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Current advance of nanotechnology in diagnosis and treatment for malignant tumors.

Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engineered nanoparticles can be employed as contrast agents in cancer diagnostics to enable high sensitivity and high-resolution tumor detection by imaging examinations. Novel approaches for tumor labeling and detection are also made possible by the use of nanoprobes and nanobiosensors. The achievement of targeted medication delivery in cancer therapy can be acc

Электронные постеры

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Inflammation in cancer: therapeutic opportunities from new insights.

As one part of the innate immune response to external stimuli, chronic inflammation increases the risk of various cancers, and tumor-promoting inflammation is considered one of the enabling characteristics of cancer development. Recently, there has been growing evidence on the role of anti-inflammation therapy in cancer prevention and treatment. And researchers have already achieved several noteworthy outcomes. In the review, we explored the underlying mechanisms by which inflammation affects the occurrence and development of cancer. The pro- or anti-tumor effects of these inflammatory factors

Late Breaking Orals.

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Совпадение в полном тексте источника
… Chin 1 ; Javier Mariscal 1 ; Minhyung Kim 1 ; Sungyong You 1 ; Agnes Kittel 5 ; Krizia Sagini 6 ; Marco De Simone 7 ; Edit I. …

Evidence for the use of intravenous immunoglobulins--a review of the literature.

Intravenous immunoglobulins (IVIg) were first introduced in the middle of the twentieth century for the treatment of primary immunodeficiencies. In 1981, Paul Imbach noticed an improvement of immune-mediated thrombocytopenia, in patients receiving IVIg for immunodeficiencies. This opened a new era for the treatment of autoimmune conditions with IVIg. Since then, IVIg has become an important treatment option in a wide spectrum of diseases, including autoimmune and acute inflammatory conditions, most of them off-label (not included in the US Food and Drug Administration recommendation). A panel

2026 Приложение к резюме Международного конгресса

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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and inva

Oral Presentations

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Energy metabolism in health and diseases.

Energy metabolism is indispensable for sustaining physiological functions in living organisms and assumes a pivotal role across physiological and pathological conditions. This review provides an extensive overview of advancements in energy metabolism research, elucidating critical pathways such as glycolysis, oxidative phosphorylation, fatty acid metabolism, and amino acid metabolism, along with their intricate regulatory mechanisms. The homeostatic balance of these processes is crucial; however, in pathological states such as neurodegenerative diseases, autoimmune disorders, and cancer, exten

2021 International Cancer Education Conference Program and Abstracts.

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Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies.

This review underscores the dynamic role of the extracellular matrix (ECM) in regulating cellular behavior and maintaining tissue homeostasis, highlighting its pivotal involvement in aging, calcification, and cancer diseases. In healthy tissues, controlled ECM remodeling provides essential biochemical and mechanical cues, but dysregulation (driven by chronic inflammation, cellular senescence, and altered intercellular communication) leads to fibrosis, calcification, and the creation of a pro-tumorigenic microenvironment. Senescent cells contribute to these changes through senescence-associated

MicroRNAs during Echinococcus spp. infection: a comprehensive systematic review and implications for diagnosis and therapy.

BACKGROUND: MicroRNAs (miRNAs) are a subclass of small non-coding RNAs that regulate gene expression and play important roles in infectious diseases. Echinococcosis is a globally distributed disease caused by various species of Echinococcus. The disease can be asymptomatic in the early stages, but if left untreated, it can lead to severe complications. Like other helminths, Echinococcus spp. exhibit immunomodulatory capacities that favour infection establishment and progression. Currently, there is no fully accurate, non-invasive method for early detection of echinococcosis. This systematic re…

Analysis of Factors Influencing the Psychological State of Patients After Autologous Liver Transplantation.

BACKGROUND The use of ex vivo liver resection and autologous liver transplantation (ELRA) for end-stage hepatic alveolar echinococcosis is gradually increasing, while postoperative psychological disorders in these patients remain underrecognized. We prespecified that longer pre-transplant waiting time, postoperative complications, and higher transfusion volume would be associated with worse anxiety, depression, and sleep disturbance at 1 month after ELRA. MATERIAL AND METHODS This single-center retrospective study enrolled 138 patients who underwent ELRA from 2020 to 2025. We collected demogra…

HLA profiles and susceptibility to Alveolar echinococcosis: evidence from a large cohort with population and household controls.

