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Probable intramural esophageal hematoma mimicking esophageal abscess.

Intramural esophageal hematoma is an uncommon condition that may mimic esophageal abscess on initial imaging. We report a 43-year-old man wh … wed a dark-red submucosal bulge with mucosal rupture. The patient improved with fasting, parenteral nutritional support, acid suppression, antibiotics, and observation, without endoscopic drainage or surgery. Follow-up endoscopy at six weeks showed healing, and no recurrence occurred during six months of follow-up.

ACUTE CELIAC CRISIS PRESENTING AS SEVERE MALABSORPTIVE DIARRHEA AND HEMODYNAMIC INSTABILITY IN AN ADULT MALE: A CASE REPORT.

Celiac crisis is a rare and life-threatening manifestation of celiac disease characterized by acute severe diarrhea, dehydration, and metabo … . The patient was successfully managed with aggressive fluid resuscitation, electrolyte correction, nutritional support, and strict gluten-free diet, resulting in rapid clinical recovery. This case highlights the importance of considering celiac crisis in adults presenting with severe unexplained diarrhea and metabolic derangements to enable early diagnosis and timel …

Peripheral Lymphatic Shunts for Protein-Losing Enteropathy in a Child with THSD1 Mutation: A Case Report.

Protein-losing enteropathy (PLE) is a rare disorder characterized by abnormal protein loss through the gastrointestinal tract, often leading to hypoalbuminemia and malnutrition. This case report describes the successful surgical management of chronic lower limb lymphedema and PLE in a 7-year-old male with a thrombospondin type 1 domain-containing 1 (THSD1) mutation, unresponsive to conventional therapies. Despite aggressive nutritional support, including albumin infusions, the patient experienced persistent hypoalbuminemia and ongoing protein loss. Imaging revealed significant lymphatic dysfun…

Postoperative management after oesophagectomy: An evidence-based approach.

Oesophagectomy is a complex surgical procedure that requires meticulous multidisciplinary care. The procedure, which typically requires mult … abilitation may reduce the incidence of postoperative complications. Dietitian-prescribed intensive nutritional support may limit the extent of postoperative weight loss and the risk of severe complications.

Camouflage Protein-Engineered Extracellular Vesicles Alleviate TMJ-OA by Hijacking Caspase-1 to Suppress Pyroptosis.

Temporomandibular joint osteoarthritis (TMJ-OA) is highly prevalent with an insidious onset. Severe inflammation and significant degenerative changes are often associated with the condition, and current clinical treatments remain inadequate. In this study, we focus on pyroptosis and engineered the camouflage protein (GSDMD-C) attached to the membrane surface of small extracellular vesicles (sEVs)-sEV-p. sEV-p has two key effects: firstly, the inherent immunomodulatory and nutritional support properties of sEVs promote the recovery of cellular function under pathological conditions; secondly, c…

New perspectives on serum-free cell culture: Harnessing microbial resources for innovative media development in food biomanufacturing.

Cell culture is a fundamental technique in food biomanufacturing. However, the inherent limitations of traditional serum-containing culture systems hinder the scalable application of cell culture in the food industry, thus driving the development of serum-free cell culture. This review summarizes the current status and technical challenges of serum-free media (SFM) for cells relevant to food biomanufacturing. In this context, we systematically compile recent advances in the use of microbial resources as potential supplements for SFM, given that their functional ingredients are capable of meeti

A sustainable functional food ingredient from Saussurea involucrata cell culture alleviates atopic dermatitis-like inflammation via arachidonic acid metabolic remodeling.

Nutritional interventions may complement established approaches for managing atopic dermatitis (AD). Here, we evaluated Saussurea involucrata cell culture (SIC), a sustainable functional-food material, in a DNCB-induced mouse model of AD-like inflammation. Chemical profiling established the phytochemical composition of SIC, and both topical and oral interventions improved macroscopic and histopathological outcomes. Under the tested conditions, the oral groups showed more consistent changes in systemic indices, providing the basis for subsequent mechanistic analyses. Integrated transcriptomic a

Taste organoids in food science: functional maturation, dietary remodelling, and biological taste evaluation.

