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In Vitro Evaluation of Antioxidant and Cytokine-Modulating Activity of Tormentil Rhizome Extract and Its Microbial Metabolites in Human Immune Cells.

The tormentil rhizome (Potentilla erecta L.) is traditionally used to treat gastrointestinal and inflammatory disorders, yet the mechanisms … as characterized by LC-MS, revealing fractions enriched in catechins and procyanidins (30% MeOH) or ellagic acid derivatives and triterpenes (100% MeOH). EtTR and all TRGM fractions significantly reduced ROS production, while the extract and selected metabolites decreased IL-1β and TNF-α secretion in neutrophils, whereas IL-8 showed marked induction. In macrop …

Modulating Active Center Microenvironment in Phthalocyanine-Based Covalent Organic Frameworks for Enhanced Electrocatalytic CO2 to CH3OH.

Developing catalysts for electrocatalytic CO2 to CH3OH still faces great challenge due to the involvement of multiple proton-coupled electron transfer (PCET) processes. Molecular phthalocyanine electrocatalysts on carbon nanotubes have achieved production of methanol as the sole liquid-phase product but with the activity and stability far from meeting industrial demands. Herein, phthalocyaninato cobalt is fabricated into covalent organic frameworks PE-COF via polymerization with ellagic acid. Subsequent hydrolyzation of the ester groups in this framework affords COOH/OH-containing PEH-COF, res…

Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model.

Microglia-mediated neuroinflammation and mitochondrial dysfunction play critical role in the pathogenic process of Parkinson's disease (PD). Mitophagy plays central role in mitochondrial quality control. Hence, regulation of microglial activation through mitophagy could be a valuable strategy in controlling microglia-mediated neurodegeneration and neuroinflammation. Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA). Several preclinical studies have reported the beneficial effects of UA on age-related conditions by increasing…

Urolithins Modulate the Viability, Autophagy, Apoptosis, and Nephrin Turnover in Podocytes Exposed to High Glucose.

Urolithins are bioactive compounds generated in human and animal intestines because of the bacterial metabolism of dietary ellagitannins (and their constituent, ellagic acid). Due to their multidirectional effects, including anti-inflammatory, antioxidant, anti-cancer, neuroprotective, and antiglycative properties, urolithins are potential novel therapeutic agents. In this study, while considering the future possibility of using urolithins to improve podocyte function in diabetes, we assessed the results of exposing mouse podocytes cultured in normal (NG, 5.5 mM) and high (HG, 25 mM) glucose c…

Pharmacological Effects of Natural Components Against Ovarian Cancer and Mechanisms.

Ovarian cancer, one of the three leading malignancies in women, has high incidence and mortality worldwide. It is hard to diagnose until ver … his chapter, we summarize recent work on a selected group of natural components, including lignans, ellagic acid, luteolin, mangiferin, and Acanthopanax senticosus, which have all been demonstrated to reduce the progress of epithelial ovarian cancer in a dose-depend manner, by both in vitro and in vivo experiments. The mechanisms of the anticancer activities b …

Rapid identification and isolation of neuraminidase inhibitors from mockstrawberry (Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS.

Neuraminidase inhibitors (NAIs) are the mainstay antiviral drugs against influenza infection. In this study, a ligand fishing protocol was d … nd Structure Identification (CSI):FingerID, including 12 ellagitannins, 4 brevifolin derivatives, 3 ellagic acid derivatives, and 4 flavonoids. Among them, 9 compounds were isolated and tested for in vitro NA inhibitory activities against NA from Clostridium perfringens, and from oseltamivir sensitive and resistant influenza A virus strains. The results indica …

Black Raspberry (Rubus coreanus Miquel) Promotes Browning of Preadipocytes and Inguinal White Adipose Tissue in Cold-Induced Mice.

The alteration of white adipose tissue (WAT) "browning", a change of white into beige fat, has been considered as a new therapeutic strategy … or gamma coactivator 1-alpha (PGC1α), and t-box protein 1 (TBX1) in cold-exposed mice. Furthermore, ellagic acid (EA), a constituent of BRWE, markedly promoted beige specific markers: UCP1, PGC1α, TBX1, and nuclear respiratory factor 1 in beige differentiation media (DM)-induced 3T3-L1 adipocytes. Our findings indicate that BRWE can promote beige differentiati …

Москито индицидальная активность листьев спондиас мамбин Л. против Aedes aegypti L. и изоляция активных принципов.

