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The application of the Palliative Prognostic Index, charlson comorbidity index, and Glasgow Prognostic Score in predicting the life expectancy of patients with hematologic malignancies under palliative care.

BackgroundThe clinical course for hematologic malignancy varies widely and no prognostic tool is available for patients with a hematologic malignancy under palliative care. To assess the application of the Palliative Prognostic Index (PPI), Charlson Comorbidity Index (CCI), and Glasgow Prognostic Score (GPS) as prognostic tools in patients with hematologic malignancies under palliative care.MethodsWe included 217 patients with pathologically proven hematologic malignancies under palliative care consultation service (PCCS) between January 2006 and December 2012 at a single medical center in Tai

Predicting Survival for Patients with Malignant Pleural Effusion: Development of the CONCH Prognostic Model.

BackgroundMalignant pleural effusion (MPE) is a frequent complication of advanced malignancies that leads to a poor quality of life and limits treatment options.ObjectiveThe objective of this study was to identify biomarkers of survival in patients with MPE, which will greatly facilitate the clinical management of this complication.MethodsThis retrospective study recruited patients who had been pathologically diagnosed with MPE, regardless of the type of primary cancer, at Beijing Chao-Yang Hospital over 158 months. Demographic, clinical, hematological, and pleural fluid data were collected an

CSI position statement on management of heart failure in India.

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Преимущество терпимости после применения триоксида-VTD в Арсенике против VRD у недавно диагностированных пациентов с несколькими миэломами: перспективное исследование с открытой маркой.

Множественная миелома — вторая по распространенности гематологическая гелингология у пожилых пациентов. Стандартный передний режим VRD (bortezomib/lenalidomide/dexametasone) обеспечивает высокую эффективность, но связан со значительной токсичностью, приводящей к инфекциям, подавлению костного мозга, а также к прекращению лечения примерно в тех случаях, когда 20% пациентов. Для этой демографической группы необходимы альтернативные режимы с уменьшенной токсичностью. В предыдущих исследованиях предлагается добавить триоксид мышьяка в борцезомиб/дексаметасон (BD) и повысить глубину ремиссии при пр

Troponins and Natriuretic Peptides in Cardio-Oncology Patients-Data From the ECoR Registry.

BackgroundThe long-term survival of cancer patients has significantly improved over the past years. Despite their therapeutic efficacy, various cancer therapies are associated with cardiotoxicity. Therefore, timely detection of cardiotoxic adverse events is crucial. However, the clinical assessment of myocardial damage caused by cancer therapy remains difficult.MethodsThis retrospective study was performed to evaluate the diagnostic value of cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) for monitoring cancer therapy-induced cardiomyopathy. A total of 485 c

Доклад по делу: Выяснение роли генетических аномалий в миэломатном плевральном эффюляции: случай с несколькими миеломами типа IgG Lambda.

A 73-year-old Мужчина с многократной миеломой, с постепенно ухудшающейся болью в левом плече, которая не реагировала на консервативное управление. После проведения всеобъемлющих диагностических процедур, включая съемку и генетическое тестирование, у него был диагностирован множественный миэлома типа IgG Lambda, осложненный развитием миэломатного плеврального эффюля (MPE). Лечение пациента состояло из сочетания химиотерапии PDD, включая Бортезомиб, Доксорубицин и Дексаметазон, наряду с адъюнктивными терапиями, направленными на контроль плевральной эфлуции. Оценка после обработки выявила разреше

Venous thromboembolism in China: epidemiology, management strategies, and future directions.

Venous thromboembolism (VTE) is one of the leading causes of unexpected death among hospitalized patients. It is also a preventable condition, and its incidence can be substantially reduced through active and effective prophylaxis. In recent years, the burden of VTE in China has continued to increase, driven by population aging, a rising prevalence of malignancy, a growing volume of complex surgery, and advances in imaging and laboratory testing. At present, the clinical management paradigm for VTE in China has gradually evolved from the traditional acute event-centered 'diagnosis-treatment' p

Совпадение в полном тексте источника
… DOAC, direct oral anticoagulant; DVT, deep vein thrombosis; INR, international normalized ratio; LMWH, low-molecular-weight heparin; PE, pulmonary embolism; VKA, vitamin K antagonist; VTE, venous thromboembolism. Figure 3 Overview of treatment and long-term management of VTE in China. … The overlap should continue until the international normalized ratio reaches and remains within the therapeutic range [ 1 , 42 ]. A multicenter randomized study from China showed that genotype-guided warfarin dosing improved dose attainment. …

Rapidly Progressive Acute Liver Failure in Relapsed Multiple Myeloma.

