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[Extracorporeal lithotripsy using the Lithoring multi-one, a third generation lithotripter].

The Lithoring multi-one is a lithotripter recently developed in Italy. Its main features are: (1) spark gap generator with large ellipsoid with tunable power for treatments with or without analgesia (2) localization by fluoroscopy and ultrasounds without moving the patient (3) isocentric variation of shock wave window (4) multi-functional table. It can treat both urinary and biliary stones. Herein we described (1) the experimental in vitro studies, including those carried out by intentionally changing the direction of the blast path during the treatment (2) the experimental in vivo studies on

["Wallstent" intra-urethral prosthesis in recurrent urethral stenosis].

Urethral strictures recur in about 30% of the cases whatever might be the treatment. We describe a new urethral stent, originally developed in our Institution for vascular use after transluminal angioplasty. Since january 1986, we previously have controlled the biocompatibility and tolerance into the normal urethra of dogs with a one year of follow-up. The stent has a braided structure, made of fine stainless steel wires and is self-expanding when released from a special endoscopic instrument. From november 1987, we have implanted the stent into 11 males (mean age 54 years), after a previous u

[Sex determination in ambiguous genitalia].

Choice of sex in children with ambiguous genitalia requires morphological evaluation of external and internal genitalia together with prevision of the kind of pubertal and psychosexual development. Female features in female pseudohermaphroditism, ambiguous in true hermaphroditism and mixed gonadal dysgenesis, male, ambiguous or female in male pseudohermaphroditism, are usually awaited. Increased risk of malignancy in poorly differentiated male gonads should be considered. In neonates diagnostic procedures should be urgently undertaken in order to choose correct sex as soon as possible. Parents

[Prosthetic implants for penile induration].

From 1982 to 1988 we have evaluated 283 patients affected by Peyronie's disease. 81 of these complained erectile disfunction. Semirigid penile prosthesis were inserted in 38 patients with severe induratio penis plastica. Following surgery the patients were given a sexual questionnaire in order to determine whether they had realised their expectations as well as partner acceptance. Our results appear to be favourable and prosthesis insertion in selected patients with Peronie's disease seems to be the safest, most economical and best accepted choice.

[Extracorporeal lithotripsy with low pressure shockwaves using a modified Dornier HM3 lithotriptor: preliminary results].

Extracorporeal shock wave lithotripsy is a well established procedure for the treatment of the renal and ureteral calculi. The technical innovations of the low-pressure generator with a modified ellipsoid installed into the Dornier HM3 lithotripter leads to decrease the pressure in the second focus F2 lowering the painful sensation linked to the treatment and allowing to perform lithotripsy without general or epidural anae sthesia. From January to March 1988 132 patients underwent 144 treatment by modified Dornier Lithotripter HM3, we performed the treatments under a combination of anxiolytic

[The retained testicle: our experience].

In our experience the undescended testis has an occurrence rate of 3-4% on the total of males born. The rate decreases to 0.3% when the occurrence is observed on males aged 1 year. The first step of treatment is hormonal followed by a surgical second step in case of failure. The Author stresses the need of the treatment as early as possible to prevent the damage of both exocrine and endocrine testicular functionality.

[Cryptorchism: long-term results in subjects evaluated in a conjugal infertility service (monolateral cryptorchism fertility)].

Infertile male subjects because of cryptorchidism have an overall rate of 0.5-1%. Undescended testis even if treated by surgery and/or hormonal therapy have a bad seminal map. However in Author's experience, the hormonal treatment give a significant improvement in terms of fertility. Biopsies carried out on undescended testis demonstrated an early cellular damage of the testis.

[Indications for the hormonal therapy of cryptorchism].

