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Caries and edentulism trends among Brazilian older adults: a comparative analysis of 2003, 2010, and 2023 surveys.

This study compared the experience of dental caries and the prevalence of edentulism in 2003, 2010, and 2023 for individuals aged 65 to 74 i … and 2003. The elderly Brazilian population is retaining more natural teeth. However, reductions in tooth loss were unequal, occurring primarily among white individuals and those with higher educational levels.

Harnessing the World Health Organization's '3 by 35' Initiative to Finance Oral Health Care in India.

BACKGROUND: Oral diseases such as dental caries, periodontal disease, tooth loss and oral cancer affect billions of people worldwide. India, with the world's largest population, carries one of the heaviest burdens of oral and other Non-Communicable Diseases (NCDs). These diseases share common risk factors such as consumption of tobacco, alcohol and sugary food and drinks. One effective approach to reducing the consumption of these products in the population is to increase taxes on them. WHO recently proposed a '3 by 35' initiative, which calls for raising the prices of these harmful products b…

Clinical Performance of Immediately Restored, Surface Modified Two-Piece Zirconia Implants. A Prospective Case Series.

PURPOSE: To evaluate the short-term success and survival rates of immediately restored surface modified two-piece zirconia implants (CL). MATERIAL AND METHODS: A total of 23 patients had received CL implants (n = 26) for single-tooth replacements in the anterior and posterior maxilla and mandible at healed extraction sites. Immediate implant restoration was accomplished if an insertion torque ≥ 30 Ncm was reached (Type 3-4 A protocol). Final occlusally screw-retained crowns were provided after 3 months of healing. Implant survival and success (i.e., bleeding on probing-BOP, probing pocket dep

Assessment of the activity of root caries lesions using short wavelength infrared imaging - an in vitro pilot study.

OBJECTIVES: New kinetic approaches that exploit differential water absorption appear to be more effective for assessing lesion activity on root surfaces using short wavelength infrared (SWIR) imaging. The aim of this pilot study was to employ multispectral time-resolved SWIR imaging to assess the activity of root caries. METHODS: A SWIR imaging array and SWIR light sources at 1040 and 1470 nm were used to assess the activity of ten arrested and ten active root caries lesions on extracted teeth during forced air drying for 60 s. Cross-polarization optical coherence tomography (CP-OCT) was used

The synergistic pro-inflammatory effect of butyric and propionic acid on human periodontal ligament cells via activation of G-protein-coupled receptor 41.

PURPOSE: Periodontitis is a chronic disease that ultimately leads to tooth loss. This study aimed to investigate the inflammatory effects of short-chain fatty acids (SCFAs) on human periodontal ligament cells (hPDLCs). METHODS: Immunofluorescence was employed to assess the expression of G protein-coupled receptors (GPRs) in hPDLCs. The Cell Counting Kit-8 and enzyme-linked immunosorbent assay kits were utilized to examine the regulatory effects of SCFAs on both the proliferation and secretion of pro-inflammatory factors in hPDLCs. Western blot analysis was performed to investigate the potenti…

Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis.

BACKGROUND: Migraine is a global public health burden, with characteristics of stabbing pain, hypersensitivity and vegetative symptoms, affecting one billion people with multiple risk factors and potential pathophysiological mechanisms, including neuroinflammation. Periodontitis is a multifactorial disease that affects the dental supporting tissues (gingiva, periodontal ligament, root cementum, and alveolar bone), which in advanced stages can cause tooth loss. This pathology can have systemic implications, and its association with migraine offers a promising area of research to understand and …

Is significant mandibular advancement possible after the peak of puberty? Dento-osseous palatal expansion and the STM4 technique (Skeletal Therapy Manni Telescopic Herbst 4 miniscrews): A case report.

INTRODUCTION: Treatment of skeletal class II growing patients often requires the use of functional appliances, aimed at promoting mandibular advancement. Among these, Herbst appliance is recommended for its effectiveness, efficiency, and reduced need for compliance. Despite its skeletal favourable effects, well-known dental compensations can occur, especially when the appliance is not used close to the pubertal peak: upper incisors retroclination, lower incisors proclination, upper molars distalization and lower molars mesialization could reduce the overjet needed for a proper mandibular advan

Contesting the conventional wisdom of periodontal risk assessment.

