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Customer-centric product presentations for monoclonal antibodies.

Delivering customer-centric product presentations for biotherapeutics, such as monoclonal antibodies (mAbs), represents a long-standing and … -centric concepts are introduced to highlight relevant market differences and similarities. Namely, rheumatoid arthritis and inflammatory bowel disease, multiple sclerosis, and oncology have been chosen due to differences in the availability of subcutaneously dosed and ready-to-use self-administration products for mAb medicines and their follow-on biolo …

Stem Cells as Potential Candidates for Psoriasis Cell-Replacement Therapy.

Recent years have seen considerable progress in explaining the mechanisms of the pathogenesis of psoriasis, with a significant role played in it by the hyper-reactivity of Th1 and Th17 cells, Treg function disorder, as well as complex relationships between immune cells, keratinocytes, and vascular endothelium. The effect of stem cells in the epidermis and stem cells on T cells has been identified and the dysfunction of various types of stem cells may be a prime cause of dysregulation of the inflammatory response in psoriasis. However, exploring these mechanisms in detail could provide a chance

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… Rheum. Dis. 2006;65:697. doi: 10.1136/ard.2005.039479. 44. Zhang K., Hou R., Niu X., Zhang J., Yin G., Li X., Jia Y. … Arthritis Rheum. 2011;63:1668–1680. doi: 10.1002/art.30326. 90. Sharma M.D., Hou D.Y., Liu Y., Koni P., Metz R., Chandler P., Mellor A.L., He Y., Munn D.H. Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes. …

DKK-1 in prostate cancer diagnosis and follow up.

BackgroundDickoppf-1 (DKK-1) is a negative regulator of bone formation with tumorigenic potential. The up-regulation of DKK-1 is an early event in prostate cancer (PCa) development, thus we investigated its role as a marker in the diagnosis and prognosis of PCa.MethodsWe retrospectively enrolled 159 patients who underwent prostate biopsy, either for elevated PSA or suspect digital rectal examination, between 2003 and 2010. During the biopsy, one serum sample was collected from all patients; PSA and DKK-1 were measured by ELISA technique. Amongst the biopsy of 159 patients 75 were affected by P

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… Semin Arthritis Rheum 2011 41 2 170 177 10.1016/j.semarthrit.2011.01.006 21435697 Thudi NK Martin CK Murahari S Shu ST Lanigan LG Werbeck JL Keller ET McCauley LK Pinzone JJ Rosol TJ Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone …

Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1.

Immunomodulatory drugs and monoclonal antibody-based immunotherapies have significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent years. These new classes of reagents target malignant plasma cells (PCs) and further modulate the immune microenvironment, which prolongs anti-MM responses and may prevent tumor occurrence. Since MM remains an incurable cancer for most patients, there continues to be a need to identify new tumor target molecules and investigate alternative cellular approaches using gene therapeutic strategies and novel treatment mechanisms. Oste

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… Arthritis Rheum ( 2010 ) 62 ( 8 ): 2328 – 38 . 10.1002/art.27535 20506516 125 Kim YG Lee CK Nah SS Mun SH Yoo B Moon HB . Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells . … Ann Rheum Dis ( 2008 ) 67 ( 11 ): 1603 – 9 . 10.1136/ard.2007.080713 18203760 127 Zaiss MM Axmann R Zwerina J Polzer K Guckel E Skapenko A Treg cells suppress osteoclast formation: a new link between the immune system and bone . …

Bispecific and multispecific T-cell engagers: advancing the future of immunotherapy.

T-cell engagers (TCEs) represent an emerging class of immunotherapies that harness T cells' cytotoxic power to eliminate diseased cells-a transformative future therapeutic strategy. TCEs form immunological synapses to trigger potent immune responses, with proven efficacy in blood cancers; research expands their use to solid tumors via innovative molecular design and improved safety profiles. Beyond oncology, TCEs hold promise in autoimmune disorders by eliminating autoreactive cells, offering novel avenues for diseases like lupus. However, achieving optimal outcomes without disrupting immune h

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… Ann Rheum Dis 2025;84:1510–1. 74. Huang Y, Zhang X, Zhao C. et al. Pos0998 Cc312, a Cd19-targeting, co-stimulatory Cd28 receptor-activating tri-specific T cell engager, for the treatment of autoimmune diseases. Ann Rheum Dis 2025;84:1111–2. 75. Zhang J, Zhou Z. …

Skeletal stem cells, a new direction for the treatment of bone and joint diseases.

