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Towards precision medicine in lymphoid malignancies.

Careful histopathologic examination remains the cornerstone in the diagnosis of the clinically and biologically heterogeneous group of lymphoid malignancies. However, recent advances in genomic and epigenomic characterization using high-throughput technologies have significantly improved our understanding of these tumors. Although no single genomic alteration is completely specific for a lymphoma entity, some alterations are highly recurrent in certain entities and thus can provide complementary diagnostic information when integrated in the hematopathological diagnostic workup. Moreover, other

A new hope for precision medicine.

The SS1P immunotoxin is combined with immunomodulatory therapy in order to improve its efficacy in human mesothelioma (Hassan et al., this issue).

Genomic Medicine Sweden: Advancing precision medicine at the national level.

High-throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease-causing genetic alterations and facilitating individualised treatment and care. In response to these advances, Genomic Medicine Sweden (GMS) was established in 2017 as a national collaborative effort to accelerate implementation of genomics-based precision medicine within Sweden's regionally organized, publicly funded healthcare system. GMS brings together the seven university healthcare regions and their associated medical faculties, i…

Collaborative AI and Laboratory Medicine integration in precision cardiovascular medicine.

Artificial Intelligence (AI) is a broad term that combines computation with sophisticated mathematical models and in turn allows the development of complex algorithms which are capable to simulate human intelligence such as problem solving and learning. It is devised to promote a significant paradigm shift in the most diverse areas of medical knowledge. On the other hand, Cardiology is a vast field dealing with diseases relating to the heart, the circulatory system, and includes coronary heart disease, cerebrovascular disease, rheumatic heart disease and other conditions. AI has emerged as a p

Женщины и множественный склероз: от гендерной медицины до точной медицины.

Различия по признаку пола в множественном склерозе (MS) проявляются в различных аспектах заболевания, включая биологические процессы, клиническое представление, результаты МРТ и результаты болезни. Формирующаяся область точной медицины предлагает многообещающий подход к решению сложных вопросов, связанных с НР. Используя генетические маркеры, биомаркеры и другие биологические факторы, точная медицина стремится адаптировать лечение к конкретным пациентам. Однако потенциальное воздействие полового и гендерного факторов на результаты лечения по-прежнему в значительной степени не изучено. Здесь мы

Совпадение в аннотации оригинала
Sex-based differences in multiple sclerosis (MS) are evident in various aspects of the disease, including biological processes, clinical presentation, MRI findings, and disease outcomes. The emerging field of precision medicine offers a promising approach to addressing the complexity of MS. By leveraging genetic markers, biomarkers, and other biological fact…

Precision medicine requires precision prescribing: rethinking antiseizure medication regulation in Europe.

Epilepsy care increasingly combines biologically informed precision medicine with individualized prescribing, yet routine personalization based on age, comorbidities, reproductive considerations, tolerability, interactions, and patient preference is good clinical care and should not, by itself, be labelled precision medicine. The unresolved problem is not a general absence of prescribing freedom in Europe. It is the mismatch that may arise among dynamic therapeutic trajectories, formal indications, reimbursement or access rules, and the evidence captured in routine datasets. We propose structu…

Precision medicine and therapies of the future.

Precision medicine in the epilepsies has gathered much attention, especially with gene discovery pushing forward new understanding of disease biology. Several targeted treatments are emerging, some with considerable sophistication and individual-level tailoring. There have been rare achievements in improving short-term outcomes in a few very select patients with epilepsy. The prospects for further targeted, repurposed, or novel treatments seem promising. Along with much-needed success, difficulties are also arising. Precision treatments do not always work, and sometimes are inaccessible or do …

Nuclear medicine in pheochromocytoma and paraganglioma: at a crossroads with precision medicine.

Precision medicine (PM) aims to maximize the risk-benefit balance of medical decisions by integrating individual patient and disease characteristics. This approach is gaining increasing recognition from clinicians, healthcare systems, pharmaceutical companies, patients, and governments. Nuclear medicine plays a critical role in PM by its virtue of providing critical information at every step of disease management, digital markers, and companion diagnostics/therapeutics. It is anticipated that technological breakthroughs and new tracers will continue to position nuclear medicine among the signi…

Blood-based biomarkers for precision medicine in lung cancer: precision radiation therapy.

Both tumors and patients are complex and models that determine survival and toxicity of radiotherapy or any other treatment ideally must tak … patients, as it allows truly precise oncological treatment. Indeed, the core for individualized and precision medicine is not only selection of patients, but even more the optimization of the therapeutic window on an individual basis. A holistic model will allow for determination of an individual dose-response relationship for each organ at risk for each tumor in ea …

From Biomarkers to Better Outcomes: Precision Medicine in Modern Internal Medicine.

