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Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis. Clinical features, immunopathology, and molecular analysis.

Monoclonal immunoglobulin deposition occurs in tissues as Congo Red binding fibrils in light chain amyloidosis, as less structured deposits … ere less common but occasionally severe. Four patients had overt multiple myeloma. Three others had hypercalcemia and mild bone marrow plasmacytosis but no lytic lesions. Analyses of immunoglobulin synthesis in bone marrow cells from seven patients showed excess light chains in all and incomplete light chains or heavy chain fragments in six, regardless of wheth …

Depression of vitamin B6 levels due to gentamicin.

The renal toxicity of gentamicin is altered by dietary protein modifications, bicarbonate and acetazolamide administration, magnesium supplementation, polyaspartic acid, piperacillin, hypercalcemia and calcium channel blockers. Renal tissue gentamicin levels have an undetermined role. Reduction of renal pyridoxal 5'-phosphate (PLP- by gentamicin has been shown, as has protection from nephrotoxicity by administration of vitamin B6. To explore an interaction between gentamicin and vitamin B6, gentamicin (5 mg/kg) was given to rabbits by ip injection, with either pyridoxine (10 mg) or isovolemic …

Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo.

MC 903 is a novel vitamin D analogue which has been tested for its effects on cell differentiation and cell proliferation in vitro using the … d was at least 100 times less active than 1,25(OH)2D3 and 1 alpha (OH)D3 in causing hypercalciuria, hypercalcemia and bone calcium mobilisation. The low vitamin D activity of MC 903 was further confirmed by administration of the compound to rachitic rats. The strong direct effects of MC 903 on cell proliferation and cell differentiation, coupled with its decrea …

Animal model of primary hyperparathyroidism.

An experimental model of hyperparathyroidism was developed in the rat to simulate primary hyperparathyroidism in humans. In this model thyroparathyroidectomized (TPTX) or parathyroidectomized (PTX) animals were infused for 6 days with an amount of bovine synthetic parathyroid hormone (PTH)-(1-34) fragment to restore plasma calcium levels to normal (0.7 U X h-1) or with PTH at twofold (1.4 U X h-1) or threefold (2.1 U X h-1) this basal level. Animals infused with 2.1 U X h-1 of bovine PTH-(1-34) exhibited hypercalcemia, hypophosphatemia, a reduction in theoretical renal threshold for phosphate …

Pulmonary calcinosis after renal transplantation in pediatric patients.

Pulmonary calcinosis is a recognized complication of renal failure. The resulting pulmonary compromise may be severe or even fatal. The potential contribution of hypercalcemia, hyperphosphatemia, and increased calcium-phosphorus product to the development of pulmonary calcinosis has been controversial. We describe four patients (ages 2 1/4 to 18 years) who had severe pulmonary calcinosis and respiratory failure within three to five days after renal transplantation. Initial clinical and roentgenographic findings suggested noncardiogenic pulmonary edema. Marked pulmonary hypertension was present…

Human T-cell leukemia-lymphoma virus type 1 and adult T-cell leukemia-lymphoma in Okinawa.

A serological survey for the presence of antibodies against the human T-cell leukemia virus, type 1 (HTLV-1) in patients seen at the Chubu Hospital in Okinawa was undertaken. All patients with the clinicopathological diagnosis of adult T-cell leukemia-lymphoma were positive. These cases had the characteristic features of adult T-cell leukemia-lymphoma: diffuse histology, often mixed cell or pleomorphic, and a high frequency of hypercalcemia, leukemic phase, diffuse visceral involvement, and opportunistic infections. The median survival of these patients was short, being only 18 weeks. Of the o…

The suppression of TSH in the presence of the normal PRL responses to TRH out of 26 patients with primary hyperparathyroidism.

The responses of TSH and PRL to intravenous doses of 500 micrograms of TRH were investigated in 26 patients with primary hyperparathyroidism … nts with primary hyperparathyroidism have a high incidence (54%) of suppressed TSH response to TRH. Hypercalcemia was obviously one of the causative factors in inducing this abnormality in six patients. However, persistently suppressed responses of TSH to TRH were observed in the other six patients in Group A even after the correction of the serum calcium level …

Changes in blood flow to bones during the hypocalcemic and hypercalcemic phases of the response to parathyroid hormone.