Alveolar echinococcosis (AE) is an emerging and potentially fatal helminthic disease. Despite widespread environmental contamination with infective Echinococcus multilocularis (EM) eggs in endemic areas, human AE remains rare, suggesting an important role of host genetic susceptibility. In this case-control study, HLA variation was assessed by amplicon-based next-generation sequencing in 360 patients with AE and compared with (i) 1,440 population controls matched, where feasible, on age, sex, and place of residence, and (ii) 100 unrelated household controls to account for shared environmental …

Surgical management of hepatic echinococcosis - a practical approach and experience from a tertiary center.

Hepatic echinococcosis is a rare parasitic disease, with the incidence of the alveolar form increasing in Central Europe in recent years. Cystic and alveolar echinococcosis differ substantially in their biological behavior and management. The aim of this study is to provide an overview of the current literature and to present the experience from a tertiary center with the surgical treatment of this disease. The study combines a review from the literature with a retrospective analysis of patients who underwent surgical treatment at the University Hospital Hradec Králové between January 2022 and…

Presence of red foxes and contamination with Echinococcus multilocularis on soft fruit farms in Limburg, the Netherlands.

Echinococcus multilocularis (fox tapeworm), with the red fox as the main definitive host, is a major foodborne parasite in Europe and is emerging in the Netherlands. While wild berry consumption is often communicated as a risk factor for foodborne E. multilocularis infection, contamination of commercially grown soft fruits remains poorly studied. This study assessed fox presence and E. multilocularis contamination on commercial soft fruit farms in Limburg, an endemic area in the Netherlands. During the 2024 harvest season (June-August), 220 soft fruit and 220 soil samples were collected on 22 …

Primary thyroid hydatid cyst: a case report.

INTRODUCTION AND IMPORTANCE: Hydatid cyst is a zoonotic infection caused by the larval form of Echinococcus granulosus, with the liver and lungs being the most frequently involved organs. Thyroid gland involvement is exceptionally rare, accounting for approximately 1% of all human hydatid cases and posing significant diagnostic challenges, particularly in endemic regions. CASE PRESENTATION: A 48-year-old woman from a rural area presented with a 5-year history of a slowly enlarging anterior neck mass, with recent progression to dysphagia and dysphonia. She reported regular consumption of raw v…

Hydatid pulmonary arterial embolization from an intracardiac cyst mimicking pulmonary thromboembolism: A case report.

BACKGROUND: Cystic echinococcosis most commonly affects the liver and lungs. Cardiac involvement is uncommon, and embolization to the pulmonary arteries is exceptionally rare. Such presentations may closely mimic pulmonary embolism, leading to diagnostic delay. CASE PRESENTATION: A 14-year-old boy from an endemic rural region presented with progressive dyspnea, intermittent chest pain, recurrent hemoptysis, and severe resting hypoxemia, with an oxygen saturation of 85% on room air. CT pulmonary angiography demonstrated extensive bilateral pulmonary arterial filling defects with cystic morphol…

Bilateral giant pulmonary hydatid cysts in a toddler presenting as severe pneumonia: a risk-adapted staged surgical approach.

BACKGROUND: Pulmonary hydatid disease is common in endemic regions, yet bilateral giant cysts in toddlers are exceptionally rare and may mimic severe pneumonia. Their management is challenging, particularly in physiologically vulnerable children. CASE PRESENTATION: We report a 32-month-old girl presenting with fever, progressive cough, and severe respiratory distress. Imaging revealed four large pulmonary hydatid cysts-three in the left lung and one in the right-complicated by superimposed bacterial infection and hypoxemia. Albendazole therapy (15 mg/kg/day) was initiated, and a risk-adapted,

Risk factors for local lymph node metastasis in hepatic alveolar echinococcosis: a 10-year retrospective cohort study.

BACKGROUND: Hepatic alveolar echinococcosis (HAE) is characterised by infiltrative growth and "cancer-like" biological behaviour. Although radical resection remains the standard treatment, the need for prophylactic lymph node dissection is still debated because preoperative identification of metastasis is difficult. This investigation assesses the risk factors associated with local lymph node metastasis in HAE. METHODS: Clinical data were retrospectively reviewed for 623 patients with HAE admitted to our hospital between January 2012 and January 2022. Based on strict screening criteria, 191 p…