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Безопасность во-первых, наука, во-вторых: условное доверие работников здравоохранения и готовность участвовать в испытаниях вакцины от лихорадки Ласса в Нигерии.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: лихорадка Ласса представляет собой постоянный профессиональный риск для медицинских работников в Нигерии. Хотя ГВУ играют ключевую роль в успешном применении вакцин, их принятие решений в условиях, обусловленных историческими разногласиями в области исследований, по-прежнему недостаточно изучено. В рамках этого исследования были изучены условия, при которых ГГВ в учебном госпитале Амину Кано (АКТХ), северная часть Нигерии, сочли участие в испытаниях вакцины от лихорадки Ласса приемлемым. МЕТОДЫ: В период с сентября по октябрь 2025 года мы провели описательное качественно

Совпадение в аннотации оригинала
BACKGROUND: Lassa fever poses a persistent occupational risk to healthcare workers (HCWs) in Nigeria. While HCWs are pivotal to vaccine tria … uring influence of the 1996 Pfizer meningitis trial in Kano. Transparent safety information, robust informed consent, credible ethical oversight, fair compensation for research-related harm, and institutional accountability emerged as essential conditions for participation. CONCLUSIONS: Within the distinctive historical and institutional context of AKTH, HCWs app …

На основе CRISPR-Cas9 лечение болезни Хантингтона и атаксии Фридрейха: механизмы, достижения и будущие перспективы.

Болезнь Хантингтона (HD) и атаксия Фридрейха (FRDA) являются прогрессивными унаследованными нейродегенеративными расстройствами, вызванными повторной экспансией тринуклеотида, но характеризующимися различными патогенными механизмами. HD возникает в результате расширения региона кодирования CAG в гене HTT, что вызывает токсичное повышение функциональности охотничьего мутанта (mHTT), в то время как FRDA является главным образом результатом интронического расширения GAA в FXN, что приводит к эпигенетическим репрессиям и фратаксиновому дефициту. Появление инженерии генома на основе CRISPR открыло

Совпадение в аннотации оригинала
Huntington's disease (HD) and Friedreich's ataxia (FRDA) are progressive inherited neurodegenerative disorders caused by trinucleotide repea … ngineering technologies. Ethical and regulatory concerns remain substantial, particularly regarding informed consent in the context of cognitive decline and the irreversibility of genomic modification.

A comparative study of spiritual health in HIV-positive patients and healthy individuals.

Given the role and importance of spiritual well-being in individuals living with AIDS and the role of psychological interventions on the spi … mple of healthy individuals visiting the Comprehensive Health Center, who participated after giving informed consent. The demographic form and the Spiritual Well-Being Questionnaire (SWBQ) were completed by the patients. The statistical analysis was performed using SPSS software (version 11.5), and the significance level was considered at p < 0.05. A total of 201 …

Pinta tu Raya ASI [Set your Limit LIKE THIS]: an educational intervention using immersive reality to prevent Child Sexual Abuse in Mexico.

BACKGROUND: Child Sexual Abuse (CSA) is a global social and health problem requiring a comprehensive, multi-level prevention approach. Schoo … ublic Health's Commissions of Research, Ethics, and Biosafety. Ethical safeguards include obtaining informed consent from guardians and assent from minors, providing trained staff, continuous monitoring during the IVR session, and having a specialized psychology team for case management and referral. TRIAL REGISTRATION: The study was approved by the Commissions o …

Diagnostic accuracy of presepsin and C-reactive protein in the early stages of neonatal sepsis: A prospective study.

Introduction. Neonatal sepsis is a common complication in the neonatal intensive care unit (NICU). Biomarkers have certain limitations, and … h congenital anomalies, those currently receiving antibiotic treatment, and those for whom parental informed consent was not obtained. ROC curves were plotted for PSEP and CRP. Results. A total of 150 suspected sepsis events in 122 newborns were included. The median gestational age was 32 weeks (IQR 29-37) and the median birth weight was 1530 grams (IQR 990-2705). …

Exploring the link between Mycobacterium avium subsp. Paratuberculosis and colorectal cancer development.

