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Сохраняется ли нерешительность в отношении вакцинации SARS-COV-2 среди людей с неврологическими заболеваниями - обследование целевой группы NeuroCOVID-19 Европейской академии неврологии.

ОБСУЖДЕНИЕ ПО 3 предметам в онлайновом режиме было направлено в Европейскую академию неврологии (ЕАН) и задалось вопросом о сохранении скептицизма прививок SARS-COV-2, а также о глубинных мыслях и факторах, ограничивающих использование вакцин среди пациентов с неврологическими заболеваниями. Результаты: Мы получили 616 ответов от 84 стран, главным образом из Европы. По мнению лечащего невролога, пациенты с множественным склерозом (MS), нейромнологическими расстройствами (ND) и хроническими неврологическими инфекциями продолжали иметь высокий уровень скептицизма по отношению к вакцинации SARS-C

Совпадение в аннотации оригинала
BACKGROUND: An online 3-item survey was sent to the European Academy of Neurology (EAN) community and inquired about the persistence of SARS … ections, and peripheral neuropathy. Patients with sleep disorders (54%), autonomic disorders (46%), movement disorders (43%), and dementia (43%) were sensed as less fearful of vaccine-related adverse events. CONCLUSION: Despite the large body of evidence proving the efficacy and safety of SARS-CoV-2 vaccination, patients with certain neurological disorders still ha …

CHD8-related disorders redefined: an expanding spectrum of dystonic phenotypes.

BACKGROUND: Heterozygous loss-of-function variants in CHD8 have been associated with a syndromic neurodevelopmental-disease spectrum, collec … ants associated with neurodevelopmental disorders, as the connection between neurodevelopmental and movement disorders is proving closer than previously appreciated.

Impact of Prenatal Exposure to Opioids, Cocaine, and Cannabis on Eye Disorders in Children.

OBJECTIVES: Prenatal substance exposure is associated with abnormal visual evoked potentials in offspring, but whether ocular abnormalities … re (95% CI 1.04-1.45). Risks were greatest for strabismus (HR 1.55, 95% CI 1.16-2.07) and binocular movement disorders (HR 1.96, 95% CI 1.00-3.83). Opioid use was strongly associated with the risk of ocular muscle disorders (HR 3.15, 95% CI 1.98-5.01). CONCLUSIONS: Prenatal substance exposure is significantly associated with future hospitalizations for eye disorder …

Feasibility of EMDR for posttraumatic stress disorder in patients with personality disorders: a pilot study.

Background: Trauma and posttraumatic stress disorder (PTSD) are prevalent in patients with personality disorders. Despite the established efficacy of eye movement desensitisation and reprocessing (EMDR) for PTSD, EMDR has barely been examined in patients with comorbid PTSD and personality disorders. Objective: The aim of this study was to explore what changes occur in symptom severity of PTSD, dissociative symptoms, insomnia, non-suicidal self-injurious behaviour and auditory verbal hallucinations in patients with personality disorders during treatment with EMDR. Method: This uncontrolled open

[Autism in children. Speech, behavior and motor activity point to diagnosis].

Austistic disorders characteristically involve specific impairments of social skills, of the language and of stereotyped body movements. L Kanner and H. Asperger were the first to describe these psychopathologic features, which still form the core of the diagnostic criteria of contemporary psychiatric classification systems, ICD-10 and DSM-IV, in the category pervasive developmental disorders. Useful diagnostic tools have been developed to establish the clinical diagnosis. The results of research point to a predominantly genetic pathogenesis involving a complex interaction of multiple genes. W

Influence of TMJ health on mandibular motion and the restorative position: A case series.

Articulator settings were compared between adapted-unstable and healthy-stable states in 5 patients with subclinical temporomandibular disorders. Leaf gauge load testing was used to identify muscle-related dysfunction, while mechanical pantography and computerized axiography recorded mandibular motion in both states. Following stabilization with occlusal device therapy, coincident centric relation recordings on a verification device confirmed the transition to a healthy state and revealed a shift in the reproducible centric relation position. Observed clinical trends indicated that mandibular

Neurosurgical Breakthroughs of the Last 50 Years: A Historical Journey Through the Past and Present.

