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Революционизация медицины сна: влияние машинного обучения на диагностику, лечение и индивидуальное лечение.

Преобразовательным инструментом в медицине сна стало обучение основам махинации (ML), предлагающее новаторские решения для диагностики, лечения и понимания расстройств сна. В настоящем обзоре рассматривается нынешнее состояние и будущий потенциал применения ML в этой области. Methods Мы провели всеобъемлющий обзор литературы с уделением особого внимания ключевым достижениям в области технологий ML, применяемых для лечения сна. Были изучены, в частности, такие конкретные области, как классификация стадий сна, оптимизация лечения апноэ и бессонницы сна, а также внедрение износостойкой технологии

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… Wang L., Liu R., Wang Y., et al., “Effectiveness of a Biofeedback Intervention Targeting Mental and Physical Health Among College Students Through Speech and Physiology as Biomarkers Using Machine Learning: A Randomized Controlled Trial,” Applied Psychophysiology And Biofeedback 49, no. 1 (2024): 71– …

Myeloma: Patient accounts of their pathways to diagnosis.

BackgroundPathways to myeloma diagnosis can be prolonged, and are often preceded by multiple GP consultations and emergency presentation. This is the first qualitative study to examine events leading to diagnosis by asking patients about their experiences during this time.MethodsSet within a UK population-based cohort, semi-structured interviews were conducted with 20 myeloma patients with varying characteristics and pathways, 12 of whom invited their relatives to take part. Interviews were audio-recorded and qualitative analysis undertaken.ResultsPre-diagnostic awareness of myeloma was minima

Гендерное неравенство в когнитивных расстройствах между неврологическими аутоиммунными расстройствами: систематический обзор.

ВВЕДЕНИЕ: Неврологические аутоиммунные расстройства (НКД) часто переплетаются с когнитивными расстройствами (КИ), что представляет собой многоуровневую проблему как с клиническим пониманием, так и с терапевтическим управлением. Усугубленное бремя NAD и CI не только оказывает значительное влияние на качество жизни пациента (QoL), прогнозы состояния и результаты лечения, но и оказывает несоразмерное воздействие на женщин, которые по своей сути более подвержены автоматическому иммунитету. Этот обзор направлен на изучение гендерных когнитивных недостатков, их основополагающих механизмов и их клини

A life span perspective on competencies for a healthy, physically active lifestyle: Findings of a data pooling initiative with over 7000 individuals.

Individuals are recommended to lead active lifestyles throughout the life course. The model of physical activity-related health competence (PAHCO) adopts a competence approach by integrating physical, cognitive, and motivational determinants for health-enhancing PA (movement competence, control competence, self-regulation competence). Drawing on a comprehensive dataset pooling, the goal of the present study was to model the idiosyncratic courses of 10 PAHCO indicators over the life span. We identified studies that empirically operationalized PAHCO, combining data of 7134 individuals (age range

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… Psychophysiology 46 ( 6 ): 1130 – 1136 . 10.1111/j.1469-8986.2009.00859.x . 19602175 PMC2865139 Kimura , Misaka , Chinatsu Mizuta , Yosuke Yamada , Yasuko Okayama , and Eitaro Nakamura . 2012 . “ Constructing an Index of Physical Fitness Age for Japanese Elderly Based on 7‐Year Longitudinal Data: Sex …

AF1q inhibited T cell attachment to breast cancer cell by attenuating Intracellular Adhesion Molecule-1 expression.

China appears to consistently lag behind developed countries like the US, Japan, and the nations of Europe in the development of pharmaceuticals, putting China in an embarrassing situation. In fact, China is still dependent on foreign imports for most highly effective cures to major diseases such as cancer, diabetes, hepatitis, and neurodegenerative disease. There is no denying the fact that governmental support, and especially a signifi cant amount of fi nancial support and political assistance to include government restructuring, is needed for the establishment of new drug Research and Devel

Оценка и лечение агрессивного сексуального поведения: нынешние ограничения и потенциальные стратегии.

Несмотря на то, что в МКБ-11 была введена соответствующая классификация и симптоматика расстройства сексуального поведения (CSBD) по-прежнему противоречива. В этом обзоре мы изучили историю, эпидемиологический статус-кво, коморбиды, теории нейрофизики, текущие диагнозы и рекомендации по лечению для CSBD. Кроме того, мы подчеркнули недостатки текущих исследований и перспективы будущей работы. Селективные ингибиторы серотонина и налтрексон обычно используются в качестве "немаркированных" наркотиков. Диагностика и лечение пациентов, проходящих курс лечения, должны включать в себя биологические, п

Healing Environments for Cancer Care: Toward a Patient-Centered Design Guideline for Inpatient Settings.