The treatment of cryptorchidism is nowadays based on one of the following drugs: chorionic gonadotropins, FSH, LHRH analogues. The chorionic gonadotropin treatment is the first choice treatment given in quite similar way by various Authors. It is furthermore the less expensive. Its activity is mainly pharmacological. The chorionic gonadotropin can be administered both as monotherapy as well as associated. The associated treatments are with FSH and with LHRH analogues. The latter way of treatment requires a skilled experience because of the precise diagnosis needed to administer the LHRH analog

Polyvinilpyrrolidone-iodine (P.V.P.-I) bladder irrigation for prevention of catheter-associated urinary infections in patients treated by T.U.R.

The incidence of urinary infection in catheterized patients is very important in those undergoing T.U.R. for bladder neck and prostatic obstructions because the risk of jatrogenic defilement, and any method of preventing, reducing or delaying the occurrence of infection in catheterized patients, should be tooking considerations. Between March 1984 and September 1985 300 male patients, requiring catheterization after T.U.R. for out-flow obstruction (80% benign, 40% malignant prostatic disease, 16% bladder-neck obstruction), were introduced to the trial. All patients were managed by closed drain

Навигатор биомаркеров человека.

Биомаркеры играют ключевую роль в современных исследованиях медицины, особенно в ранней диагностике заболеваний и персонализированном лечении. Несмотря на то, что предыдущие исследования систематически обзоры маркеров в различных областях заболеваний, интегрированная система, которая связывает основные физиологические системы, охватывает множество органов и охватывает широкий спектр заболеваний, все еще отсутствует. В контексте современных вызовов здоровья, характеризующихся высокой распространенностью хронических заболеваний и широкими сопутствующими заболеваниями, создание панорамной системы

Резюме докладов 51st Конференция Европейского общества генетики человека: плакаты

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Совпадение в полном тексте источника
… Laan 1 1 Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia, 2 Andrology Centre, Tartu University Hospital, Tartu, Estonia Introduction: Infertility affects 5-7% of men. … The current pipeline at the andrology clinic is able to assign a definite cause for 40% of patients, including genetic errors in 8% of cases, whereas 60% of them remain idiopathic (Punab M et al. 2017 Hum Reprod). …

Резюме докладов 53rd Конференция Европейского общества генетики человека: интерактивные электронные постеры.

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… Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, Netherlands, 2 Centre of Reproductive Medicine and Andrology, Department of Clinical and Surgical Andrology, University of Münster, Münster, Germany, 3 Institute of Genetic Medicine … Horsthemke 1,5 1 Institute of Human Genetics, University Hospital Essen, Essen, Germany, 2 Centre of Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany, 3 Institute of Medical Informatics, University Münster, Münster, Germany, 4 Centre of Reproductive Medicine and Andrology …

40th Annual CAPO Conference-Responding to the Human Experience of Cancer and Caring for the Soul: Building on 40 Years of Global Leadership in Psychosocial Oncology.

On behalf of the Canadian Association of Psychosocial Oncology, we are pleased to present the Abstracts from the 2025 Annual Conference, titled "Responding to the Human Experience of Cancer and Caring for the Soul: Building on 40 years of global leadership in psychosocial oncology". The 40th Annual CAPO Conference was held in Toronto from 23 April 2025 to 25 April 2025. In an era marked by the rapid advancement of biologically focused precision medicine, it is imperative to redirect our attention towards the human experience of illness and the soul of medicine. Biomedicine has conceptualized i

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… Despite guidelines from the American Society of Clinical Oncology (ASCO) and the Canadian Fertility & Andrology Society (CFAS) recommending that clinicians address the possibility of infertility as early as possible before treatment begins, studies in Canada and elsewhere show that these conversations …

Program-Abstracts

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The sirtuin family in health and disease.

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a

Cyclic nucleotide phosphodiesterases as drug targets.

Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) intracellular levels by mediating their quick return to the basal steady state levels. This often takes place in subcellular nanodomains. Thus, PDEs govern short-term protein phosphorylation, long-term protein expression, and even epigenetic mechanisms by modulating cyclic nucleotide levels