Результаты поиска

Detection of TORCH pathogens in children with congenital cataracts.

The aim of the present study was to investigate the correlation between infection rates with TORCH pathogens including toxoplasma, rubella virus, cytomegalovirus, and herpes simplex virus (HSV) I and II and congenital cataracts. In total, the data from 69 children with congenital cataract treated at the Children's Hospital of the Zhejiang University School of Medicine between May 2006 and September 2013 were examined, including the complete serum test results for immunoglobulin (Ig)G and IgM that target TORCH pathogenic antibodies. These results were compared with the antibody levels of 5,914 …

Atypical VZV Retinitis in a Patient with Good Syndrome.

PURPOSE: To describe atypical varicella zoster virus (VZV) retinitis in a patient with Good syndrome. METHODS: A 63-year-old patient with Good syndrome presented with bilateral necrotizing retinitis starting from the posterior pole. He had a history of thymoma status post thymectomy 4 years previously, left-sided sinusitis, and recent pulmonary aspergillosis. Qualitative PCR was performed on aqueous fluid. RESULTS: Immunological investigations revealed reduced levels of CD4+ T cells and immunoglobulins. Qualitative PCR was positive for VZV and negative for cytomegalovirus, herpes simplex vir…

Antiherpes evaluation of soybean isoflavonoids.

The antiviral effects of soybean isoflavonoids have been investigated recently, especially those of genistein. It has been reported that this isoflavone is able to inhibit herpes simplex virus (HSV) replication, which is associated with skin and epithelial mucosa infections. The treatment of these infections with antiherpes drugs has resulted in the emergence of resistant viral strains. Based on this evidence, the aim of this study was to investigate the anti-HSV effects of soybean isoflavonoids: daidzein, genistein, glycitein, and coumestrol. Genistein and coumestrol inhibited HSV-1 (KOS and …

Tectonic lamellar keratoplasty: simplified management of corneal perforations with an automated microkeratome.

OBJECTIVE: To describe a simplified tectonic lamellar keratoplasty (LK) technique, which can be used to manage full-thickness corneal perforations. DESIGN: Case series demonstrating a new surgical technique. PARTICIPANTS: A 69-year-old female with rosacea keratitis and peripheral corneal perforation; a 49-year-old male with keratoconus, ipsilateral herpes simplex keratitis and an inferonasal corneal perforation; and a 12-year-old female with an apparently spontaneous central corneal perforation. RESULTS: These 3 patients with full-thickness corneal perforations were successfully managed wit…

Catastrophic gastrointestinal complication of systemic immunosuppression.

We present a case of acute upper gastrointestinal haemorrhage in a patient with systemic vasculitis immunosuppressed on cyclophosphamide and prednisolone. The patient presented with a diffuse haemorrhagic oesophagitis and a non-specific duodenitis. Biopsies taken from the oesophagus and duodenum demonstrated infection with herpes simplex virus (HSV) and cytomegalovirus (CMV) respectively. Viral infection of the upper gastrointestinal tract is a recognised complication of immunosuppression and HSV is one of the most common pathogens. CMV on the other hand most commonly causes a colitis or less …

[Expression and function of microRNAs in the cornea].

MicroRNAs (miRNAs) are a class of small (21-2i nucleotictes), single-stranded, noncoding RNA molecules that regulate gene expression at the … s in the cornea, such as keratoconus, corneal neovascularization caused by corneal transplantation, herpes simplex virus infection and alkali burns. Therefore, miRNAs are expressed in a tissue-specific manner and regulate physiological and pathological processes in the cornea. The study of miRNA expression and regulation in the cornea would provide a theoretical …

Potential Antiviral Agents from Marine Fungi: An Overview.

Biodiversity of the marine world is only partially subjected to detailed scientific scrutiny in comparison to terrestrial life. Life in the … ungi as a promising source to develop new antivirals against different important viruses, including herpes simplex viruses, the human immunodeficiency virus, and the influenza virus. Various genera of marine fungi such as Aspergillus, Penicillium, Cladosporium, and Fusarium were subjected to compound isolation and antiviral studies, which led to an illustration …

Chemokine-mediated immune responses in the female genital tract mucosa.

The genital tract mucosa is the site where sexually transmitted infections gain entry to the host. The immune response at this site is thus … our understanding of the immune response in the female genital tract to infectious pathogens, using herpes simplex virus-2, human immunodeficiency virus-1 and Chlamydia trachomatis as examples, with a particular focus on the role of chemokines in orchestrating immune cell migration necessary to achieve effective innate and adaptive immune responses in the female …

Deep sequencing to identify the causes of viral encephalitis.

Deep sequencing allows for a rapid, accurate characterization of microbial DNA and RNA sequences in many types of samples. Deep sequencing ( … pecific PCR. This analysis successfully identified measles virus sequences in two brain samples and herpes simplex virus type-1 sequences in three brain samples. No pathogen was identified in the other two brain specimens. These results were concordant with pathogen-specific PCR and partially concordant with prior neuropathological examinations, demonstrating th …

Drug-induced hypersensitivity syndrome due to minocycline complicated by severe myocarditis.

A 60-year-old woman presented with a 13-day history of a generalized erythematous rash accompanied by fever, periorbital edema and axillary … , resulting in satisfactory resolution. A rise in titer of human herpesvirus-6, cytomegalovirus and Herpes simplex virus-1 antibodies was detected. Although minocycline-induced myocarditis is rare, this severe drug reaction should be considered with DIHS.

Sexually transmitted diseases: epidemiological and clinical aspects in adults.

