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Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… activity of essential oil from Satureja Intermedia Iranian Red Crescent Medical Journal 2012 15 1 70 74 2-s2.0-84872131902 10.5812/ircmj.4989 PMC3589783 23487431 126 do Eraldo NF Ferraz RPC Britto ACS Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae) Chemistry and Biodiversity … oil from different ways of extraction towards ovarian cancer cells Food and Bioproducts Processing 2011 89 4 328 332 2-s2.0-80054812417 145 Bezerra DP Marinho Filho JDB Alves APNN Antitumor activity of the essential oil from the leaves of Croton regelianus and its component ascaridole Chemistry and Biodiversity …

Modulation of miR-204 and miR-375 Expression by Flavonoid Chrysin Treatment During Melphalan-Induced Histopathological Damage in Adult Rat Skin and Hair Tissue.

Chemotherapy-induced skin and hair follicle damage, driven in part by miRNAs such as miR-204 and miR-375 that regulate apoptosis and autophagy after alkylating agent exposure, significantly impacts patient quality of life. While chrysin-a common food-derived flavonoid and nutritional bioactive with antioxidant and cytoprotective properties-has shown potential to modulate miRNA activity, its role in melphalan-induced injury and associated miRNA expression remains unclear. This study investigated the effects of melphalan on skin and hair follicle integrity in rats, focusing on miR-204 and miR-37

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… Chemistry & Biodiversity 19, no. 3: e202100886. 10.1002/cbdv.202100886. Zhai, K. , Duan H., Wang W., et al. 2021. “Ginsenoside Rg1 Ameliorates Blood–Brain Barrier Disruption and Traumatic Brain Injury via Attenuating Macrophages Derived Exosomes miR‐21 Release.” …

Bright Spots in The Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action.

The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable. Oceans, due to their wide diversity of marine species and environmental conditions have proven to be precious sources of potential natural drugs with active properties. As an example, in this context several studies performed on sponges, tunicates, mollusks, and soft corals have brought evidence of the interesting biological activities of the molecules derived from these species. Also, echinoderms constitute an import

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… For this purpose, the ocean, thanks to its huge biodiversity and to the peculiar characteristics of secondary metabolites produced from marine organisms, constitutes an invaluable and promising resource for years now. … Accordingly, the characterization of the molecular structures of the extracted compounds is certainly a priority, in order to obtain the molecules through organic synthesis in the laboratory, with the aim to give an important contribution to the medical field while ensuring the safeguard of biodiversity …

Взрывы в кишечном микробиотическом составе у пациентов с аутоиммунными неврологическими заболеваниями: систематический обзор и метаанализ.

UNLABELLED: Исследования показывают, что дисбиоз кишечника происходит в аутоиммунных неврологических заболеваниях, однако всеобъемлющего обобщения данных не имеется. Наша цель заключалась в систематическом анализе и метаанализе взаимосвязи между кишечными микробиотами и аутоиммунными неврологическими расстройствами, с тем чтобы получить информацию о клиническом диагнозе и терапевтическом вмешательстве. Мы обыскали базы данных PubMed, Embase, Web of Science, и Kochrane Bibrary. 1 Март 2024 для исследования связи между кишечными микробиотами и аутоиммунными неврологическими расстройствами. Всего

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… Synthesis of α-diversity Data on α-diversity were contributed by 42 studies, encompassing metrics of richness [observed species, abundance-based coverage estimator (ACE), Chao1, richness, and Good’s coverage), evenness (Shannon index, Simpson index, Pielou’s evenness, and evenness), and biodiversity …

A 3-dimensional математическая модель микробного распространения, которая порождает характерное кумулятивное распределение относительного плотности в кишечных микробиомах.

Микробиомы кишечника сильно различаются между людьми, главным образом из-за различий в образе жизни и физиологии. Однако мало что известно о глубинных процессах или правилах, которые формируют сложное микробное сообщество. В этом документе мы показываем, что кумулятивное распределение относительного избытка (КРАД) микробных видов можно приблизить с помощью функции закона о силе, и обнаруживаем, что показатель мощности CRAD, полученный из гена 16S rRNA и метагеномических данных для обычных микробиомов кишечника человека и мышей, был таким же, как и в случае :0.9. Аналогичным образом, в CRADs бы

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… The exponent serves as an index of the biodiversity of the ecosystem. …

Gut microbiota deficiency ameliorates multiple myeloma and myeloma-related bone disease by Th17 cells in mice models.

