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[Principles of diet therapy for sarcopenic obesity: A review].

Nutrition and physical activity play a key role in the onset and progression of sarcopenic obesity (SO). Therefore, dietary interventions ar … he need for protein increases. The role of ù-3 polyunsaturated fatty acids, vitamin D, calcium, and polyphenols in the treatment of SO may be due to their anti-inflammatory effect, as well as, possibly, activation of mitochondrial functions and regulation of myogenesis processes. Developing and using specialized foods containing proteins, branched-chain amino …

Diet in Knee Osteoarthritis-Myths and Facts.

Knee osteoarthritis (OA) is a common degenerative joint disease affecting global health. Its increasing prevalence, particularly among aging … nflammation and contribute to cartilage degradation. Conversely, diets rich in omega-3 fatty acids, polyphenols, and dietary fiber have shown anti-inflammatory and chondroprotective properties. A Mediterranean diet rich in these nutrients effectively prevents the development of OA and its comorbidities, including obesity and cardiovascular disease. The role o …

Amelioration of ochratoxin A-Induced immunotoxicity and lymphoid tissue injury in poultry using pumpkin seed supplementation: A natural feed-based approach.

This study tested pumpkin seeds (Cucurbita spp.) against OTA toxicity in broilers. One hundred forty chicks were divided into seven groups: … ive effects may be attributed to the bioactive constituents of pumpkin seeds, such as antioxidants, polyphenols, and unsaturated fatty acids, which are known for their immunomodulatory properties. This suggests that PS may offer a practical and natural alternative to synthetic binders for mitigating OTA toxicity in poultry.

Management and Prevention of Neurodegenerative Disorders: Can Antioxidant-Rich Dietary Interventions Help?

Neurodegenerative diseases are associated with the senescence of functional neurons, which hampers brain functions. These diseases are cause … al manifestations of such deadly diseases. Consumption of sufficient antioxidants, fatty acids, and polyphenols in regular diets delays the onset of neurodegenerative diseases. Several medicinal plants, such as Withania somnifera, Curcuma longa, Panax ginseng, Ginkgo biloba, aloe vera, Punica granatum, and various phytoextracts, contain such micronutrients in …

Balancing the Oral Redox State: Endogenous and Exogenous Sources of Reactive Oxygen Species and the Antioxidant Role of Lamiaceae and Asteraceae.

Background/Objectives: Oral health is a complex concept involving physical, psychological, emotional, and social components. A key factor in … hanisms of selected Asteraceae species. Special attention was given to their phytochemical contents-polyphenols, flavonoids, and essential oils-and their biological relevance to oral health. Results: OS plays a critical role in the onset and progression of oral conditions such as caries, periodontitis, gingivitis, aphthous ulcers, abscesses, precancerous lesi …

Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.

The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in man … interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, furt …

От профилактики к управлению: изучение воздействия рациона питания на множественный склероз.

Множественный склероз (MS) — хроническое имунное заболевание центральной нервной системы, характеризующееся нейроинфламмацией и прогрессивным нейродегенерацией. Растущие данные свидетельствуют о том, что диетическое вмешательство может влиять на прогресс и управление симптомами MS, изменяя воспаление, окислительный стресс и кишечный микробиотический состав. В настоящем описательном обзоре рассматриваются последствия средиземноморского, растительного, кетогенного, вальса, сванка, периодического постирования и без глютена наряду с такими ключевыми питательными веществами, как жирные кислоты омег

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system characterized by neuroinflammation and progressiv … ent fasting, and gluten-free diets, alongside key nutrients such as omega-3 fatty acids, vitamin D, polyphenols, and antioxidants. Among these, Mediterranean and plant-based diets have shown the most consistent benefits, including reductions in fatigue, improved quality of life, and modulation of inflammatory markers. The Wahls and Swank diets show promise bu …

Effects of Complex Antioxidants Added to Chicken Diet on Growth Performance, Serum Biochemical Indices, Meat Quality, and Antioxidant Capacity.

