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The adverse effect of commercial dentine-bonding systems on the skin of guinea pigs.

It was widely known that 2-hydroxyethyl methacrylate (2-HEMA) can cause contact dermatitis. Commercially available dentine primers and dentine bonding agents that contain 2-HEMA are widely used. The purpose of this study was to investigate the cumulative irritation and delayed hypersensitivity caused by commercial dentine bonding systems when applied to the skin of guinea pigs. We have concluded that almost no dentine bonding systems cause cumulative irritation, but some commercially available dentine bonding systems may produce delayed hypersensitivity.

[Occupational allergy in the production of drugs].

Quinazoline oxide--an intermediate in chlordiazepoxide synthesis--is the most potent contact allergen in the pharmaceutical industry. Penicillins proved to be potent allergens. Conditions of the technological process favor development of hypersensitivity to tetracyclines. No single case of allergy to erythromycin was noted. In case of employees hypersensitive to disulfiram and aminophylline cross reactions with compounds of similar structure were observed. The authors discuss also some problems concerning contact allergy in all persons occupationally dealing with various medicines.

Induction of immunological tolerance by oral administration of nickel and chromium.

Oral administration of nickel-chromium to guinea pigs by way of a fixed occlusal splint, or the incorporation of metallic powder or salts into the pelleted food, did not induce hypersensitivity to these metals. In addition, a subsequent attempt to immunize the pre-treated guinea pigs failed in most animals, whereas non-pre-treated guinea pigs became clearly hypersensitive. These results show that oral administration of nickel and chromium induced a state of (partial) tolerance to both metals.

Anaphylaxis to rifampicin and pyrazinamide in a child with tuberculous meningitis: A case report.

Rifampicin (RFP) and pyrazinamide (PZA) are the primary anti-tubercular drugs with a considerably safe profile. However, none of the drugs are without adverse reactions. They both can lead to a variety of adverse effects including life-threatening anaphylaxis. We report an interesting and possibly the first case of concurrent hypersensitivity to two primary anti-tubercular treatment (ATT) drugs. Hypersensitivity to RFP and PZA was confirmed in this patient by drug provocation and intradermal skin testing. He improved on alternative ATT regime withdrawing RFP and PZA.

[Latex allergy].

Latex is an ubiquitous natural product, frequently used at home or at work (gloves, balloon, condom...). Latex hypersensitivity is an increasing problem and now presents worrying prevalence among exposed subjects, particularly health care workers or atopic subjects or patients with multiple invasive procedures. Latex allergy generally refers to a type 1 reaction to natural rubber latex proteins with clinical manifestations ranging from contact urticaria to asthma and anaphylaxis. But eczema reaction of type IV hypersensitivity to latex rubber adding (anti-oxidant, preservative, accelerator) is…

[The usefulness of the desensitization to rifampin in the treatment of mycobacterial disease in patients with AIDS].

BACKGROUND: Hypersensitivity reactions to rifampin are relatively uncommon, but they may result in cessation of therapeutic medications. PATIENTS AND METHODS: We report our experience with oral desensitization protocol to rifampin in a group of 35 HIV-positive patients with mycobacterial disease who had some hypersensitivity reaction to this drug. RESULTS: Adverse reactions with this protocol were few and easily treated. CONCLUSIONS: Oral desensitization to rifampin is safe and effective, allowing some of these patients (60%) to reintroduce the drug and to reduce the time of treatment.

Phenylmercury transport mediated by merT-merP genes of Pseudomonas K-62 plasmid pMR26.

The merB-merA-deleted plasmid pMRD141 which contains the intact merT-merP genes of pMRA17 conferred bacterial hypersensitivity not only to Hg2+ but also to C6H5Hg+. The bacterium with pMRD141 took up significantly more C6H5Hg+ than its isogenic strain with the cloning vector Bluescript II. The hypersensitivity to C6H5Hg+ seems to be based on hyperaccumulation of toxic C6H5Hg+ in the absence of detoxifying enzymes encoded by merB and merA. Our results show that bacterial transport of C6H5Hg+ into the cytoplasm is regulated by merT-merP genes.

[Latex allergy].

Within the last ten years, the IgE mediated type of allergy to natural rubber latex has become an increasing and clinically important problem. Health professionals, rubber industry workers and individuals with spina bifida have been found to be at special risk of latex allergy. Clinical symptoms manifest as contact urticaria, rhinoconjunctivitis, asthma or even as intraoperative anaphylactic shock. An association between allergies to latex proteins and to various food-"Latex fruit syndrome "has been reported. Strict avoidance of the use of latex products is the primary preventive measure. In t

[Structural changes in the auditory field in relation to age].

Using a category scale we measured the loudness of narrow band noises experienced in 3 age groups (15-23, 33-45, and 60-75 years old). The narrow band noises had center frequencies between .125 and 8 kHz with sound pressure levels of 60, 75, and 90 dB each. We found the well-known high-frequency loss. However, we also found a hypersensitivity at middle frequencies correlated with high-frequency loss. The presumable causes of this hypersensitivity and its consequences for hearing aid fitting will be discussed.

Нейрональный метаболизм в совершенствовании кетогенного рациона в болезненной модели мыши, вызванной бортезомибами.

