Результаты поиска

Биологические движущие силы инъекции периферальной Neurophy в Множестве миеломы.

Внедрение иммуноводных препаратов (ИМИД), таких, как талидомид, линалидомид и помалидомид, привело к значительному улучшению методов лечения миеломы (ММ). Многие пациенты в настоящее время живут 10 или более лет со своим заболеванием, в результате чего побочные эффекты, связанные с лечением, приобретают все большее значение. Периферальная нейропатия (PN) является общим побочным эффектом терапии IMID, которая оказывает существенное воздействие на качество жизни пациентов, и в настоящее время не имеется никаких профилактических или целевых терапевтических стратегий. В ходе этого обзора изучаются

Совпадение в полном тексте источника
… Argyriou , “ Vinca Alkaloids, Thalidomide and Eribulin‐Induced Peripheral Neurotoxicity: From Pathogenesis to Treatment ,” Journal of the Peripheral Nervous System 24 ( 2019 ): S63 – S73 , 10.1111/jns.12334 . 31647152 70 N. A. Duggett and S. J. L. …

Double Repositioning: Veterinary Antiparasitic to Human Anticancer.

Drug repositioning, the approach of discovering different uses for existing drugs, has gained enormous popularity in recent years in the anticancer drug discovery field due to the increasing demand for anticancer drugs. Additionally, the repurposing of veterinary antiparasitic drugs for the treatment of cancer is gaining traction, as supported by existing literature. A prominent example is the proposal to implement the use of veterinary antiparasitics such as benzimidazole carbamates and halogenated salicylanilides as novel anticancer drugs. These agents have revealed pronounced anti-tumor act

Совпадение в полном тексте источника
… The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma Blood 2010 115 4824 4833 10.1182/blood-2009-09-243055 20348394 31. Hou Z.-J. Luo X. Zhang W. Peng F. Cui B. Wu S.-J. Zheng F.-M. …

Impact of physical exercise in cancer survivors during and after antineoplastic treatments.

Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological and cost-effective therapy that can provide several health benefits in cancer patient and survivors, reducing cancer symptoms and cancer treatment side effects. The purpose of this review is to describe how the physical exercise is capable to reduce cancer symptoms and cancer treatment side effects. We realized a pragmatic classification of symptoms, dividing them into physical, psychological and psycho-physical aspects. For each symptom

Совпадение в полном тексте источника
… Chemotherapeutics that causes CIPN include platinum drugs (such as cisplatin, carboplatin and oxaliplatin), Microtubule-Targeting Agents (- MTAs - such as taxanes and vinca alkaloids), proteasome inhibitors (such as bortezomib) and angiogenesis inhibitors (such as bevacizumab and thalidomide) [ 67 ]. … Vinca alkaloids (used to treat acute lymphocytic leukemia, lymphomas, and neuroblastoma) alter the axonal cytoskeleton (length and orientation of microtubules) inducing a sensory neuropathy similar to taxanes but are also associated with an autonomic neuropathy [ 75 ]. …

Targeting the proteasome in cancer therapy: development and future opportunities in natural products.

BACKGROUND: The ubiquitin-proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma therapy and now constitutes the backbone of frontline treatment regimens. However, primary and acquired resistance remain a major challenge, underscoring the need to identify new PIs as well as agents that can resensitize resistant cells. METHOD: This review provides an overview of the current clinical applications of PIs and offers a comprehensive summary of natural products that

The therapeutic potential of colchicine in oncology studies: from structural modification and targeted delivery to clinical management.

Colchicine, a classical microtubule-targeting agent (MTA), exhibits remarkable anti-tumor potential, but its clinical translation is severely restricted by a narrow therapeutic window, systemic off-target toxicity, and complex pharmacokinetic vulnerabilities. Driven by the objective of "toxicity reduction and efficacy enhancement," this review comprehensively summarizes colchicine's multidimensional translational research. First, precise chemical modifications of its tricyclic scaffold and multi-site synergistic strategies are analyzed, exploring structure-activity relationship (SAR) mechanism

Совпадение в полном тексте источника
… Distinct from traditional chemotherapeutics that target taxane or vinca alkaloid sites, colchicine binds specifically to the β-tubulin subunit near the α/β heterodimer interface and the α-subunit’s GTP N- site. …

Surgical approaches to fertility preservation in the cancer patient: current and future directions.

