… PDPN + CAFs (podoplanin-positive CAFs) promote resistance of HER2 -positive breast cancer to trastuzumab by secreting immunosuppressive factors IDO1 and TDO2 (Ref. 132 ). …

&quot; Interleukin-27 &quot; и &quot; Аутоиммунные расстройства: компрессивный обзор иммунных функций &quot; .

Аутоиммунные расстройства (АД) создают значительное бремя для здоровья и экономики во всем мире, характеризующееся ошибочной атакой иммунной системы организма на его собственные ткани. Хотя конкретные механизмы, лежащие в основе их развития, по-прежнему остаются неясными, речь идет о сочетании генетической предрасположенности (генетических предрасположений) и экологических факторов. Interleukin-27 (IL-27), среди многочисленных участвующих цитокинов, стал ключевым регулятором, выполняющим двойную роль в иммунной модуляции. Этот обзор погружается в молекулярную структуру и механизмы сигнализации

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… Th17 cells and T follicular helper (TFH) cells that express podoplanin are necessary for the development of these lymphoid aggregates. Ectopic lymphoid structures substantially increase in quantity and severity in experimental arthritis in the absence of IL-27 [ 73 ]. …

Recent advances in biomimetic nanodelivery systems for cancer Immunotherapy.

Tumor immunotherapy is a developing and promising therapeutic method. However, the mechanism of tumor immune microenvironment and individual differences of patients make the clinical application of immunotherapy still very limited. The resulting targeting of the tumor environment and immune system is a suitable strategy for tumor therapy. Biomimetic nanodelivery systems (BNDS) coated with nanoparticles has brought new hope for tumor immunotherapy. Due to its high targeting, maximum drug delivery efficiency and immune escape, BNDS has become one of the options for tumor immunotherapy in the fut

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… Platelets act as targeted anti-tumor agents under the action of a variety of surface receptors and glycoproteins, such as podoplanin, GPPIb-IX-V complex, GPVI, and integrin αIIbβ3. The platelet-derived membrane still retains its original adhesion function [ [133] , [134] , [135] ]. …