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Induction and augmentation of labor in India: A systematic review.

BACKGROUND: A recent publication regarding intrapartum care in low- and middle-income countries (LMICs) found that India has the one of the … tation and complications were not assessed. Included studies also revealed varied and inappropriate oxytocin storage conditions across settings. Finally, this review indicated that women were generally satisfied with the care provided to them during induction and augmentation of labor. CONCLUSIONS: This review documented high use of pharmaceuticals for th …

Corroborating evidence for platelet-induced epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis.

STUDY QUESTION: Do platelets play any role in the development of adenomyosis? SUMMARY ANSWER: As in endometriosis, adenomyotic lesions show … nesis. Staining for α-SMA, a marker for myofibroblast, desmin, smooth muscle myosin heavy chain and oxytocin receptor was significantly increased in adenomyotic lesions versus control, concomitant with increased staining of collagen I and lysyl oxidase (all P-values <0.001). Histochemistry analysis indicates that the extent of fibrosis is high in adenomyot …

Midwife-led continuity models versus other models of care for childbearing women.

BACKGROUND: Midwives are primary providers of care for childbearing women around the world. However, there is a lack of synthesised informat … ks, induction of labour, antenatal hospitalisation, antepartum haemorrhage, augmentation/artificial oxytocin during labour, opiate analgesia, perineal laceration requiring suturing, postpartum haemorrhage, breastfeeding initiation, low birthweight infant, five-minute Apgar score less than or equal to seven, neonatal convulsions, admission of infant to spec …

Midwife-led continuity models versus other models of care for childbearing women.

BACKGROUND: Midwives are primary providers of care for childbearing women around the world. However, there is a lack of synthesised informat … th, induction of labour, antenatal hospitalisation, antepartum haemorrhage, augmentation/artificial oxytocin during labour, opiate analgesia, perineal laceration requiring suturing, postpartum haemorrhage, breastfeeding initiation, low birthweight infant, five-minute Apgar score less than or equal to seven, neonatal convulsions, admission of infant to spec …

Alexithymia in multiple sclerosis: past, present and future.

Alexithymia denotes the "absence" of "words" for "emotion" and has its roots in the Greek words "a," "lexis," and "thymos." It is sometimes referred to as "emotional blindness," "blunted feeling," or "disrupted emotional awareness." The term "alexithymia" first appeared in the 1970s in the works of Sifneos, Nemiah, and colleagues. It entails difficulties in identifying and expressing emotions and an externally oriented thinking style. It is not a psychiatric disorder but rather a multidimensional personality trait or construct, appearing to be normally distributed in the general population, wi

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… Other experimental tools could include interoceptive technologies and treatment trials (e.g., intranasal oxytocin), but no studies have yet been conducted in MS ( Samur et al., 2013 ; Schoeller et al., 2024 ). …

Biology and Diseases of Dogs

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… As the fetus engages the cervix, the neuroendocrine system induces the release of oxytocin; this is referred to as the Ferguson reflex. Oxytocin strengthens the uterine contractions and may elicit voluntary abdominal contractions as well. … The postpartum use of oxytocin is required only in the event of uterine inertia, stillbirths, or agalactia. In these cases, 5–20 units of oxytocin may be administered intramuscularly. Uterine involution occurs during anestrus within 4–5 weeks of parturition. …

RNA therapeutics in targeting G protein-coupled receptors: Recent advances and challenges.

G protein-coupled receptors (GPCRs) are the major targets of existing drugs for a plethora of human diseases and dominate the pharmaceutical market. However, over 50% of the GPCRs remain undruggable. To pursue a breakthrough and overcome this situation, there is significant clinical research for developing RNA-based drugs specifically targeting GPCRs, but none has been approved so far. RNA therapeutics represent a unique and promising approach to selectively targeting previously undruggable targets, including undruggable GPCRs. However, the development of RNA therapeutics faces significant cha

