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Research Progress and Potential Applications of Spermidine in Ocular Diseases.

Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell proliferation activation, and ion channel regulation. Considering that spermidine is already present in human nutrition, recent studies targeting supplementing exogenous sources of this polyamine appear feasible. The protective role of spermidine in various systems has been illuminated in the literature, while recent progress of spermidine administration in ocular diseases remains to be clarified. This study shows the cur

Research on Gambling in Young People: A Co-Occurrence Analysis.

Gambling as a risk factor in youth development, particularly its causes and consequences, has been the subject of a growing number of studies. However, the literature relating to young people has yet to be compiled in a systematic form. The present study adopts a descriptive bibliometric approach to map global Исследование on gambling in young people using metadata from the Web of Science database. The results show that Исследование on gambling in young people at a country level has increased in recent years, though some regions are underrepresented. Co-occurrence analysis revealed the frequent use of…

Recent Microscopy Advances and the Applications to Huntington's Disease Research.

Huntingtin is a 3144 amino acid protein defined as a scaffold protein with many intracellular locations that suggest functions in these compartments. Expansion of the CAG DNA tract in the huntingtin first exon is the cause of Huntington's disease. An important tool in understanding the biological functions of huntingtin is molecular imaging at the single-cell level by microscopy and nanoscopy. The evolution of these technologies has accelerated since the Nobel Prize in Chemistry was awarded in 2014 for super-resolution nanoscopy. We are in a new era of light imaging at the single-cell level, n

Research progress of natural products for the treatment of ischemic stroke.

Stroke is a leading cause of death and disability world-widely. The incidence rate of stroke has been increasing due to the aging population and lifestyle changes. At present, the only drug approved by the US Food and Drug Administration (FDA) for the treatment of ischemic stroke is tissue plasminogen activator (t-PA), but its clinical application is greatly limited because of its narrow time window and bleeding risk. Natural products have a long history of being used in traditional medicine with good safety, making them an important resource for the development of new drugs. Indeed, some natu

Quality of Occupational Therapy Research in India - A Descriptive Review.

BACKGROUND: Occupational therapy (OT) enhances functional independence in the daily activities of people with disabilities and subsequently their quality of life. Research in OT generates evidence to provide safe and effective services to the disabled. However, OT Исследование in India has been shown to have various methodological limitations. These methodological limitations are expected to impact the quality of OT Исследование as well as the evidence derived from this Исследование to inform decision-making in rehabilitation. The majority of the OT Исследование is disseminated and promoted through the All In…

Using social network analysis as a tool in action Исследование.

The following paper presents case examples of one Исследование team's use of social network analysis (SNA) with three different collaboratives in South Florida: (a) a Collective Impact initiative seeking to end youth homelessness, (b) a university collaborative of campus organizations working towards Black students' concerns, and (c) a movement network of local social justice organizations. The Исследование team used SNA to assess the level of connectivity of three different community coalitions. While Исследование questions were slightly different for each collaborative, each project asked about the freq…

Keeping an eye on circadian time in clinical Исследование and medicine.

BACKGROUND: Daily rhythms are observed in humans and almost all other organisms. Most of these observed rhythms reflect both underlying endogenous circadian rhythms and evoked responses from behaviours such as sleep/wake, eating/fasting, rest/activity, posture changes and exercise. For many Исследование and clinical purposes, it is important to understand the contribution of the endogenous circadian component to these observed rhythms. CONTENT: The goal of this manuscript is to provide guidance on best practices in measuring metrics of endogenous circadian rhythms in humans and promote the inclus…

A scoping review on occupational science Исследование in European contexts.

BACKGROUND: A survey showed European occupational scientists cover a broad range in occupational science (OS) Исследование, however, no contemporary overviews of European OS Исследование exists, and current Исследование may provide valuable information for OS and occupational therapy. AIM: The aim was to provide an overview of contemporary European OS Исследование. MATERIALS AND METHOD: A scoping review was performed, including studies conducted in Europe and published in the British Journal of Occupational Therapy (BJOT), the Scandinavian Journal of Occupational Therapy (SJOT) or the Journal of Occupationa…

Neuroimmune crosstalk and its impact on cancer therapy and Исследование.