This study aimed to evaluate the effects of diets supplemented with various levels of complex antioxidants (CA) containing tertiary butylhydroquinone (TBHQ) and tea polyphenols (TP) on growth performance, meat quality of breast and leg muscles, serum biochemistry, and antioxidant capacity of serum, liver, breast meat, jejunum, and ileum in broilers. A total of 600 one-day-old Arbor Acres male broilers with similar body weights were randomly divided into three groups (10 replicates/group, 20 broilers/replicate). Birds in the three experimental groups were fed a basal diet with CA at 0, 300, and…

Dietary phytochemicals alleviate the premature skin aging: A comprehensive review.

Skin aging, often called as premature skin aging, is the hastened deterioration of the skin resulting from multiple factors, including UV radiation, environmental contaminants, inadequate nutrition, stress, etc. Dietary phytochemicals, present in fruits, vegetables, and other plant-derived meals, have gained interest due to their efficiency to eradicate free radicals and lowering the release of inflammatory mediators which accounts for premature skin aging. Several dietary phytochemicals, i.e., carotenoids, polyphenols, flavonoids, terpenes, alkaloids, phytosterols, etc., exhibited potential a…

Fermented Polyherbal Formulation Restored Ricinoleic Acid-Induced Diarrhea in Sprague Dawley Rats and Exhibited In Vitro Antibacterial Effect on Multiple Antibiotic-Resistant Gastrointestinal Pathogens.

The involvement of multiple antibiotic-resistant gastrointestinal pathogens in diarrhea aggravates the disease condition uncontrollably. The … es of antibiotics in culture media. Chemical analysis revealed different alkaloids, flavonoids, and polyphenols that probably work in unison through multiple modes of action to arrest diarrhea and inhibit pathogens simultaneously. These promising results shown by AP-01 should evoke an effort to dive deep into research and development for better therapeutic fo …

Machine learning and SHAP value interpretation for predicting comorbidity of cardiovascular disease and cancer with dietary antioxidants.

OBJECTIVE: To develop and validate a machine learning model incorporating dietary antioxidants to predict cardiovascular disease (CVD)-cancer comorbidity and to elucidate the role of antioxidants in disease prediction. METHODS: Data were sourced from the National Health and Nutrition Examination Survey. Antioxidants, including vitamins, minerals, and polyphenols, were selected as key features. Additionally, demographic, lifestyle, and health condition features were incorporated to improve model accuracy. Feature preprocessing included removing collinear features, addressing class imbalance, a…

Functional Food Chemical Ingredient Strategies for Non-alcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis: Chemical Properties, Health Benefits, Action, and Application.

PURPOSE OF REVIEW: The liver is an important digestive gland in the body. Lifestyle and dietary habits are increasingly damaging our liver, … and prevent NAFLD and liver fibrosis through different mechanisms, including flavonoids, alkaloids, polyphenols, polysaccharides, unsaturated fatty acids, and peptides. On the other hand, the relevant mechanisms include oxidative stress, inflammation, and immune regulation, and a large number of literature studies have confirmed a close relationship between t …

The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review.

Understanding the molecular signaling pathways of colorectal cancer (CRC) can be accepted as the first step in treatment strategy. Permanent mTOR signaling activation stimulates the CRC process via various biological processes. It supplies the survival of CRC stem cells, tumorigenesis, morbidity, and decreased response to drugs in CRC pathogenesis. Therefore, inhibition of the mTOR signaling by numerous bioactive components may be effective against CRC. The study aims to discuss the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. The…

Alcohol, health loss, and mortality: can wine really save the good name of moderate alcohol consumption?

It is estimated that one‑third of the world's population consumes alcohol. At the same time, it is well‑known that excessive alcohol consump … l, red wine consumption may have different health effects, due to its high content of antioxidative polyphenols. Wine, together with abundance of plant‑based foods, olive oil, and fish, is an important part of the Mediterranean diet. There are both observational and randomized studies documenting a wide spectrum of health‑promoting effects of such a diet, esp …

Insights into the in vitro biological properties of Australian beach-cast brown seaweed phenolics.

