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beta Testing a Medical Symptom Management для людей с продвинутым раком: Исследование одноразовой осуществимости и приемлемости.

КОЛИЧЕСТВО: Люди, страдающие раком, имеют более частые и серьезные симптомы, чем лица, страдающие ранней стадией заболевания. Обычные, тревожные симптомы включают трудности со сном, беспокойство и неуверенность, усталость и депрессию. Когнитивная поведенческая терапия (КБТ) и терапия принятия и принятия обязательств (АКТ) эффективно устраняют эти симптомы, но зачастую они являются слишком продолжительными для пациентов с несколькими назначениями, ограниченной энергией и конкурирующими приоритетами. Кратко говоря, мобильные медицинские услуги (медицинское обслуживание) являются доступной альтер

Питание N-6 Полиненасыщенное содержание жира в кислоте и здоровье мозга у взрослых людей среднего и старшего возраста.

ПАФА играет важную роль в возникновении и развитии нейродегенеративных заболеваний. С тех пор, как нейрозащитные эффекты n-3 ПУФА получил широкую поддержку, роль n-6 ПУФА по-прежнему обсуждается, а их основополагающие механизмы до сих пор не в полной мере понятны. В этом исследовании 169,295 Участники из Биобанка Соединенного Королевства были включены для анализа связей между питанием n-6 Поступление ПУФА и нейродегенеративные заболевания с использованием моделей коксовой регрессии с полной корректировкой для потенциальных сомнителей. Кроме того, для оценки воздействия различных моделей линейн

Methods for measuring financial toxicity after cancer diagnosis and treatment: a systematic review and its implications.

Patients experiencing financial distress as a side-effect of cancer are not only reported in the United States, but also in third-party payer healthcare systems in Europe. Since validated survey instruments are a prerequisite for robust and comparable results, we aimed to compile and classify available instruments to enable both a better understanding of the underlying construct of financial toxicity and to facilitate further studies that are adjustable to various healthcare systems. We did a systematic literature search on studies that provide data on perceived cancer-related financial distre

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… While items from the material subscale include questions on financial spending as well as financial resources, the social capital subscale comprise aspects of psychosocial resources such as family support or the person’s health literacy. …

Feasibility and Effectiveness of Assessing Subhealth Using a Mobile Health Management App (MibyeongBogam) in Early Middle-Aged Koreans: Randomized Controlled Trial.

BackgroundMobile health (mHealth) is a major source of health management systems. Moreover, the demand for mHealth, which is in need of change due to the COVID-19 pandemic, is increasing worldwide. Accordingly, interest in health care in everyday life and the importance of mHealth are growing.ObjectiveWe developed the MibyeongBogam (MBBG) app that evaluates the user's subhealth status via a smartphone and provides a health management method based on that user's subhealth status for use in everyday life. Subhealth is defined as a state in which the capacity to recover to a healthy state is dimi

Exploring Barriers and Facilitators to Engagement of an Online Acceptance and Commitment Therapy Intervention for Cancer Survivors With Chronic Painful Chemotherapy-Induced Peripheral Neuropathy: Qualitative Interview Study.

BackgroundOnline self-management interventions for cancer survivors are increasingly being used, but engagement is often difficult for patients. Given the importance of engagement for intervention effectiveness, identifying patient-reported barriers and facilitators is essential.ObjectiveThe aim of this study was to qualitatively examine barriers and facilitators influencing engagement with an online self-management intervention, offered with or without guidance, for cancer survivors experiencing chronic painful chemotherapy-induced peripheral neuropathy (CIPN).MethodsPatients who took part in

Psychometric validation of a Patient-Centred Quality of Cancer Care Questionnaire in Mexico.

ObjectivesTo develop and validate a Patient-Centred Quality of Cancer Care Questionnaire in Spanish (PCQCCQ-S) appropriate to the Mexican context.DesignPsychometric validation of a questionnaire.SettingTwo public oncology hospitals in Mexico City.Participants1809 patients with cancer aged ≥18 years.Source of informationCross-sectional survey.MethodsThe validation procedures comprised (1) content validity through a group of experts and patients; (2) item reduction and evaluation of the factor structure, through an exploratory factor analysis based on the polychoric correlation matrix; (3) inter

Some Aspects and Convergence of Human and Veterinary Drug Repositioning.

Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter, cheaper, and less risky. This review provides an overview of drug innovation in both human and veterinary medicine, with a focus on drug repositioning. The evolution of drug repositioning and the effectiveness of this approach are presented, including the growing role of data science and computational modeling methods in identifying drugs with po

Eliminating REMS for CAR T-Cell Therapies: An Opportunity to Improve Access.

Autologous Chimeric antigen receptor (CAR) T-cell therapies have demonstrated substantial efficacy in patients with relapsed or refractory hematologic malignancies; however, their implementation has been constrained by regulatory barriers. Risk Evaluation and Mitigation Strategies (REMS), mandated by the U.S. Food and Drug Administration (FDA), were initially implemented to mitigate risks associated with cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and other treatment-related toxicities. On 27 June 2025, the FDA removed REMS requirements for

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… Factors such as income, insurance coverage, transportation, caregiver availability, health literacy, and language proficiency influence both access and outcomes. …

Psychological Resilience, Symptom Burden, and Supportive Care Needs in Chemotherapy Patients: A Path Analysis

ABSTRACT Introduction and Aim While chemotherapy contributes to the survival of cancer patients, it also leads to various psychological and physiological problems, increasing the need for supportive care. This study aimed to determine the relationship between psychological resilience, chemotherapy symptoms, and supportive care needs in patients undergoing chemotherapy. Method This is a descriptive and correlational study. Data were collected using the Descriptive Characteristics Form, the Psychological Resilience Scale (PRS), the Nightingale Symptom Assessment Scale (N‐SAS), and the Supportive

Объединение медицинских услуг с предпочтением лечения: стимулирование правдивых самоотчетов.

ЦЕЛЬ: Самосообщенное соблюдение лекарств может зависеть от социально желательных ответов и неправдоподобной отчетности. Неправильная отчетность о поведении, связанном с присоединением, может привести к перекосам в оценках эффективности лечения (затратной). В ходе этого исследования были изучены пути обеспечения правдивого самосообщения в отношении лекарств и проведена оценка того, каким образом самосообщение (сопровождаемое правдой или регулярно сообщаемое) было связано с соблюдением и предпочтением лечения лекарств. МЕТОДЫ: Соблюдение лекарств было измерено после проведения эксперимента по ди

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… Fig. 2 Example of a choice set Example of a choice set In addition, the questionnaire contained questions about respondent’s demographics, health status, numeracy skills [ 45 , 46 ], health literacy [ 47 , 48 ] and health-risk attitude items [ 49 ]. …

Advancing access to CAR T-cell therapy: insights and real-world experience from a community oncology practice.

IntroductionChimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of hematologic malignancies, offering durable remissions for patients with otherwise refractory disease. However, access to these therapies remains limited and primarily restricted to academic medical centers, contributing to significant geographic and demographic disparities in care delivery.MethodsWe conducted a retrospective review of a community practice-based outpatient CAR T-cell therapy program, independent of academic or hospital affiliation, treating patients with relapsed hematologic malignancies

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… Frequent clinic visits can be financially burdensome and poor health literacy or lack of adequate caregiver support can restrict eligibility and increase risk. …

Psychometric properties of the Thai version of the Illness-Specific Social Support Scale Short Version-8 (ISSS-8) among hematological malignancy patients in the Northeastern region of Thailand: A multicenter study.

Social support, which is an essential aspect influencing health, has resulted in the development of several approaches for assessment in cancer patients. The Illness-Specific Social Support Scale Short Version-8 (ISSS-8) effectively evaluates social support among diverse patient demographics; however, its psychometric validity has yet to be established in Asian cultural contexts. The objectives of this study were to translate and culturally adapt the ISSS-8 for the Thai setting and to assess its psychometric properties in patients with hematological malignancies (HMs). This study employed a co

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… Materials and methods Study design and participants This study employed a multicenter, methodological design using data from a larger project, namely “Self-care behaviors and the relationship between health literacy, self-efficacy, social support, and self-care behaviors among patients with lymphoma …

Adaptation of Coping Together - a self-directed coping skills intervention for patients and caregivers in an outpatient hematopoietic stem cell transplantation setting: a study protocol.

BackgroundDespite numerous reports of significant distress and burden for hematopoietic stem cell transplantation (HSCT) patients and caregivers (CGs), HSCT-specific coping interventions remain rare. The few in use lack specificity and are often not easily accessible or cost-effective. Whereas the development of new interventions is resource-intensive, theory-informed adaptation of existing evidence-based interventions is promising. To date, no HSCT-specific intervention has relied on a formal adaptation approach.MethodsUsing the Center for Disease Control and Prevention's Map of Adaptation, t

Facing the COVID-19 pandemic: An Italian feasibility study of a mixed in-person/telerehabilitation intervention for cancer patients.

