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Изучение цереброваскулярных проявлений нейроборлиоза: обзор.

Заболевание Lyme - это зоонотическая инфекция, передающаяся Боррелией Бурдорфери, и, если ее не диагностировать, она может появиться на более поздних этапах с неврологическими проявлениями. Цель этого обзора заключается в обобщении данных о инсультовом или аналогичном цереброваскулярном исходе нейроборрелиоза Лайма (НБ) для содействия раннему распознаванию и лечению. 90 - пациенты, отвечающие критериям Европейской федерации неврологических обществ/Американской академии неврологических заболеваний/Американской школы ревматологии (EFNS/IDSA/AAN/ACR) для ЛНБ с радиологически или серологически под

Совпадение в аннотации оригинала
Background and objectivesLyme disease is zoonotic infection transmitted by Borrelia burgdorferi and, if left undiagnosed, can present in lat … intrathecal Borrelia Immunoglobulin G (IgG) appeared in the majority of cases. Antibiotics (mainly ceftriaxone) were used in 85% of cases and interventional management in 13% of cases. Ninety percent of cases improved after 6 months of treatment. Mortality and persistent tetraplegia were reported in 5% and 3% of cases, respectively.ConclusionsLNB should be s …

Evaluation of antibiotic consumption in Intensive Care Units of a teaching hospital based on defined daily dose metrics and WHO Access, Watch, Reserve classification framework.

INTRODUCTION: Antimicrobial resistance (AMR) represents a global public health crisis. The WHO Global Action Plan and India's National Actio … m 359 eligible ICU patients were analyzed. The DU75% segment included 'Watch' category antibiotics, ceftriaxone, meropenem, and 'Access' category antibiotics, metronidazole and doxycycline. 'Watch' category antibiotics were used most frequently, with a cumulative DDD/100 patient days of 71.8. This was followed by the 'Access' category with a cumulative DDD/10 …

Antibiotic-Resistant Salmonella Enteritidis in Raw Chicken Meat of Dhaka City, Bangladesh.

Foodborne zoonotic Salmonella is transmitted through contaminated meat, milk, and eggs. This study is aimed at investigating the antimicrobi … S. Enteritidis were sensitive to gentamicin (86.5%), meropenem (64.9%), ciprofloxacin (62.2%), and ceftriaxone (59.5%). The TetA gene, which causes AMR against tetracycline, was shown to be present in all phenotypically resistant Salmonella species. Multiple antibiotic resistance index (MARI) ranged between 0.3 and 0.8. Overall, multidrug resistant (MDR) Sal …

Antibiotic use patterns and factors associated with leukocyte decrease in COVID-19 patients with suspected secondary infections: A cross-sectional study in Indonesia.

Antibiotics are frequently prescribed to coronavirus disease 2019 (COVID-19) patients, often without evidence of bacterial superinfection, i … d Escherichia coli. The most frequently prescribed antibiotics were azithromycin, levofloxacin, and ceftriaxone. No significant association was found between the number of antibiotics prescribed and clinical outcome (leukocyte normalization). Broad-spectrum antibiotics from the World Health Organization (WHO) AWaRe "Watch" category dominated the antibiotic pr …

Molecular detection and prevalence of colistin-resistant Escherichia coli in poultry and humans: a one health perspective.

Multidrug-resistant (MDR) bacteria significantly threaten humans and animals worldwide. Colistin is the last resort of antibiotics against g … coli isolates from humans exhibited 90% resistance to ciprofloxacin, 88% to ampicillin, and 85% to ceftriaxone. Among these, MDR E. coli isolates of both commercial poultry and humans, colistin resistance was found in 78.6% and 48.1%, respectively. Genotypic confirmation of mcr genes such as mcr-1 (42%), mcr-2 (19.6%), mcr-3 (15.1%), mcr-4 (7.6%), and mcr-5 …

A 12-year surveillance study on distribution and antimicrobial resistance of gram-positive bacteria in Iran.

Strengthening knowledge through surveillance and research is one of the main steps in treating antibiotic-resistant infections. The present … iotics: from 33.9% in 2013 to 54.5% in 2023 for gentamicin; from 51.2% in 2013 to 76.4% in 2023 for ceftriaxone; from 34.5% in 2013 to 54.8% in 2023 for imipenem; and from 66.7% in 2012 to 81.8% in 2023 for cefixime. The present research suggests that vancomycin and nitrofurantoin are effective antibiotics against infections caused by Staphylococcus and Enter …

Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years.