Labeled microspheres were used to measure blood flow to the leg bones of the laying hen at 0, 3, and 30 min after iv injection of parathyroid hormone (PTH) (Wilson) or the synthetic 1 to 34 fragment of bovine parathyroid hormone (PTH 1-34). At 3 min, which corresponds to the hypocalcemic phase of the PTH response, blood flow to the combined femur, tibia, and metatarus was significantly reduced by PTH (Wilson) relative to 0 time and to carrier-injected controls. At 30 min, i.e., the time of maximum hypercalcemia in the hen, blood flow to these bones was significantly increased relative to 0 tim…

Pseudohypoparathyroidism: defective excretion of 3',5'-AMP in response to parathyroid hormone.

Urinary excretion of cyclic adenosine 3',5'-monophosphate (3',5'-AMP) was tested in normal subjects and patients with pseudohypoparathyroidi … cium was increased above 12 mg/100 ml. Suppression of parathyroid hormone secretion by induction of hypercalcemia did not alter the deficient response to exogenous hormone. The results indicate that: (a) parathyroid hormone circulates in abnormally high concentrations in pseudohypoparathyroidism and secretion of the hormone responds normally to physiological co …

Sciatica как нетипичное первоначальное представление множественной миеломы: отчет о деле.

ВЕРТЕБРАЛЬНОЕ участие в множественной миеломе является частой причиной заболеваемости и связано с сильной болью, деформацией позвоночника и неврологическим компромиссом. Несмотря на то, что боль в спине является широко распространенной особенностью, сицика в качестве первоначального проявления множественной миеломы является крайне редким явлением, особенно у пациентов, не имеющих истории травм или остеопоротических факторов риска. Признание таких нетипичных презентаций имеет решающее значение для своевременной диагностики и управления. ОПИСАНИЕ СЛУЧАИ: Мужчина среднего возраста без какой-либо

Совпадение в аннотации оригинала
BACKGROUND: Vertebral involvement in multiple myeloma is a frequent cause of morbidity and is associated with severe pain, spinal deformity, … ging revealed multiple vertebral compression fractures, and laboratory studies demonstrated anemia, hypercalcemia, renal dysfunction, and elevated inflammatory markers. Bone marrow biopsy and serum protein electrophoresis confirmed the diagnosis of multiple myeloma. The patient was managed conservatively with analgesia, spinal bracing, and correction of metabol …

Vitamin D-AMP axis in host defense against fungal infections.

Vitamin D-mediated regulation of antimicrobial peptides (AMPs) is an important focus in innate immunology and is aimed at elucidating the ro … use is limited by supraphysiologic dosing requirements, pharmacologic impracticality, and risks of hypercalcemia and hyperphosphatemia, especially in patients with granulomatous diseases. Model limitations and species differences are also discussed, including primate-specific CAMP vitamin D response element regulation, which constrains direct translation of ro …

From mechanisms to clinical practice: a review of diuretic therapy in pediatric nephrology.

Diuretics are a cornerstone of supportive therapy in pediatric patients, widely used for the management of edema, fluid overload, hypertensi … ephrology, including nephrotic syndrome, chronic kidney disease, acute kidney injury, hypertension, hypercalcemia, hypercalciuria, and nephrogenic diabetes insipidus. Special populations, including neonates and adolescents, are discussed, highlighting developmental pharmacology, vulnerability to toxicity, and long-term growth and bone health concerns. The revie …

Laboratory Identification of Pseudohypercalcemia Induced by Hyperglobulinemia in Multiple Myeloma: A Case Report.

BackgroundPseudohypercalcemia is easily misdiagnosed in clinical practice, potentially leading to unnecessary interventions. Multiple myeloma (MM) presenting with concurrent hypergammaglobulinemia represents a rare etiology of pseudohypercalcemia, and there are few reports of systematic laboratory validation of this pathological entity.MethodsWe report a patient with MM who presented with markedly elevated serum total calcium on routine biochemical testing. The hypercalcemia persisted despite 1 month of calcitonin therapy administered at an external hospital. After admission, the clinical labo…

Adult T-Cell Leukemia/Lymphoma and Epstein-Barr Virus-Positive DLBCL: A Rare Concomitant Association.