Taste is the primary interface for chemical sensing and nutritional decision making, shaping food choice, feeding behaviour, and metabolic homeostasis. In food science, taste has become an important biological indicator for evaluating flavour active compounds and diet related responses, yet current models still struggle to combine physiological relevance, mechanistic interpretability, and standardized functional assessment. This review summarizes the biological basis of taste organoid construction, highlights key determinants of functional maturation, and discusses their emerging applications

Managing hematological toxicity in [¹⁷⁷Lu]Lu-DOTATATE for NET patients: a national survey from the French group of endocrine tumors (GTE) on the clinical need for harmonized monitoring strategies.

Peptide receptor radionuclide therapy (PRRT) with [¹⁷⁷Lu]Lu-DOTATATE is a standard treatment for metastatic neuroendocrine tumors (NET), but management of hematological toxicity beyond the thresholds defined in the Summary of Product Characteristics (SmPC) relies heavily on individualized clinical judgment. To characterize real-world practices, we conducted a national anonymous survey among French nuclear medicine physicians and medical oncologists involved in PRRT, under the auspices of the SFMN, GTE, and ENDOCAN-RENATEN network. Forty expert physicians completed the 45-item LutaViRe question

Psoas metastasis of urothelial carcinoma: A rare case.

INTRODUCTION: Urothelial carcinoma (UC) is a common malignancy with a high propensity for metastasis, typically to the lungs, liver, bones, and lymph nodes. Metastasis to the psoas muscle is exceedingly rare and poorly documented. CASE PRESENTATION: We report a 46-year-old chronic smoker with a history of muscle-invasive bladder UC treated with cystectomy and urinary diversion. After two years of lost follow-up, he presented with hematuria, lumbar pain, and a large left psoas tumor confirmed as recurrent UC. Surgical resection of the psoas and excretory tract tumor was performed, coupled with

The effect of wheat bran soluble dietary fiber on the digestion characteristics of noodles.

This study utilized the fourth-generation Dynamic Human Stomach-Intestine (DHSI-IV) system to evaluate the impact of varying levels of wheat bran soluble dietary fiber (WBSDF) on the digestion characteristics of noodles. The results indicated that with increasing WBSDF content, the gastric pH and solid content of the noodles significantly increased, and the particle size of the digestive chyme gradually decreased. After 180 min of digestion, the starch and protein hydrolysis rates of regular wheat noodles were 41.69 % and 74.01 %, respectively, while noodles with 10 % WBSDF had starch and prot

Emerging Technologies and Integrated Strategies for Microbial Detection and Control in Fresh Produce.

The global consumption of fresh and ready-to-eat (RTE) fruits and vegetables has surged due to increasing awareness of their nutritional benefits. However, this trend has been accompanied by a rise in foodborne illness outbreaks linked to microbial contamination. This narrative review synthesizes current knowledge on the prevalence and diversity of foodborne pathogens in fresh produce, including bacterial, viral, and fungal agents. It critically evaluates both conventional and emerging detection methods, ranging from culture-based techniques and immunoassays to advanced molecular diagnostics,

Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine.

The small intestine (SI) absorbs nutrients and acts as a barrier against pathogens. Diet enables the absorptive function of the SI while maintaining immune homeostasis. But how the SI transmits nutritional signals to the immune response and adapts to dietary intake remains unclear. Here, we demonstrated that epithelial gasdermin D (GSDMD) in the SI facilitated the absorptive function of enterocytes, subsequently empowering an epithelial-immune cooperation to modulate host defense. Unlike its pyroptotic function, GSDMD determines the absorptive versus the defensive zonation of enterocytes and p

Duodenal Amyloidosis Inducing Malabsorption in Hepatitis B-Related Liver Cirrhosis: A Rare Case Presentation.

Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis worldwide. While hepatic complications are well-documented, ex … ointestinal tract as the cause of malabsorption. Persistent diarrhea and malabsorption necessitated nutritional support and symptomatic management. This case highlights the rare association between chronic liver disease (CLD), secondary amyloidosis, and malabsorption syndrome, emphasizing the importance of clinical suspicion for timely diagnosis. Early recognition an …

A Mucosal Change like Hypertrophic Gastritis Following Zolbetuximab-Based Therapy in a Conversion Surgery Case of Advanced Gastric Cancer.

Background and Clinical Significance: Zolbetuximab, a claudin 18.2-targeted monoclonal antibody, has demonstrated efficacy in advanced gastr … d with zolbetuximab therapy. Clinicians should monitor albumin levels during treatment and consider nutritional support when indicated. These findings provide important insights for optimizing patient management and ensuring safe conversion surgery planning.

Экспертный консенсус в отношении многодисциплинарного подхода к лечению множественных заболеваний костей, связанных с миеломой.

Этот консенсус по множественным болезням костей, связанным с миеломой, подчеркивает важность многодисциплинарного подхода, который охватывает гематологию, радиологию, ортопедию и дополнительные специальности для решения сложных проблем. МБД, широко распространенное и изнуряющее осложнение множественной миэломы, приводит к боли в костях, переломам и событиям, связанным со скелетом, что оказывает глубокое воздействие на качество жизни пациентов. Эти руководящие принципы обеспечивают тщательную основу для диагностики, лечения и постоянной оценки с уделением особого внимания раннему обнаружению и

Совпадение в аннотации оригинала
This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses … ctural or pain-related issues. Supportive care measures, including pain management, rehabilitation, nutritional support, and dental evaluations, play a crucial role in enhancing patient outcomes and preserving quality of life. This consensus advocates a standardized, evidence-based approach to managing MBD, ensuring comprehensive and coordinated care for patients.

Intussusception following feeding jejunostomy in a post-esophagectomy patient: a rare complication and its surgical management.

Feeding jejunostomy is performed commonly following esophagectomy to ensure postoperative nutritional support. However, it can occasionally lead to rare complications, such as intussusception. Adult intussusception, especially secondary to a feeding jejunostomy, is an uncommon occurrence. Timely diagnosis and surgical intervention are essential to treat this potentially life-threatening condition. We report a 69-year-old male, who has received neoadjuvant chemoradiotherapy followed by a thoraco-laparoscopic Ivor Lewis esophagectomy and a feeding jejunostomy. The immediate postoperative course …

Perioperative Evaluation and Risk Stratification of the Elderly Patient Undergoing Vascular Intervention.

The surgical management of elderly patients has become increasingly important as the population ages in the U.S. and globally, and the incidence of cardiovascular risk factors continues to rise. Geriatric surgical patients face heightened surgical risks due to age-related physiological changes, which may extend beyond comorbidities, best described as geriatric syndromes. A thorough geriatric evaluation involves examining risk factors for these syndromes, which includes an extensive review of the patient's medical history, frailty assessment, nutritional evaluation, medication review, and evalu

Case Report: A female patient with gastrointestinal perforation, acute diffuse peritonitis, and Crohn's disease needs homeostasis management.

A 47-year-old married woman presented with abdominal discomfort, distension, and nausea following a two-day episode of constipation accompan … leakage and a severe infection. In spite of these challenges, the patient received intensive care, nutritional support, and treatment for short bowel syndrome. Over span of a month, her health significantly improved, and she was ultimately discharged with ongoing management for her Crohn's disease. This case underscores the intricacies involved in addressing intesti …

Metabolic characteristics and nutritional quality of fresh jujube (Ziziphus jujuba mill.) fruits in eleven producing areas.

Jujube (Ziziphus jujuba Mill.) is an economically important fruit tree in China, yet systematic evaluations of fresh jujube quality across major production regions remain limited, constraining industry development. In this work, an integrated LC-MS/MS based metabolomics strategy combined with multivariate statistical analyses and comprehensive ranking was employed to characterize metabolic composition and overall fruit quality of 30 fresh jujube varieties from 11 major producing regions. A total of 460 metabolites spanning 30 categories were identified and quantified, with organic acids, flavo