This article presented the author's historical perspective on 25 of the most significant neurosurgical breakthrough events of the last 50 years. These breakthroughs have advanced neurosurgical patient care and management. They have improved the management of aneurysms, arteriovenous malformations, tumors, stroke, traumatic brain injury, movement disorders, epilepsy, hydrocephalus, and spine pathologies. Neurosurgery has evolved through research, innovation, and technology. Several neurosurgical breakthroughs were achieved using neuroendoscopy, neuronavigation, radiosurgery, endovascular techni…

Nonpsychiatric Comorbidities in Pediatric Restless Leg Syndrome.

Many medical disorders coexist with restless leg syndrome (RLS) and frequently have a bidirectional relationship. Specific examination of these relationships can help in more timely identification and intervention of RLS, as well as more comprehensive care delivery of the various related morbidities resulting in improved health outcomes, sleep, and quality of life. RLS in the pediatric population can be difficult to identify and frequently can be missed or mischaracterized as normal growth-related features. The goal is to enhance recognition of RLS, periodic limb movement disorder, and their m

Oromandibular Dystonia and Dysphagia in Hyperglycemic Brainstem Dysfunction.

BACKGROUND: Hyperglycemia-induced movement disorders usually present as hemichorea or hemiballismus. Non-choreiform presentations are rare and often overlooked. CASE REPORT: We present the case of a 36-year-old man with uncontrolled type 2 diabetes who developed painful oromandibular dystonia, dysarthria and dysphagia. These symptoms were investigated using flexible endoscopic evaluation of swallowing (FEES). An MRI revealed reversible T2 hyperintensities in the pons without striatal involvement. The symptoms resolved with insulin normalization and tetrabenazine treatment. DISCUSSION: Transi…

Acute Encephalopathy in 3 Adolescent Patients With Acute Lymphoblastic Leukemia During Induction Chemotherapy: A Case Series.

Three adolescent patients with B-cell acute lymphoblastic leukemia (B-ALL) presented with psychotic symptoms, mutism, movement disorders, and day-night disturbances during induction chemotherapy, which clinically resembled anti-NMDAR encephalitis. However, all patients were negative for anti-NMDAR antibodies. They also experienced chemotherapy-induced liver dysfunction, weight loss, and malnutrition, which led to biochemical changes (elevated blood ammonia, elevated blood glutamate, and copper deficiency) known to affect NMDA receptor activity. This suggests that there may be some common, unde…

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Diagnosis of a sleep disorders is multimodal. An overview is presented in this review. The medical history leads to a tentative diagnosis supported by questionnaires, sleep diary and objective methods. Examination may reveal upper airway problems in a patient suspected to have obstructive sleep apnoea or rigidity in an elderly patient with shouting during sleep, suggestive of rapid eye movement sleep behaviour disorder. The choice of diagnostic sleep test is based on the tentative diagnosis. Other tests (e.g., lumbar puncture, brain scan) may be indicated. Wearables pose the advantage of docum

A Patient with a History of Multiple Myeloma Presents for the Evaluation of Oral Lesion and Burning Sensation of the Mouth.

Multiple myeloma (MM) is a hematologic malignancy belonging to a class of disorders known as plasma cell dyscrasias. Common oral manifestations of MM include osteolytic lesions in the mandible and maxilla that can present as painful bony swellings, epulis formation, or sudden teeth movement. MM treatment is coordinated by a multidisciplinary team and is dependent upon the age and physical fitness of the patient, as well as the staging of the disease. A large proportion will be treated with intravenous bisphosphonates, such as pamidronate and zoledronic acid, which places the patients at high r

An unusual way to improve lung function in congenital myopathies: the power of singing.

Congenital myopathies (CMs) are a clinically and genetically heterogeneous group of disorders characterized by early onset weakness, hypotonia and characteristic structural abnormalities in muscle fibres. Hypotonia and weakness can be present at birth or appear in infancy, and a static or slowly progressive clinical course may present with muscle weakness, loss of spontaneous movement, involuntary muscle activity, and muscle atrophy. Often patients develop a restrictive syndrome and respiratory failure and require respiratory support In our case, we described lung improvement and respiratory m

Auditory Cueing of Pre-Learned Skills and Role of Subcortical Information Processing to Maximize Rehabilitative Outcomes Bridging Science and Music-Based Interventions.