Advances in oncologic therapies have markedly improved survival among reproductive-age female patients, making fertility preservation an essential component of comprehensive cancer care. Gonadotoxic treatments, including chemotherapy, radiotherapy, and surgery, can disrupt ovarian and uterine endocrine function, resulting in premature ovarian insufficiency and infertility. This narrative review summarizes current and emerging surgical approaches to fertility preservation, organized by anatomic focus on the ovary, uterus, and cervix. Ovarian transposition preserves ovarian endocrine function by

Совпадение в полном тексте источника
… Moreover, vinca alkaloids (e.g., vincristine), anthracycline antibiotics (e.g., doxorubicin), and platinum-based agents (e.g., cisplatin) have also been shown to impair female reproductive function ( 7 ). …

The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review.

Chemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for cancer therapies, offering a possible solution to overcome chemoresistance. This systematic review aimed to explore the role of mushroom extracts in enhancing chemotherapy and reversing chemoresistance in cancer cells. We searched the PubMed, Web of Science and Scopus databases, following the PRISMA guidelines, and registered on PROSPERO. The extracts acted by inhibiting the proliferation of cancer cells, as well as enhancing the effect of che

Совпадение в полном тексте источника
… This protein is linked to resistance to anthracyclines, vinca alkaloids, actinomycin D, Taxol (e.g., paclitaxel) and other substances [ 3 , 12 , 13 ]. …

Cardiogenic shock among cancer patients.

Sophisticated cancer treatments, cardiovascular risk factors, and aging trigger acute cardiovascular diseases in an increasing number of cancer patients. Among acute cardiovascular diseases, cancer treatment, as well as the cancer disease itself, may induce a cardiogenic shock. Although increasing, these cardiogenic shocks are still relatively limited, and their management is a matter of debate in cancer patients. Etiologies that cause cardiogenic shock are slightly different from those of non-cancer patients, and management has some specific features always requiring a multidisciplinary appro

Совпадение в полном тексте источника
… Other mechanisms may include plaque rupture resulting from cisplatin and vinca alkaloids ( 20 ), or coronary thrombosis due to pro-inflammatory and prothrombotic conditions associated with increased platelet aggregability induced by specific cancer therapies (e.g., cisplatin, vascular endothelial growth …

Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer.

The HER2-targeted antibody-drug conjugate trastuzumab emtansine (T-DM1) is approved for the treatment of metastatic, HER2-positive breast cancer after prior trastuzumab and taxane therapy, and has also demonstrated efficacy in the adjuvant setting in incomplete responders to neoadjuvant therapy. Despite its objective activity, intrinsic and acquired resistance to T-DM1 remains a major clinical challenge. T-DM1 mediates its activity in a number of ways, encompassing HER2 signalling blockade, Fc-mediated immune response and payload-mediated microtubule poisoning. Resistance mechanisms relating t

Совпадение в полном тексте источника
… to induce a cytotoxic bystander effect. 15 Proteolysis of trastuzumab spares the MCC moiety on DM1, but this retained linker does not impair payload potency, ensuring that lysine-MCC-DM1 liberated from lysosomes binds efficiently to tubulin to prevent microtubule polymerisation. 1 , 16 Analogous to vinca …

Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy.

Chemotherapy-induced painful peripheral neuropathy (CIPN) is the most common toxicity associated with widely used chemotherapeutics. CIPN is the major cause of dose reduction or discontinuation of otherwise life-saving treatment. Unfortunately, CIPN can persist in cancer survivors, which adversely affects their quality of life. Moreover, available treatments are vastly inadequate, warranting a better understanding of the biochemical and metabolic mechanisms that occur in response to chemotherapeutics which would be critical for the development of novel therapies for CIPN. Using extracellular f

Совпадение в полном тексте источника
… Introduction Chemotherapy-induced painful peripheral neuropathy (CIPN) is the most prevalent toxicity associated with widely used anti-cancer drugs which include taxanes, platinum-based drugs, vinca alkaloids, and proteasome inhibitors. …

Bortezomib treatment produces nocifensive behavior and changes in the expression of TRPV1, CGRP, and substance P in the rat DRG, spinal cord, and sciatic nerve.

