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Effects of the Buteyko breathing technique on sleep quality, fatigue, and oxygen saturation in patients with acute coronary syndrome: a randomized controlled trial.

INTRODUCTION: Acute coronary syndrome is frequently accompanied by sleep disturbance, fatigue, and hypoxemia; this study aimed to evaluate the effects of Buteyko breathing on these clinical outcomes. METHODS: This randomized triple-blind clinical trial was conducted in two Iranian hospitals among 92 adults with acute coronary syndrome. Participants were randomly assigned to Buteyko breathing or diaphragmatic breathing for six weeks alongside routine care. Primary outcomes included sleep quality (PSQI), fatigue (MFI-20), and peripheral oxygen saturation (SpO₂), measured at baseline and post-in…

Assessment of the MFSAF v4.0 and PROMIS Fatigue 7a to Measure Outcomes in Myelofibrosis: Validation from a Non-interventional Mixed Methods Study.

INTRODUCTION: Myelofibrosis (MF) is a bone marrow cancer causing impactful symptoms, notably excessive fatigue. While the Myelofibrosis Symptom Assessment Form (MFSAF) v4.0 and PROMIS Fatigue 7a are frequently used in clinical trials, they lack published evidence for content validity in MF. This study evaluated the content validity, psychometric properties, and patient-perceived meaningful change for both measures in an MF population. METHODS: This observational, mixed-methods study involved qualitative concept elicitation (CE) and cognitive debriefing (CD) interviews (n = 17) with patients w…

Is there a difference in knee biomechanics due to fatigue of the quadriceps versus hamstrings during landing on a single limb? a randomized comparative laboratory study.

BACKGROUND: The quadriceps and hamstring muscles play a central role in absorbing impact forces and maintaining dynamic knee stability during landing tasks. Together, these muscle groups also strongly influence knee joint kinematics and kinetics. This study aimed to compare the effects of induced fatigue of the quadriceps and hamstring muscles on the kinematics and kinetics of the knee joint during a single-leg landing in a forward-drop jump task. METHODS: Of the 108 athletes (aged 20-25 years) randomized to either the quadriceps or hamstring fatigue group, 93 completed the study and were ana…

Fatigue and Cognitive Impairment in Patients with Kidney Failure Not Requiring Kidney Replacement Therapy and Patients Receiving Hemodialysis: A Cross-Sectional Study.

Background: Cognitive impairment and fatigue are common in patients with advanced chronic kidney disease (CKD). However, whether these symptoms reflect kidney failure itself or factors associated with hemodialysis (HD) remains unclear. This study compared cognitive performance and fatigue between patients with CKD G5 not requiring kidney replacement therapy, referred to as CKD G5 not on dialysis (CKD G5 ND), and those receiving maintenance HD. Methods: In this cross-sectional, single-center study, 68 clinically stable patients with kidney failure were enrolled, including 27 patients with CKD G…

In-game monitoring of adolescent handball players: a preliminary examination of associations between external load parameters and objective and subjective fatigue markers.

BACKGROUND: Advances in local positioning systems (LPS) have enabled detailed monitoring of external load in handball. However, the relationship between external load and internal fatigue under real match conditions remains insufficiently understood, particularly in adolescent players. This study examined associations between external load parameters and both objective and subjective fatigue markers during an official match and evaluated agreement between players 'ratings of perceived exertion (RPE) and coaches' ratings of observed exertion (ROE). METHODS: Highly trained adolescent male handb…

Dietary intake of live microbes is inversely associated with fatigue and modified by serum folate among adults aged 40 years or more.

OBJECTIVES: To investigate the independent associations between dietary live-microbe intake, as well as circulating levels of folate metabolites, and fatigue, and to examine their interaction as a potential biological pathway underlying fatigue in aging adults. STUDY DESIGN: Cross-sectional analysis of adults aged ≥40 years participating in the National Health and Nutrition Examination Survey 2011-2023. MAIN OUTCOME MEASURES: Fatigue was assessed using the Patient Health Questionnaire fatigue item and categorized as none/low versus moderate/severe. Dietary intake of live-microbe foods was de…

Dyspnea and fatigue in Long-COVID: definition of risk factors and of DLCO-based phenotypes in a multicenter study of 765 patients from Italy.

