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Эффективность транскраниального прямого тока (tDCS) на нейропсихиатрических Симптомах в множестве склерозов (MS) - обзор и понимание возможных механизмов действий.

Введение: Нейропсихиатрические симптомы, такие, как депрессия и беспокойство, являются значительным бременем для пациентов с множественным склерозом (МС). Их патофизиология сложна и еще не до конца понятна. Существует срочная потребность в неинвазивных методах лечения, которые непосредственно нацелены на мозг и помогают пациентам с склерозом. Одним из таких возможных способов лечения является транскраниальная стимуляция прямого тока (TDCS) - популярный и эффективный метод неинвазивной стимуляции мозга. Методы: В рамках этого механистического обзора изучается эффективность ТДСС в лечении депрес

Амиотропический латеральный склероз и лобовое дегенерация: сходства в генетическом фоне

Амиотрофический боковой склероз (ALS) — это разрушительное, равномерно смертоносное прогрессивное дегенеративное расстройство моторных нейронов, которое перекликается с клиническим, морфологическим и генетическим дегенерацией лобар (FTLD). Хотя известно, что многие различные мутации в различных генах вызывают амиотрофный боковой склероз, по-прежнему мало что известно о том, как они избирательно влияют на биологию моторных нейронов и сходятся ли они на общих путях, чтобы вызвать нейронное дегенерацию. Многие генные мутации содержатся в белках, которые имеют схожие функции. Их можно сгруппироват

Совпадение в полном тексте источника
… Besides riluzole, a second medication, edaravone, was approved by the FDA last year [ 224 ]. Whether it is beneficial to all ALS patients or just to subgroups needs to be evaluated over the next few years [ 2 ]. …

Nontraumatic Spinal Cord Injury: Epidemiology, Etiology and Management.

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing communication between the brain and the rest of the body, conveying complex sensory and motor information necessary for safety, movement, reflexes, and optimization of autonomic function. After a traumatic spinal cord injury (SCI), supraspinal influences on the peripheral nervous system and autonomic nervous system (ANS) are disrupted, leading to spastic paralysis, sympathetic blunting, and parasympathetic dominance, resulting in cardiac dysrhythmias, systemic hypotension, bronchoconstriction, copious re

Совпадение в полном тексте источника
… Riluzole improves 1-year survival by approximately 15% and improves overall survival by approximately 2 to 3 months. Management of ALS focuses on mobility assistance, respiratory care, and nutritional support. …

ИАНКОН 2023 Выдержки из плаката

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Совпадение в полном тексте источника
… Tablet Riluzole 50 mg BD was given simultaneously. … Discussion: Both Riluzole and IV Edaravone have been approved by many regulatory bodies for treatment of MND. Long term follow up data are scanty. From India no published data. Conclusion: The prognosis of ALS continues to remain poor despite the use of Riluzole and IV Edaravone regimen. …

Oral Presentations

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Mechanisms of Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically, CIPN is a mostly sensory neuropathy that may be accompanied by motor and autonomic changes of varying intensity and duration. Due to its high prevalence among cancer patients, CIPN constitutes a major problem for both cancer patients and survivors as well as for their health care providers, especially because, at the moment, there is no single effective method of preventing CIPN; moreover, the possibilities of treating t

Совпадение в полном тексте источника
… Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin. Neuropharmacology. 2018;140:43–61. doi: 10.1016/j.neuropharm.2018.07.026. 86. Thibault K., Calvino B., Dubacq S., Roualle-de-Rouville M., Sordoillet V., Rivals I., Pezet S. …

Physiological functions and pharmacological targeting of transient receptor potential channels.

Transient receptor potential (TRP) channels represent an extensive and diverse protein family fulfilling salient roles as versatile cellular sensors and effectors. The pivotal role of TRP and related ion channels in sensory processes has been well documented. Over the last few years, a new concept has emerged that TRP proteins control an exceptionally broad spectrum of homeostatic physiological functions such as maintenance of body temperature, blood pressure, transmitter release from neurons, mineral and energy homeostasis, and reproduction. This notion is further supported by more than 20 he