ObjectivesThis study proposes an evidence-based design guideline for oncology inpatient rooms that addresses the physical, emotional, and psychosocial needs of cancer patients.BackgroundCancer inpatients frequently experience long hospital stays with emotional vulnerability and clinical stress. Growing evidence suggests environmental design can shape patient experience, comfort, and recovery. Yet, current literature lacks an integrated framework for the spatial and sensory needs of this population.MethodA systematic literature review was conducted across Web of Science, Scopus, and PubMed. Fro

Advances in Neuroimaging of Breast Cancer Pain: An Overview.

Breast cancer is currently the most common malignant tumor, primarily affecting women, and it frequently leads to chronic pain that significantly impairs physical and mental health. Neuroimaging studies have demonstrated that breast cancer-related pain is associated with specific brain alterations, including changes in activation, connectivity, and structure of pain-processing regions. This review synthesizes findings on functional and structural brain changes related to chronic pain in breast cancer and compares them with non-cancer chronic pain patterns. By integrating recent evidence, it pr

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… Pearls and pitfalls in brain functional analysis by event-related potentials: a narrative review by the Italian psychophysiology and cognitive neuroscience society on methodological limits and clinical reliability-part I. Neurol Sci . 2020;41:2711–2735. doi: 10.1007/s10072-020-04420-7 29. …

Protective Buffering and Individual and Relational Adjustment Following Hematopoietic Stem Cell Transplantation: A Dyadic Daily-Diary Study.

BackgroundSupportive communication (e.g., protective buffering, PB) may impact individual and relational adjustment in patients following hematopoietic stem cell transplantation (HSCT) and their caregivers. Previous studies revealed that PB (i.e., hiding one's concerns and denying one's worries) has mixed effects, namely it is beneficial, costly or unrelated to dyadic adjustment. This study aimed to verify these findings by addressing some unresolved issues, i.e., examining (1) both individual and relational as well as both positive and negative indicators of adjustment, (2) the effect of with

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… Psychophysiology 39 281 – 291 . 10.1017/s0048577201393198 12212647 Hagedoorn M. Dagan M. Puterman E. Hoff C. Meijerink W. J. H. J. Delongis A. ( 2011 ). Relationship satisfaction in couples confronted with colorectal cancer: the interplay of past and current spousal support. J. Behav. …

Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics.

Mice with gene-targeted deletion of the Kv1.3 channel were generated to study its role in olfactory function. Potassium currents in olfactory bulb mitral cells from Kv1.3 null mice have slow inactivation kinetics, a modified voltage dependence, and a dampened C-type inactivation and fail to be modulated by activators of receptor tyrosine signaling cascades. Kv1.3 deletion increases expression of scaffolding proteins that normally regulate the channel through protein-protein interactions. Kv1.3-/- mice have a 1,000- to 10,000-fold lower threshold for detection of odors and an increased ability

Efficacy and safety of acupuncture for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis of randomized controlled trial.

OBJECTIVE: Chemotherapy-induced nausea and vomiting (CINV) represents a common and debilitating side effects in cancer patients, often compromising treatment adherence and quality of life. Current management remains suboptimal, necessitating the exploration of complementary therapies. Acupuncture, as a widely used adjunctive therapy, has been attempted for the treatment of CINV. This study aims to systematically evaluate the effect and safety of acupuncture in managing CINV. METHODS: We comprehensively searched seven electronic databases (EMBASE, Cochrane Library, Web of Science, PubMed, Chin

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… The psychophysiology of nausea . Acta Biol Hung . ( 2002 ) 53 : 589 – 600 . doi: 10.1556/ABiol.53.2002.4.17 , 12501940 74. Hornby PJ . Central neurocircuitry associated with emesis . Am J Med . ( 2001 ) 111 : 106 – 12 . doi: 10.1016/S0002-9343(01)00849-X , 11749934 75. …

Влияние жизненных поступков, способствующих укреплению здоровья, на микробиоту у выживших жертв гематологического рака: обзор скопирования.

Целью этого аналитического обзора является изучение взаимосвязи между поведением, способствующим здоровому образу жизни, и микробиотой кишечника у выживших жертв гематологического рака, включая лейкемию, лимфому и множественную миелому. С учетом растущего числа таких случаев и связанных с этим проблем с лечением понимание того, как факторы образа жизни влияют на состояние здоровья, может дать представление о том, как улучшиться состояние выживших жертв. МЕТОДЫ: Мы провели всеобъемлющий поиск по нескольким базам данных, включая PubMed/Medline, CINAHL и Scopus, вслед за предпочтительными элемент

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… Telles , “ Oxygen Consumption and Respiration During and After Two Yoga Relaxation Techniques ,” Applied Psychophysiology and Biofeedback 31 ( 2006 ): 143 – 153 . 16838123 10.1007/s10484-006-9012-8 …

The Effects of Light Therapy on Cognitive Function and Stress in Women With Breast Cancer Before Systemic Treatment.