Purpose: Multiple myeloma, the second most common hematological tumor, is currently incurable. Multiple myeloma-related bone disease is a characteristic clinical symptom that seriously affects the survival and prognosis of patients. In recent years, gut microbiota has been shown to play an important role in the occurrence and development of multiple myeloma. However, whether and how it affects the development of myelomatous bone disease is unclear. Methods: To investigate the mechanism and influence of the microbiota on multiple myeloma and myeloma bone disease, a myeloma-gut microbiota deleti

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… In addition, the reduction of periodontal disease and oral biodiversity was also accompanied by a higher incidence of osteonecrosis of the jaw (ONJ) ​​in the treatment of MMBD treated with higher bisphosphonate concentrations. …

Promising Activities of Marine Natural Products against Hematopoietic Malignancies.

According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially avai

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… The marine environment is characterized by huge biodiversity of species (about 240,000 known species according to The World Register of Marine Species; http://www.marinespecies.org/ ; Accessed on 6 May 2021) which have adapted to live in multiple extreme environments, e.g., temperatures from −1.5 °C … Even if knowledge related to extreme environments is still limited, recent metagenomics and/or bioactivity screening approaches have demonstrated the biodiversity richness and biotechnological potential of less studied species [ 16 , 23 , 152 ]. …

Cancer-Associated Thrombosis: Not All Low-Molecular-Weight Heparins Are the Same, Focus on Tinzaparin, A Narrative Review.

Cancer-associated thrombosis (CAT) is the second main cause of cancer death with high related mortality and morbidity, leading to anticancer agent delays and interruptions. The recommended therapy, low-molecular-weight heparin (LMWH), however, is burdensome for patients and costly for society, as treatment should last until cancer is no longer active, even indefinitely. Tinzaparin is a manageable, efficient, safe, and cost-effective option. Compared to the other LMWHs, advantages are single-daily dose and safety in the elderly and those with renal impairment (RI). The purpose of this review is

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… Biosimilars of low-molecular-weight heparin products: fostering competition or reducing “biodiversity?”. J ThrombHaemost . 2016;14(3):421–426. doi: 10.1111/jth.13237. 55. Leizorovicz A., Siguret V., Mottier D. …

Продольная стабильность микробиоты Гут в релапсирующих и излучающих множественных склерозах: перспективное исследование наблюдений.

Микробиота кишечника играет ключевую роль в регулировании иммунной системы в множестве склерозов (MS), однако продольные данные о динамике микробиома и их связи с инвалидностью и биомаркерами остаются ограниченными. Цель этого исследования заключалась в выявлении продольных микробиомных изменений кишечника у пациентов с повторно излучающимся множественным склерозом (RRMS) и их связи с инвалидностью и конкретными биомаркерами сыворотки, включая прогнозируемые метаболические пути. В ходе этого перспективного продольного исследования была проведена оценка 29 пациентов, проходящих курс лечения наи

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… S100B Affects Gut Microbiota Biodiversity. Int. J. Mol. Sci. 2023;24:2248. doi: 10.3390/ijms24032248. 27. Rinninella E., Raoul P., Cintoni M., Franceschi F., Miggiano G., Gasbarrini A., Mele M. What is the Healthy Gut Microbiota Composition? …

Cutaneous Skin Toxicities of Oncological Targeted Therapies: Comprehensive Overview of Mechanisms, Management, and Research Gaps-A Narrative Review.

Targeted therapies in oncology have become a mainstay in therapy of numerous types of cancers. They work by targeting and utilizing (activating, inhibiting, or modulating) molecular pathways that are crucial in pathogenesis of certain cancers and can be divided into numerous classes according to their mechanism. However, since the antigens and molecules they target can take part in homeostasis of the skin and the integument, cutaneous toxicities are a common occurrence. The frequency of certain cutaneous adverse events (CAEs) depends on the causal drug and varies even between drugs of the same

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… Ciardiello T Pinto D Marotta L Giuliani G Rinaldi F Effects of fermented oils on alpha-biodiversity and relative abundance of cheek resident skin microbiota Cosmetics 2020 7 2 34 10.3390/cosmetics7020034 Ciardiello T, Pinto D, Marotta L, Giuliani G, Rinaldi F. … Effects of fermented oils on alpha-biodiversity and relative abundance of cheek resident skin microbiota. Cosmetics. 2020;7(2):34. 10.3390/cosmetics7020034. 91. …

Health problems in agricultural workers occupationally exposed to pesticides.