BACKGROUND: Antibiograms monitor antibiotic resistance trends and help guide empiric antibiotic treatment. A statewide pediatric antibiogram … reased. For E. coli, there was a significant decrease in susceptibility for cefazolin (90% to 84%), ceftriaxone (95% to 92%), and meropenem (100% to 99%). There were nonsignificant decreases in susceptibility for K. pneumoniae. CONCLUSION: Over the past 10 years, MRSA rates decreased, S. pneumoniae antibiotic susceptibility increased, and gram-negative bacil …

Assessing antibiotics consumption, use and outcomes in a Yemeni tertiary hospital: A prospective cross-sectional study.

BACKGROUND: Antibiotics (ABs) have saved countless lives, but their misuse has led to a serious problem: antibiotic resistance. This growing … -44 years), gender (female), and ward type (private). The most commonly prescribed antibiotics were Ceftriaxone (33.6%), Metronidazole (21.8%), Vancomycin (6.0%), Levofloxacin (4.9%), Imipenem/Cilastatin (4.7%), and Moxifloxacin (3.6%). Notable deviations from DDD were observed for Levofloxacin (overuse by 28%), Imipenem/Cilastatin (underuse by 40.5%), and ot …

Colistin and β-lactam resistance in Escherichia coli isolates from bovines, swine, and humans.

INTRODUCTION: Colistin and β-lactams are widely investigated because of their effectiveness in the treatment of human diseases. This study investigated the phenotypic and genotypic profiles of colistin- and β-lactam-resistant Escherichia coli (n = 235) obtained from bovines, swine, and workers from a mixed slaughterhouse in Brazil. METHODOLOGY: The disk diffusion method was used to test the resistance against β-lactams (amoxicillin, ampicillin, cefaclor, cefazolin, cefepime, cefotaxime, ceftazidime, ceftriaxone, imipenem, meropenem, and aztreonam). In order to test colistin resistance, the is…

Investigation of CTX-M Type Extended-Spectrum β-Lactamase, Carbapenem and Colistin Resistance in Enterobacterales Isolated From Dairy Cattle in Turkey.

BACKGROUND: The increasing prevalence of antimicrobial resistance in animals, particularly the spread of multidrug-resistant Enterobacterales, poses a significant zoonotic and public health risk. OBJECTIVE: The aim of this study was to investigate extended-spectrum β-lactamase (ESBL), carbapenem and colistin resistance among Enterobacterales in faecal swabs of dairy cattle. METHODS: A total of 400 samples were cultured on Mac Conkey screening media for ESBL, carbapenem and colistin resistance. The grown Enterobacterales were identified by MALDI-TOF-MS, followed by ceftriaxone, cefotaxime and…

Persistent symmetrical white matter hyperintensities: a case report.

INTRODUCTION: White matter hyperintensities on magnetic resonance imaging are a frequent finding. Anaplastic astrocytoma as a cause of persi … eated with intravenous 3% sodium chloride for a few days and intravenous dexamethasone, intravenous ceftriaxone, and intravenous acyclovir for 14 days. There was no significant clinical or radiological improvement. A ventricular wall biopsy was performed. This showed an anaplastic astrocytoma (World Health Organization Grade III). The patient was subsequently …

Bacteremia caused by Helicobacter trogontum indicative of zoonotic infection in a pig farmer: a case report.

BACKGROUND: Helicobacter pylori was first isolated from humans in 1983. Since then, >50 Helicobacter species have been registered. Helicobac … nd fever. Plain computed tomography revealed small lymph nodes in the ileocecal region. Intravenous ceftriaxone, vancomycin, and acyclovir were administered for suspected meningoencephalitis. She was discharged from the hospital on day 9 after her symptoms improved. The cerebrospinal fluid culture was negative. However, an aerobic bottle was positive in one o …

Risk factors for drug-resistant pathogens in community-acquired pneumonia: systematic review and meta-analysis.

