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Second-Trimester Uterine Rupture in a Multiple-Scar Uterus Complicated by Placenta Accreta Spectrum: A Case Report and Literature Review.

Uterine rupture is a rare but life-threatening obstetric emergency, most commonly occurring in women with a scarred uterus. Placenta accreta spectrum (PAS) increases the risk of uterine wall disruption and severe hemorrhage, while spontaneous rupture before labor, particularly in the second trimester, remains uncommon. We report a 28-week pregnant woman with two prior cesarean sections who presented after a fall with abdominal pain and vaginal bleeding. Evaluation revealed intrauterine fetal demise and findings consistent with uterine rupture. Emergency laparotomy confirmed a complete rupture …

Mechanistic study of miR-486-5p targeting Claudin-10 in placenta accreta spectrum pathogenesis and its impact on trophoblast behavior.

INTRODUCTION: Placenta accreta spectrum (PAS) is a severe pregnancy complication characterized by abnormal invasion of trophoblasts into the myometrium. Despite improved diagnosis, its molecular mechanisms remain unclear. Emerging evidence highlights microRNAs in regulating epithelial-mesenchymal transition (EMT). Here, we focus on miR-486-5p and its target Claudin-10 to explore their roles in PAS pathogenesis. METHODS: Placental tissues from 40 PAS patients and 40 controls were collected. RNA-seq was performed in an exploratory subset of five paired implanted and adjacent non-implanted tissu…

Prenatal NO₂ exposure and cardiac developmental dysfunction: CD4⁺ T cell imbalance drives cardiac fibrosis through placenta-heart axis immune transmission.

Epidemiological studies show maternal nitrogen dioxide (NO2) exposure associates with congenital heart disease (CHD) risk, but subtypes and … reduced Th1/Th2 and Th17/Treg ratios (key mediators of the above fibrotic phenotype). Importantly, placental proteomics showed activated immune responses and upregulated pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-17) in fetal circulation, disrupting fetal cardiac CD4+ T-cell homeostasis and inducing fibrosis. Together, these findings identify …

Preconditioning with Rapamycin Improves Therapeutic Potential of Placenta-Derived Mesenchymal Stem Cells in Mouse Model of Hematopoietic Acute Radiation Syndrome.

Acute radiation syndrome (ARS) results from high-dose ionizing radiation (IR) exposure, with bone marrow (BM) being highly susceptible due to its proliferative activity. BM injury causes pancytopenia, leading to infections, anemia, and bleeding. Mesenchymal stem cells (MSCs) hold promise for ARS treatment because of their immunomodulatory, anti-inflammatory, and regenerative properties. However, challenges such as replicative senescence, poor survival, and engraftment in irradiated microenvironments limit their efficacy. This study evaluated rapamycin-preconditioned placenta-derived MSCs (rPD-…

Comparison of Maternal Outcomes Between Cesarean Hysterectomy and Wedge Resection in Pregnant Women with Figo Grade 2 Placenta Accreta Spectrum.

OBJECTIVE: To compare maternal outcomes between cesarean hysterectomy and wedge resection in pregnant women diagnosed with FIGO grade 2 placenta accrete spectrum (PAS). METHODS: This retrospective cohort study with a cross-sectional design included pregnant women diagnosed with FIGO grade 2 PAS by ultrasonography who underwent either cesarean hysterectomy or wedge resection at Hasan Sadikin General Hospital between 2022-2025. The maternal outcomes analyzed included the amount of bleeding, duration of surgery, and the need for transfusion. Statistical analyses were conducted using the chi-squa…

Placenta hIGF1 nanoparticle treatment in guinea pigs mitigates FGR-associated fetal sex-dependent effects on liver metabolism-related signaling pathways.

Fetal development in an adverse in utero environment significantly increases the risk of developing metabolic diseases in later life, including dyslipidemia, nonalcoholic fatty liver diseases, and diabetes. The aim of this study was to determine whether improving the in utero fetal growth environment with a placental nanoparticle gene therapy would ameliorate fetal growth restriction (FGR)-associated dysregulation of fetal hepatic lipid and glucose metabolism-related signaling pathways. Using the guinea pig maternal nutrient restriction (MNR) model of placental insufficiency and FGR, placenta …

New derivatives of 6-nitrocoumarin-3-thiosemicarbazone exhibit improved antiparasitic activity in the placenta against Trypanosoma cruzi and Toxoplasma gondii.

Congenital infections by Trypanosoma cruzi and Toxoplasma gondii pose significant clinical challenges due to the lack of safe and effective treatments. This study evaluates eight novel 6-nitrocoumarin-3-thiosemicarbazone derivatives in an ex vivo human placenta model, assessing their antiparasitic activity and impact on tissue integrity. Two therapeutic approaches were tested: pre-infection (preventive) and post-infection (therapeutic). In vitro and ex vivo assays revealed strong activity trends. Compound 7 was the most effective against T. cruzi (IC50 = 22.4 ± 0.8 µM, logP = 2.49), while comp…

Клеточная терапия с мезентичными стволовыми клетками, изготовленными плацентой, для вторичных прогрессивных пациентов с множественным склерозом в а фазы 1 Клинические испытания.

Мезенхимальные стволовые клетки (МСЦ) привлекли значительное внимание к клиническим исследованиям в связи с их иммуномодулятивными свойствами и потенциалом уменьшения воспаления при аутоиммунных расстройствах, таких, как множественный склероз (МС). В настоящем исследовании оценивается безопасность и осуществимость использования МСЦ-В (МСЦ-В) на основе плаценты в five - участники с множественным склерозом второго этапа (СФМ). Основные результаты были сосредоточены на безопасности и терпимости, которые были оценены на основе мониторинга неблагоприятных явлений. six месяцев. Вторичные результаты

Совпадение в аннотации оригинала
Mesenchymal stem cell (MSC) has attracted significant attention in clinical research due to their immunomodulatory properties and potential to reduce inflammation in autoimmune disorders, such as multiple sclerosis (MS). This study evaluates the safety and feasibility of placenta-derived MSCs (PLMSCs) in five participants with secondary-progressive multiple …

Paternal DDT exposure induces sex-specific programming of fetal growth, placenta development and offspring's health phenotypes in a mouse model.

