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Exploring the molecular biomarker utility of circCCT3 in multiple myeloma: A favorable prognostic indicator, particularly for R-ISS II patients.

Circular RNAs (circRNAs) are associated with the pathobiology of multiple myeloma (MM). Recent findings regarding circCCT3 support its involvement in the development and progression of MM, through microRNA sponging. Thus, we aimed to examine the expression of circCCT3 in smoldering and symptomatic MM and to assess its clinical importance. Three cell lines from plasma cell neoplasms were cultured and bone marrow aspirate (BMA) samples were collected from 145 patients with MM or smoldering MM. Next, CD138+ enrichment was performed in BMA samples, followed by total RNA extraction and reverse tran

Prognostic nomogram for multiple myeloma early relapse after autologous stem cell transplant in the novel agent era.

BackgroundThe present study intended to establish a predictive nomogram for early relapse (ER) (Patients and methodsThe nomogram was designed and constructed to a retrospective clinical data of newly diagnosed MM patients received novel agent induction therapy and subsequent ASCT at three centers in China from July 2007 to December 2018. The retrospective study was conducted among 294 patients in the training cohort and 126 in the validation cohort. The nomogram's predictive accuracy was evaluated by the concordance index, calibration curve and decision clinical curve.ResultsThe study cohort i

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… Clinical utility for COX regression was estimated by decision curve analysis (DCA) using the “stdca.R" via Memorial Sloan Kettering Cancer Center [ https://www.mskcc.org/departments/epidemiology‐biostatistics/biostatistics/decision‐curve‐analysis ] in R which was modified based on “rmda” package in R …

The burden of metastatic disease of the femur on the Medicare system.

BackgroundIn the United States, over 1,650,000 new cases of cancer are being diagnosed yearly with almost 50 % of them being the top five bone-seeking cancers. Since cancer risk increases with age, this suggests that orthopedic oncology services may be a strain on the Medicare system. The femur is the most common site of long bone metastases. Prophylactic fixation techniques prevent pathologic fractures, reduce morbidities, and enhance the quality of life of patients with femoral metastases. This study aims to assess the rate of metastatic disease to the skeleton and evaluate the use and finan

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… Acknowledgements Scott Hetzel M.S., Associate Researcher at the University of Wisconsin Department of Biostatistics and Medical Informatics, for consulting with us on the biostatistics used in this paper. Competing interests The authors declare that they have no competing interests. …

Сохранение структурной связи мозга у людей с множественным склерозом.

Множественный склероз (MS) — нейродегенеративное заболевание, которое влияет на центральную нервную систему. Структуры, затронутые в MS, включают корпус каллосум, соединяющий полушарие. Исследования показали, что в мозгах млекопитающих структурная соединяемость организована в соответствии с принципом охраны природы, а также обратной связью между внутриконтинентальными и межвековыми связями. Цель этого исследования состояла в том, чтобы воспроизвести этот принцип сохранения в предметах с MS и изучить вопрос о том, как болезнь взаимодействует с ним. Был проанализирован набор многоцентрических да

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… Biostatistics , 8 ( 1 ), 118 – 127 . 10.1093/biostatistics/kxj037 , 16632515 Kellner , E. , Dhital , B. , Kiselev , V. G. , & Reisert , M. ( 2016 ). Gibbs-ringing artifact removal based on local subvoxel-shifts . …

Profiling of Small Nucleolar RNAs by Next Generation Sequencing: Potential New Players for Breast Cancer Prognosis.

One of the most abundant, yet least explored, classes of RNA is the small nucleolar RNAs (snoRNAs), which are well known for their involvement in post-transcriptional modifications of other RNAs. Although snoRNAs were only considered to perform housekeeping functions for a long time, recent studies have highlighted their importance as regulators of gene expression and as diagnostic/prognostic markers. However, the prognostic potential of these RNAs has not been interrogated for breast cancer (BC). The objective of the current study was to identify snoRNAs as prognostic markers for BC. Small RN

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… Biostatistics . 2007 ; 8 : 101 – 117 . 16613833 10.1093/biostatistics/kxj036 34 Dobbin KK , Zhao Y , Simon RM . How large a training set is needed to develop a classifier for microarray data? …

Patient-reported outcomes in patients with hematological relapse or progressive disease: a longitudinal observational study.