Multiple myeloma affects upwards of 30,000 people every year and has significant morbidity and mortality. Common complications of the disease involve lytic bone lesions, hypercalcemia, anemia, and acute renal failure. A rare, yet serious, complication includes acute liver failure secondary to hepatic plasma cell infiltration. While this is reported seldom in living patients, it is found in upwards of 40% of patients incidentally on imaging or during autopsy. Conscientious and meticulous monitoring of liver function tests allows for early detection of liver failure in multiple myeloma; thus, al

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… Synthetic function of the liver yielded an albumin level of 2.1 g/dL and international normalized ratio (INR) of 3.30 with partial thromboplastin time of 90.8 seconds that was significantly elevated from laboratory workup done two weeks prior to admission, which showed an INR of 1.52. …

Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing.

Circulating cell-free mRNA (cf-mRNA) holds great promise as a non-invasive diagnostic biomarker. However, cf-mRNA composition and its potential clinical applications remain largely unexplored. Here we show, using Next Generation Sequencing-based profiling, that cf-mRNA is enriched in transcripts derived from the bone marrow compared to circulating cells. Further, longitudinal studies involving bone marrow ablation followed by hematopoietic stem cell transplantation in multiple myeloma and acute myeloid leukemia patients indicate that cf-mRNA levels reflect the transcriptional activity of bone

Разработка и проверка новой хрупкой модели для пациентов с недавно поставленным диагнозом множественной миэломы.

Преобладание старения у пациентов с множественной миеломой (ММ) приводит по крайней мере к тому, что 30% пациентов, отнесенных к категории слабых при диагностике. По сравнению со здоровыми людьми слабые люди демонстрируют снижение терпимости к лечению и более низкое качество жизни, что связано со снижением показателей выживаемости. Несмотря на то, что были разработаны различные модели слабостей для MM, по-прежнему сохраняются проблемы с их широким применением и своевременной корректировкой лечения на основе оценок слабых мест в различных группах пациентов. МЕТОДЫ: В настоящем ретроспективном и

Evaluating natural history and treatment response in cardiac amyloidosis: the evolving role of multimodality imaging.

Cardiac amyloidosis, characterized by the accumulation of misfolded proteins in the heart, is a major cause of restrictive cardiomyopathy. It includes two main forms-transthyretin and immunoglobulin light chain amyloidosis-and carries a poor prognosis if left untreated. With emerging new therapies, the growing need to assess treatment response highlights imaging biomarkers as valuable and promising surrogate endpoints. This review discusses current evidence on changes in imaging markers following treatment, contrasting them with the natural progression of the disease. The focus is on magnetic

Activation of Kir4.1 Channels by 2-D08 Promotes Myelin Repair in Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory disease that leads to myelin loss and neurological dysfunction. Clinical studies show increased anti-Kir4.1 antibody levels in MS patients' serum, indicating its diagnostic potential. However, the specific mechanism has remained elusive. In a mouse model of experimental autoimmune encephalomyelitis (EAE), it is found that impaired Kir4.1 channels in oligodendrocyte precursor cells (OPCs) hindered myelin repair in the spinal cord. Using a thermal shift assay (TSA), the small molecule 2-D08 is identified, which effectively activated Kir4.1 channe

Thrombosis in Neuromuscular Medicine: Current Evidence, Unmet Needs, and Future Directions.

Venous thromboembolism (VTE), comprising deep vein thrombosis and pulmonary embolism, is an important but under-recognised complication in neuromuscular diseases. In adults, emerging epidemiological data suggests increased VTE occurrence in conditions such as Amyotrophic Lateral Sclerosis, myotonic dystrophy, myasthenia gravis, inflammatory neuropathies, inflammatory myopathies, and POEMS syndrome. This heightened risk reflects not only disease-related immobility but also disorder-specific biological mechanisms, including inflammation, endothelial dysfunction and cardiomyopathy-related stasis.

Prediction of myelosuppression in cervical cancer after concurrent chemoradiotherapy by CT radiomics-based model.

