Результаты поиска

Long-term prognosis of patients with congestive heart failure.

Factors determining prognosis in 100 patients with recent onset of congestive heart failure (CHF) were evaluated. The 1 year, 3 year, 5 year, and 10 year survival rates in the entire CHF group were 78.5%, 59.8%, 50.4% and 14.7%, respectively. No correlations between age, sex, heart rate and cardiothoracic ratio, and the cumulative survival rate were found. The prognosis of patients with CHF due to underlying coronary artery disease or primary cardiomyopathy was poor compared with that of patients with other types of heart disease. Patients whose NYHA classification was class III or VI had a si…

Cardiac regulation in bulimia nervosa.

Heart rate and vagal tone were assessed during sleep and bed rest conditions in nine patients with bulimia nervosa (BN), six patients with concomitant anorexia nervosa and bulimia nervosa (AN + BN) and five control subjects. During bed rest conditions AN + BN patients had significantly lower heart rates than BN or control subjects. During sleep, the heart rate differed significantly for all three groups. The AN + BN group had a significantly lower heart rate than either the BN or control groups and the BN group had a significantly lower heart rate than controls. On the other hand, measures of …

Acute Octodrine (DMHA) Exposure Disrupts Cardiac Function, Locomotor Activity, and Neuronal Activity-Responsive Transcription in Zebrafish Larvae.

Octodrine (2-amino-6-methylheptane; DMHA) is a sympathomimetic stimulant detected in sports-performance and weight-loss supplements despite limited toxicological characterization and regulatory concerns. Here, we used 7-day-post-fertilization zebrafish larvae to characterize the acute cardiac, neurobehavioral, and transcriptional effects of octodrine after 2 h of exposure. Cardiac responses were biphasic: 5 µM octodrine significantly increased atrial and ventricular rates, whereas concentrations ≥ 150 µM produced progressive cardiac depression and higher concentrations disrupted atrioventricul

Cardiac-vagal rhythm echoes on the heartbeat's mechanosensory imprint in the brain.

The heart, a highly reactive and innervated organ, plays a crucial role in brain-viscera communications. Recent research has highlighted the … participants are in horizontal position. By modeling HBS, we demonstrate that fast fluctuations in heart rate variability significantly influences the final HBS. This suggests a direct relationship between vagal tone and subsequent neural responses to heartbeats, highlighting the necessity of studying visceral oscillations in the context of mechanosensation …

Ось сердечного мозга в эпоху искусственного интеллекта: интеграция старых и новых знаний в новые цели и инновационные нейро- и кардиотерапии.

Ось сердечного мозга (HBA) представляет собой динамичную систему взаимного общения между сердечно-сосудистой и центральной нервной системами, включающую нейронные, иммунологические, молекулярные и гормональные пути. Центральная автономическая сеть описывается как ключевой регулятор сердечно-сосудистой деятельности и автономной дисфункции как важный механизм, лежащий в основе различных неврологических и сердечных расстройств. Изменчивость сердечника (HRV) определяется в качестве ключевого биомаркера оси, отражающего балансы автономной нервной системы. Более глубокое понимание его молекулярных м

Совпадение в аннотации оригинала
The heart-brain axis (HBA) is a dynamic system of reciprocal communication between the cardiovascular and central nervous system, incorporat … utonomic dysfunction as an important mechanism underlying various neurologic and cardiac disorders. Heart rate variability (HRV) is identified as the key biomarker of the axis reflecting autonomic nervous system balance. Increased understanding of its molecular mechanisms has led to the proposal of new therapeutic strategies focused on modulating heart-brain …

Autonomic neuronal modulations in cardiac arrhythmias: Current concepts and emerging therapies.

The pathophysiology of atrial fibrillation and ventricular tachycardia that result in cardiac arrhythmias is related to the sustained compli … Additionally, we provide a summary of the numerous techniques for measuring autonomic tone such as heart rate oscillations and its association with cutaneous sympathetic nerve activity appear to be substitute indicators and predictors of the outcome of treatment.