BackgroundCancer-related cognitive impairment (CRCI), for example, impairments in reaction time, processing speed, memory and executive function, may be associated with breast cancer (BC) surgery which can disrupt biological and psychological stress markers. Evidence suggests that light therapy may ameliorate cognitive impairment and stress. In this double-blind, randomized controlled trial, we investigated the efficacy of light therapy on mitigating the impact of BC surgery on CRCI in a national Icelandic cohort of women with BC.MethodsParticipants were randomly allocated to receive circadian

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… Rohleder , “ Salivary α‐Amylase Stress Reactivity Across Different Age Groups ,” Psychophysiology 47 , no. 3 ( 2010 ): 587 – 595 . 20070573 10.1111/j.1469-8986.2009.00957.x 72 C. A. Larsson , B. Gullberg , L. Råstam , and U. …

Abstract Proceedings of the 38th Annual Canadian Association of Psychosocial Oncology (CAPO) Conference, June 2023.

On behalf of the Canadian Association of Psychosocial Oncology, we are pleased to present the Abstracts from the 2023 Annual Conference, titled "Co-designing Psychosocial Oncology: Optimizing Outcomes for All". The conference was held in Montreal from 20 June 2023 to 22 June 2023. This conference brought together key stakeholders including multidisciplinary professionals from nursing, psychology, psychiatry, social work, spiritual care, nutrition, medicine, rehabilitation medicine, occupational health and radiation therapy for both adult and pediatric populations. Participants included clinici

Efficacy of expressive helping in adult hematologic cancer patients undergoing stem cell transplant: protocol for the Writing for Insight, Strength, and Ease (WISE) study's two-arm randomized controlled trial.

BackgroundDuring, shortly after, and sometimes for years after hematopoietic stem cell transplant, a large proportion of hematological cancer patients undergoing transplant report significant physical and psychological symptoms and reduced health-related quality of life. To address these survivorship problems, we developed a low-burden, brief psychological intervention called expressive helping that includes two theory- and evidence-based components designed to work together synergistically: emotionally expressive writing and peer support writing. Building on evidence from a prior randomized c

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… Psychophysiology. 2016;53(4):427–435. doi: 10.1111/psyp.12578. 40. Lepore SJ, Revenson TA. Social constraints on disclosure and adjustment to cancer. Soc Personal Psychol Compass. 2007;1(1):313–333. doi: 10.1111/j.1751-9004.2007.00013.x. 41. …

Cardiac autonomic dysfunction in patients with cancer: exploring the role of physical exercise.

PURPOSE: Cardiovascular diseases are a leading cause of non-cancer mortality among patients with cancer, with cardiac autonomic dysfunction identified as a significant predictor of future cardiovascular conditions. Despite the importance of autonomic dysfunction as a prognostic marker being well-established in healthy individuals and other chronic conditions, its role in patients with cancer remains underexplored. This narrative review aims to synthesize existing literature on the role of cardiac autonomic dysfunction in patients with cancer and explore the potential of physical exercise as a

Навязчивое сексуальное поведение и проблематичное использование порнографии: всеобъемлющий, междисциплинарный и экспертный обзор описательной информации с указанием предлагаемых направлений будущей деятельности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И МАТЕРИАЛЫ: Характер и классификация дисрегулированного сексуального поведения по-прежнему широко обсуждаются. Сексуальные расстройства, связанные с сексуальным поведением, и проблематичное использование порнографии (PUP) two Наиболее часто изученные конструкции в этой области, каждая из которых имеет значительные последствия для психического здоровья, межличностного функционирования и более широкого благосостояния. Хотя научные результаты по этим темам за последнее десятилетие быстро расширились, в последних обзорах основное внимание, как правило, уделялось конкретным п

Creative Arts Therapy for Anxiety, Depression, and Quality of Life in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BackgroundCancer is a significant psychological burden for patients. Previous evidence syntheses suggest creative arts therapies (CATs) may improve psychological outcomes, but are limited by heterogeneity in intervention types, study designs, and outcomes, and the lack of a certainty of evidence assessment.AimsWe conducted a robust systematic review and meta-analysis of current randomized trial literature to explore the efficacy of CATs in improving anxiety, depression, and quality of life in cancer patients.MethodsWe searched PubMed, Embase, and PsycInfo databases for peer-reviewed randomized

Effects of Exercise Programs on Psychoemotional and Quality-of-Life Factors in Adult Patients with Cancer and Hematopoietic Stem Cell Transplantation or Bone Marrow Transplantation: A Systematic Review.

This review analyzed the effects of an exercise program on psychoemotional and quality-of-life (QoL) factors in adult patients with cancer and hematopoietic stem cell transplantation (HSCT) or bone marrow transplantation (BMT). Studies were identified from the PubMed and Web of Science databases (from inception to 24 August 2022), according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The methodological quality of the included studies was assessed with the Physiotherapy Evidence Database (PEDro) scale, based in turn on the Delphi list. A total o

Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation.

Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. Therefore, inhibitors of endosomal TLR activation are being investigated for their ability to treat this disease. The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis. Several immune modulatory oligonucleotides and small molecular weight compounds, incl