Результаты поиска

[Odontogenic tumors and neoplastic-like changes of the jaw bone. Clinical study and evaluation of treatment results].

The purpose of the study was clinical analysis of 164 odontogenic tumours and tumour-like lesions of the jaws treated at the Department of Maxillofacial and Oral Surgery, Jagiellonian University College of Medicine between 1956 and 1996, and to evaluate early late and therapeutic results. Odontogenic tumours have a specific histological structure reflecting various stages of odontogenesis and are located mainly in the jaws, exceptionally in other parts of the skeletal system. Due to their specific structure and location they have been identified and classified by pathologists into a separate g

Vibration acceleration promotes bone formation in rodent models.

All living tissues and cells on Earth are subject to gravitational acceleration, but no reports have verified whether acceleration mode influences bone formation and healing. Therefore, this study was to compare the effects of two acceleration modes, vibration and constant (centrifugal) accelerations, on bone formation and healing in the trunk using BMP 2-induced ectopic bone formation (EBF) mouse model and a rib fracture healing (RFH) rat model. Additionally, we tried to verify the difference in mechanism of effect on bone formation by accelerations between these two models. Three groups (low

Sequence variants in nine different genes underlying rare skin disorders in 10 consanguineous families.

BACKGROUND: Genodermatoses represent genetic anomalies of skin tissues including hair follicles, sebaceous glands, eccrine glands, nails, and teeth. Ten consanguineous families segregating various genodermatosis phenotypes were investigated in the present study. METHODS: Homozygosity mapping, exome, and Sanger sequencing were employed to search for the disease-causing variants in the 10 families. RESULTS: Exome sequencing identified seven homozygous sequence variants in different families, including: c.27delT in FERMT1; c.836delA in ABHD5; c.2453C>T in ERCC5; c.5314C>T in COL7A1; c.1630C>T i

[Repair of osteoarthritis in animal model with exosomes derived from BMSCs transfected by the siRNA -Piezo1 through CT navigation].

OBJECTIVE: To investigate the effect of the exosomes from bone marrow mesenchymal stem cells (BMSCs) transfected with silence plasmid of Piezol small interference RNA (siRNA)on osteoarthritis (OA) animal model. METHODS: Twenty male SD rats with specific pathogen free (SPF) were selected, ranging in age from 5.46 to 6.96 months, with a mean of (6.21± 0.75) months;and ranging in weight from 385.76 g to 428.66 g, with a mean of (407.21±21.45) g. BMSCs were extracted. The siRNA silencing plasmid of piezo1 was constructed by siRNA technology. After lentivirus was transfected into BMSCs, the exosom

Histologic and morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in postmortem eyes with age-related macular degeneration and histologic examination of surgically excised choroidal neovascular membranes.

OBJECTIVE: Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized countries. Different risk factors have been associated with AMD. We performed a histopathologic and morphometric study to compare eyes with different stages of AMD to age-matched eyes. This study aimed to investigate the correlation among morphometric characteristics of choroidal vessels, the retinal pigment epithelium, and Bruch's membrane, to study the association between these characteristics and the presence and type of AMD, and to identify morphologic risk factors for exudati

External fixation in war traumatology: report from the Rwandese war (October 1, 1990 to August 1, 1993).

Modern missiles cause important damage in the tissues. In case of bone injury, apart from the presence of foreign bodies and soil dirt in the foyer, the lesion is characterized by a certain instability caused by the smashing and resulting in the comminutive fractures, as well as severe lesions of the soft tissues. If primary treatment includes the necessity of a large wound excision, of which the modalities have been described for centuries, it also includes a rigorous immobilization of the foyer as precaution against shock and infection. All techniques proposed during former conflicts proved

[Angelica sinensis promotes thymic cortical regeneration in mice with acute thymic involution induced by short-term rapamycin treatment].

OBJECTIVES: To investigate the effect of Angelica sinensis on thymic cortical regeneration in rapamycin-treated mice and its underlying mechanisms. METHODS: Seventy-eight 6-8-week female BALB/c mice were randomly assigned by weight into six groups: blank control, model control, normal regeneration, and Angelica sinensis low-dose, medium-dose, and high-dose groups (the blank control group n=18, each of the other groups n=12). The blank control group received a daily intraperitoneal injection of isotonic saline (0.1 mL/10 g), while the other groups were intraperitoneally administered rapamycin

The stereological investigation of conditioned medium originated from human adipose tissue-derived mesenchymal stem cells and platelet-rich plasma effects on polycystic ovary syndrome in a rat model.