Auditory entrainment of motor function is a fundamental tool in neurologic music therapy with many studies demonstrating improved clinical outcomes in people with movement disorders such as Parkinson's Disease, acquired brain injuries, and stroke. However, the specific mechanisms of action within neural networks and cortical regions that are aroused and influenced by auditory entrainment still need to be identified. This paper draws from some contemporary neuroscience studies that indicate the role of the cerebellum and other subcortical systems in modulating pre-learned motor schema and propo…

DELAYED NEUROPSYCHIATRIC SYNDROME AFTER CARBON MONOXIDE POISONING.

arbon monoxide (CO) is an odorless, tasteless, colorless and nonirritating gas 1. In Spain, most of the accidents due to CO poisoning are caused by water heaters2,3,4. CO binds to hemoglobin with much greater affinity than oxygen, for- ming carboxyhemoglobin (COHb) and resulting in impaired oxygen transport and utilization.XS In up to 40 percent of patients with significant CO exposure, a delayed neuropsy- chiatric syndrome (DNS) can arise 3 to 240 days after appa- rent recovery, characterized by cognitive deficits, personality changes, movement disorders, and focal neurologic deficits, which …

Sleep Disturbances During Shift Work.

Around 21% of workers reported working on shifts in 2017, and consequently, shift workers experience multiple sleep disturbances such as excessive sleepiness, insomnia, sleep deprivation, and social jet lag. These eventually lead to shift work disorder or exacerbation of other sleep disorders such as insomnia, obstructive sleep apnea, restless legs syndrome, and nonrapid eye movement parasomnia. Despite multiple interventions and guidelines, poor compliance to treatment is often encountered due to temporary relief of sleep disturbances provided by the treatment. Hence there is a need for compr

Intrathecal baclofen therapy for Lesch-Nyhan disease: illustrative case.

BACKGROUND: Lesch-Nyhan disease (LND) is a very rare metabolic disorder involving the purine salvage pathway. LND manifests hyperuricemia, self-mutilation, cognitive impairment, and movement disorders such as spasticity and dystonia, whose control is difficult pharmaceutically. OBSERVATIONS: Intrathecal baclofen (ITB) therapy was received by a 22-year-old male for generalized dystonia. His paroxysmal abnormal dystonic posturing reduced after surgery, making the task of caregivers easier despite the unchanged assignment on the dystonia scale during a follow-up period of 4 years. LESSONS: ITB …

Effective Treatment of Adult Parasomnias with Keishikaryukotsuboreito in Four Cases.

Parasomnias are undesirable behaviors or experiences during sleep that manifest clinically as abnormal behavior, emotions, and nightmares. We herein report four elderly parasomnia patients who were successfully treated for abnormal nocturnal behaviors, including rapid eye movement (REM) sleep behavior disorders, with Keishikaryukotsuboreito (KRB), a Japanese traditional herbal medicine. KRB resolved nocturnal violent behaviors and sleep walking without any adverse effects. In one patient, occipital dominant spike-wave complexes induced by 3-Hz photic stimulation were reduced after KRB treatmen

Complex dystonias: an update on diagnosis and care.

Complex dystonias are defined as dystonias that are accompanied by neurologic or systemic manifestations beyond movement disorders. Many syndromes or diseases can present with complex dystonia, either as the cardinal sign or as part of a multi-systemic manifestation. Complex dystonia often gradually develops in the disease course, but can also be present from the outset. If available, the diagnostic workup, disease-specific treatment, and management of patients with complex dystonias require a multi-disciplinary approach. This article summarizes current knowledge on complex dystonias with a pa…

Drugs Used in Parasomnia.

Patient education and behavioral management represent the first treatment approaches to the patient with parasomnia, especially in case of disorders of arousal (DOA). A pharmacologic treatment of DOA may be useful when episodes are frequent and persist despite resolution of predisposing factors, are associated with a high risk of injury, or cause significant impairment, such as excessive sleepiness. Approved drugs for DOA are still lacking. The most commonly used medications are benzodiazepines and antidepressants. The pharmacologic treatment of rapid eye movement sleep behavior disorder is sy