BACKGROUND: Dyspnea and fatigue represent common Long-COVID symptoms, but their presence is not always accompanied by lung function abnormalities. Aim of the study was to evaluate dyspnea and fatigue in relation to pulmonary function and exercise capacity. METHODS: Multicenter cohort study. Multivariable analyses were used to characterize, for both symptoms, functional phenotypes with and without pulmonary impairment according to the diffusing lung capacity for carbon monoxide (DLCO). Exercise capacity was assessed through the distance walked in 6 min (6MWD). RESULTS: Among 765 patients eval…

The Effect of Crown Height and Retentive Height of Abutment on the Fracture Resistance of Fatigued Monolithic Zirconia Anterior Implant Crowns-An In Vitro Study.

OBJECTIVES: This laboratory study investigated the effect of two different retentive heights of Ti-base abutments (3.5 and 5.5 mm) and crown heights (13 and 16 mm) on the load at failure and survival of monolithic zirconia implant-supported crowns replacing a maxillary central incisor. MATERIALS AND METHOD: Forty implant-supported crowns were divided into four groups (n = 10 each): short crown/long abutment (SCLA), short crown/short abutment (SCSA), long crown/long abutment (LCLA), and long crown/short abutment (LCSA). Specimens underwent thermal cycling and incremental mechanical cyclic load

Erratum: Effects of Education on Treatment Adherence and Fatigue in Individuals with Treatment-Inadherent Iron Deficiency Anemia: A Randomized Trial in Türkiye [Corrigendum].

[This corrects the article DOI: 10.2147/PPA.S565466.].

Testing a Personalised Dysautonomia Management Protocol in Patients with Orthostatic Intolerance and a Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome or Long COVID.

Background/Objectives: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC) are complex multisystem conditions with significant functional disability. Many patients experience symptoms of orthostatic intolerance, which can be captured in some cases as Orthostatic Hypotension (OH) or Postural orthostatic Tachycardia Syndrome (PoTS) on objective testing. Conservative treatments are recommended for first-line symptom management, but there is a lack of efficacy evidence. This study aims to assess the feasibility of an 8-week clinically supervised, personalised Dysautonom…

Digital Phenotyping and Lifestyle Intervention in Patients With Myasthenia Gravis (DIG-MG): A Randomized Controlled Trial of Feasibility, Adherence, and Effects on Fatigue.

INTRODUCTION/AIMS: Physical activity and sleep influence fatigue in myasthenia gravis (MG), and digital health technologies (DHT) enable objective monitoring of these behaviors in daily life. Using this approach, we evaluated whether a lifestyle intervention targeting physical activity or sleep hygiene could reduce fatigue in MG. METHODS: In this three-arm, randomized controlled trial (DIG-MG; NCT05992025), 72 MG patients completed 6 weeks of baseline monitoring with a DHT ring (OURA), followed by 12 weeks of (i) physical activity guidance, (ii) sleep hygiene education, or (iii) observation, …

Воздействие акватической терапии на усталость, мобильность, физическую функцию и качество жизни людей с множественным склерозом: систематический обзор и мета-анализ.

Справочная информация: Водная терапия стала перспективной стратегией реабилитации людей с множественным склерозом (МС), потенциально повышающей физические и психологические результаты благодаря уникальным свойствам воды. Цель этого исследования заключалась в систематической оценке воздействия водной терапии на усталость, мобильность, физическую функцию и качество жизни людей, имеющих MS. Методы: В соответствии с руководящими принципами ПРИСМА был проведен систематический обзор и метаанализ. Электронные базы данных (PubMed, Scopus, Web of Science, PEDro, CINAHL и Cochrane) подвергались обыску с

Совпадение в аннотации оригинала
Background: Aquatic therapy has emerged as a promising rehabilitation strategy for people with multiple sclerosis (MS), potentially improving physical and psychological outcomes through the unique properties of water. The aim of the study was to systematically evaluate the effects of aquatic therapy on fatigue, mobility, physical function, and quality of lif…

The Effects of Multimodal Exercise on Sleep Quality and Architecture, Motor Function, Cognition, Fatigue, and Systemic Inflammation in Corticobasal Syndrome: A Case Report.