BACKGROUND: Colorectal cancer (CRC) ranks third in incidence and fourth in cancer-related mortality worldwide. It typically begins as benign … Cs). The Participants underwent colonoscopy at a clinical center in Golestan province, and provided informed consent and relevant health data. Exclusion criteria included recent antibiotic use and a history of gastrointestinal disease. Genomic DNA was extracted from intestinal mucus samples and analyzed using nested PCR. RESULTS: In our study, the prevalence of M …

Hidden burdens: The dual burden of subclinical iron deficiency and hemoglobinopathies in afro-descendant populations of Colombia's Pacific coast: A public health concern.

BACKGROUND: Iron deficiency and hemoglobinopathies significantly impact public health, affecting morbidity, mortality, and quality of life. … e sampling from various healthcare centers in the Pacific region. All participants provided written informed consent prior to enrollment. Blood samples were analyzed for total hemoglobin, ferritin levels, and hemoglobin variants. RESULTS: Only 18.1% of participants reported a previous anemia diagnosis. Low hemoglobin was found in 23.2% of participants, ferritin d …

The science and conduct of surgical trials in gynecologic oncology: A practical framework.

Surgical trials have been among the most important drivers of practice change in gynecologic oncology, generating evidence across ovarian, e … ity assurance, outcome selection, the integration of patient-reported outcomes, patient accrual and informed consent, and equitable trial participation. By outlining principles that balance methodological rigor with pragmatic relevance, this review highlights how optimized trial conduct is essential to generating reliable evidence, accelerating surgical innovation …

Patient-facing materials for hip and knee preservation surgery are written well above recommended reading level.

Hip and knee preservation have rapidly expanded over the past decade. As technology and surgeon familiarity have increased, patient interest … and the literacy of the target patient population may hinder patient comprehension, engagement, and informed consent, potentially impacting healthcare outcomes.

Safety & efficacy of thulium laser endoscopic en bloc resection versus conventional trans urethral resection of bladder tumors, for treatment of non muscle invasive bladder tumors: A prospective randomized trial.

INTRODUCTION: Non-muscle invasive bladder cancers (NMIBCs) are managed with endoscopic resection and intravesical therapy. Lasers, particularly thulium and holmium, are now central to bladder tumor management. This study assesses the safety and efficacy of thulium laser enucleation of bladder tumors (Tm-LRBT). PATIENTS & METHODS: A prospective randomized clinical study was conducted from June 2022 to December 2023, involving 100 patients. Group A was treated with TmLRBT and Group B with conventional monopolar TURBT. Informed consent was obtained from all participants. Inclusion criteria were …

Polyp prophylactic properties of polyacetylenes from carrots in patients with previous polypectomy-Px7 The study protocol of a multicentre binational randomised controlled trial.

INTRODUCTION: A large bowel cancer chemoprevention potential has been demonstrated by the consumption of carrots, which represent the major dietary source of polyacetylenes. Their interaction with cancer cells and enzyme systems of animals and humans has been systematically investigated over the last 15 years and has now been characterised as anti-inflammatory compounds with antineoplastic effect. Our objective is to investigate whether selected carrot species with a high content of the polyacetylenes falcarinol (FaOH) and falcarindiol (FaDOH) prevent neoplastic transformation and growth in hu

Artificial wombs in perinatal medicine: a transformative frontier in neonatal care and bioethics.

OBJECTIVES: To evaluate the current state and translational readiness of artificial womb technology (AWT), focusing on its technical feasibi … ng-term neurodevelopmental outcomes. Ethical tensions surround maternal autonomy, fetal personhood, informed consent, and global equity in access. CONCLUSIONS: Artificial wombs represent a paradigm shift in neonatal care, offering the potential to extend viability and reduce preterm morbidity. As AWT approaches clinical translation, interdisciplinary coordination …

Influence of Behavioral and Sociodemographic Factors on Dental Caries in Mexican Children.

BACKGROUND: In Mexico, tooth decay is common among children and is on the rise. A strong relationship exists between behavioral, socioeconomic, demographic, and biological factors and the severity and development of dental caries. OBJECTIVE: The present study analyzed the risk factors contributing to dental caries in a Mexican pediatric population. MATERIALS AND METHODS: This study employed a cross-sectional design. One hundred fifty-one children were evaluated after providing their assent and the informed consent of their legal guardians. The study subjects recruited underwent dental assess…

Peripheral TERT- positive leukocytes as a biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression.

