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Войти в исследования Neoplasms occurring in aged Fischer rats, with special reference to testicular, uterine, and thyroid tumors.
Inbred Fischer rats were set aside as nonbreeders specifically to obtain tumors of endocrine organs and endocrine-responsive tissues that might be used in studies of hormone responsivity. The average age at death or autopsy was 675 days for 102 females, and 725 days for 92 males. The tumor data are recorded for those animals that were autopsied (91%). Sixty-eight percent of the males developed testicular interstitial (Leydig) cell tumors and in three fourths these were bilateral. One half of the 20 tumors transplanted into isologous hosts grew to a palpable size. In all instances where growth
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