Результаты поиска

Testosterone maintenance therapy. Effects on vulvar lichen sclerosus treated with clobetasol propionate.

OBJECTIVE: To evaluate the possible effects of topical testosterone as maintenance therapy after clobetasol propionate treatment. STUDY DESIGN: Thirty-two patients with biopsy-proven vulvar lichen sclerosus (LS), after 24 weeks of treatment with 0.05% clobetasol propionate cream, were randomly distributed into two groups of 16 each and treated for a further length of time (24 weeks) with testosterone 2% ointment or a cream-based preparation (placebo). The patients were examined before and after treatment for symptoms, gross aspects and histologic features. RESULTS: With clobetasol propionate

Lanolin allergy: crisis or comedy.

Lanolin has been applied to human skin from at least Egyptian times. Its virtues as an emollient and vehicle for cosmetics and drugs have been extolled for centuries. 50 years ago, a fly was found in the ointment--the first case of lanolin allergy was reported (1). Since then lanolin has achieved considerable notoriety as a contact sensitizer. Dozens of articles in the dermatologic literature emphasize the high frequency of lanolin allergy. European dermatologists seem to have become especially sensitized to lanolin allergy. Medical students learn early on, that medicaments in lanolin bases ar

Demodex Mite Infestation in Patients Suffering from Atopic Dermatitis and Psoriasis.

The role of Demodex mites in the pathogenesis of skin diseases still needs updating. The aim of the study was to determine the relationship … dex infestation was 4.25 in the AD patients, 3.4 in the PsO patients, and 2.8 in the control group. Emollients were used in the treatment by 76.7% of the AD patients and 64.8% of patients with PsO; however, this type of skin care did not significantly increase the risk of skin colonization by Demodex. AD and PsO do not seem to facilitate excessive Demodex sp …

Arriving at SKINTED (Surgery of the Knee, Injury to the Infrapatellar Branch of the Saphenous Nerve, Traumatic Eczematous Dermatitis): A Case Report.

Surgery of the knee, injury to the infrapatellar branch of the saphenous nerve, traumatic eczematous dermatitis (SKINTED) is a postsurgical localized dermatitis specifically linked to total knee arthroplasty (TKA). It is due to autonomic denervation following surgically inflicted nerve injury. It develops several months to years following a surgical trauma. It is being referred to by various names in the literature. Locoregional immune dysfunction due to lymphatic injury after surgery is the currently accepted theory. It must be distinguished from atopic dermatitis, allergic contact dermatitis

Pruritus: Diagnosis and Management.

Pruritus is the sensation of itching; it can be caused by dermatologic and systemic conditions. An exposure history may reveal symptom triggers. A thorough skin examination, including visualization of the finger webs, anogenital region, nails, and scalp, is essential. Primary skin lesions indicate diseased skin, and secondary lesions are reactive and result from skin manipulation, such as scratching. An initial evaluation for systemic causes may include a complete blood count with differential, creatinine and blood urea nitrogen levels, liver function tests, iron studies, fasting glucose or A1

Vehicles for Drug Delivery and Cosmetic Moisturizers: Review and Comparison.

Many dermatological conditions, such as eczema and psoriasis, are treated with topical therapeutic products. Instead of applying the active drug directly onto the skin, it is combined with a vehicle to aid in its delivery across the stratum corneum (SC) and into deeper regions of the skin, namely the epidermis and dermis. Absorption into the systemic circulation is minimized. Topical vehicles are also used as cosmetic moisturizers (often termed emollient therapy) to ameliorate dry skin, which is a cornerstone of the management of various dermatological conditions, including xerosis, eczema, ps

Systemic Treatment for Severe Atopic Dermatitis.

Atopic dermatitis (AD) is a chronic inflammatory, relapsing disease of the skin, characterized by intense pruritus, maculopapular or vesicul … even if the diagnostic is correct. If all is being done and topical treatment with corticosteroid, emollients and phototherapy have not been sufficient to achieve a good control in AD of adults or children patients, it is time to consider systemic agents. Up to now, most of systemic treatments were based on immunosuppressive therapies, being cyclosporine A, …

[Chronic papulosquamous lesion: papilloma should be suspected].

Papilloma is a benign tumor of the malpighian layer, usualy affecting the skin. Thickened epithelium doesn't show cytological or architectural abnormalities; the epithelial proliferation is still clearly separated from the dermis by the basal membrane, that is to say absence of tumor infiltration. We here report the case of a 15-year-old boy presenting with oozing plague in his left elbow that had evolved over the previous two months. The patient had no particular previous history. Physical examination showed good general condition and a papular, squamous, itchy, oozing lesion measuring 4 cm a

Atopic dermatitis in infants and children in India.

Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease characterized by pruritus and inflammation and accompanied by cutaneous physiological dysfunction, with a majority of the patients having a personal or family history of "atopic diathesis." The term "atopic diathesis" refers to the presence of allergic rhinitis, bronchial asthma or AD. The universal occurrence of AD is no longer debated. However, published material about its natural history, etiopathogenesis, epidemiology, clinical patterns and management leave a lot to be known in the Indian scenario. In the present write-u

Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis.

OBJECTIVE: In the present study, we evaluated the anti-inflammatory activity of Poria cocos (PoCo) on experimentally induced irritant contact dermatitis (ICD) in a repeated sodium lauryl sulphate (SLS) irritation model. METHODS: The anti-irritative effect of PoCo was evaluated with a visual score and quantified by non-invasive bioengineering methods, namely chromametry and transepidermal water loss. Three concentrations of PoCo in base cream DAC (amphiphilic emollient; German pharmacopoeia) were tested in a 4-day repetitive irritation test using SLS. RESULTS: A statistically significant anti

Atopic dermatitis and fungi.