Sexually transmitted diseases (STDs) are the first 10 causes of unpleased diseases in young adult women in the world. The concept of STDs in … gonorrhoeae, Chlamydia trachomatis, Treponema pallidum, Haemophilus Ducreyi, Trichomonas vaginalis, herpes simplex virus, human papilloma virus (HPV) with the exception of hepatitis, and HIV infections for which we suggest specific guidelines.To attain this objective, we analyzed the results of epidemiological and clinical aspects of STDs through a review of the …

Granuloma annulare masquerading as erythema multiforme.

Erythema multiforme (EM) is a serious cutaneous and/ or mucocutaneous disorder that typically develops within 10-14 days of exposure to an offending medication or infection and resolves within 4 weeks. Common offending agents include antibiotics, anticonvulsants, nonsteroidal anti-inflammatory medications, and various viral, fungal, and bacterial infections. Herpes simplex virus is a common cause of recurrent EM. Although this condition may be relatively benign in its minor form, EM major can lead to serious complications and even death. As such, it is imperative to find and remove the etiolog…

Interpretation of positive molecular tests of common viruses in the cerebrospinal fluid.

Many central nervous system infections are historically difficult to diagnose. Polymerase chain reaction (PCR) has revolutionized the diagnosis of these infections because of their high sensitivity despite the lack of data on clinical usefulness. We conducted a retrospective study that included patients with positive cerebrospinal fluid (CSF) PCR for herpes simplex virus, varicella-zoster virus, JC virus, cytomegalovirus (CMV), and Epstein-Barr virus (EBV) between January 2009 and December 2011. The positive results were grouped into definite, likely, and possible true positives and likely fal…

совершенствование управления атемой первичной медико-санитарной помощи.

Хотя, как правило, считается детской болезнью, 38% пациентов в Великобритании с аттракционной экземой являются взрослыми. Диагностика несложной атемы основана на клинической истории и визуальной оценке. Вторичная инфекция может осложнить экзему, особенно стафилококкаль и стрептококкал, а герпес с помощью вируса simpex может вызвать герпетику экземы, которая неудобна и потенциально опасна. Пациенты или лица, осуществляющие уход, должны получить полное объяснение того, как использовать тематические методы лечения и, в соответствующих случаях, продемонстрировать, как применять перевязку. Эмуллиен

Совпадение в аннотации оригинала
Although generally considered a childhood ailment, 38% of patients in the UK with atopic eczema are adults. The diagnosis of uncomplicated atopic eczema is based on clinical history and visual assessment. Atopic eczema may be complicated by secondary infection, particularly staphylococcal and streptococcal, and herpes simplex virus may cause eczema herpeticu…

Viral infections of the pubis.

There are no demographic data published on those with viral infections of the pubis (VIPs). We conducted a two-year prospective study to col … s identified in 71%, condylomata acuminata (CA) in 11%, concomitant MC and CA infections in 11% and herpes simplex virus (HSV) infection in 4.8%. Shaving represented a risk factor for a high lesion number, but not for the extension beyond the pubis. MC, CA and HSV infections affecting the pubis are uncommon and often asymptomatic. As they may represent a hidden …

Viral infections detected by serology and PCR of perilymphatic fluid in children with idiopathic sensorineural hearing loss.

The etiology of sensorineural hearing loss (SNHL) in children may be viral. This cross-sectional study aimed to determine the role of viral infectious agents in children with idiopathic SNHL. Of 119 children with SNHL aged 3-168 months undergoing cochlear implant surgery at a hospital in Tehran, no cause could be established in 18 cases (15.1%). Cytomegalovirus (CMV) and herpes simplex virus (HSV) active infections (detected by DNA-PCR, confirmed by serology) were found in the perilymphatic fluid of 16.7% (3/18) cases of idiopathic SNHL. Serology was performed on blood samples from 11 of these…

Recognition of Dual or Multiple Pathology in Skin Biopsies from Patients with HIV/AIDS.

A large percentage of patients with HIV/AIDS will develop dermatological complications. Consequently, all practising clinicians and pathologists in regions with a high prevalence of HIV/AIDS must be familiar with the diverse cutaneous manifestations of the disease. This paper highlights the fact that biopsy material in this clinical context may occasionally reveal more than one pathological process. The potential spectrum includes two or more infections in a single skin biopsy (e.g., herpes simplex and cytomegalovirus infection), neoplastic lesions containing infective organisms (Kaposi sarcom…

Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum.

Background. Eczema herpeticum (EH) is a potentially serious, systemic complication in subjects with atopic dermatitis (AD) caused by herpes simplex virus (HSV). The innate immune dysregulation that predisposes these subjects to cutaneous viral infections is not well understood. We tested the hypothesis that defects in mannan-binding lectin (MBL) may be associated with an increased risk of EH. Methods. We evaluated serum MBL levels and functional activity in 13 AD subjects with a history of EH (EH+) and 21 AD subjects with no history of EH (EH-). MBL levels were detected by enzyme immunoassay. …

Religious involvement and seroprevalence of six infectious diseases in US adults.

OBJECTIVE: In the United States, religious practice is inversely associated with several chronic conditions, but no reports show whether it … attending religious services weekly (19.8%) or more (19.6%) were less likely to be seropositive for herpes simplex type 2 (HSV-2) than those attending less frequently (23.7%) or never (25.1%, P = 0.001). Analyses revealed the association to be partially accounted for by reduced risky sexual behavior and illegal drug use among frequent attenders. No associations …

Alcohol use, sexual risk behavior and STIs among married men in Mumbai, India.

This paper examines the relationship of frequency, type of alcohol use, sexual risk behaviors and sexually transmitted infections (STIs) amo … and Chlamydia (CT) infection and three times more likely to have had a past history of exposure to herpes simplex virus-2 (HSV-2) and/or syphilis as determined by biological testing. These results demonstrate that men with daily alcohol use are at greatest risk for STIs and need to be targeted for community outreach, de-addiction services and sex risk reduction …