Internal medicine has traditionally focused on population-based approaches, utilizing diagnostic algorithms and treatment thresholds designed for the "average" patient. While beneficial, this one-size-fits-all model often leads to treatment failures. Precision medicine addresses this limitation by tailoring medical care to an individual's unique molecular, genetic, and clinical profile. Driven by advancements in multi-omics platforms, novel biomarkers, artificial intelligence (AI), and pharmacogenomics, precision medicine is transforming modern internal medicine from oncology into routine clin…

Next-generation osteosarcoma models for precision medicine.

Osteosarcoma (OS) is a highly aggressive bone malignancy that predominantly affects adolescents and young adults. Despite the progress in conventional treatment approaches, such as surgery and chemotherapy, patient outcomes remain poor due to OS metastatic potential, chemoresistance and frequent recurrence. Although recent advancements in novel therapeutic strategies, such as molecular inhibitors, gene-based interventions, alongside immuno- and radiotherapies, have emerged in recent years, OS is still not well understood due to its complexity and heterogeneity. Tissue engineering and predictiv

Precision medicine targeting ferroptosis in cerebrovascular diseases.

Ferroptosis has emerged as a critical contributor to secondary brain injury in cerebrovascular diseases (CVDs). However, the clinical transl … ms-from iron overload modes to lipid vulnerability-we emphasize a paradigm shift for CVD: advancing precision medicine requires mechanism-stratified, context-dependent interventions rather than uniform ferroptosis inhibition.

Advancing Precision Medicine in Degenerative Cervical Myelopathy.

Degenerative cervical myelopathy (DCM) is the leading cause of nontraumatic spinal cord dysfunction and remains clinically heterogeneous in presentation and course. This review synthesizes current evidence on predictors of neurological outcomes across conventional prognostic factors (clinical and macrostructural metrics) and quantitative neuroimaging (microstructural metrics), as well as how machine learning (ML) models integrate these predictors into a precision medicine framework to aid in DCM management. We explore evidence on conventional clinical and radiographic factors. Although several…

Precision medicine approaches to CNS metastatic disease.

Brain metastases (BrM) and leptomeningeal metastases (LM) are increasingly common neurologic complications of cancer. The era of precision oncology has ushered in a deeper understanding of the molecular alterations that drive oncogenesis, subsequently informing and accelerating the drug development process. New systemic treatments, including oral tyrosine kinase inhibitors (TKIs), immune checkpoint inhibitors (ICIs) as well as antibody-drug conjugates (ADCs), have substantial intracranial efficacy with meaningful clinical benefit for BrM patients. Our understanding of LM continues to evolve wi

Immunotherapy for precision medicine in colorectal cancer.

IntroductionColorectal cancer (CRC) is the fourth most common cancer and second leading cause of cancer-related death in the United States. The implementation of CRC screening has decreased CRC incidence in adults older than 65 years. However, among young adults who experience more aggressive disease progression, CRC incidence has been increasing for decades. Immunotherapy represents a collection of innovative and promising approaches with greater efficacy and safety. In this review, we discuss modalities and selected targets of immunotherapies for CRCs that are guided by precision medicine.Ar…

Pursuing Precision Medicine in Managing Rheumatoid Arthritis.

Rheumatoid arthritis, characterized by immune dysregulation and joint destruction, is managed through a stepwise algorithm that combines met … sis of rheumatoid arthritis and underscores the need to address the disease's heterogeneity through precision medicine. Moving forward, a deeper investigation into rheumatoid arthritis pathogenesis, encompassing both genetic and environmental factors, is crucial. Pursuing precision medicine, grounded in accurate patient stratification, should be embraced as a "moons …

Precision Medicine in Periodontics: A Literature Review.

Periodontitis, a widespread health issue, requires effective prevention and management strategies due to its increasing prevalence and detrimental social consequences. The chronic inflammation associated with periodontitis also exacerbates systemic conditions, emphasizing the need for advanced approaches in addressing this public health concern. The traditional methods of periodontal diagnosis, which primarily rely on clinical indicators such as pocket depth, clinical attachment loss, mobility, and radiographic measurements of alveolar bone loss, have limitations in guiding therapy due to the

Challenges in IBD Research 2024: Precision Medicine.

Precision medicine is part of 5 focus areas of the Challenges in IBD Research 2024 research document, which also includes preclinical human IBD mechanisms, environmental triggers, novel technologies, and pragmatic clinical research. Building on Challenges in IBD Research 2019, the current Challenges aims to provide a comprehensive overview of current gaps in inflammatory bowel diseases (IBDs) research and deliver actionable approaches to address them with a focus on how these gaps can lead to advancements in interception, remission, and restoration for these diseases. The document is the resul…

Imagenetics for Precision Medicine in Dilated Cardiomyopathy.

Dilated cardiomyopathy (DCM) is a common heart muscle disorder of nonischemic etiology associated with heart failure development and the ris … ion of imaging and genetics, is expected to further advance research in the field and contribute to precision medicine in DCM management and treatment. In the present article, we review the existing literature in the field, summarize the established knowledge and emerging data on the value of genetics and imaging in establishing genotype-phenotype associations in DC …