To investigate neurochemical changes associated with bortezomib-induced painful peripheral neuropathy (PN), we examined the effects of a single-dose intravenous administration of bortezomib and a well-established "chronic" schedule in a rat model of bortezomib-induced PN. The TRPV1 channel and sensory neuropeptides CGRP and substance P (SP) were studied in L4-L5 dorsal root ganglia (DRGs), spinal cord, and sciatic nerve. Behavioral measures, performed at the end of the chronic bortezomib treatment, confirmed a reduction of mechanical nociceptive threshold, whereas no difference occurred in the

Совпадение в полном тексте источника
… It has been demonstrated for instance that platinum-based compounds, taxanes, and vinca alkaloids modulate the expression of TRPV1, as well as other TRP receptors, in DRG neurons in vitro and in vivo [ 77 – 79 ]. …

Cancer in Pregnancy: Therapeutic Decisions at the Intersection of Two Lives.

Background: Cancer during pregnancy is a rare but increasingly encountered condition due to delayed childbearing and improved survival of women with cancer. The coexistence of malignancy and pregnancy poses complex diagnostic and therapeutic challenges, requiring careful balance between maternal prognosis and fetal safety. Objective: This review aims to summarize current evidence on the diagnosis and multidisciplinary management of cancer during pregnancy, focusing on the safe use of oncologic therapies, obstetric decision-making, and maternal and fetal outcomes. Methods: A narrative review wa

Совпадение в полном тексте источника
… Vinca alkaloids, including vinblastine and vincristine, as well as vinorelbine in selected cases, are also considered safe during the second and third trimesters [ 35 ]. 6.1.2. …

Pharmaceutical Prevention and Management of Cardiotoxicity in Hematological Malignancies.

Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies. Nevertheless, many new or conventional anticancer drugs affect the cardiovascular system, resulting in various cardiac disorders, including left ventricular dysfunction, heart failure, arterial hypertension, myocardial ischemia, cardiac rhythm disturbances, and QTc prolongation on electrocardiograms. As these complications may jeopardize the significantly improved outcome of modern anticancer therapies, it is crucial to become familiar with all aspects of cardiotoxicity and pr

Совпадение в полном тексте источника
… Vinca Alkaloids Vincristine and vinblastine are used in the treatment of leukemias, lymphomas, as well as multiple myelomas. They can result in myocardial ischemia, infarction, and arrhythmias [ 8 , 24 ]. …

Repurposing drugs in oncology (ReDO)-selective PDE5 inhibitors as anti-cancer agents.

Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension. They are also well-known as examples of successful drug repurposing in that they were initially developed for angina and only later developed for erectile dysfunction. However, these drugs may also be effective cancer treatments. A range of evidentiary sources are assessed in this paper and the case made that there is pre-clinical and clinical evidence that these drugs may offer clinical benefit in a range of can

Совпадение в полном тексте источника
… MRP7/ABCC10 is another of the MRP family is associated with resistance to a number of chemotherapeutic agents, including vinca alkaloids and taxanes, which has been shown to be amenable to PDE5 inhibitor-mediated sensitisation [ 83 ]. …

Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition.

The properties and meridian affinities of Chinese herbal medicine are closely associated with their therapeutic efficacy. This review focuses on approved antitumour Chinese medicines listed in the Pharmacopoeia of the People's Republic of China (2020 Edition, Volume I), highlighting their key components. Statistical methods were used to analyse the properties, flavours and channel tropisms of antitumour traditional Chinese medicine (TCM), including both proprietary formulations and commercially available individual herbs. Distinctive patterns were identified by comparing herb profiles with con

Совпадение в полном тексте источника
… Alkaloids, such as vinblastine, vincristine and vinorelbine, extracted or semi-synthesised from the Vinca species, have been successfully applied clinically for the treatment of leukaemia and solid tumours. …

Charting the Current Landscape and Future Prospects of Cancer Therapy-Related Cardiovascular Toxicity in Cancer Survivors: From Bench to Bedside.