Совпадение в полном тексте источника
… Inhibition hTRPC5 IC 50 = 0.54 μ M | 302 Pico145 (85473438) | Inhibition hTRPC4 IC 50 = 0.35 nM; hTRPC5 IC 50 = 1.3 nM | 303 HC-070 (85473309) | Inhibition hTRPC4 and hTRPC5 IC 50 = 0.35–3.4 nM | 304 GFB-8438 (138471783) | Inhibition hTRPC5 IC 50 = 0.18 μ M; hTRPC4 IC 50 = 0.29 μ M | 305 Activators Riluzole … Activators of TRPC4/5 channels Riluzole, which is the only Food and Drug Administration (FDA)-approved drug to treat amyotrophic lateral sclerosis, activates TRPC5 with low potency (EC 50 = 9.2 μ M) but is, at least within the TRPC family, specific for TRPC5. 306 A screening approach by Beckmann et …

Устные доклады

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A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

Совпадение в полном тексте источника
… Safety and Efficacy of Nanocurcumin as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: a Pilot Randomized Clinical Trial. Neurotherapeutics 15 (2), 430–438. 10.1007/s13311-018-0606-7 Ahsan A., Farooq M. A. (2019). …

Географическая связь множественного склероза и амиотропического бокового склероза.

Амиотрофический боковой склероз (ALS) и множественный склероз (MS) являются разрушительными, неизлечимыми нейродегенеративными заболеваниями, которые в значительной степени считаются неизвестными этиологами. Хотя эти болезни имеют некоторые сходства, они, как правило, не считаются тесно связанными между собой. У них разные патологические маркеры и разные прогнозы. Кроме того, MS (но не ALS) считается аутоиммунным заболеванием. Кроме того, уже давно отмечается, что НР имеет мощный градиент север-юг в своем распределении, в то время как лишь недавно стало известно о таком градиенте в БАС. Вместе

Совпадение в полном тексте источника
… There is no known cure for ALS or treatment to reverse its damage; however, several medications—including Riluzole, Edaravone, and most recently Tofersen (Qalsody), an antisense oligonucleotide therapy targeting SOD1 mutations—are used to slow the progression of the disease. …

Peripheral Neuropathy under Oncologic Therapies: A Literature Review on Pathogenetic Mechanisms.

Peripheral neurologic complications are frequent adverse events during oncologic treatments and often lead to dose reduction, administration delays with time elongation of the therapeutic plan and, not least, worsening of patients' quality of life. Experience skills are required to recognize symptoms and clinical evidences and the collaboration between different health professionals, in particular oncologists and hospital pharmacists, grants a correct management of this undesirable occurrence. Some classes of drugs (platinates, vinca alkaloids, taxanes) typically develop this kind of side effe

Совпадение в полном тексте источника
… Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin Neuropharmacol. 2018 140 43 61 10.1016/j.neuropharm.2018.07.026 30056126 86. Descoeur J. Pereira V. Pizzoccaro A. Francois A. Ling B. Maffre V. Couette B. Busserolles J. …

Exploiting Nanomedicine for Cancer Polychemotherapy: Recent Advances and Clinical Applications.

The most important limitations of chemotherapeutic agents are severe side effects and the development of multi-drug resistance. Recently, the clinical successes achieved with immunotherapy have revolutionized the treatment of several advanced-stage malignancies, but most patients do not respond and many of them develop immune-related adverse events. Loading synergistic combinations of different anti-tumor drugs in nanocarriers may enhance their efficacy and reduce life-threatening toxicities. Thereafter, nanomedicines may synergize with pharmacological, immunological, and physical combined tre

Совпадение в полном тексте источника
… Albumin NPs loaded with two complementary drugs, riluzole, an inhibitory regulator of glutamate receptors, and curcumin, a phytochemical anticancer agent, were also decorated with collagenase [ 85 ]. …

Current Advancement of Immunomodulatory Drugs as Potential Pharmacotherapies for Autoimmunity Based Neurological Diseases.

Dramatic advancement has been made in recent decades to understand the basis of autoimmunity-mediated neurological diseases. These diseases create a strong influence on the central nervous system (CNS) and the peripheral nervous system (PNS), leading to various clinical manifestations and numerous symptoms. Multiple sclerosis (MS) is the most prevalent autoimmune neurological disease while NMO spectrum disorder (NMOSD) is less common. Furthermore, evidence supports the presence of autoimmune mechanisms contributing to the pathogenesis of amyotrophic lateral sclerosis (ALS), which is a neurodeg

Совпадение в полном тексте источника
… Riluzole is the only FDA-approved drug currently used for ALS to slow down the progression of the disease and enhance the survival rate. Currently, the major focus is to investigate the potential role of miRNAs in the etiology of ALS disease. …

Эгоистические нейрофармацевтики: открытие кровеносного барьера для лечения следующего поколения.