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… OXR A, orexin insomnia 2022 Ganaxolone ZTALMY GABA C, GABA CDKL5 deficiency disorder 2022 Dexmedetomidine Igalmi α 2 -AR A, adrenaline agitation 2022 Tirzepatide Mounjaro GLP-1 B, glucagon type 2 diabetes in adults to decrease blood sugar levels 2022 Terlipressin Terlivaz V1R/V2R A, vasopressin and oxytocin … Gilteritinib | Xospata (Astellas) | Serotonin receptors | A, 5-hydroxytryptamine | relapsed or refractory acute myeloid leukemia | 2018 Revefenacin | Yupelri (Mylan Ireland) | CHRM1-CHRM5 | A, acetylcholine | chronic obstructive pulmonary disease | 2018 Tolvaptan | Jynarque | V2R | A, vasopressin and oxytocin …

Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling.

Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic prevalence between 1:400 and 1:1,000 individuals, is the third most common cause of end stage kidney disease after diabetes mellitus and hypertension. Over the last 3 decades there has been great progress in understanding its pathogenesis. This allows the stratification of therapeutic targets into four levels, gene mutation and polycystin disruption, proximal mechanisms directly caused by disruption of polycystin function, downstream regulatory and signaling pathways, and non-specific pathophysiologic processes sha

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… Both vasopressin and oxytocin bind to the V2R. … Consistent with these effects, vasopressin has strong antidiuretic and antinatriuretic effects as opposed to oxytocin which has weak effects only measurable in the absence of natural vasopressin. …

Сексуальные отношения с лицами, страдающими расстройством бдительности: обзор.

Целью этого обзора повествования является проведение синтетического обзора современных знаний о взаимосвязи между расстройством гиперактивности (АДХД) и сексуальным функционированием взрослых с уделением особого внимания нейробиологическим механизмам, коморбидным расстройствам и воздействию фармакотерапии. Шесть независимых исследователей провели всеобъемлющий обзор литературы с использованием баз данных PubMed, Scopus и Google Scientist, охватывающих публикации, имеющиеся по состоянию на май 2024 года. Были включены первоначальные исследовательские документы, обзоры и метаанализы на английско

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… Stokholm et al. proposed a new direction in ADHD pathogenesis research, suggesting a possible link between prenatal exposure to synthetic oxytocin, administered to induce labor, and the risk of developing ADHD later in life in the fetus. …

Combination of tocolytic agents for inhibiting preterm labour.

BACKGROUND: Preterm birth represents the single largest cause of mortality and morbidity for newborns and a major cause of morbidity for pre … n regimens using widely used tocolytic agents, such as calcium channel blockers (nifedipine) and/or oxytocin receptor antagonists (atosiban). Further trials are needed before specific conclusions on use of combination tocolytic therapy for preterm labour can be made.

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

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… Oxytocin regulates gastrointestinal motility, inflammation, macromolecular permeability, and mucosal maintenance in mice. Am. J. Physiol. Liver Physiol. 2014;307:G848–G862. doi: 10.1152/ajpgi.00176.2014. 97. Padurariu M., Antioch I., Ciobica A., Lefter R., Simion L. … Intranasal oxytocin in Autism: Models, pain and oxidative stress. Rev. Chim. 2017;68:1879–1883. doi: 10.37358/RC.17.8.5784. 98. Bergenheim F., Seidelin J.B., Pedersen M.T., Mead B.E., Jensen K.B., Karp J.M., Nielsen O.H. …

RESEARCH COMMUNICATIONS OF THE 34th ECVIM-CA CONGRESS.

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… as indicators of glycemic control in diabetic dogs: a comparative study using FreeStyle Libre‐derived metrics ESVE‐O‐3 | 08.45‐09.00 | Miceli | Cabergoline for the treatment of feline hypersomatotropism without concurrent diabetes mellitus ESVE‐O‐4 | 09.00‐09.15 | Kaemper | Does hypophysectomy cause oxytocin …

Diabetes Insipidus: A Pragmatic Approach to Management.