BACKGROUND: Platelet-rich plasma (PRP) and conditioned medium (CM) originating from human adipose tissue mesenchymal stem cells (ATMSCs) as two enriched sources of growth factors have a potential impact on tissue repair. OBJECTIVE: This investigation aimed to investigate the effects of PRP and CM on ovarian structures in letrozole-induced polycystic ovarian syndrome (PCOS) in female rats through the stereological methods. MATERIALS AND METHODS: To obtain PRP, blood samples from Wistar rats were collected in citrate tubes, centrifuged (400g, 10 min) to separate components. Plasma+Buffy coat w

Targeting the DNA Damage Response for Cancer Therapy.

Over the course of long-term evolution, cells have developed intricate defense mechanisms in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic stability. Defects in the DNA damage response pathways can give rise to various diseases, including cancer. The DNA damage response (DDR) system is instrumental in safeguarding genomic stability. The accumulation of DNA damage and the weakening of DDR function both promote the initiation and progression of tumors. Simultaneously, they offer opportunities and targets for cancer therapeutics. This article primarily elucid

Совпадение в полном тексте источника
… Base Excision Repair Manipulation in Breast Carcinoma: A Prospective Avenue to Potentiate Genome Insulting Approach Oncomedicine 2017 2 42 51 10.7150/oncm.16758 21. Krokan H.E. Bjørås M. Base excision repair Cold Spring Harb. Perspect. … Mammalian base excision repair: The forgotten archangel Nucleic Acids Res. 2013 41 3483 3490 10.1093/nar/gkt076 23408852 PMC3616742 184. Liuzzi M. Talpaert-Borlé M. A new approach to the study of the base-excision repair pathway using methoxyamine J. Biol. …

2021 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Las Vegas, Nevada, 31 August–3 September 2021: Video Loops

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

The Role of DNA Repair in Genomic Instability of Multiple Myeloma.

Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair can influence genomic changes and drug resistance in MM. The dysregulation of DNA repair function may provide an alternative explanation for genomic instability observed in MM cells and in cells derived from MM patients. This review provides an overview of DNA repair pathways with a special focus on their involvement in MM and discusses the role th

Совпадение в полном тексте источника
… Mammalian cells are equipped with several DNA repair pathways, including base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), inter cross-link repair pathway, non-homologous end-joining (NHEJ), and homologous recombination (HR) to repair DNA damage. … Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences Front. Immunol. 2020 11 1084 10.3389/fimmu.2020.01084 32547565 PMC7272602 43. Krokan H.E. Bjørås M. Base excision repair Cold Spring Harb. Perspect. …

Collateral Victim or Rescue Worker?-The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer.

Disrupted DNA damage signaling greatly threatens cell integrity and plays significant roles in cancer. With recent advances in understanding the human genome and gene regulation in the context of DNA damage, chromatin biology, specifically biology of histone post-translational modifications (PTMs), has emerged as a popular field of study with great promise for cancer therapeutics. Here, we discuss how key histone methylation pathways contribute to DNA damage repair and impact tumorigenesis within this context, as well as the potential for their targeting as part of therapeutic strategies in ca

Совпадение в полном тексте источника
… 1989 ), and Aziz Sancar for defining the reversal of ultraviolet damage to DNA by nucleotide excision repair (NER) ( Petit and Sancar, 1999 ). … Base excision repair is impaired in mammalian cells lacking poly(ADP- ribose) polymerase-1. Biochemistry 39 7559–7569. 10.1021/bi0003442 Demple B., Sung J. S. (2005). Molecular and biological roles of Ape1 protein in mammalian base excision repair. …

[Clinical application of expanded internal mammary artery perforator flap combined with vascular supercharge in reconstruction of faciocervical scar].

Objective: To summarize the clinical experience of expanded internal mammary artery perforator (IMAP) flap combined with vascular supercharge in reconstruction of faciocervical scar. Methods: The retrospective observational study was conducted. From September 2012 to May 2021, 23 patients with postburn or posttraumatic faciocervical scars who met the inclusion criteria were admitted to Shanghai Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, including 18 males and 5 females, aged from 11 to 58 years, all of whom were reconstructed with expanded IMAP flaps. At the f

Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment.

Platinum-based chemotherapies, such as cisplatin, play a large role in cancer treatment. The development of resistance and treatment toxicity creates substantial barriers to disease control, yet. To enhance the therapeutic index of cisplatin-based chemotherapy, it is imperative to circumvent resistance and toxicity while optimizing tumor sensitization. One of the primary mechanisms by which cancer cells develop resistance to cisplatin is through upregulation of DNA repair pathways. In this review, we discuss the DNA damage response in the context of cisplatin-induced DNA damage. We describe th

Совпадение в полном тексте источника
… The primary DNA repair pathways include homologous recombination (HR), nucleotide excision repair (NER), NHEJ, base excision repair (BER), and mismatch repair (MMR). When cells are defective in one of these pathways, DNA damage accumulates. … Role of Nucleotide Excision Repair in Cisplatin Resistance Int. J. Mol. Sci. 2020 21 9248 10.3390/ijms21239248 PMC7730652 33291532 59. Zhang Y. Cao J. Meng Y. Qu C. Shen F. Xu L. …

Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches.