Agricultural workers are susceptible to several health problems as a result of occupational exposure to toxic substances, especially pesticides. The aim of this review was to describe the health issues associated with occupational exposure to pesticides in agricultural workers. A descriptive study, in the form of an integrative literature review, was conducted based on articles retrieved from the LILACS, SciELO and PubMed databases, published between January 2015 and October 2018. The searches were conducted using the keywords "pesticides," "workers' health," "occupational exposure" and "agric

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… The indiscriminate use of these substances has a significant impact on health and the environment, leading to soil and groundwater contamination, and reducing biodiversity. …

Механистические знания о перекрестке нейроглии в нейродегенеративных заболеваниях.

Нейродегенеративные заболевания, такие, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), Множественный Склероз (MS) и болезнь Хантингтона (HD), хотя и отличаются по своим клиническим проявлениям, имеют общую отличительную черту: нарушенная нейро-воспалительная среда, вызванная дисрегулированием нейроглиальной межклеточной связи. Нейроглиальный перекресток физиологически обеспечивается внеклеточными посредниками и деятельностью коннексинов (Cxs), формирующими белки пятен соединений пятен (Gjs) и гемиханнелей (HC), которые поддерживают внутриклеточный и внеклеточный гомеостаз. Однако накоп

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… Incentivi per la Ricerca di Ateneo 2020–2022 - PIA.CE.RI. 2020–2022-Linea di intervento 3-Starting Grant, CHRONOS and by the grant Piano di Incentivi per la Ricerca di Ateneo 2024–2026 - PIA.CE.RI. 2024–2026-Linea di intervento 1, ACHIEVE from the University of Catania to NV and by the grant National Biodiversity …

Thalidomide attenuates radiation-induced apoptosis and pro-inflammatory cytokine secretion in oral epithelial cells by promoting LZTS3 expression.

Radiation-induced oral mucositis (RIOM) is a prevalent oral complication that occurs in individuals undergoing radiotherapy or radiation treatment for head and neck tumors. The presence of oral mucosal rupture and ulcerative lesions, which are the defining features of this condition, can significantly affect the quality of life of patients. Additionally, it can interfere with tumor therapy and contribute to an unfavorable prognosis. Current evidence suggests that cellular inflammation and programmed cell death are important factors in disease development. Moreover, thalidomide (THD) has been r

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… Declarations Ethics approval I promise that the study was performed according to the international, national and institutional rules considering animal experiments, clinical studies and biodiversity rights. The study protocol was approved by the Guangxi Medical University. …

Recent Insights in Multi-Target Drugs in Pharmacology and Medicinal Chemistry.

Many of the drugs used in treatment today have been designed based on the "specificity paradigm". Resistance has developed against drugs designed using this approach, leading to a decrease in their effectiveness. In addition, it is well-documented in the literature that diseases with complex etiologies, such as Alzheimer's, Parkinson's, and cancer are influenced by multiple genetic and/or environmental factors. As a result, specificity paradigm is often insufficient for treating these diseases. Therefore, there is a need to develop drugs that interact with multiple targets simultaneously throu

Pulmonary hypertension and the potential of 'drug' repurposing: A case for African medicinal plants.

AbstractPulmonary hypertension (PH) is a haemodynamic disorder in which elevated blood pressure in the pulmonary circulation is caused by abnormal vascular tone. Despite advances in treatment, PH mortality remains high, and drug repurposing has been proposed as a mitigating approach. This article reviews the studies that have investigated drug repurposing as a viable option for PH. We provide an overview of PH and highlight pharmaceutical drugs with repurposing potential, based on limited evidence of their mechanisms of action. Moreover, studies have demonstrated the benefits of medicinal plan

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… This is strange, as Africa boasts rich biodiversity and a wide range of plant species that have medicinal properties. …

CD200 является мощным новым фактором роста в Мультимиломе, зависящим от сигнала рецептора IGF1.