Cardio-oncology represents an emerging interdisciplinary discipline focusing on optimizing oncologic efficacy while mitigating treatment-related cardiovascular complications. The advent of novel anticancer agents such as targeted therapies, immune checkpoint inhibitors, and endocrine therapies has transformed cancer care, significantly improving survival rates. Nevertheless, prolonged patient survivorship has unmasked clinically significant cardiovascular sequelae, termed cancer therapy-related cardiovascular toxicity (CTR-CVT), which manifests as acute manifestations during therapy and delaye

Совпадение в полном тексте источника
… pre-existing LV dysfunction, where anthracyclines should be avoided, yet the exact cardiotoxic risks with taxanes remain incompletely characterized. 27 Paclitaxel may disrupt cardiac autonomic regulation and conduction system function, predominantly manifesting as asymptomatic sinus bradycardia, while vinca …

Parallel Toxicities: A Comparative Analysis of Chemotherapy-Induced Neutropenia and Alopecia.

Chemotherapy-induced neutropenia (CIN) and chemotherapy-induced alopecia (CIA) are significant toxicities affecting cancer patients. CIN is a potentially fatal complication of chemotherapy caused by myelosuppression and increased infection susceptibility, while CIA, although not fatal, severely affects treatment adherence and mental health. This study provides a comprehensive comparative analysis of CIN and CIA, focusing on patient, disease, treatment, and genetic risk factors. Key risk factors for CIN and CIA include age, poor performance status, body mass index (BMI), laboratory abnormalitie

Совпадение в полном тексте источника
… In contrast, treatment with 5-fluorouracil, methotrexate, vinca alkaloids (vinorelbine and vinblastine), erlotinib, gefitinib, or pembrolizumab had a lower incidence and severity of alopecia [ 87 , 93 , 107 , 115 , 116 , 117 , 118 ]. …

Primary prophylaxis of invasive fungal diseases in patients with haematological malignancies: 2022 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO).

Patients with haematological malignancies (HM) are at high risk of developing invasive fungal disease (IFD) with high morbidity and attributable mortality. We reviewed data published until September 2021 to update the 2017 antifungal prophylaxis recommendations of the German Society of Haematology and Medical Oncology (DGHO). The strong recommendation to administer antifungal prophylaxis in patients with HM with long-lasting neutropenia, i.e. 7 days remains unchanged. Posaconazole remains the drug of choice for mould-active prophylaxis in these patients. Novel treatment options in HM, such as

Совпадение в полном тексте источника
… Intravenous (IV) L-AmB prophylaxis has been evaluated in adult ALL patients during RIC. 18 The choice of L-AmB in this specific setting arises from CYP3A4-mediated DDI of azoles with vinca-alkaloids that prohibit the concomitant use of azoles during chemotherapy. …

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main and most prevalent side effects of chemotherapy, significantly affecting the quality of life of patients and the course of chemotherapeutic treatment. Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossible to prevent with currently available agents. Therefore, it is imperative to find better options for patients diagnosed with this condition. While the search for the new agents must continue, anothe

Совпадение в полном тексте источника
… The medications most frequently associated with the development of CIPN are platinum-based drugs, taxanes, thalidomide and its analogues, vinca alkaloids, bortezomib and ixabepilone [ 3 , 11 , 12 ]. …

Intestinal barrier functions in hematologic and oncologic diseases.

The intestinal barrier is a complex structure that not only regulates the influx of luminal contents into the systemic circulation but is also involved in immune, microbial, and metabolic homeostasis. Evidence implicating disruption in intestinal barrier functions in the development of many systemic diseases, ranging from non-alcoholic steatohepatitis to autism, or systemic complications of intestinal disorders has increased rapidly in recent years, raising the possibility of the intestinal barrier as a potential target for therapeutic intervention to alter the course and mitigate the complica

Совпадение в полном тексте источника
… chemotherapy | Chemotherapeutic agents Alkylating agents | Busulfan Chlorambucil Melphalan Cisplatin Anthracyclines | Doxorubicin Daunorubicin Antimetabolites | Cytarabine Methotrexate 5-Fluorouracil Antitumors | Actinomycin-D Bleomycin Podophyllotoxin derivatives | Etoposide Texanes | Docetexal Paclitaxel Vinca …