Aedes aegypti — домашний комарь и один из основных переносчиков денге и желтой лихорадки. Поскольку она является вектором смертельных заболеваний, ее борьба становится крайне важной. Лекарственные растения могут быть альтернативой индицидным агентам, поскольку они содержат богатый источник биоактивных соединений. Цель этого исследования состояла в том, чтобы определить индицидную активность метанола из спондиасских мамбинов, н-гексана, дихлорметана и этиловых ацетатовых фракций в отношении взрослых женщин Аэ. агипти комаров и выделить активное(ые) соединение(а), ответственное(ые) за биоактивно

Совпадение в аннотации оригинала
BACKGROUND & OBJECTIVES: Aedes aegypti is a domestic mosquito and one of the primary vectors for dengue and yellow fever. Since, it is a vec … was the most effective fraction with LC50 value of 2172.815 μg/ml. Compounds identified were mainly ellagic acid and 1-O-Galloyl-6-O-luteoyl-α-D-glucose. INTERPRETATION & CONCLUSION: The S. mombin leaf extracts and fractions proved to be a strong candidate for a natural, safe and stable adulticide, alternative to synthetic adulticide.

Small molecule inhibitors of HCV replication from pomegranate.

Hepatitis C virus (HCV) is the causative agent of end-stage liver disease. Recent advances in the last decade in anti HCV treatment strategies have dramatically increased the viral clearance rate. However, several limitations are still associated, which warrant a great need of novel, safe and selective drugs against HCV infection. Towards this objective, we explored highly potent and selective small molecule inhibitors, the ellagitannins, from the crude extract of Pomegranate (Punica granatum) fruit peel. The pure compounds, punicalagin, punicalin, and ellagic acid isolated from the extract sp…

Enrichment of Rapeseed Honey with Combined Polyphenol-Rich Dry Extracts from Mandarin Peels and Clove Buds.

Enriching honey with plant additives allows for increasing its antioxidant potential in an additive-dependent manner and at the same time sh … yphenols content. Phenolic HPLC-DAD profiles were compared and selected polyphenols (syringic acid, ellagic acid, hesperidin and eugenol) were quantified. The dry extracts were incorporated into rapeseed honey (0.25% w/w) during the creaming process. No significant changes in color and texture were visually noted; whereas, some changes (p < 0.05) in titrable a …

Fenugreek seed meal as a partial replacement for soybean meal: Dose-dependent effects on in vitro rumen fermentation and greenhouse gas production.

The use of alternative protein sources in ruminant diets has the potential to reduce feed costs and mitigate environmental impacts associate … s total polyphenols were higher in FSM (2014.9 µg/g) than SBM (1453.3 µg/g), particularly catechin, ellagic acid, methyl gallate, and rutin. Ruminal gas production kinetics were altered. The asymptotic gas volume (b) increased with 25% FSM inclusion (323.9 mL/g DM) relative to the control (300.7 mL/g DM; P = 0.005), but decreased at higher inclusion levels, wi …

Effect of Dealcoholized Muscadine Wine on the Development of Spontaneous Colitis and Gut Microbiome in IL-10-/- Mice.

Background/Objectives: Colitis is a chronic condition affecting millions worldwide. Purple muscadine wine polyphenols have a unique composit … rRNA gene sequencing. Results: DMW contained predominantly anthocyanins and a significant amount of ellagic acid. IL-10-/- mice developed mild colitis as indicated by the disease activity index. DMW × gene interactions decreased intestinal permeability, colonic mRNA levels of IL-1β, and serum TNF-α in the IL-10-/- mice. DMW suppressed the colonic mRNA levels o …

Both plants Sebastiania chamaelea from Niger and Chrozophora senegalensis from Senegal used in African traditional medicine in malaria treatment share a same active principle.

ETHNOPHARMACOLOGICAL RELEVANCE: Based on ethnobotanical data obtained from Nigerien and Senegalese traditional healers, two Euphorbiaceae pl … uided fractionation of aqueous extracts of these plants enabled the isolation and identification of ellagic acid (EA, 1) as the main compound responsible for their antiplasmodial activity. Together with EA, other derivatives belonging to different chemical groups were isolated but showed moderate antimalarial activity: gallic acid (2), brevifolin carboxylic ac …

Syzygium cumini(L.),Skeels fruit extracts: In vitro and in vivo anti-inflammatory properties.