INTRODUCTION: Community-acquired pneumonia (CAP) is a leading cause of death worldwide. Reducing inappropriate and excessive use of extended-spectrum antibiotics is essential for treating CAP effectively. Evaluating the risk of drug-resistant pathogens (DRPs) is crucial for determining initial antibiotic therapy in clinical settings. METHODS: This systematic review and meta-analysis assessed the risk factors for DRPs in patients with CAP. CAP-DRPs were defined as pathogens resistant to commonly used antibiotics for CAP, including nonpseudomonal β-lactams such as ceftriaxone or sulbactam-ampic…

Beta-lactam antibiotics under light: optical and photochemical characterization.

Antibiotics (ATBs) remain a cornerstone in the treatment of bacterial infections, yet clinical practice increasingly incorporates photonic t … ncluding penicillins (amoxicillin, oxacillin), cephalosporins (cephalothin, cefazolin, ceftazidime, ceftriaxone, cefuroxime), and a carbapenem (meropenem). Using diffuse transmittance and reflectance spectroscopy, we calculated absorption and scattering coefficients via the Kubelka-Munk function. Reactive oxygen species (ROS) generation was assessed under dir …

Air Rifle Injury: Rare Bullet Lodgement in the Right Ventricle and Successful Surgical Removal.

BACKGROUND Air rifles, frequently used in sports, can cause complex, violent, and traumatic cardiac injury associated with significant morbi … brief tonic-clonic seizure, which was managed with midazolam and propofol. He received prophylactic ceftriaxone, intravenous phenytoin, vitamin B6, and folic acid and oral aspirin, ibuprofen, and omeprazole. The patient showed improvement by postoperative day 3 and was discharged on day 4. Weekly follow-ups and an EEG 1 month after discharge showed normal res …

An infant brucellosis meningitis caused by Brucella strain.

Brucellosis poses a significant health threat to the population, particularly to vulnerable populations, including infants. In this investig … ning for brucellosis should have been prioritized. Following diagnosis, the infant was treated with ceftriaxone sodium (2.0 g/day) and rifampicin (0.5 g/day) for four weeks, ultimately achieving full clinical recovery. This case highlights the importance of brucellosis screening in infants presenting with unexplained fever, especially in families whose member …

Attenuated Salmonella typhimurium L forms combined with lentivirus shRNA-HOTAIR effectively inhibit tumor growth and metastasis in murine epithelial ovarian cancer.

Epithelial ovarian cancer (EOC) is a common gynecological malignant tumor, with a high mortality rate. HOX antisense intergenic RNA (HOTAIR) in lncRNAs is involved in various tumor epithelial-mesenchymal transition (EMT) processes. For seeking better treatment strategies, we studied the effects of attenuated Salmonella typhimurium (ST) L forms combined with lentivirus shRNA-HOTAIR on in vivo tumorigenicity and metastasis of murine EOC cells, and the related anti-tumor mechanisms. Attenuated ST VNP20009 was induced into bacterial L forms by using ceftriaxone. ST L forms were appeared red in Gra…

Molecular detection and serotyping of acute bacterial meningitis pathogens in Indian children.

BACKGROUND: Acute bacterial meningitis (ABM) is a medical emergency that requires early diagnosis and prompt treatment. Understanding bacter … 20 pneumococcal serotypes, with 19 F, 6 A, and 6B being the most prevalent, and 32.5% resistance to ceftriaxone was observed among pneumococcal isolates. CONCLUSION: This study underscores the diagnostic value of molecular techniques in accurately determining the burden of ABM in young children, with Streptococcus pneumoniae identified as the predominant pat …

Community-acquired pneumonia-causing bacteria and antibiotic resistance rate among Syrian patients.

INTRODUCTION: Antimicrobial resistance poses a critical global health concern, particularly in developing countries like Syria, and is respo … positive bacteria showed high sensitivity to other recommended options such as cefotaxime (71%) and ceftriaxone (81%). CONCLUSIONS: These findings underscore the importance of being able to adapt the general World Health Organization recommendations according to local evidence. It is crucial to emphasize the need for continuous local monitoring, functioning …

Genetic characterization of Haemophilus ducreyi from non-genital skin lesions in Cameroon.

BACKGROUND: Haemophilus ducreyi, traditionally recognized as the etiological agent of chancroid, a genital ulcer disease, is increasingly be … y testing of H. ducreyi cultured isolates revealed sensitivity to all tested antibiotics, including ceftriaxone, azithromycin, and ciprofloxacin. MLST analysis, using data extracted from WGS and directly from clinical samples, identified 38 complete profiles across the six loci (34 from direct samples and four from cultured isolates), identifying 14 distinct …