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoma with a poor prognosis. The human T-lymphotropic virus 1 (HTLV-1) is associat … marrow biopsy/aspiration confirmed 50% T-cell lymphoid infiltration. Biochemistry results revealed hypercalcemia and a high lactate dehydrogenase value. Results of a CT scan indicated abdominal and thoracic adenopathy as well as moderate splenomegaly. A supraclavicular lymph node biopsy established a DLBCL diagnosis. The final diagnosis was composite lymphoma, …

One Lobe, Two Pathologies: First Report of an Intrathyroidal Parathyroid Adenoma Invaded by Papillary Thyroid Cancer and Review of the Literature.

Intrathyroidal parathyroid adenomas (ITPAs) are rare causes of primary hyperparathyroidism, with type III variants, being the rarest. Coexistence of ITPA and papillary thyroid carcinoma (PTC) in the same lobe is exceedingly rare. The pathogenesis of this rare coexistence is unclear, possibly related to embryologic displacement or local microenvironmental factors. No prior reports have documented direct invasion of ITPA by PTC. We report a 63-year-old woman with hypercalcemia and osteopenia. Imaging suggested a right lobe ITPA. Hemithyroidectomy revealed a type II ITPA and multifocal PTC, with …

[Mechanisms of Exosomes in Lung Cancer Bone Metastasis and Related Clinical Advances].

Lung cancer is the malignant tumor with the highest morbidity and mortality, and it is usually diagnosed with advanced metastasis. Tumor metastasis is an important factor affecting treatment resistance and poor prognosis of lung cancer, among which bone metastasis is a common metastatic pattern of lung cancer and is associated with a particularly dismal prognosis. Meanwhile, bone metastasis frequently causes skeletal-related events such as bone pain, pathological fractures, nerve compression, and hypercalcemia. Exosomes are extracellular vesicles with a diameter of 40-160 nm that are released …

Chapter 8: Management of aggressive forms of primary HPT: Parathyroid carcinoma and atypical parathyroid tumor.

Parathyroid carcinoma is extremely rare, affecting 1% of cases of primary hyperparathyroidism. For this reason, management is poorly codified and requires expertise in specialized center. PC is genetically determined in a quarter to a third of cases, notably involving the CDC73 gene coding for parafibromin. Since 2004, malignancy has been diagnosed on both macroscopic and microscopic invasion criteria, as set out in the WHO 2022 histopathological classification. Surgery is an essential part of treatment. Resection must be oncological, after prior medical treatment for hypercalcemia that are of…

Adrenal Insufficiency in Dialysis Patients.

The aim of this review is to summarize the literature on the pathophysiology, diagnosis, and etiology of adrenal insufficiency (AI) in dialy … osteroid therapy, unexplained chronic arterial hypotension, recurrent hypoglycemia, and unexplained hypercalcemia.

Development and Mechanistic Evaluation of a Lithocholic Acid Derivative as an Environmentally Safe Rodenticide.

Control of rodents remains a critical global challenge due to their role in spreading zoonotic diseases and damaging ecosystems, but current … tamin D3, Dcha-20 impeded plasma calcium elevation observed with vitamin D3, minimizing the risk of hypercalcemia in nontarget animals. Transcriptome analysis highlighted upregulation of pathways associated with vitamin D metabolism and inflammatory responses, indicating acute renal failure as the primary toxic mechanism. Histopathological and biochemical analy …

Pitfalls of Intraoperative Parathyroid Hormone Monitoring in Achieving Complete Surgical Resection of Ectopic Mediastinal Parathyroid Adenoma: A Case Report and Literature Review.

Ectopic mediastinal parathyroid adenoma is rare and is generally managed by surgical resection as a definitive treatment. Intraoperative parathyroid hormone (ioPTH) monitoring is valuable for ensuring the complete removal of a target lesion. However, there is no consensus criteria regarding the utilization of ioPTH for complete resection in patients with ectopic mediastinal parathyroid adenomas. A 65-year-old woman presented with asymptomatic hypercalcemia, and was subsequently diagnosed as having hyperparathyroidism. Radiological imaging displayed a solid mediastinal tumor, suspected to be ec…