CD200 — это иммунный контрольно-пропускной пункт, безошибочно выраженный в 70% недавно диагностированных пациентов с множественной миеломой (ММ) и связанный с плохим исходом. Выражение CD200 клетками опухоли препятствует иммунной реакции через взаимодействие с CD200R и участвует в устойчивости к иммунной терапии. Однако его роль в опухоли остается слабой. В этом исследовании мы показываем, что клетки MM, перевыражающие CD200, представляют собой значительное пролиферативное преимущество в свободных культурных сыворотках, средних и клоногенных анализах. Преимущество роста клеток, опосредованное

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… FFRMG (AAP-FFRMG-2021 ), AAP ECOPHYTO – PELYCANO (This action is led by the Ministries for Agriculture and Food Sovereignty, for an Ecological Transition and Technical Cohesion, for Health and Prevention, and for Higher Education and Research, with the financial support of the French Office for Biodiversity …

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense.

In the present study, we evaluated the potential of the plant E. arvense against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the Chromosome assay (CA) and Mitotic index (MI) in vivo as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with the ethanolic extract of the plant. The results demonstrated that the plant extract was not cytotoxic and mutagenic and has a protective effect against the mutagenicity induced by cyclophosphamide in pre, s

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… The plant was identified and authenticated by the Centre of Biodiversity and Plant Taxonomy, Department of Botany, University of Kashmir. A specimen under voucher number KASH-2348 was preserved in the respective department for future reference. …

Rethinking corticosteroids use in oncology.

Corticosteroids (CSs), widely used in oncology for their anti-inflammatory and immunosuppressive properties, help manage cancer-related symptoms and side effects. However, their long-term use may negatively affect patient survival and exacerbate tumor progression. Elevated glucose and glutamine metabolism, disruption of vitamin D levels, and alterations in the microbiome are some of the key factors contributing to these adverse outcomes. Approaches such as ketogenic diets, fasting, sartans, and vitamin D supplementation have shown promise in providing similar benefits to CSs while mitigating t

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… Many cancers are generally associated with dysbiosis of the microbiome (an imbalance in gut flora biodiversity), including those affecting the airways and lungs, esophagus, gastric, small intestine, large intestine, liver, pancreas, and kidneys (see Table 2 in Martinez and Sabatier, 2025 ). …

Ликопен дополнил средиземноморские диеты экспериментальными аутоиммунными энцефаломелитами (EAE) в мышах и изменениями кишечного микробиома.

Цель этого исследования заключалась в определении воздействия средиземноморского рациона питания (MD) и ликопена на развитие EAE и на подстрекательские маркеры. В 43-day :: исследование, 72 Женский C57BL/6 Мыши были случайно разделены на eight группы в зависимости от того, были ли они EAE или наивными (контрольными) мышами, питались западной диетой или MD, и получали ли они ликопен. Во время исследования мышей кормили ад-либитумом, а ликопиновые группы - ликопинами. 10 мг/кг/сут ликопен на мышь каждый день 28 днями в оральной желудке. Мыши были забраны за EAE, принесены в жертву, и их селезенк

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… Diet notably influences this composition; the Western diet (WD) is linked to dysbiosis, reduced diversity, and gut permeability, while the Mediterranean diet (MD) enhances microbial biodiversity (Barber et al. 2023 ; Merra et al. 2020 ). …

Study of Liposomes Containing Extract from the Leaves of Protium heptaphyllum (Aubl.) March in Animals Submitted to a Mutagenic Model Induced by Cyclophosphamide.

Cyclophosphamide (CPA) is an alkylating agent used as a chemotherapy agent in the treatment of cancer, but it has immunosuppressive effects. Protium heptaphyllum (P. heptaphyllum) is a plant rich in triterpenes and flavonoids, with some bioactive and therapeutic properties presented in the literature. Thus, the present study aimed to investigate the chemoprotective potential of P. heptaphyllum extract inserted into liposomes against oxidative damage chemically induced by CPA. Male Swiss mice received 1.5 mg/kg of P. heptaphyllum liposomes as a pre-treatment for 14 consecutive days (via gavage)

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… Medicinal Plants: Biodiversity, Biotechnology Conservation. Volume 33. Springer; Singapore: 2023. 22. Hua S., WU S.Y. The use of lipid-based nanocarriers for targeted pain therapies. Front. Pharmacol. 2013;4:143. doi: 10.3389/fphar.2013.00143. 23. Malone M.H. …