ETHNOPHARMACOLOGICAL RELEVANCE: Syzygium cumini (L.) Skeels is an important medicinal plant utilized in the health care systems of Pakistan, … nd rosmanol from the 100% methanolic fractions. Myricetin, catechin, quinic acid, chlorogenic acid, ellagic acid, gallic acid, and caffeic acid were identified in the 50% methanolic fractions. CONCLUSIONS: These results demonstrate that S. cumini fruit extracts are a rich source of bioactive compounds that are worthy of further investigation as leads for anti …

Chemical profile and bacterial potential of Psidium cattleyanum leaf extract against multidrug-resistant Staphylococcus aureus.

The increasing prevalence of multidrug-resistant (MDR) Staphylococcus aureus represents a major challenge for global public health and highl … Phytochemical analyses revealed the presence of bioactive metabolites, particularly flavonoids and ellagic acid derivatives. Antimicrobial activity was evaluated through minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays, as well as growth curve analysis. The extract inhibited all tested strains, with MIC values ranging …

Oral Milk-Derived Extracellular Vesicles: A Promising Drug Delivery System for Neuroinflammatory Diseases.

Oral drug delivery is the most patient-friendly and safest approach for disease treatment; however, the bioavailability of macromolecular dr … n, especially in oligodendrocytes and neurons. To address the poor stability and bioavailability of ellagic acid (EA) and to explore the therapeutic potential of mEVs in neuroinflammation treatment, we encapsulated EA and interferon-β (IFN-β) into mEVs and evaluated their therapeutic effects in experimental autoimmune encephalomyelitis (EAE) and lipopolysaccha …

Hydrogel-Delivered Standardized Pomegranate (Punica granatum) Extract Suppresses Quorum Sensing and Disrupts the Biofilm Structure in Pseudomonas aeruginosa.

Pomegranate (Punica granatum) peel is a rich source of polyphenols with recognized bioactivities. This study evaluated the quorum sensing (QS)-inhibitory and anti-biofilm properties of a standardized pomegranate extract, as well as its major ellagitannins (punicalagin and ellagic acid), against Pseudomonas aeruginosa, an important opportunistic pathogen associated with multidrug-resistant infections. Using the P. aeruginosa strain (ATCC 27853) and the QS biosensor Chromobacterium violaceum, the pomegranate extract and punicalagin (MIC = 0.5 and 0.1 mg/mL, respectively) suppressed the productio…

Inhibition of α-Glucosidase Activity and Islet Amyloid PolyPeptide Fibril Formation by Rubusulmifolius Fruit Extract: A Potential Therapeutic Approach for Type 2 Diabetes Mellitus.

This study examines the antidiabetic potential of Rubus ulmifolius, a shrub traditionally used for medicinal and nutritional purposes. The a … avonoids, the most represented ones were quercetin-HMG-glucoside and a kaempferol derivative, while ellagic acid glucuronide was the predominant ellagitannin. The extract showed significantly higher α-glucosidase inhibition with an IC50 value of 2.8 µg/mL, 32 times more effective than acarbose, and it markedly inhibited IAPP aggregation in a dose-dependent man …

Multiscale Interactome-Guided Discovery Candidate Herbs and Active Ingredients Against Hyperthyroidism by Biased Random Walk Algorithm.

Hyperthyroidism features excess thyroid hormone and a hypermetabolic state; although drugs and definitive therapies exist, mechanism-anchore … and RNA polymerase II-dependent transcription. Compound-level analysis recovered evidence-supported ellagic acid and diosgenin and proposed resveratrol, cardamomin, 20-hydroxyecdysone, and (Z)-anethole as novel candidates. Subnetwork mapping linked these compounds to phosphorylation, GPCR-cAMP/TSH signaling, and transcriptional control. This framework recapitu …

Catechol-grafted chitosan-based antioxidant hydrogel with rapid self-healing property for wound healing.

Chronic wounds, particularly those with non-healing ulcers, show high levels of oxidant stress, such as excessive reactive oxygen species (R … l-grafted chitosan (CS-CA) and polyvinyl alcohol in the presence of borax with the incorporation of ellagic acid (EA). Benefiting from the catechol groups from EA and CS-CA, the resulting hydrogel exhibited desirable adhesive property, excellent antioxidant and intensified antibacterial dual functions. Furthermore, the hydrogel demonstrated remarkable biocompa …