IntroductionThe COVID-19 pandemic impacted healthcare organizations, necessitating a rapid transition from in-person to virtual care. Our study explored the feasibility of a mixed in-person/telerehabilitation intervention for cancer patients and its effects on cancer-related fatigue (CRF), quality of life (QoL), physical function, patient satisfaction, and perceived usefulness.MethodsTRACE 2020 is an observational prospective study that enrolled adult cancer patients, between January 2021 and March 2023, who were eligible for a rehabilitation program to be provided also in telerehabilitation.

Empowering Patients in Clinical Research: A Narrative Review.

This narrative review focuses on the evolving shift toward patient centricity in Indian clinical research, highlighting persistent gaps in structured patient engagement. The review synthesizes existing literature on patient-centered clinical research and contextualizes these principles through two India-based initiatives: Patient Advocates for Clinical Research (PACER) and Patient Recommendations for Ethical Decentralized and Inclusive Clinical Trials (PREDICT). A targeted literature search was conducted across Medline (via PubMed), Google Scholar, and the Cochrane Library to identify publishe

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… Despite these advantages, challenges remain in the implementation of PROs and preference studies, including preference heterogeneity, equity considerations, and variations in health literacy, which may limit their consistent application across diverse populations [ 34 ]. …

Количественная оценка предпочтений CAR-T по сравнению со стандартом ухода за пациентами с множественными миеломами.

Для лечения повторной рефракторной множественной миэломы (ММ) была утверждена терапия фонкар-Т, и в настоящее время изучается возможность диагностики MM (NDMM). В связи с использованием новых методов лечения в раннем режиме ММ возникают вопросы о приемлемости рисков на начальном этапе в обмен на продолжительные периоды без рецидивов без бремени лечения и ограничений на повседневную деятельность, связанную с лечением. Эксперимент MethodsA с дискретным выбором был разработан в целях выявления предпочтений взрослых к гипотетическому лечению NDMM. Выгоды включают время, необходимое для возобновлен

Sitz bath with different concentrations of diluted povidone-iodine for prevention of perianal infection in patients with hematological malignancies undergoing chemotherapy: a randomized controlled trial in a tertiary hospital in China.

BackgroundThe incidence of perianal infection in patients with hematologic malignancies undergoing chemotherapy can reach 40-50%. Despite advances in medical technology and improved management strategies, the rate of perianal infection following chemotherapy remains substantial. Currently medicated sitz baths are not widely adopted in clinical practice due to their side effects and limited applicability. Povidone-iodine (PI) is a commonly used clinical broad-spectrum antiseptic, yet its efficacy in preventing perianal infection has not been adequately studied. Therefore, we aimed to evaluate t

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… Educational attainment can influence patient compliance through several pathways: it often correlates with health literacy, affecting the comprehension of medical instructions and it can impact the ability to accurately recognize and report early symptoms. …

Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature.

N-acetylcysteine (NAC) is a membrane-permeable cysteine precursor capable of enhancing the intracellular cysteine pool, enhancing cellular glutathione (GSH) synthesis, and thus potentiating the endogenous antioxidant mechanism. Late administration of NAC after cisplatin has been shown in different in vivo studies to reduce the side effects caused by various toxicities at different levels without affecting the antitumor efficacy of platinum, improving total and enzymatic antioxidant capacity and decreasing oxidative stress markers. These characteristics provide NAC with a rationale as a potenti

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

Quality of Online Information on Multiple Myeloma Available for Laypersons.

Online information can increase patients' competence and engagement. However, there are concerns regarding invalid information. Overall, 300 websites and 50 YouTube videos on multiple myeloma (MM) were evaluated. The websites did not differ between the search engines or search ranks. The median time since the last update was 9 months. The 63 unique websites showed a poor general quality (median JAMA score 2 of 4, only 18% with a valid HON certificate). The patient- (user-) focused quality was medium to poor (median sum DISCERN score 41 out of 80 points). The overall reading level was difficult

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… Health literacy: The gap between physicians and patients. Am. Fam. Physician. 2005;72:463–468. 29. Zraick R.I., Azios M., Handley M.M., Bellon-Harn M.L., Manchaiah V. Quality and readability of internet information about stuttering. J. Fluen. …