Over the years, several reviews of periodontal risk assessment tools have been published. However, major misunderstandings still prevail in … ntitis deserve proper information about their risk of developing patient-important outcomes such as tooth loss or pain. The primary objective of disseminating such information should not be to emphasize assumed treatment efficacy, hype individualization of care, or promote business interests. Instead, the focus should be on providing individuals with locally …

Nanoemulsion and nanoemulgel-based carriers as advanced delivery tools for the treatment of oral diseases.

Oral diseases rank among the most widespread ailments worldwide posing significant global health and economic challenges affecting around 3.5 billion people, impacting the quality of life for affected individuals. Dental caries, periodontal disease, bacterial and fungal infections, tooth loss and oral malignancies are among the most prevalent global clinical disorders contributing to oral health burden. Traditional treatments for oral diseases often face challenges such as poor drug bioavailability, breakdown of medication in saliva, inconsistent antibiotic levels at the site of periodontal in…

Correlation of serum vitamin D and IL-8 to stages of periodontitis: a case-control analysis.

OBJECTIVES: The current literature lacks the correlation between serum levels of vitamin D and interleukin-8 (IL-8) to the stages of periodontitis. The present research objectives are to evaluate the serum levels of vitamin D and IL-8 in periodontitis participants and healthy controls and to measure their correlation with the stages of periodontitis. METHODS: The current case-control study was conducted on patients with periodontitis and healthy controls. After obtaining a questionnaire from the participants, the following clinical parameters were measured; periodontal probing depth (PPD), cl

Periodontitis associated with risk of obstructive sleep apnea in Peruvian adult patients: A cross-sectional study.

BACKGROUND: Patients at high risk for obstructive sleep apnea (OSA) are characterized by intermittent transient hypoxias and upper respiratory tract collapse, with reactive oxygen production and oxidative imbalance which causes an inflammatory cascade. This can generate negative effects on the periodontium, causing severe tooth attachment loss. This study aimed to determine the association between periodontitis and the risk of OSA in adults who attend outpatient otolaryngology consultations. MATERIAL AND METHODS: A cross-sectional observational study was carried out with 118 patients seen in

Effect of Omega-3 Fatty Acid Supplementation on Periodontal Inflammation and Pocket Depth Reduction.

BACKGROUND: Chronic inflammation of the tooth's supporting tissues is known as periodontal disease. It causes pockets to develop, attachments to break, and eventually the loss of teeth. Because of their well-known anti-inflammatory qualities, omega-3 fatty acids have been recommended as an additional therapy for periodontal inflammation. MATERIALS AND METHODS: A randomized controlled study of 60 individuals suffering from persistent periodontitis was carried out. Two groups of participants were randomly assigned: The test group (n = 30) got conventional periodontal treatment with omega-3 fatt

Impact of Bisphosphonate Therapy on Oral Health in Patients with Breast and Prostate Cancer and Bone Metastases: A Comprehensive Study.

This study investigates the impact of bisphosphonate therapy on the stomatognathic system in 80 patients with cancer of the breast and prostate with bone metastases. Bisphosphonates are integral for managing skeletal complications in these malignancies but are associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ), affecting 0.8-18.5% of patients. BRONJ manifests with pain, neuropathy, tissue swelling, mucosal ulceration, tooth mobility, and abscesses, yet its pathogenesis remains elusive, complicating risk prediction. The research employed comprehensive dental and radiologica

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… Furthermore, we will ascertain the influence of tooth loss and the utilization of dental prostheses on manifestations within the stomatognathic system in patients receiving intravenous bisphosphonate therapy for bone metastases. …

Unveiling an Uncommon Scenario of Co-occurrence of Multiple Odontomes With Impacted Maxillary Lateral Incisor and Canine in a 17-Year-Old Girl: A Unique and Rare Case Report.