Mounting evidence suggests that environmentally induced epigenetic inheritance occurs in mammals and that traits in the progeny can be shape … nce compared to controls. These phenotypes in DDT offspring were linked to reduced fetal growth and placenta size as well as placenta-specific reduction of glycogen levels and the nutrient sensor and epigenetic regulator OGT, with more pronounced phenotypes observed in male placentas. However, placenta-specific genetic reduction of OGT only partially repli …

Temporal metabolomics state in pregnant rat: Analysis of amniotic fluid, placenta, and maternal plasma at embryonic and fetal time points.

INTRODUCTION: During pregnancy, the dynamic metabolic demands for fetal growth require a continuous supply of essential metabolites. Understanding maternal metabolome changes during gestation is crucial for predicting disease risks in neonates. METHODS: The study aimed to characterize the placental and amniotic fluid (AF) metabolomes during gestation in rats at gestational days GD-13 and 19 reflecting the end of the embryonic and fetal periods, respectively, and the maternal plasma, using metabolomics (LC-MS) and chemometrics. The objective was to highlight, through univariate and multivariat…

Prophylactic Radiologic Interventions for Postpartum Hemorrhage Control in Women With Placenta Accreta Spectrum Disorder: A Systematic Review and Meta-analysis.

OBJECTIVE: To quantify the association between prophylactic radiologic interventions and perioperative blood loss during cesarean delivery in women with placenta accreta spectrum disorder through a systematic review and network meta-analysis. DATA SOURCES: On January 3, 2023, a literature search was conducted in PubMed, EMBASE, Cochrane Library, and Web of Science. We also checked ClinicalTrials.gov retrospectively. Prophylactic radiologic interventions to reduce bleeding during cesarean delivery involved preoperative placement of balloon catheters, distal (internal or common iliac arteries) …

Cow Placenta Extract Ameliorates Cyclophosphamide-Induced Intestinal Damage by Enhancing the Intestinal Barrier, Improving Immune Function, and Restoring Intestinal Microbiota.

Immunosuppression undermines intestinal barrier integrity. Cow placenta extract (CPE) primarily consists of active peptides with immunomodulatory and antioxidant effects. This study aimed to examine the preventive effect of CPE against intestinal damage induced by cyclophosphamide (Cy) in immunosuppressed mice. Thirty-six mice were randomly allocated into three groups: control group (C), model group (M), and treatment group (CPE). The mice in the CPE group were provided with 1500 mg/kg/day of CPE via gavage. In the last 3 days, mice in the groups M and CPE received intraperitoneal injections o…

HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions.

INTRODUCTION: Spontaneous abortion (SAB) affects approximately 10% of clinically recognized pregnancies. Fetal trophobalst invasion and remodeling of maternal spiral arteries is reported to be dependent on crosstalk between HLA-C/HLA-G expressed on extra villous trophoblast (EVTs)and Killer cell Immunoglobin like receptors (KIRs) of decidual NK (dNK). Immune dysfunction in decidua contributes to early miscarriage. METHODOLOGY: The study used mother neonate paired cord blood and term placenta samples (n = 46), elective abortus (n = 17,gestational age = 10-12 weeks of pregnancy) and SAB abortus…

Assessment of Fetal Exposure and Elimination of Perfluoroalkyl and Polyfluoroalkyl Substances: New Evidence from Paired Serum, Placenta, and Meconium Samples.

Multiple pieces of evidence have shown that prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) is closely related to adverse birth outcomes for infants. However, difficult access to human samples limits our understanding of PFASs transport and metabolism across the human placental barrier, as well as the accurate assessment of fetal PFASs exposure. Herein, we assess fetal exposure to 28 PFASs based on paired serum, placenta, and meconium samples. Overall, 21 PFASs were identified first to be exposed to the fetus prenatally and to be metabolized and excreted by the fetus…

Prophylactic common iliac artery temporary clamping versus balloon occlusion for management of placenta accreta spectrum disorders: A prospective clinical trial.

OBJECTIVE: The present study aims to compare prophylactic common iliac artery (CIA) temporary clamping and preoperative balloon occlusion for managing placenta accreta spectrum (PAS) disorders. STUDY DESIGN: Between January 2019 and June 2020, 46 patients with PAS disorders were included. Of them, 26 patients were offered CIA balloon occlusion (Group A), while temporary CIA clamping was done for the other 20 patients (Group B). Primary outcomes were procedure-related complications, and secondary outcomes included intraoperative and postoperative complications, reoperation rates, total procedu…

Prophylactic resuscitative endovascular balloon occlusion of the aorta use during cesarean hysterectomy for placenta accreta spectrum: a retrospective cohort study.

OBJECTIVE: Resuscitative endovascular balloon occlusion of the aorta for placenta accreta spectrum is used to control maternal hemorrhage during cesarean hysterectomy. This study aimed to assess the efficacy of resuscitative endovascular balloon occlusion of the aorta for placenta accreta spectrum by examines the change in the quantitative blood loss after applying resuscitative endovascular balloon occlusion of the aorta. METHODS: This retrospective cohort study included patients with placenta accreta spectrum who required cesarean hysterectomy (n = 37) between 2003 and 2022 at a tertiary ca…