The prognosis of early-stage lung adenocarcinoma (LUAD) worsens significantly during the progression from adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA) to invasive adenocarcinoma (IAC), emphasizing the importance of understanding the molecular mechanisms underlying this transition for effective clinical intervention. This study analyzed data from 990 eligible early-stage LUAD patients meeting the following inclusion criteria: written informed consent, absence of neoadjuvant therapy, planned surgical resection, postoperative pathological confirmation of LUAD, and an Eastern…

Nurture-U student mental health longitudinal survey: a study protocol.

INTRODUCTION: University life represents a critical period for young adults, providing opportunities for personal growth and development of … has been obtained from relevant committees at each participating university. Students will provide informed consent prior to participation, with risk messages and support information provided for those indicating self-harm or suicidal thoughts. Data will be de-identified and securely stored, with results disseminated through academic publications, social media an …

Sexual functioning after vaginal natural orifice transluminal endoscopic surgery: combined results of two randomized controlled trials.

OBJECTIVE: To explore women's sexual functioning and associated quality of life after vaginal natural orifice transluminal endoscopic surgery (vNOTES) as an alternative to laparoscopy. DESIGN: Two parallel group, 1:1 randomized single-centre single-blinded trials comparing the effects of vNOTES and laparoscopy. SETTING: Gynaecology unit of a Belgian teaching hospital. POPULATION: Women aged between 18 and 70 years with a benign indication for hysterectomy or adnexectomy. METHODS: After informed consent, women were randomized for vNOTES (experimental group) or laparoscopy (control group). P…

[Effectiveness of Pulsed Radiofrequency on Peripheral Nerves in Severe Refractory Focal Spasticity: An Ambispective Observational Study].

OBJECTIVES: To evaluate the efficacy and safety of pulsed radiofrequency (PRF) in spasticity. DESIGN: Ambispective observational study of patients with spasticity refractory to conventional treatment, enrolled from July/2019 to December/2024 and treated with PRF. MATERIALS AND METHODS: The following scales were evaluated: Modified Ashworth (MAS), Visual Analogue (VAS) before, 2 and 6 months after the procedure, and GAS, PGA and PGI-C. The study was approved by the Galician Ethics Committee for Pharmaceutical Research (registration number 2023/153). All patients signed the informed consent fo…

Depressive symptoms in workers with subsistence jobs in the pandemic context, according to working and extra-working conditions, Medellín, Colombia 2021.

INTRODUCTION: Although mental health is a topic of interest in public health, there is still little evidence on depressive symptoms among informal workers in times of pandemic. OBJECTIVES: To identify the prevalence of depressive symptoms and their relationship with working and socioeconomic conditions among informal workers in the context of the pandemic, Medellin, Colombia, 2021. METHODS: Cross-sectional study using primary data collected from 656 workers, after obtaining informed consent. A pilot test was conducted, and selection and information biases were controlled. Exploratory, bivari…

Effectiveness of AI-generated orthodontic treatment plans compared to expert orthodontist recommendations: a cross-sectional pilot study.

INTRODUCTION: Artificial intelligence (AI) has become a prominent focus in orthodontics. OBJECTIVE: This study aimed to compare treatment plans generated by AI platforms (ChatGPT, Google Bard, Microsoft Bing) with those formulated by an experienced orthodontist. METHODS: This observational cross-sectional pilot study aims to evaluate the effectiveness of AI-powered platforms in creating orthodontic treatment plans, using a clinical case treated by an experienced orthodontist as a benchmark. A clinical case was selected, and after obtaining informed consent, detailed case information was pres…

Coping mechanisms for students with mental disorders: An exploratory qualitative study at Busitema University's Mbale and Busia Campuses.

In recent years, Ugandan universities have faced a rising incidence of mental health issues among students, with prevalence rates of mental … were guided by a structured protocol developed by the research team, and all participants provided informed consent. The interviews were audiotaped, transcribed verbatim, and analyzed using thematic analysis. This approach was chosen for its efficiency and directness. Nvivo software facilitated the coding and organization of themes. The study identified several c …