Skeletal stem cells (SSCs) are tissue-specific stem cells characterized by their capacity for self-renewal and their position at the apex of the differentiation hierarchy. They can generate mature bone cell types essential for bone development, maintenance, and repair. Lineage tracing experiments have demonstrated that SSCs reside in the bone marrow, periosteum, and the resting zone of the growth plate. These findings not only enhance our understanding of bone growth and development mechanisms but also offer novel therapeutic strategies for conditions such as epiphyseal injuries, fractures, os

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… Ann Rheum Dis. 2006;65:1261–1264. doi: 10.1136/ard.2006.058347. 91. Felson DT. Clinical practice. Osteoarthritis of the knee. N Engl J Med. 2006;354:841–848. doi: 10.1056/NEJMcp051726. 92. Makris EA, Gomoll AH, Malizos KN, Hu JC, Athanasiou KA. … Arthritis Rheum. 2012;64:3302–3312. doi: 10.1002/art.34535. 95. Zhang FX, Dou Y, Zhang B, Zhang Z, Du MZ, Chien MH, Du JK, Ai LY, Chen R, Jiang D. Skeletal Stem Cell-Derived Exosomes Promote Meniscal Tear Healing and Ameliorate Secondary Osteoarthritis. …

A bibliometric research based on hotspots and frontier trends of denosumab.

Denosumab is a monoclonal antibody that targets and inhibits the osteoclast activating factor receptor activator for nuclear factor-κB ligand (RANKL). It has been widely used in the treatment of osteoporosis, giant cell tumors of bone, and in the prevention of malignant skeletal-related events (SREs). We collected the research results and related MeSH terms of denosumab from 2011 to 2021 through the Web of Science and PubMed, respectively. The literature was visualized and analyzed by CiteSpace and bibliometric online analysis platforms. The MeSH terms were biclustered using the Bibliographic

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… | 904 | 12 | 91.2/(Q1) | 0.32 | Circulation 3 | OSTEOPOROSIS INT | 816 | 145 | 4.507/(Q2) | 0.32 | CELL MOL LIFE SCI 4 | BONE | 756 | 81 | 4.398/(Q1) | 0.29 | EUR UROL 5 | J CLIN ENDOCRINOL METAB | 680 | 78 | 5.958/(Q1) | 0.23 | AM J CLIN NUTR 6 | Lancet | 594 | 14 | 79.321/(Q1) | 0.22 | ARTHRITIS RHEUM-ARTH … Arthritis Rheum. 60 , 3346 – 3355 . 10.1002/art.24879 19877063 Samelson E. J. Miller P. D. Christiansen C. Daizadeh N. S. Grazette L. Anthony M. S. ( 2014 ). …

Osteoporosis case ascertainment strategies in European and Asian countries: a comparative review.

While many clinical guidelines recommend screening for osteoporosis for early detection and treatment, there is great diversity in the case-finding strategies globally. We sought to compare case-finding strategies, focusing on the approaches used in European and Asian countries. This article provides an overview of the current case-finding strategies in the UK, Germany (including Austria and German-speaking regions of Switzerland), China, Japan, and Korea. We conducted a review of current treatment guidelines in each country and included expert opinions from key opinion leaders. Most countries

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… R Zamani O Lee SJ Kim HU Park W Müller-Ladner U A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: the PLANETRA study Ann Rheum … JAP Herrera A Hoffmeyer P Kvien T Maalouf G Marsh D Puget J Puhl W Poor G Rasch L Roux C Schüler S Seriolo B Tarantino U van Geel T Woolf A Wyers C Geusens P EULAR/EFORT recommendations for management of patients older than 50 years with a fragility fracture and prevention of subsequent fractures Ann Rheum …

Evidence for the use of intravenous immunoglobulins--a review of the literature.

Intravenous immunoglobulins (IVIg) were first introduced in the middle of the twentieth century for the treatment of primary immunodeficiencies. In 1981, Paul Imbach noticed an improvement of immune-mediated thrombocytopenia, in patients receiving IVIg for immunodeficiencies. This opened a new era for the treatment of autoimmune conditions with IVIg. Since then, IVIg has become an important treatment option in a wide spectrum of diseases, including autoimmune and acute inflammatory conditions, most of them off-label (not included in the US Food and Drug Administration recommendation). A panel

Informed appropriate imaging for low back pain management: A narrative review.

Most patients with acute low back pain (LBP), with or without radiculopathy, have substantial improvements in pain and function in the first 4 weeks, and they do not require routine imaging. Imaging is considered in those patients who have had up to 6 weeks of medical management and physical therapy that resulted in little or no improvement in their LBP. It is also considered for those patients presenting with suspicion for serious underlying conditions, such as cauda equina syndrome, malignancy, fracture and infection. In western country primary care settings, the prevalence has been suggeste

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… Arthritis Rheum. 2009;60:3072–3080. doi: 10.1002/art.24853. 30. Downie A., Williams C.M., Henschke N. Red flags to screen for malignancy and fracture in patients with low back pain: systematic review. BMJ. 2013;347:f7095. doi: 10.1136/bmj.f7095. 31. Underwood M., Buchbinder R. … Semin Arthritis Rheum. 2015;44(5):571–585. doi: 10.1016/j.semarthrit.2014.10.006. 61. Wang Y.X. Postmenopausal Chinese women show accelerated lumbar disc degeneration compared with Chinese men. J Orthop Transl. 2015;3:205–211. doi: 10.1016/j.jot.2015.09.001. 62. …

Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management.