Five Australian seaweed species, Phyllosphora comosa, Ecklonia radiata, Durvillaea potatorum, Sargassum fallax, and Cystophora siliquosa, th … stigation identified 48 phenolic compounds, including 19 phenolic acids, 20 flavonoids, and 9 other polyphenols. The presence of these compounds in extracts correlated with observed biological activities. These results support the potential health benefits of these seaweeds and link this activity to the presence of bioactive phenolics.

Impact of Reductive Stress on Human Infertility: Underlying Mechanisms and Perspectives.

Antioxidants have a well-established effect on general health and are essential in preventing oxidative damage to cells by scavenging free radicals. Free radicals are thought to be neutralized by these substances, which include polyphenols, β-carotene, and vitamins C and E, reducing cellular damage. On the other hand, recent data indicates that consuming excessive amounts of antioxidants may have side effects. Apoptosis and cell signaling are two beneficial physiological processes that are affected by excessive supplementation. Other negative effects include paradoxical enhancement of oxidativ…

Evaluation of the Effects of Mulberry Leaf Extracts Morus alba L. on Cardiovascular, Renal, and Platelet Function in Experimental Arterial Hypertension.

INTRODUCTION: Numerous epidemiological studies have demonstrated that consuming foods rich in polyphenols and flavonoids can have beneficial effects on various diseases, including arterial hypertension (HTN). Recent research from our laboratory has shown that certain flavonoids exhibit antihypertensive properties in several animal models of HTN. Our objective was to evaluate the effect of Morus alba L. (white mulberry) extracts in an experimental HTN model characterized by nitric oxide (NO) deficiency. METHODS: Male Sprague-Dawley rats were divided into four groups: a control group, hypertens…

Variations in the biochemical characteristics of Lavandula sublepidota Rech.f. in response to the foliar enrichment of green-synthesized copper nano complexes from extract of neem and jujube.

Copper (Cu) is an essential micronutrient in plant physiology and biochemistry. This article synthesized copper nano complexes (Cu-NCs) based on aqueous extracts of jujube and neem leaves. The effects of foliar application of Cu-jujube and Cu-neem Cu-NCs at concentrations of 0, 10, 25, and 50 mg L-1 on the bioactive compounds, antioxidant capacity, and essential oil of the Iranian native medicinal herb Lavandula sublepidota Rech. f. was investigated. The highest levels of flavonoids and polyphenols were observed in the plants treated with Cu-NCs at 25 mg L-1. However, no superiority was observ…

UV-induced reactive oxygen species and transcriptional control of 3-deoxyanthocyanidin biosynthesis in black sorghum pericarp.

Black pericarp sorghum has notable value due to the biosynthesis of 3-deoxyanthocyanidins (3-DOAs), a rare class of bioactive polyphenols valued as antioxidant food additives and as bioactive compounds with cytotoxicity to human cancer cells. A metabolic and transcriptomic study was conducted to ascertain the cellular events leading to the activation of 3-DOA biosynthesis in black sorghum pericarp. Prolonged exposure of pericarp during grain maturation to high-fluence ultraviolet (UV) light resulted in elevated levels of reactive oxygen species (ROS) and the activation of 3-DOA biosynthesis in…

Triphala ameliorates cognitive deficits and anxiety via activation of the Nrf2/HO-1 axis in chronic sleep-deprived mice.

Triphala is renowned for its curative attributes and has been utilized for centuries to address diverse health ailments. Moreover, the active component of Triphala, polyphenols, is widely recognized for its excellent pharmacological activities, such as anti-inflammatory properties, and has been utilized as a potential natural remedy. However, the precise mechanism through which Triphala alleviates cognitive dysfunction and anxiety induced by chronic sleep deprivation (SD) remains restricted. The objective of this investigation is to examine and clarify the potential mechanism of action that un…