This case report presents the enigma of multiple odontomes with overretained deciduous teeth leading to the impaction of permanent successors (22, 23) in an abnormal position in a 17-year-old female patient who reported the chief complaint of maligned teeth. Permanent maxillary canines and lateral incisors are the most common teeth to face the brunt of impaction due to a wide range of etiological factors. It is imperative for a clinician to diagnose cases at an early stage to accelerate the rate of eruption of such teeth. This is especially important in cases where initially the etiology seems

Omega-3 fatty acids as a treatment option in periodontitis: Systematic review of preclinical studies.

Background: Periodontitis presents as a chronic inflammatory disease that affects the gingival tissues and structures surrounding the tooth. However, the existing approaches for periodontitis do not allow complete control of the disease. In this regard, an active search is being carried out both in preclinical and clinical studies for new approaches based, among other things, on nutraceuticals. Aim: This systematic review aimed to summarize and systematize data from preclinical studies on the effects of the use of polyunsaturated omega-3 fatty acids in experimentally induced periodontitis. Met

Tooth morphology fusion technique is more accurate than conventional technique in transferring morphology of provisional to definitive screw-retained, implant-supported crown: A preliminary intervention study.

PURPOSE: To compare the accuracy of the tooth morphology fusion (TMF) digital technique and customized impression transfer coping (conventional) technique when transferring the morphology of a provisional crown to a definitive screw-retained implant-supported crown. METHODS: Six cases of partial edentulism (one anterior and five posterior) treated with oral implant placement in our clinic for the loss of three or fewer teeth in the maxilla or mandible between April 2017 and September 2018 were included. After implant placement and re-entry surgery, provisional restorations were made and adjus

Targeting phosphatidylinositol-3-kinase for inhibiting maxillary bone resorption.

Previous studies have suggested a role of phosphatidylinositol-3-kinase gamma (PI3Kγ) in bone remodeling, but the mechanism remains undefined. Here, we explored the contribution of PI3Kγ in the resorption of maxillary bone and dental roots using models of orthodontic tooth movement (OTM), orthodontic-induced inflammatory root resorption, and rapid maxillary expansion (RME). PI3Kγ-deficient mice (PI3Kγ-/- ), mice with loss of PI3Kγ kinase activity (PI3KγKD/KD ) and C57BL/6 mice treated with a PI3Kγ inhibitor (AS605240) and respective controls were used. The maxillary bones of PI3Kγ-/- , PI3KγKD

The Salivary Microbiome and Predicted Metabolite Production are Associated with Progression from Barrett's Esophagus to Esophageal Adenocarcinoma.

Esophageal adenocarcinoma (EAC) is rising in incidence and associated with poor survival, and established risk factors do not explain this t … associated with progression to advanced neoplasia, with these associations occurring independent of tooth loss, and the largest shifts were with the genus Streptococcus. Microbiome metabolic models predicted significant shifts in the metabolic capacities of the salivary microbiome in patients with advanced neoplasia, including increases in L-lactic acid and …

INF2 mutations in patients with a broad phenotypic spectrum of Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis.

Mutations in INF2 are associated with the complex symptoms of Charcot-Marie-Tooth disease (CMT) and focal segmental glomerulosclerosis (FSGS). To date, more than 100 and 30 genes have been reported to cause these disorders, respectively. This study aimed to identify INF2 mutations in Korean patients with CMT. This study was conducted with 743 Korean families with CMT who were negative for PMP22 duplication. In addition, a family with FSGS was included in this study. INF2 mutations were screened using whole exome sequencing (WES) and filtering processes. As the results, four pathogenic INF2 mut

Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interface.

Periodontitis is a ubiquitous chronic inflammatory, bacteria-triggered oral disease affecting the adult population. If left untreated, periodontitis can lead to severe tissue destruction, eventually resulting in tooth loss. Despite previous efforts in clinically managing the disease, therapeutic strategies are still lacking. Herein, melt electrowriting (MEW) is utilized to develop a compositionally and structurally tailored graded scaffold for regeneration of the periodontal ligament-to-bone interface. The composite scaffolds, consisting of fibers of polycaprolactone (PCL) and fibers of PCL-co…