ВВЕДЕНИЕ: Кетогенная диета (КД) может способствовать целому ряду неврологических заболеваний, включая различные виды периферической нейропатии. Бортезомиб (ББТ) — первая химиотерапия для лечения множественной миэломы, оказывает нейротоксичное воздействие и часто вызывает периферическую нейропатию, вызванную химиотерапией. ЦЕЛИ: Здесь мы проверили, может ли KD предотвратить возникновение небольшой волокнистой нейропатии и поведенческой гиперчувствительности, связанной с периферической нейропатией (BIPN), вызванной бортезомибами. МЕТОДЫ: C57BL/мужчина6 Мышей кормили либо стандартной диетой, либо

Совпадение в аннотации оригинала
INTRODUCTION: A ketogenic diet (KD) can benefit a range of neurological conditions, including different types of peripheral neuropathy. Bort … IVES: Here, we tested whether a KD could prevent the onset of small fiber neuropathy and behavioral hypersensitivity associated with bortezomib-induced peripheral neuropathy (BIPN). METHODS: Male C57BL/6 mice were fed either a standard chow diet or a KD for 10 days. During the first 5 days of KD administration, mice received daily intraperitoneal injections of BT …

Rapid drug desensitization in pediatric patients: A multicenter study.

BACKGROUND: Drug hypersensitivity is often managed by drug desensitization, yet published data remain scarce in children. This study evaluated the safety and efficacy of rapid desensitization to chemotherapeutic agents, monoclonal antibodies, and disease-modifying antirheumatic drugs (DMARDs). OBJECTIVE: To evaluate the safety and efficacy of rapid desensitization for managing drug hypersensitivity in pediatric patients. METHODS: This is a multicenter retrospective analysis of rapid drug desensitizations performed at Boston Children's Hospital, Hong Kong Children's Hospital, and Queen Mary H…

Successful azithromycin desensitization using a modified protocol after initial reaction: A pediatric case report.

Pertussis is a highly contagious infection associated with significant morbidity and mortality in young infants despite widespread vaccinati … he second dose, he developed facial puffiness and lip swelling consistent with a probable immediate hypersensitivity reaction. This complicated management because alternative antimicrobial agents, including trimethoprim-sulfamethoxazole and fluoroquinolones, were considered unsuitable owing to age-related safety concerns and limited clinical applicability. Followi …

Role of Polyethylene Glycol in Dermatology.

BACKGROUND: Polyethylene glycol (PEG) is commonly used in dermatology due to its excellent solubility, nontoxic nature, and compatibility with various therapeutic agents. Its applications extend from moisturizing creams to chemical peels, improving skin hydration and facilitating drug delivery. Despite its broad utility, PEG is associated with hypersensitivity reactions, including rare cases of anaphylaxis, that necessitates a thorough assessment of its safety profile. This review evaluates PEG's therapeutic roles, safety, and dermatological applications, focusing on its pharmacokinetics, chem…

The RNA-binding protein CELF4 is a negative regulator of sensory neuron excitability and mechanical and heat behavioral sensitivity.

RNA-binding proteins (RBPs) regulate gene function by controlling RNA processing, transport, stability, and translation. Recent mechanistic … to controls. Behavioral assessments revealed that these mice display robust mechanical and thermal hypersensitivity and an exaggerated evoked hypersensitivity response to intraplantar capsaicin and nerve growth factor. These studies reveal that the translational regulator CELF4 is a powerful negative regulator of sensory neuron excitability and sensory thresholds …

Drug provocation tests in children: All that glitters is not gold.

A proper allergy work-up, based on the gold standard drug provocation test (DPT), usually rules out suspected drug hypersensitivity in children. These tests are generally open, given their high efficiency compared with double-blind placebo-controlled DPTs. Although their negative predictive value is excellent, no studies have calculated their positive predictive value, highly dependent on the prevalence of the disease. Most studies have found a rate of <5%-10% of true beta-lactam hypersensitivity in children. Given this low prevalence (pre-test probability), a few false-positive results can si…

Use of antithymocyte globulin (rabbit) in a patient with known alpha-gal syndrome undergoing allogenic stem cell transplantation.

INTRODUCTION: Alpha-gal syndrome (AGS) is a hypersensitivity disorder in which tick bites-most commonly from the lone star tick (Ambylomma americanum)-trigger immunoglobulin E-mediated hypersensitivity reaction upon exposure to oligosaccharide galactosse-alpha-1,3-galactose (α-gal). α-gal is most notorious for being found in "red meat" products but is present in mammalian meats such as beef, pork, lamb, rabbit, and others. Manifestations of AGS hypersensitivity are variable. There is currently no in vivo data describing allergic reactions against rabbit products in patients with AGS. CASE REP…

CoREST1 in primary sensory neurons regulates neuropathic pain in male mice.

AIMS: Epigenetic regulation is implicated in the neurogenesis of neuropathic pain. The repressor element 1 (RE1) silencing transcription fac … injured DRGs in male mice. Furthermore, CoREST1 siRNA prevented the development of SNL-induced pain hypersensitivity as well as led to the reduction of established pain hypersensitivity during the maintenance period in SNL mice. Conversely, the overexpression of CoREST1 in DRGs by in vivo transfection of virus-induced pain hypersensitivity in naive mice. SIGNIFIC …

Banana anaphylaxis in Thailand: case series.

BACKGROUND: Banana fruit has been recognized as an important food allergen source. Nowadays banana hypersensitivity had been reported more frequently with various presentations from oral allergy syndrome to anaphylaxis. OBJECTIVE: This study aims to describe the pattern of banana hypersensitivity and the sensitivity of diagnostic test. METHODS: Six patients who experienced banana hypersensitivity were recruited from adult allergy clinic, Ramathibodi Hospital, Mahidol University between 2015-2018. Demographic data, pattern of banana allergy consisted of the onset of reaction, symptoms, severi…

Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats.

Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. Rats in t…