Cancer is a major health problem as it is the first or second leading cause of death worldwide. The global cancer burden is expected to rise … and miRNA roles. The second aim is to elaborate neuroimmune crosstalk impact on cancer therapy and Исследование highlighting various potential novel strategies such as use of immune checkpoint inhibitors and anti-neurogenic drugs as single agents, drug repurposing, miRNA-based and si-RNA-based therapies, tumor denervation, cellular therapies, and oncolytic vi …

PB1975: THE RESEARCH ON THE MECHANISM OF RRAD GENE IN MULTIPLE MYELOMA

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… Aims: The Исследование on the mechanism of RRAD gene in multiple myeloma Methods: The study collected bone marrow specimens and 9 healthy volunteers from 20 newly diagnosed MM patients admitted to the Affiliated Hospital of Zunyi Medical University from January 2019 to June 2020.The RT-qPCR method was used …

The abortion and contraceptive behavior: results of the all-Russian Research.

The problem of abortion is actual in all spheres of public life. Despite the fact that in Russia, according to the Ministry of Health, the n … last, etc. The total sampling consisted of 5 616 respondents. The study implemented such scientific Исследование methods as: analysis, synthesis, generalization, statistical analysis, sociological analysis. The state policy implementation related to the decrees of the President of the Russian Federation "On measures to implement the Demographic Policy of the R …

Voicing the need to consider sex-specific differences in Исследование.

Researchers are exploring sex differences in experimental models of both development and disease-but are we doing enough? In this collection of Voices, we celebrate Исследованиеers who are asking this question and starting to offer mechanistic clues on sexually dimorphic differences seen in interorgan communication, metabolic disease, neurological disorders, and more.

Advances in Mechanism Research on Polygonatum in Prevention and Treatment of Diabetes.

Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life. Oral hypoglycemic drugs and insulin are curr … on owing to their unique therapeutic role in the treatment and prevention of diabetes. However, the Исследование on the mechanism of these three Polygonatum spp. in diabetes has not been reviewed. This review provides a summary of the Исследование progress of three Polygonatum spp. on diabetes and its complications, reveals the potential antidiabetic mechanism of …

[Research progress on the pathogenesis of diabetes-related dry eye].

In recent years, with the further understanding of medical circles on diabetic ocular complications, the ocular surface abnormalities of dia … eneration of corneal nerve caused by diabetes. In this paper, we summarized and analyzed the recent Исследование progress on the effect of diabetes on lacrimal film, corneal innervation and lacrimal gland innervation, and the correlation between oxidative stress, advanced glycation end products and diabetes-related dry eye, to explore the pathogenesis of diabe …

[Research progress on interference in the identification of accelerants in a fire scene].

Fire is one of the most common disasters threatening public safety and social development; arson, a typical violent crime, is a serious thre … eriously influences the accuracy of accelerant identification. This study describes the progress of Исследование on the interference in accelerant identification induced by various factors at fire scenes from four aspects: thermal environment, matrix interference, weathering effect, and microbial degradation, with emphasis on the interference from the first as …

[Research advances in classifications and functions of retinal ganglion cells].

Retinal ganglion cells (RGCs) are the most important type of neurons in the visual pathway. RGC axons exit the eye to form the optic nerve, which connects with the brain. The visual signals carried by RGC axons establish the only link between the outside world and our internal perception of sight. Researches on the morphological, physiological, molecular, and mosaic features of RGCs are of great significance. This article reviews the Исследование advances of RGC classifications, definitive types of RGCs, and selective vulnerability of specific RGC types after various injuries.

Role of Animal Models to Advance Research of Bacterial Osteomyelitis.

Osteomyelitis is an inflammatory bone disease typically caused by infectious microorganisms, often bacteria, which causes progressive bone destruction and loss. The most common bacteria associated with chronic osteomyelitis is Staphylococcus aureus. The incidence of osteomyelitis in the United States is estimated to be upwards of 50,000 cases annually and places a significant burden upon the healthcare system. There are three general categories of osteomyelitis: hematogenous; secondary to spread from a contiguous focus of infection, often from trauma or implanted medical devices and materials;

[Latest Research Findings on the Regulation of Bone Homeostasis by ALK3].

Bone remodeling, which is well orchestrated by osteogenesis of osteoblasts and osteoclastogenesis of osteoclasts, maintains the homeostasis … ling have been extensively studied. Many new discoveries have been reported in recent years through Исследование based on transgenic mice models and focused on ALK3 as targets, shedding new light on the regulations of bone remodeling, cartilage and joint development, and the occurrence and treatment of bone-related diseases. Established understanding has been …