BackgroundPatients with hematological cancer who experience relapse or progressive disease often face yet another line of treatment and continued mortality risk that could increase their physical and emotional trauma and worsen their health-related quality of life. Healthcare professionals who use patient-reported outcomes to identify who will have specific sensitivities in particular health-related quality of life domains may be able to individualize and target treatment and supportive care, both features of precision medicine. Here, in a cohort of patients with relapsed or progressive hemato

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… Biostatistics. 2010;11(2):373–374. doi: 10.1093/biostatistics/kxp050. 34. Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. J Stat Softw 2015;67(1). 35. Kuznetsova A, Brockhoff PB, Christensen RHB. lmerTest Package: tests in linear mixed effects models. …

Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration.

Randomised controlled trials often use surrogate endpoints to substitute for a target outcome (an outcome of direct interest and relevance to trial participants, clinicians, and other stakeholders—eg, all cause mortality) to improve efficiency (through shortened duration of follow-up, reduced sample size, and lower research costs), and for ethical or practical reasons. However, their use has a fundamental limitation in terms of uncertainty of the intervention effect on the target outcome and limited information on potential intervention harms. There have been increasing calls for improved repo

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… RC acknowledges that the Section for Biostatistics and Evidence-Based Research (Parker Institute, Bispebjerg and Frederiksberg Hospital) is supported by core grants. … Biostatistics 2000;1:49-67. 10.1093/biostatistics/1.1.49. 56. Buyse M, Saad ED, Burzykowski T, Regan MM, Sweeney CS. Surrogacy Beyond Prognosis: The Importance of “Trial-Level” Surrogacy. Oncologist 2022;27:266-71. 10.1093/oncolo/oyac006. 57. …

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk-outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk-outcome pairs, and new data on risk exposure levels and risk-outcome associations. METHODS: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and

Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study.

BackgroundIngestion of AndoSan™, based on the mushroom Agaricus blazei Murill, has previously been shown to exhibit anti-inflammatory effects because of reduction of pro-inflammatory cytokines in healthy individuals and patients with ulcerative colitis. In this randomized single-blinded placebo controlled study we examined whether intake of AndoSan™ also resulted in clinical effects.Methods and findings50 patients with symptomatic ulcerative colitis were block-randomized and blinded for oral daily intake of AndoSan™ or placebo for the 21 days' experimental period. The patients reported scores

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… calculated for prospective differences of 20% between the experimental and placebo group and assumed standard deviation of 20% for the different parameters with a significant level of 5% and a power of 90% (ß = 0.10), demands about 25 patients per randomized arm (calculated in cooperation Oslo Center for Biostatistics … The skillful statistical guidance by professor Leiv Sandvik, Oslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Norway, is gratefully acknowledged. …

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill

Transcriptome Meta-Analysis of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy.

Triple-negative breast cancer (TNBC) is a heterogeneous disease with varying responses to neoadjuvant chemotherapy (NAC). The identification of biomarkers to predict NAC response and inform personalized treatment strategies is essential. In this study, we conducted large-scale gene expression meta-analyses to identify genes associated with NAC response and survival outcomes. The results showed that immune, cell cycle/mitotic, and RNA splicing-related pathways were significantly associated with favorable clinical outcomes. Furthermore, we integrated and divided the gene association results from

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… Frozen robust multiarray analysis (fRMA) Biostatistics 2010 11 242 253 10.1093/biostatistics/kxp059 20097884 PMC2830579 34. Karn T. Metzler D. Ruckhaberle E. Hanker L. Gatje R. Solbach C. Ahr A. Schmidt M. Holtrich U. Kaufmann M. …

Estimating and validating disability-adjusted life years at the global level: a methodological framework for cancer.