In the last few years, substantial progress has been made in the treatment of ovarian cancer, with increased knowledge about the biology of the disease. Ovarian cancer is a neoplasm strongly linked to defects in DNA repair mechanisms, where deficiency in the homologous recombination (HR) system results in a better response of ovarian cancers to therapy, whether platinum-based chemotherapy, anthracyclines, or poly (ADP-ribose) polymerase (PARP) inhibitors. More recently, it has been demonstrated that different ovarian cancer histotypes may have different immunogenicity. Interestingly, defects i

Совпадение в полном тексте источника
… Five DNA repair mechanisms are exploited by cells: base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), homologous recombination (HR), and non-homologous end-joining (NHEJ). We briefly described the main characteristics of DNA repair mechanisms below. … Nucleotide excision repair in humans DNA Repair 2015 36 13 18 10.1016/j.dnarep.2015.09.003 26388429 PMC4688078 30. Schärer O.D. Nucleotide excision repair in eukaryotes Cold Spring Harb. Perspect. Biol. 2013 5 a012609 10.1101/cshperspect.a012609 24086042 PMC3783044 31. Slyskova J. Naccarati A. …

Biological implant-associated granulomatous inflammation resulting in secondary hypercalcemia and azotemia in a dog.

Implant associated granulomatous inflammation causing hypercalcemia can occur following use of commercial xenogeneic pericardial tissue patches in dogs. Removal of the implant can result in resolution of the hypercalcemia, suggesting a causal relationship between the tissue reaction to a xenogeneic implant and development of hypercalcemia.

DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities.

Resistance to chemo- and radiotherapy is a common event among cancer patients and a reason why new cancer therapies and therapeutic strategies need to be in continuous investigation and development. DNA damage response (DDR) comprises several pathways that eliminate DNA damage to maintain genomic stability and integrity, but different types of cancers are associated with DDR machinery defects. Many improvements have been made in recent years, providing several drugs and therapeutic strategies for cancer patients, including those targeting the DDR pathways. Currently, poly (ADP-ribose) polymera

Совпадение в полном тексте источника
… To repair single-strand breaks (SSBs), the mismatch repair (MMR), base excision repair (BER), and nucleotide excision repair (NER) are activated, while homologous recombination (HR) and non-homologous end joining (NHEJ) pathways repair the double-strand breaks (DSBs) [ 5 ]. … Distinct Roles for the XPB/p52 and XPD/p44 Subcomplexes of TFIIH in Damaged DNA Opening during Nucleotide Excision Repair. Mol. Cell. 2007;26:245–256. doi: 10.1016/j.molcel.2007.03.009. 18. …

The effect of rabbit skeletal muscle on the large segment autologous bone ectopic preconstruction of vascularized bone flap.

AIM OF THE STUDY: To investigate the spatiotemporal secretion patterns of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) in rabbit skeletal muscle and their effects on the ectopic prefabrication of vascularized osteocutaneous flaps using large-segment autologous bone grafts. METHODS: Seventy adult Chinese white rabbits (gender-neutral) were randomly assigned: 60 rabbits to the experimental group and 10 to the blank control group. In the experimental group, a 1.5 cm midshaft tibial segment from the left hindlimb was aseptically excised, stripped of soft tiss

Proximal Scaphoid Pole Reconstruction Utilizing Ipsilateral Proximal Hamate Autograft.

BACKGROUND: Proximal pole scaphoid fractures complicated by nonunion and osteonecrosis present a challenging scenario with few good reconstructive options, especially when the proximal fragment is small or fragmented1-4. The use of an ipsilateral proximal hamate osteochondral autograft has emerged as a promising technique for reconstructing the proximal scaphoid pole, with the potential to restore carpal mechanics while avoiding the morbidity associated with free vascularized bone grafts or distant autograft sites. DESCRIPTION: The procedure involves replacing the diseased proximal scaphoid w

Functional Outcomes of Surgical Management for Spinal Epidural Masses in an Egyptian Tertiary Hospital.

BACKGROUND: The spinal epidural space, covering the dural sac, is located along the posterior longitudinal ligament anteriorly, the ligamentum flavum and the periosteum of laminae posteriorly, and the pedicles of the spinal column by the intervertebral foramina containing their neural elements laterally. It could be affected variably by different types of diseases, either as primary lesions or as an extension from a disease process in the nearby tissues and organs. AIM: We aimed to present clinically and surgically patients with spinal epidural masses operated in the Neurosurgery Department o