Advanced Imaging Integration for Catheter Ablation of Ventricular Tachycardia.

PURPOSE OF REVIEW: Imaging plays a crucial role in the therapy of ventricular tachycardia (VT). We offer an overview of the different methods and provide information on their use in a clinical setting. RECENT FINDINGS: The use of imaging in VT has progressed recently. Intracardiac echography facilitates catheter navigation and the targeting of moving intracardiac structures. Integration of pre-procedural CT or MRI allows for targeting the VT substrate, with major expected impact on VT ablation efficacy and efficiency. Advances in computational modeling may further enhance the performance of i

Characterization of autonomic states by complex sympathetic and parasympathetic dynamics.

Assessment of heartbeat dynamics provides a promising framework for non-invasive monitoring of cardiovascular and autonomic states. Nevertheless, the non-specificity of such measurements among clinical populations and healthy conditions associated with different autonomic states severely limits their applicability and exploitation in naturalistic conditions. This limitation arises especially when pathological or postural change-related sympathetic hyperactivity is compared to autonomic changes across age and experimental conditions. In this frame, we investigate the intrinsic irregularity and

Left cardiac vagotomy rapidly reduces contralateral cardiac vagal electrical activity in anesthetized Göttingen minipigs.

BACKGROUND: The impact of acute unilateral injury on spontaneous electrical activity in both vagus nerves at the heart level is poorly under … p (-30.7% vs pre-cut) and intact right VN (-21.8% vs pre-cut) at the heart level, without affecting heart rate, heart rate variability, or hemodynamics. In contrast, right cardiac VNTx did not acutely alter MUA in either VN but slightly increased (p < 0.022) the root mean square of successive RR interval differences (rMSSD), an index of parasympathetic outfl …

Epicardial Roof-Dependent Macro-Re-Entrant Tachycardia After Ablation of Atrial Fibrillation: Electrophysiological Characteristics and Ablation.

BACKGROUND: Epicardial roof-dependent macro-re-entrant tachycardias (epi-RMAT) after catheter ablation of persistent atrial fibrillation are not rare but the prevalence and characteristics remain unclear. OBJECTIVES: The purpose of this study was to investigate the prevalence, electrophysiological characteristics and ablation strategy of recurrent epi-RMATs after ablation of atrial fibrillation. METHODS: A total of 44 consecutive patients with 45 roof-dependent RMATs after atrial fibrillation ablation were enrolled. High-density mapping and appropriate entrainment were performed to diagnose

Differences between typical and reverse typical atrial flutter identified by ultrahigh resolution mapping.

BACKGROUND: Although atrial flutter (AFL) is a common arrhythmia that is based on a macro-reentrant tachycardia around the tricuspid annulus, the factors giving rise to typical AFL (t-AFL) versus reverse typical AFL (rt-AFL) are unknown. To investigate the difference between t-AFL and rt-AFL circuits using ultrahigh resolution mapping of the right atrium. METHODS: We investigated 30 isthmus-dependent AFL patients (mean age 71, 28 male) who underwent first-time cavo-tricuspid isthmus (CTI) ablation guided by Boston Scientific's Rhythmia mapping system and divided them into two groups: t-AFL (2

In vivo and ex vivo electrophysiological study of the mouse heart to characterize the cardiac conduction system, including atrial and ventricular vulnerability.

The mouse is a common and cost-effective animal model for basic research, and the number of genetically engineered mouse models with cardiac phenotype is increasing. In vivo electrophysiological study in mice is similar to that performed in humans. It is indispensable for acquiring intracardiac electrocardiogram recordings and determining baseline cardiac cycle intervals. Furthermore, the use of programmed electrical stimulation enables determination of parameters such as sinoatrial conduction time, sinus node recovery time, atrioventricular-nodal conduction properties, Wenckebach periodicity,

Stress-related dysautonomias and neurocardiology-based treatment approaches.