Блокирование мозга крови (ББД) представляет собой огромную проблему в нейрофармакологии, ограничивая доставку терапевтических агентов в мозг. Экзосомы, нанокарьеры природы, стали многообещающим решением из-за их биосовместимости, низкой иммуногенности и врожденной способности пересекать ББД. Тщательное изучение анатомии и физиологии ББД свидетельствует о сложности доставки неврологических наркотиков и подчеркивает ограниченность традиционных методов. В настоящем обзоре изучается потенциал нейрофармацевтики с экзосомной силой, при этом особое внимание уделяется их структурным и функциональным с

Совпадение в полном тексте источника
… For ALS, FDA-approved drugs such as riluzole and edaravone offer limited efficacy, only slightly prolonging survival and reducing oxidative stress, respectively. …

From HDAC to Voltage-Gated Ion Channels: What's Next? The Long Road of Antiepileptic Drugs Repositioning in Cancer.

Cancer is a major health burden worldwide. Although the plethora of molecular targets identified in the last decades and the deriving developed treatments, which significantly improved patients' outcome, the occurrence of resistance to therapies remains the major cause of relapse and mortality. Thus, efforts in identifying new markers to be exploited as molecular targets in cancer therapy are needed. This review will first give a glance on the diagnostic and therapeutic significance of histone deacetylase (HDAC) and voltage gated ion channels (VGICs) in cancer. Nevertheless, HDAC and VGICs hav

Совпадение в полном тексте источника
… Differential inhibition by riluzole, lamotrigine, and phenytoin of sodium and calcium currents in cortical neurons: Implications for neuroprotective strategies. Exp. Neurol. 1997;147:115–122. doi: 10.1006/exnr.1997.6554. 100. Xie X., Hagan R.M. …

ePoster.

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Кровавая добавка и болезни человека: обзор клинических испытаний.

Медицинальные свойства турмеров (Curcuma longa L.) — растения, использовавшегося на протяжении веков в качестве противовоспалительного средства, объясняются его полифеноловыми каркуминоидами, где преобладает кёркумин. Хотя «куркуминовые» добавки являются топ-продаваемыми ботаническими с перспективными доклиническими эффектами, остаются вопросы о биологической активности у человека. Для решения этой проблемы был проведен обзор аналитического исследования с целью оценки клинических испытаний человека, в ходе которых сообщалось о пероральном воздействии каркумина на результаты лечения. Eight :: п

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.

Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood. Early immune checkpoint inhibitors have delivered significant clinical benefit, but their efficacy and durability remain limited in many patients. These limitations have driven the exploration of next-generation immune checkpoints and additional regulatory pathways that shape tumor-immune interactions. Recent advances have broadened the immune checkpoint landscape and revealed new targets. These targets operate within inter

Совпадение в полном тексте источника
… alpha and beta receptor subunit 1 [IFNAR1] knockout) enhances anti‐PDCD1 efficacy in cutaneous squamous cell carcinoma [ 108 ]; 3) Inhibiting neurotransmitter signaling: Targeting glutamate pathways (e.g., glutamate metabotropic receptor 8 (GRM8) receptor inhibitor DCPG or glutamate release inhibitor Riluzole …

Role of Nanomedicine-Based Therapeutics in the Treatment of CNS Disorders.

Central nervous system disorders, especially neurodegenerative diseases, are a public health priority and demand a strong scientific response. Various therapy procedures have been used in the past, but their therapeutic value has been insufficient. The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier is two of the barriers that protect the central nervous system (CNS), but are the main barriers to medicine delivery into the CNS for treating CNS disorders, such as brain tumors, Parkinson's disease, Alzheimer's disease, and Huntington's disease. Nanotechnology-based medicinal

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients.

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. CIPN can greatly impair quality of life and increases morbidity of pediatric patients with cancer, with the accompanying symptoms frequently remaining underdiagnosed. Little is known about the incidence of CIPN, its impact on the pediatric population, and the underlying pathophysiological mecha