Bisphosphonates (BPs) are widely used in the treatment of postmenopausal osteoporosis and other metabolic bone diseases. They bind strongly to bone matrix and reduce bone loss through inhibition of osteoclast activity. They are classified as nitrogen- and non-nitrogen-containing bisphosphonates (NBPs and NNBPs, respectively). The former inhibit farnesyl diphosphate synthase while the latter induce the production of toxic analogs of adenosine triphosphate. These mechanisms of action are associated with different antifracture efficacy, and NBPs show the most powerful action. Moreover, recent evi

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… Dalle Carbonare L Valenti MT Zanatta M Donatelli L Lo Cascio V Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis Arthritis Rheum 2009 60 11 3356 3365 19877060 10.1002/art.24884 39. … Reginster JY Adami S Lakatos P Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: Two year results from the MOBILE study Ann Rheum Dis 2006 65 5 654 661 16339289 10.1136/ard.2005.044958 PMC1798147 43. …

Association between advanced lung cancer inflammation index and acute gouty arthritis in Dalian, China: a cross-sectional study.

IntroductionAcute gouty arthritis (AGA) is an inflammatory joint disease. The advanced lung cancer inflammation index (ALI) evaluates inflammation. This study investigates the association between ALI and AGA.MethodsWe included 652 participants in this cohort study, dividing them into two groups: those with AGA and a control group without AGA. We employed logistic regression to examine the ALI-AGA relationship, using restricted cubic splines (RCS) to assess dose-response relationships, performing subgroup analyses, and conducting interaction tests. K-fold cross-validation was applied for model

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… Semin Arthritis Rheum . ( 2020 ) 50 : S11 – 6 . doi: 10.1016/j.semarthrit.2020.04.008 , PMID: 32620196 2. Weaver JS Vina ER Munk PL Klauser AS Elifritz JM Taljanovic MS . Gouty Arthropathy: review of clinical manifestations and treatment, with emphasis on imaging . … Ann Rheum Dis . ( 2019 ) 78 : 1592 – 600 . doi: 10.1136/annrheumdis-2019-215933 , PMID: 31501138 PMC7288724 5. Guo J Sun D Xu X Liu P Sun H . Relief effects of Laoshan cherry extracts as a dietary supplement against the symptoms of acute gouty arthritis in rats induced by urate crystals . …

Genetically predicted immune cells and metabolites mediate the causal relationship between inflammatory factors and rheumatoid arthritis.

This study investigates the causal relationship between inflammatory factors and rheumatoid arthritis (RA) and potential immune cells and metabolites mediator using Mendelian randomization. A bidirectional Mendelian randomization study was conducted using statistics from a genome-wide association study database to explore the causal relationship between inflammatory factors and RA, combined with mediation analysis, to discover potential immune cells and metabolites with mediating effects, and to estimate the proportion of total effects mediated by each immune cell and metabolite. The level of …

Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia.

INTRODUCTION: Non-cystic fibrosis bronchiectasis is a complex medical condition with multiple etiologies, characterized by chronic productive cough and radiologic evidence of airway lumen dilation and wall thickening. Associated exacerbations and declining lung function contribute to increasing disability and mortality. There are no data about the prevalence of non-cystic fibrosis bronchiectasis etiologies in the Colombian population. OBJECTIVE: To investigate non-cystic fibrosis bronchiectasis etiology and clinical characteristics in adults evaluated in the southwest of Colombia. MATERIALS

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… Semin Arthritis Rheum. 2018;48:70–76. doi: 10.1016/j.semarthrit.2017.12.002. 33. Martin LW, Prisco LC, Huang W, McDermott G, Shadick NA, Doyle TJ, et al. Prevalence and risk factors of bronchiectasis in rheumatoid arthritis: A systematic review and meta-analysis. … Semin Arthritis Rheum. 2021;51:1067–1080. doi: 10.1016/j.semarthrit.2021.08.005. 34. Chalmers JD, Polverino E, Crichton ML, Ringshausen FC, De Soyza A, Vendrell M, et al. …

Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists.

Amyloidosis is a localized or systemic disease caused by deposition of proteins in the extracellular space of various organs and tissues. As … system (sensorimotor polyneuropathy and autonomic dysfunction). This condition is important to the rheumatologist for several reasons, such as its systemic involvement that mimics autoimmune rheumatic diseases, its musculoskeletal manifestations, which when recognized can allow the diagnosis of amyloidosis, and also because reactive or secondary AA amy …

Dual-energy CT virtual non-calcium: an accurate method for detection of knee osteoarthritis-related edema-like marrow signal intensity.