Diabetes insipidus (DI) is a disorder of water balance characterized by polyuria and polydipsia. It can occur due to genetic and acquired causes that affect the secretion or action of arginine vasopressin (AVP) or antidiuretic hormone (ADH).Markedly increased thirst and urination are not only quite distressing but also increases the risk of volume depletion and hypernatremia in severe situations. A careful diagnosis of the type of DI and its etiology is based on careful clinical evaluation, measurement of urine and serum osmolality, and water deprivation test. Management includes the correctio

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… Desmopressin Posterior pituitary extracts that contained vasopressin and oxytocin were used for the management of DI in the early 1900s. Pitressin (vasopressin tannate in oil) later became widely available but had significant vasopressor effects. …

Probiotics: Potential Benefits and Safety in Hematological Malignancies.

Cancer remains one of the most significant global health challenges, with increasing incidence and mortality rates and a substantial socioeconomic burden. Traditional cancer treatments such as chemotherapeutic drugs and radiation therapies, while effective, have significant adverse effects on the body, prompting the search for less invasive treatment options. In recent years, probiotics have emerged as a promising alternative in the prevention and treatment of cancer and its associated complications, especially in gastrointestinal malignancies. Probiotics have been found to have several benefi

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… Probiotic and oxytocin combination therapy in patients with autism spectrum disorder: a randomized, double-blinded, placebo-controlled pilot trial . Nutrients. 2021;5(13):1552–1552. doi: 10.3390/nu13051552. …

Acupuncture for cancer-induced bone pain?

Bone pain is the most common type of pain in cancer. Bony metastases are common in advanced cancers, particularly in multiple myeloma, breast, prostate or lung cancer. Current pain-relieving strategies include the use of opioid-based analgesia, bisphosphonates and radiotherapy. Although patients experience some pain relief, these interventions may produce unacceptable side-effects which inevitably affect the quality of life. Acupuncture may represent a potentially valuable adjunct to existing strategies for pain relief and it is known to be relatively free of harmful side-effects. Although acu

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… It has also been suggested that the release of oxytocin in response to non-noxious sensory stimulation such as manual acupuncture may give rise to long-term elevations in pain threshold [ 35 ]. …

Cyclo-oxygenase (COX) inhibitors for treating preterm labour.

BACKGROUND: Preterm birth is a major cause of perinatal mortality and morbidity. Cyclo-oxygenase (COX) inhibitors inhibit uterine contractio … maternal, fetal or neonatal outcomes.No data were available to assess COX inhibitors compared with oxytocin receptor antagonists (ORAs). Further, no data were available on extremely preterm birth (before 28 weeks of gestation), longer-term infant outcomes or costs. AUTHORS' CONCLUSIONS: In this review, no clear benefit for COX inhibitors was shown over p …

Clinical Practice Guidelines for management of Sexual Disorders in Elderly.

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… The neurohormone oxytocin is also released during orgasm and reinforces pleasure. …

Epidural versus non-epidural or no analgesia for pain management in labour.

BACKGROUND: Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that tran … ary retention. They also had longer first and second stages of labour, and were more likely to have oxytocin augmentation than the women in the opioid group. Women receiving epidurals had less risk of respiratory depression requiring oxygen, and were less likely to experience nausea and vomiting than women receiving opioids. Babies born to women in the epi …

Implementation of Virtual Integrative Oncology Shared Medical Appointment Series (VIOSMAS) Within Mixed Diagnosis Population.

BackgroundIntegrative oncology [IO] is sought-after by patients, endorsed by clinical guidelines, and valued within National Cancer Institute Centers. Shared Medical Appointments [SMA] leverage health education and social connection to deliver enhanced patient experience, population health, cost-reduction, and clinician well-being. Integrative Oncology Shared Medical Appointments increase access to integrative medicine but delivering these services via telehealth have not been evaluated.ObjectiveWe created, and pilot tested a Virtual Integrative Oncology Shared Medical Appointment Series (VIOS

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… Oxytocin and microglia in the development of social behaviour . Philos Trans R Soc Lond B Biol Sci . 2022 ; 377 : 20210059 . doi: 10.1098/rstb.2021.0059 35858111 PMC9272152 45 Kligler B Brooks AJ Maizes V , et al . Interprofessional competencies in integrative primary healthcare . …