Cardiovascular and psychiatric disorders are among the most commonly treated conditions worldwide. Research in neurocardiology, psychiatry, and epidemiology have defined bidirectional relationships between psychiatric disorders and heart disease, affirming the role of impaired autonomic nervous system, or dysautonomia in the prognosis and development in these disorders. These studies have fueled rapid clinical translation of experimental findings, with potential to complement existing pharmacological therapies. In this review, we comprehensively discuss the state-of-the-art investigations and

Joint cardiac tissue conductivity and activation time estimation using confirmatory factor analysis.

Mathematical models of the electrophysiology of cardiac tissue play an important role when studying heart rhythm disorders like atrial fibrillation. Model parameters such as conductivity, activation time, and anisotropy ratio are useful parameters to determine the arrhythmogenic substrate that causes abnormalities in the atrial tissue. Existing methods often estimate the model parameters separately and assume some of the parameters to be known as a priori knowledge. In this work, we propose an efficient method to jointly estimate the parameters of interest from the cross power spectral density

High-resolution mapping of reentrant atrial tachycardias: Relevance of low bipolar voltage.

BACKGROUND: Bipolar voltage is widely used to characterize the atrial substrate but has been poorly validated, particularly during clinical tachycardias. OBJECTIVE: The purpose of this study was to evaluate the diagnostic performance of voltage thresholds for identifying regions of slow conduction during reentrant atrial tachycardias (ATs). METHODS: Thirty bipolar voltage and activation maps created during reentrant ATs were analyzed to (1) examine the relationship between voltage amplitude and conduction velocity (CV), (2) measure the diagnostic ability of voltage thresholds to predict CV,

The feasibility of predicting impending malignant ventricular arrhythmias by using nonlinear features of short heartbeat intervals.

BACKGROUND AND OBJECTIVE: Malignant ventricular arrhythmias (MAs) occur unpredictably and lead to emergencies. A new approach that uses a timely tracking device e.g., photoplethysmogram (PPG) solely to predict MAs would be irreplaceably valuable and it is natural to expect the approach can predict the occurrence as early as possible. METHOD: We assumed that with an appropriate metric based on signal complexity, the heartbeat interval time series (HbIs) can be used to manifest the intrinsic characteristics of the period immediately precedes the MAs (preMAs). The approach first characterizes th

Substrate mapping of the left atrium in persistent atrial fibrillation: spatial correlation of localized complex conduction patterns in global charge-density maps to low-voltage areas in 3D contact bipolar voltage maps.

PURPOSE: This study aimed to investigate the spatial relationship between low-voltage areas (LVAs) in bipolar voltage mapping (BVM) and localized complex conduction (LCC)-cores in a global, non-contact, charge-density-based imaging, and mapping system (AcM). METHODS: Patients with history of index PVI for PsAF and scheduled for a repeat ablation procedure for recurrence of the same arrhythmia were enrolled between August 2018 and February 2020. All patients underwent both substrate mappings of the left atrium (LA) with the CARTO 3D map-ping system and with AcM. RESULTS: Ten patients where in

Coronary blood flow influences tolerance to environmental extremes in fish.

Approximately half of all fishes have, in addition to the luminal venous O2 supply, a coronary circulation supplying the heart with fully ox … ke volume relative to trout with intact coronaries, cardiac output was maintained by an increase in heart rate. However, in hypoxia, coronary-ligated trout were unable to increase stroke volume to maintain cardiac output when bradycardia developed, which was associated with a slightly reduced hypoxia tolerance. Moreover, during acute warming, coronary ligati …

Effect of levosimendan combined with recombinant human brain natriuretic peptide on diuretic resistance.

Levosimendan is a calcium sensitizer used for managing heart failure (HF) because of its inotropic and vasodilatory effects. As many patient … poor curative effect (P < .05). No significant change was observed in the systolic blood pressure, heart rate, and serum creatinine level before and after treatment in both groups.Levosimendan in combination with rhBNP can effectively relieve diuretic resistance, reduce body weight, improve dyspnea, and ensure safety in the treatment process.