IMPORTANCE: Corticobasal syndrome (CBS) is a rare tauopathy, with a complex pathophysiology that usually includes neuroinflammation. Parkins … cale part III (MDS-UPDRS-III), respectively, functional mobility with the Time Up and Go (TUG), and fatigue with the PD Fatigue Scale. Concentrations of inflammatory markers, including interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor, and C-reactive protein, were measured from serum collected after a 12-hour fasting period. RESULTS: Following the …

The impact of academic anxiety on smartphone addiction among college students: the mediating role of self-regulatory fatigue and the moderating role of mindfulness.

BACKGROUND: Academic anxiety is recognized as a risk factor of smartphone addiction among college students. However, the underlying mechanisms and moderating factors remain insufficiently explored. METHOD: This study examines the impact of academic anxiety on smartphone addiction, focusing on the mediating role of self-regulatory fatigue and the moderating role of mindfulness. Using convenience sampling strategy, a cross-sectional survey was implemented. Data were collected from a survey of 685 college students by using the Academic Anxiety Scale, Smartphone Addiction Scale, Self-Regulatory F…

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein.

OBJECTIVE: This study investigates the effects of acute hypobaric hypoxia (HH) on the anti-fatigue properties of pitolisant and explores the underlying mechanisms. The aim is to provide a theoretical basis for expanding its clinical indications and optimizing its use in individuals exposed to HH conditions. METHODS: The anti-fatigue effects of pitolisant were evaluated using the water maze, novel object recognition, and rotating rod tests. Drug concentrations and dopamine levels were analyzed using High-Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS). Additi…

A latent profile analysis of self-regulatory fatigue and its relationship with activation in patients receiving chemotherapy for breast carcinoma: An observational study.

This study explores the profiles of self-regulatory fatigue (SRF) in patients with breast cancer who received chemotherapy and their influencing factors and to analyze the relationships between these profiles and patient activation. A total of 315 individuals with breast cancer who received chemotherapy were chosen using convenience sampling between January and April 2024, and a cross-sectional survey was conducted, comprising a self-administered basic information questionnaire, the SRF Scale, and the Patient Activation Measure. SRF profiles were identified utilizing latent profile analysis, a…

Running and Jumping After Muscle Fatigue in Subjects with a History of Knee Injury: What Are the Acute Effects of Wearing a Knee Brace on Biomechanics?

The knee is one of the most frequently injured joints, involving various structures. To prevent reinjury after rehabilitation, braces are commonly used. However, most studies on knee supports focus on subjects with anterior cruciate ligament (ACL) injuries and do not account for muscle fatigue, which typically occurs during prolonged intense training and can significantly increase the risk of injury. Hence, this study investigates the acute effects of wearing a knee brace on biomechanics in subjects with a history of various unilateral knee injuries or pain under muscle fatigue. In total, 50 s…

Mental fatigue increases perception of effort but does not compromise the inhibitory control of football referees during a match simulation physical task.

Executive functioning (EF) in referees is associated with their decision-making during a match and can be affected by mental fatigue (MF), a psychobiological state induced by prolonged periods of cognitive activity or high cognitive demand within a short timeframe. Therefore, the aim of this study was to investigate the impact of MF on EF and the perception of effort during a physical task for football referees. Twelve male professional football referees were recruited (32 ± 7.3 years; 1.75 ± 0.06 cm; 85 ± 13.32 kg; 41.4 ± 5.92 mL kg-1 min-1 VO2max), visiting the laboratory on three occasions:…

Prevalence of and factors associated with clinically important levels of fatigue, pain, and insomnia in survivors of cancer: a population-based cross-sectional study.

PURPOSE: To identify risk factors and patient characteristics in survivors who report clinically important fatigue, pain, and insomnia. METHODS: Cross-sectional study including 39,374 survivors of breast, prostate, lung, colon, rectum cancer, melanoma, and lymphoma diagnosed at age 40 or older between Jan 2010 and Dec 2019. Prevalences and odds ratios (ORs) with 95% confidence intervals (CI) for clinically important fatigue, pain, and insomnia by sociodemographic, clinical, and lifestyle factors were calculated. RESULTS: Among all survivors, 42% reported clinically important fatigue, pain, o…