Atopic dermatitis (AD) is a chronic, itching, inflammatory skin disease which is associated with asthma and/or hay fever and a familial occurrence of these conditions. Genetic factors are important in the development of AD, but the exact hereditary pathway is still unknown. Dry skin and the weakened barrier function in patients with AD is very important for the patient's reactions to irritants and other external trigger factors including microorganisms. The standard treatments are topical corticosteroids, topical immunomodulating agents, and emollients. If AD cannot be controlled by this type …

Squamometry in seborrheic dermatitis.

BACKGROUND: Seborrheic dermatitis is a corticosteroid-responsive condition. Topical corticosteroids exhibit distinct activities according to the type and cellular site of action of the hormone and its vehicle. The latter influences not only drug penetration, but also the structure and function of the horny layer. OBJECTIVE: The present study compared the early response of seborrheic dermatitis to two topical corticosteroids using objective quantifications of the stratum corneum alterations. METHOD: Squamometry was used to supplement the clinical assessment of the therapeutic activity of 0.1%

Skin care practices in the neonatal nursery: a clinical survey.

OBJECTIVE: To survey the details of skin care practices in a sample of level I, II, and III nurseries in the United States. DESIGN: A survey conducted by written questionnaire, personal inspection, and phone contact. PARTICIPANTS: Information was obtained from staff physicians and nurses about routine neonatal skin care practices, including bathing, cord care, emollient use, diapering, use of antimicrobial skin preparations, management of intravenous infiltration, approach to diaper rash, and methods used to minimize transcutaneous water loss. SETTING: Fifteen nurseries from twelve hospital

Atopic dermatitis: new therapeutic considerations.

Atopic dermatitis is a genetically determined inflammatory condition in which the primary defect is expressed in one or more hematopoietic c … opic dermatitis may be directed at several points in the evolution of the disease. Agents including emollients are needed to preserve and restore the stratum corneum barrier, and effective antipruritics are required to reduce the self-inflicted damage to the involved skin. Various other agents may be needed to antagonize mediators or cytokines and to inhibit …

Dermatologic Adverse Events Associated with T-Cell Engager Therapy.

T-cell engager therapies, including bispecific T-cell engagers and the immune-mobilizing monoclonal T-cell receptor against cancer tebentafu … ashes. Across agents, most dermatologic adverse events can be managed with topical corticosteroids, emollients, antihistamines, or brief courses of systemic corticosteroids without requiring treatment discontinuation. Recognition of these agent-specific and mechanistically linked patterns is essential for dermatologists as T-cell engager therapies become inc …

Intra-Familial Phenotypic Variability in Lipoid Proteinosis: A Case Series of Three Siblings.

Lipoid proteinosis (LP), or Urbach-Wiethe disease, is an ultra-rare autosomal-recessive disorder caused by loss-of-function variants in the … on symptomatic control using oral acitretin (0.5 mg/kg/day), antihistamines, and intensive topical emollients. At 12-week follow-up, patients showed significant reduction in pruritus and stabilization of skin lesions, though hoarseness and established scarring remained unchanged. This series underscores the importance of recognizing cardinal clinical triads …

Регулирование пациентов с реанимированными/реферантными миеломами, лечившимися с Талкетамабом: основные моменты из точки зрения фармацевтов.

Talquetamab — семейство рецепторов с белковым белком в классе G. 5 член D (GPRC5D) и CD3-targeting bi специфическая антитела с > 71% :: общее реагирование пациентов с рецидивной или рефрактной множественной миеломой, three другие виды наркотиков. GPRC5D сильно отражается на клетках миэломы, а также некоторое выражение в обычных волосатых фолликах, коже и языке. Его уникальное выражение на этих нормальных тканях приводит к явной структуре неблагоприятных явлений (АЭ), как это было отмечено на этапе I/II. MonumenTAL-1 суд. GPRC5D-related АО включали оральные побочные эффекты (например, дисгейсия

Совпадение в аннотации оригинала
Talquetamab is a first-in-class G protein-coupled receptor family C group 5 member D (GPRC5D) and CD3-targeting bispecific antibody with > 7 … ia) and dermatologic toxicities (e.g., skin, nail). These AEs can be managed by dose modifications, emollients, and/or topical or oral corticosteroids. Cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome were consistent with the T-cell redirection mechanism of talquetamab and can be managed consistent with other trials of T-c …

Challenges in diagnosing occupational allergic contact dermatitis: a case report.

BACKGROUND: In Malaysia, occupational allergic contact dermatitis (ACD) is often under-reported. This case report describes a chemical engin … ccupational Safety and Health. The patient was prescribed symptomatic topical treatments, including emollients and topical corticosteroids. Additionally, he was advised to switch to hypoallergenic products. On follow-up, his chronic inflammatory skin lesions showed improvement. CONCLUSIONS: Thorough occupational history-taking and patch testing are essentia …

Predicting Factors and Clinical Characteristics of Pruritus in Psoriasis: A Cross-Sectional Survey.

Pruritus is an important symptom among patients affected by psoriasis. To date, no general agreement has been established regarding pruritus … skin and aggravated by stress and temperature variation. It had a moderate intensity (6.18 ± 2.46). Emollients were the treatment preferred by most patients in alleviating itch, while biologics exerted a protective effect on itch development (OR = -0.24; p < 0.0001) and negatively correlated with itch intensity (r = -0.23; p < 0.0001). Advanced age, high BMI …

Relationship Between Atopic Dermatitis and Food Allergy in Children.

Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a compromised skin barrier due to a variety of reasons, suc … e of a specialist. Topical treatments are crucial for all individuals with AD. Early skin care with emollients, topical steroid treatment, and early introduction of highly allergenic foods are promising methods of alleviating symptoms of AD.