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Fatigue fracture: the basic lesion is inthmic spondylolisthesis.

The defect in the pars interarticularis in spondylolysis and spondylolisthesis is most often the result of repeated trauma, stress, and factors other than acute fracture. These fatigue fractures develop early in life, may have a strong hereditary basis, and most often represent incidental roentgenographic findings. Attention should be given to the youngster or adolescent with low-back pain and paraspinal muscle spasm. If these patients are followed closely, the incidence of pars interarticularis defect is higher than appreciated. The lesion in some of these individuals may progress to signific…

Fatigue and fatigability in Parkinson's disease: a neurophysiological perspective.

Fatigue is one of the most frequent and disabling non-motor symptoms in Parkinson's disease (PD). Its multidimensional nature and overlap with related symptoms contribute to diagnostic and therapeutic challenges. A distinction has been proposed between fatigue, defined as the subjective perception of lack of energy and fatigability, defined as an objective decline in performance during sustained activity. However, their underlying pathophysiological mechanisms are still unclear. We conducted a narrative review of studies investigating PD-related fatigue and fatigability with neurophysiological…

Validation of the Japanese Version of the Rating of Fatigue Scale.

BACKGROUND: Fatigue research remains important across a wide range of fields. In Japan, fatigue has become a major social issue, and research using Japanese population data is expected to contribute to both practical interventions and theoretical advances. Although several Japanese scales for assessing fatigue have been developed, brief instruments designed to measure fatigue during ongoing activity are limited. Therefore, this study translated the Rating of Fatigue (ROF) scale into Japanese and examined the validity of the Japanese version (ROF-J). METHODS: First, the original ROF was transl…

A Comparison of Experimental Methods to Induce Mental Fatigue.

Appropriate induction of mental fatigue in the lab is imperative for properly investigating the effects of mental fatigue on behavior. In this study, we aimed to (1) identify a task for inducing mental fatigue that is both effective (i.e. sufficiently demanding) and feasible (i.e., sufficiently short in duration), and (2) to assess its effects on boredom, loss of motivation, and sleepiness. Therefore, we compared the following tasks: (1) an individualized TloadDback task (16 minutes), (2) an individualized TloadDback task (32 minutes), (3) an N-back task (32 minutes), and (4) a control task in…

A Call to Investigate the Association Between Histoplasmosis and Fatigue.

Historically, infections are subjectively associated with fatigue, a common yet poorly delineated syndrome. The impact on patient quality of life is the ultimate justification to evaluate fatigue in patients with infections. While fungal infections are subjectively associated with fatigue, there are minimal quantifiable fungal research outcomes that evaluate histoplasmosis and fatigue.

Присутствие и воздействие усталости у пациентов с множественным склерозом.

Усталость часто встречается в множестве склерозов (MS) и отрицательно сказывается на функционировании и качестве жизни. Мы изучили клинические корреляции усталости, ее связь с депрессией и сонливостью, а также вопрос о том, улучшают ли лекарственные препараты, связанные с усталостью, результаты, о которых сообщают пациенты. В. МАТЕРИАЛЫ И МЕТОДЫ 203 Ветераны, классифицируемые по признаку наличия или отсутствия усталости. Первичными результатами были изменения в шкале усталости (СФС), изменённой шкале воздействия на усталость (MFIS) и шкале сна Epworth (ESS) от базового уровня до базового уровн

Совпадение в аннотации оригинала
BACKGROUND Fatigue is common in multiple sclerosis (MS) and adversely affects function and quality of life. We examined clinical correlates of fatigue, its relationship with depression and sleepiness, and whether fatigue-related medications improve patient-reported outcomes. MATERIAL AND METHODS This single-center, longitudinal observational study retrospect…

[Factors associated with fatigue in patients with Parkinson's disease].

Fatigue is one of the most frequent non-motor symptoms associated with people with Parkinson's disease (PwPD). In this study, we investigated the relationship between fatigue and patients' background characteristics, disease severity, motor and non-motor symptoms, and cognitive and psychological assessments in PwPD. A total of 80 PwPD were included in this study, 40% of whom experienced fatigue. PwPD with fatigue were associated with being female, dyskinesia, and higher levels of levodopa equivalent daily dose, as well as increased severity of depression, apathy and sleep disturbances, in addi…

The association of ınsomnia with fatigue and mood in postmenopausal osteoporosis.

OBJECTIVE: The aim of the study was to investigate the prevalence of insomnia in postmenopausal osteoporotic women. It also evaluated the relationship between insomnia, fatigue, and mood disorders. METHODS: This cross-sectional study was conducted with 200 postmenopausal osteoporotic women aged 50-75 years. Insomnia severity was assessed using the Insomnia Severity Index, while fatigue and mood disorders were measured using the Fatigue Severity Scale and the Hospital Anxiety and Depression Scale, respectively. The participants were divided into two groups based on the Insomnia Severity Index …

A 64-Year-Old Woman with Fatigue and Dyspnea.

AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry on this tradition by presenting a patient's chief concern and story, inviting the reader to develop a differential diagnosis and discover the diagnosis alongside the authors of the case. This report describes the story of a 64-year-old woman with a remote history of rheumatic heart disease who presented with progressive fatigue and exertional dyspnea more t…

Sleep and Fatigue in Children and Adolescents With Multiple Sclerosis.

Fatigue is common in children with multiple sclerosis. This cross-sectional study aimed to determine the prevalence of fatigue, sleep disorders, and subjective sleep quality in children with multiple sclerosis, along with their relationships to mood, quality of life, physical activity, and multiple sclerosis disease characteristics. Validated questionnaires were completed, and objective sleep quality was evaluated with polysomnography. Of the 18 children recruited (median age 16.0 years), 72% reported fatigue and 61% experienced subjective sleep disturbance. Fourteen sleep studies were complet…

Improvement of fatigue in generalised myasthenia gravis with zilucoplan.

BACKGROUND: Fatigue is a debilitating symptom of myasthenia gravis (MG). The impact of fatigue on MG can be assessed by Quality of Life in Neurological Disorders (Neuro-QoL) Short Form Fatigue scale. Transformation of raw Neuro-QoL fatigue scores to T-scores is a known approach for facilitating clinical interpretation of clinically meaningful and fatigue severity thresholds. METHODS: In the Phase 3, double-blind, placebo-controlled RAISE study (NCT04115293), adults with acetylcholine receptor autoantibody-positive generalised MG (MG Foundation of America Disease Class II-IV) were randomised 1…

The impact of fatigue on people with Fibromyalgia Syndrome: A survey.

INTRODUCTION: Fibromyalgia syndrome (FMS) is a common pain syndrome associated with fatigue and anxiety. The aim of this survey was to determine the impact of fatigue on the quality of life (QoL) of people with FMS and to explore the relationships between fatigue, pain, and anxiety. METHODS: A postal survey was conducted among support groups. Demographic data were collected and participants were asked to complete the Multi-dimensional Assessment of Fatigue Scale (MAF) and two visual analog scales (VAS) measuring pain and anxiety. Data were analysed using descriptive statistics, and relationsh…

Effects of Pregnant Fatigue on the Development of Offspring in Rats.

AIM: To explore the correlation between pregnant fatigue and intrauterine physical and neural development of offspring in rats. METHODS: Sprague-Dawley pregnant rats were randomly divided into a normal control group, a mild fatigue group (stand in water for 6 hours/day), and a severe fatigue group (stand in water for 15 h/day). The levels of lactic acid, 5-Hydroxytryptamine and Interleukin-6 in cardiac serum of rats were used to evaluate the fatigue. The expression of S100β in the telencephalon, Insulin-like growth factor-1 (IGF-1) in the liver and Cyclooxygenage-2 (COX-2) in the small intest…

PREVALENCE AND PREDICTORS OF FATIGUE IN PATIENTS WITH EPISODIC MIGRAINE.

OBJECTIVE: The aim: We studied prevalence, intensity and predictors of fatigue in patient with episodic migraine (EM). PATIENTS AND METHODS: Materials and methods: We enrolled in the study 85 patients with EM and 88 healthy subjects. Fatigue was identified according to Fatigue Severity Scale. We recorded socio-demographic factors: gender, age, marital status, formal education level, employment status, smoking. Anxiety and depression symptoms were assessed by Hospital Anxiety and Depression Scale, daytime sleepiness was measured by Epworth scale. The co-morbidities included history of low back…

Effects of Mental Fatigue on Reaction Time in Sportsmen.

AIM: Mental fatigue (MF) has been defined as a psychobiological state commonly caused by prolonged periods of demanding cognitive activity. However, the differences between women and men in their reaction times (RTs) to visual stimuli due to mental fatigue remain largely unknown. We compare the differences in RT and heart rate after an acute intervention of mental fatigue between male and female athletes. MATERIALS AND METHODS: For this aim, 64 participants (age 31.7 ± 6.2 y) performed a routine of 15 min of the Stroop test (PsyTool), with 600 tasks and five different colors. Their heart rate…

Approach to the child with fatigue: A focus for the general pediatrician.

BACKGROUND: Fatigue is a common, nonspecific complaint commonly used to describe various conditions, ranging from a vague, subjective sense of weariness to muscular weakness, fatigability, exercise intolerance or excessive daytime somnolence. Despite its high frequency in the general population, literature addressing the approach to the child with fatigue from a general pediatrician perspective is poor. We herein propose a review of the available evidence on the topic, providing a practical framework to assist physicians in dealing with the issue. METHODS: Data were identified by searches of …

Fatigue in an AZ31 Alloy Subjected to Rotary Swaging.

The magnesium AZ31 alloy was swaged with rotary pressure with the aim of redefining the microstructure and improving mechanical and fatigue properties. The rotary swaging process and subsequent ageing improved the yield stress in tension and compression. In the present study, the investigation was focused on fatigue behaviour. The samples were cycled in a symmetric regime with a frequency of 35 Hz. A dependence of the stress amplitude on the number of cycles up to the fracture was estimated. The microstructure of the samples and fracture surfaces was analysed with a scanning electron microscop…