BackgroundConcurrent chemoradiotherapy (CCRT) was highly effective in treating cervical cancer (CC) but raised the risk of bone marrow suppression. However, models to predict the risk of myelosuppression in CC patients after CCRT based on computed tomography (CT) imaging histology are immature.MethodsThe Region of interest (ROI) of the CT images was segmented, and radiomic features were extracted. Next, important features were further selected. The training and test sets were split 7:3, and 8 machine learning algorithms were applied to classify the features in the training set. The model's per

PET/CT Imaging for Therapy Assessment in Multieloma, включая MRD.

Фон/цели: Множественная миелома (ММ) представляет собой сложную гематологическую порчу, характеризующуюся аномальным распространением плазменных клеток в костном мозге. [18F]FDG PET/CT стала одним из ключевых способов визуализации, демонстрируя высокую чувствительность и специфичность для обнаружения метаболически активных заболеваний по сравнению с обычными методами визуализации. В настоящем обзоре рассматривается роль изображений ПЕТ/КТ в оценке терапевтической реакции в симптоматической миеломе, включая оценку минимальных остаточных заболеваний (ОРЗ). Методы: Мы изучили литературу, опублико

Multidisciplinary Approach to Spinal Metastases and Metastatic Spinal Cord Compression-A New Integrative Flowchart for Patient Management.

Metastatic spine disease (MSD) and metastatic spinal cord compression (MSCC) are major causes of permanent neurological damage and long-term disability for cancer patients. The development of MSD is pathophysiologically framed by a cooperative interaction between general mechanisms of bone growth and specific mechanisms of spinal metastases (SM) expansion. SM most commonly affects the thoracic spine, even though multiple segments may be affected concomitantly. The great majority of SM are extradural, while intradural-extramedullary and intramedullary metastases are less frequently seen. The ma

Влияние износимой ритмической стимуляции слуха на болезнь Паркинсона, множественный склероз и инсульт: систематический обзор и метаанализ.

Движущаяся терапия с использованием рифмического стимула (RAS) оказалась полезной для болезни Паркинсона (PD). Вместе с тем необходимо провести исследования, касающиеся применения изношенных устройств во всех неврологических расстройствах. Цель этого исследования состоит в том, чтобы изучить эффективность терапии с использованием изношенных устройств при перемещении лиц с неврологическими расстройствами. Систематический обзор и метаанализ. Источники данных 27, 2024. Были проведены обыски PubMed, Web of Science, Medline, PEDro и ScienceDirect. В соответствии с руководящими принципами ПРИСМА 202

Безопасность подкожного Даратумумаба Anti-CD38 Моноклональные антитело-наивные пациенты с расстройствами плазменных клеток: опыт мультицентральной реальной жизни.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: anti-CD38 моноклональная антитела используется для лечения множественной миэломы (ММ) и легкой цепи амилоидоз при внутривенной дозировке 16 мг/кг или при подкожной фиксированной дозе 1800 мг. Однако подкожный состав был только недавно утвержден в Европе, и по-прежнему мало реальных данных о его безопасности. ЦЕЛЬ: В этом многоцентровом ретроспективном опыте реальной жизни мы предоставили доказательства безопасности подкожного даратумумаба при расстройствах плазменных клеток. ПАТИЕНТЫ И МЕТОДЫ: Всего 189 В это ретроспективное исследование были включены пациенты с диагнозо

Gastrointestinal bleeding as initial presentation of extramedullary plasma cell neoplasms: A case report and review of the literature.

BackgroundPlasma-cell neoplasms rarely involve the gastrointestinal tract and manifest as gastrointestinal bleeding. Plasmablastic myeloma is an aggressive plasma cell neoplasm associated with poor outcomes. A small number of cases with gastrointestinal involvement is reported in the literature and therefore high index of suspicion is essential for avoiding delays in diagnosis and treatment.Case summaryOur aim is to present our experience of a 70-year-old patient with a secondary presentation of plasmablastic myeloma manifesting as unstable upper gastrointestinal bleeding and to review the lit

Theranostics - a sure cure for cancer after 100 years?

Cancer has remained a formidable challenge in medicine and has claimed an enormous number of lives worldwide. Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer. This review aims to provide an overview of theranostics in oncology: exploring its history, current advances, challenges, and prospects. We present the fundamental evolution of theranostics from radiotherapeutics, cellular therapeutics, and nanotherapeutics, showcasing critical milestones in the last decade. From the early concept of targeted d