ObjectivesTo evaluate the performance of a dual-energy computed tomography (DECT) virtual non-calcium (VNCa) technique in the detection of edema-like marrow signal intensity (ELMSI) in patients with knee joint osteoarthritis (OA) compared to magnetic resonance imaging (MRI).MethodsThe study received local ethics board approval, and written informed consent was obtained. DECT and MRI were used to examine 28 knees in 24 patients with OA. VNCa images were generated by dual-energy subtraction of calcium. The knee joint was divided into 15 regions for ELMSI grading, performed independently by two m

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… Hunter DJ Zhang Y Niu J Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis Arthritis Rheum 2006 54 1529 1535 10.1002/art.21789 16646037 3. … Ann Rheum Dis 2016 75 390 395 10.1136/annrheumdis-2014-205894 25488799 PMC4916836 15. Geurts J Patel A Hirschmann MT Elevated marrow inflammatory cells and osteoclasts in subchondral osteosclerosis in human knee osteoarthritis J Orthop Res 2016 34 262 269 10.1002/jor.23009 26250062 16. …

Chimeric antigen receptor T cell therapy for the treatment of systemic rheumatic diseases: a comprehensive review of recent literature.

Systemic rheumatoid diseases (SRDs) are autoimmune and inflammatory disorders that affect multiple organ systems, impacting patients' quality of life, and survival rates. Standard treatment requires continuous drug therapy and immunosuppression. Chimeric antigen receptor (CAR) T cell therapy has the potential to target and eliminate pathologically activated immune cells and re-establish tolerance in organs affected by dysregulated immunity, making them a promising treatment option for autoimmune diseases. In autoimmune diseases, CAR T cells have the advantage of being able to kill B cells effe…

The Schnitzler syndrome.

The Schnitzler syndrome is a rare and underdiagnosed entity which is considered today as being a paradigm of an acquired/late onset auto-inflammatory disease. It associates a chronic urticarial skin rash, corresponding from the clinico-pathological viewpoint to a neutrophilic urticarial dermatosis, a monoclonal IgM component and at least 2 of the following signs: fever, joint and/or bone pain, enlarged lymph nodes, spleen and/or liver, increased ESR, increased neutrophil count, abnormal bone imaging findings. It is a chronic disease with only one known case of spontaneous remission. Except of

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… Semin Arthritis Rheum. 2007;37(3):137–48. doi: 10.1016/j.semarthrit.2007.04.001. Schnitzler L. Lésions urticariennes chroniques permanentes (érythème pétaloïde ?) Cas cliniques, n° 46 B. Journée Dermatologique d'Angers. 1972. Schnitzler L, Schubert B, Boasson M, Gardais J, Tourmen A. … Arthritis Rheum. 2005;52(7):2226–7. doi: 10.1002/art.21101. Cascavilla N, Bisceglia M, D'Arena G. Successful treatment of Schnitzler's syndrome with anakinra after failure of rituximab trial. Int J Immunopathol Pharmacol. 2010;23(2):633–6. doi: 10.1177/039463201002300226. …

Successful treatment of ulcerated pyoderma gangrenosum with baricitinib, a novel JAK inhibitor.

Pyoderma gangrenosum manifests as an ulceration of the skin often associated with several systemic diseases. The diagnosis is usually made by exclusion criteria with suggestions made by clinical findings and histological features. It can occur any site but more common in the legs. Advances in translational medicine led to the development of new forms of therapy in chronic inflammatory diseases by the oral administration of Janus kinase inhibitors. We report two cases of chronic ulceration of the skin consistent with the diagnosis of Pyoderma Gangrenosum that went into complete remission after

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… Rheum. Dis. 2020 doi: 10.1136/annrheumdis-2020-217271. (epub ahead of print) 8. Ahn C., Negus D., Huang W. Pyoderma gangrenosum: a review of pathogenesis and treatment. Expet Rev. Clin. Immunol. 2018 Mar;14(3):225–233. doi: 10.1080/1744666X.2018.1438269. 9. …

Precision medicine: The use of tailored therapy in primary immunodeficiencies.

Primary immunodeficiencies (PID) are rare, complex diseases that can be characterised by a spectrum of phenotypes, from increased susceptibility to infections to autoimmunity, allergy, auto-inflammatory diseases and predisposition to malignancy. With the introduction of genetic testing in these patients and wider use of next-Generation sequencing techniques, a higher number of pathogenic genetic variants and conditions have been identified, allowing the development of new, targeted treatments in PID. The concept of precision medicine, that aims to tailor the medical interventions to each patie