BackgroundDisability-adjusted life years (DALYs) link data on disease occurrence to health outcomes, and they are a useful aid in establishing country-specific agendas regarding cancer control. The variables required to compute DALYs are however multiple and not readily available in many countries. We propose a methodology that derives global DALYs and validate variables and DALYs based on data from various cancer registries.MethodsWe estimated DALYs for four countries (Norway, Bulgaria, India and Uganda) within each category of the human development index (HDI). The following sources (indicat

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… Biostatistics. 2007;8(3):576–594. doi: 10.1093/biostatistics/kxl030. Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer. 1999;83(1):18–29. doi: 10.1002/(sici)1097-0215(19990924)83:1<18::aid-ijc5>3.0.co;2-m. …

Эпигенетические достижения в педиатрическом многоразовом склерозе: ДНК-метилирование примечательно участие Эпштейна-Барра заражённых вирусом и принимающих иммунных сетей.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Педиатрический множественный склероз (PedMS) предоставляет уникальную возможность для изучения патогенеза MS с учетом короткого интервала между воздействием на окружающую среду и возникновением заболеваний. Цель этого исследования состояла в том, чтобы выявить различные метилированные регионы (ДМР), которые способствуют взаимодействию между экологическими факторами и геномными факторами на ранних этапах заболевания. В этом многоцентровом исследовании мы проанализировали периферическую ДНК крови. 175 Итальянские предметы122 Пациенты педиатрии, 53 - здоровый контрол

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… Biostatistics. 2007 ; 8 ( 1 ): 118 - 127 . doi: 10.1093/biostatistics/kxj037 16632515 23. Horvath S . DNA methylation age of human tissues and cell types . Genome Biol. 2013 ; 14 ( 10 ): 3156 . doi: 10.1186/gb-2013-14-10-r115 PMC4015143 24138928 24. Ritchie ME , Phipson B , Wu D , et al . …

The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods.

BACKGROUND: The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors. METHODS: The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study was established to examine how a hospitalized episode of AKI independently affects the risk of chronic kidney disease development and progression, cardi

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… Biostatistics. 2005;6(1):77–91. doi: 10.1093/biostatistics/kxh019. Bihorac A, Yavas S, Subbiah S, Hobson CE, Schold JD, Gabrielli A, Layon AJ, Segal MS. Long-term risk of mortality and acute kidney injury during hospitalization after major surgery. …

Alternative Cancer Therapeutics: Unpatentable Compounds and Their Potential in Oncology.

Cancer remains a leading cause of death globally. Cancer patients often seek alternative therapies in addition to, or instead of, conventional treatments like chemotherapy, radiation, and surgery. The progress in medical advancements and early detection provides more treatment options; however, the development of cancer drugs requires a significant amount of time, demands substantial investments, and results in an overall low percent of regulatory approval. The complex relationship between patent protection and pharmaceutical innovation complicates cancer drug development and contributes to hi

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… Biostatistics. 2019;20:273–286. doi: 10.1093/biostatistics/kxx069. Erratum in Biostatistics 2019, 20, 366. 2. Scott E.C., Baines A.C., Gong Y., Moore R., Pamuk G.E., Saber H., Subedee A., Thompson M.D., Xiao W., Pazdur R., et al. …

Meperidine compared to morphine for rigors associated with monoclonal antibody-related infusion reactions.

IntroductionInfusion reactions, characterized by symptoms such as rigors, fever, and hypotension, are common adverse events that occur during monoclonal antibody (MAB) therapy. The treatment of rigors often involves opioids, most commonly meperidine, despite limited evidence supporting use in the setting of MAB infusions. This study aims to compare the efficacy and safety of intravenous (IV) meperidine and morphine is treatment of MAB-related rigors, filling a significant gap in the literature.MethodsThis was a single-center, retrospective cohort study which reviewed patients either inpatient

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… Meperidine compared to morphine for rigors associated with monoclonal antibody-related infusion reactions by Hanna Yakubi, Aaron Paul Steele and Megan Tsao in Journal of Oncology Pharmacy Practice Acknowledgements The authors thank Machelle Wilson, PhD and Jeffrey Robert Fine, MPH from the Division of Biostatistics …

Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration.

Randomised controlled trials commonly use surrogate endpoints to substitute for a target outcome (outcome of direct interest and relevance to trial participants, clinicians, and other stakeholders—eg, all cause mortality) to improve their efficiency (through shorter trial duration, reduced sample size, and thus lower research costs), or for ethical or practical reasons. But reliance on surrogate endpoints can increase the uncertainty of an intervention’s treatment effect and potential failure to provide adequate information on intervention harms, which has led to calls for improved reporting o

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… RC acknowledges that the Section for Biostatistics and Evidence-Based Research (Parker Institute, Bispebjerg and Frederiksberg Hospital) is supported by core grants. … Biostatistics 2000 ; 1 : 49 - 67 . 10.1093/biostatistics/1.1.49 . 12933525 48 Buyse M Saad ED Burzykowski T Regan MM Sweeney CS . Surrogacy Beyond Prognosis: The Importance of “Trial-Level” Surrogacy . …

Схемы проявления автоантибиоза в множестве склероза, выявленные благодаря разработке технологии обнаружения автоантигенов.

Множественный склероз (MS) — изнурительное аутоиммунное заболевание CNS, которое характеризуется демиэлированием и аксонной травмой и которому часто предшествует демиелионирующее явление, называемое клинически изолированным синдромом (CIS). Несмотря на важность клеток B и автоантител в патологии MS, их целевые особенности остаются в значительной степени неизвестными. Для агностической и всеобъемлющей оценки автоантител в MS мы разработали и использовали то, что мы считаем новой автоантигенной технологией открытия, Антигеномной платформой. Эта Платформа представляет собой высокопроизводительный

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… Supplementary Material Supplemental data Supplemental data set 1 Supplemental data set 2 Supplemental data set 3 Supplemental data set 4 Supplemental data set 5 Supplemental data set 6 Supporting data values Acknowledgments We thank Cliburn Chan (Duke University, Professor in Biostatistics … and Bioinformatics) and Joshua Granek (Duke University, Assistant professor in Biostatistics and Bioinformatics). …

Applying State-of-the-Art Survival Extrapolation Techniques to the Evaluation of CAR-T Therapies: Evidence from a Systematic Literature Review.

IntroductionTraditional statistical techniques for extrapolating short-term survival data for anticancer therapies assume the same mortality rate for noncured and "cured" patients, which is appropriate for projecting survival of non-curative therapies but may lead to an underestimation of the treatment effectiveness for potentially curative therapies. Our objective was to ascertain research trends in survival extrapolation techniques used to project the survival benefits of chimeric antigen receptor T cell (CAR-T) therapies.MethodsA global systematic literature search produced a review of surv

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… Biostatistics. 2007;8(3):576–594. doi: 10.1093/biostatistics/kxl030. 11. Andersson TM-L, Lambert PC. Fitting and modeling cure in population-based cancer studies within the framework of flexible parametric survival models. Stata J. 2012;12(4):623–638. doi: 10.1177/1536867X1201200404. 12. …

Воздействие множественных склерозов на распределение нагрузки, давление Плантара и диапазон движений на лодыжках у женщин.

Изменения в распределении статического давления на плантаре служат важными показателями походов и нарушений баланса у лиц с множественным склерозом (MS). Кроме того, выявление изменившихся моделей распределения нагрузки на плантар, наряду с ограничением дорсифлексии лодыжки, может служить ранним индикатором посттуральной нестабильности и походной дисфункции у женщин с НР. Цели: Оценка различий в статическом давлении на плантаре, распределении нагрузки и диапазоне движения дорсифлексии на лодыжках между женщинами, у которых диагностированы НР, и женщинами без каких-либо условий. Методы: В перио

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… Sample Size The sample size was calculated using software developed by the Clinical Epidemiology and Biostatistics Unit of the University Hospital Complex of A Coruña, Universidade da Coruña ( www.fisterra.com , accessed on 16 February 2025). …