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Атрофия мозга и когнитивное расстройство в начальной и вторичной прогрессивной склерозовой кохёрт-семилярной прогрессивной MS Фенотип.

Диагностика и мониторинг прогрессивного множественного склероза (ПМС) требуют дальнейшей разработки быстрых и эффективных клинических инструментов. Взаимоотношения между показателями атрофии мозга на основе МРТ и когнитивными расстройствами у людей с первичным прогрессивным и вторичным прогрессивным MS (PwPPMS, n = 20 и PwSPMS, n = 19), были исследованы в перспективном исследовании с последующими исследованиями по истечении среднего периода 14,97 ± 4,67 месяца. Анализ МРИ показал, что при исходных условиях и последующей деятельности в рамках PwSPMS левая таламическая фракция и каллосумная фрак

Совпадение в аннотации оригинала
The diagnosis and monitoring of progressive multiple sclerosis (PMS) require further development of fast and effective clinical tools. Relations between MRI-based brain atrophy measures and cognitive impairment in people with primary progressive and secondary progressive MS (PwPPMS, n = 20 and PwSPMS, n = 19, respectively) were investigated in a prospective …

Экономическое бремя вторичного прогрессивного множественного склероза: исследование DISCOVER.

ОКРУЖАЮЩАЯ СРЕДА: Оценить социально-экономическое бремя людей со вторичным прогрессивным множественным склерозом (ПВСПМС), принимая во внимание прямое медико-санитарное обслуживание, прямое немедицинское обслуживание и косвенные издержки, а также оценить взаимосвязь между издержками и функциональными результатами пациентов. МЕТОДЫ: Изучение наблюдений, перекрестных и многоцентральных исследований с ретроспективным сбором данных о реальной клинической практике, полученных в ходе посещения служб неврологии 34 Больницы в период 2019-2020. Клинические данные включали в себя оценки по расширенной ш

Совпадение в аннотации оригинала
BACKGROUND: To estimate the socioeconomic burden of people with secondary progressive multiple sclerosis (pwSPMS), considering direct health care, direct non-health care, and indirect costs, and to evaluate the relationship between costs and patients' functional outcomes. METHODS: Observational, cross-sectional, multicenter study with retrospective real-lif…

Step to the beat: Auditory-motor coupling during walking to higher and lower tempi with music and metronomes in progressive multiple sclerosis: An observational study.

BACKGROUND: Many persons with multiple sclerosis (MS) are confronted with fatigue and difficulties with walking and even more so in persons with progressive subtypes of MS. Task-oriented training, and more specifically in the form of auditory-motor coupling, where persons are asked to synchronise their steps to beats in music and metronomes, is promising. However, it is currently not known whether persons with progressive MS (PwPMS) can synchronise their steps to beats in music and metronomes and if they can adapt their gait to slower and higher tempi. METHODS: The study is a case control stu…

Оценка дисфагии и ее связей у пациентов с вторичным прогрессивным множественным склерозом.

В этом перекрестном исследовании у пациентов с вторичным прогрессивным множественным склерозом, получающих антиCD20 моноколональные антитела, мы провели оценку жалобы на дисфагию и оценили их связь с полом, возрастом, продолжительностью болезни, степенью инвалидности и лечением с целью изменения заболеваний. Была использована проверенная персидская версия вопросника Dysphagia в мультиклерозе (DYMUS). В общей сложности было охвачено 66 пациентов. Средний балл DYMUS составил 1,0 [внутренний диапазон: 0,0-2,3] и 40 (60,6%) был положительным. Только DMT продемонстрировал значительную связь с оценк

Совпадение в аннотации оригинала
In this cross-sectional study in patients with secondary progressive multiple sclerosis receiving anti-CD20 monoclonal antibodies, we assessed complaint of dysphagia and evaluated their association with sex, age, disease duration, disability severity, and disease-modifying therapies (DMTs). The validated Persian version of Dysphagia in Multiple Sclerosis (DY…

Intranasal anti-caspase-1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis.

Inflammatory demyelination and axonal injury in the central nervous system (CNS) are cardinal features of progressive multiple sclerosis (MS), and linked to activated brain macrophage-like cells (BMCs) including resident microglia and trafficking macrophages. Caspase-1 is a pivotal mediator of inflammation and cell death in the CNS. We investigated the effects of caspase-1 activation and its regulation in models of MS. Brains from progressive MS and non-MS patients, as well as cultured human oligodendrocytes were examined by transcriptomic and morphological methods. Next generation transcripti…

Postmortem magnetic resonance imaging to guide the pathologic cut: individualized, 3-dimensionally printed cutting boxes for fixed brains.

Interfacing magnetic resonance imaging (MRI) with pathology is critically important for understanding the pathologic basis of MRI signal changes in vivo and for clinicopathologic correlations. Postmortem MRI is an intermediate step in this process; unfortunately, however, relating the data to standard pathologic sections, which are relatively thick and often nonparallel, is both time-consuming and insufficiently accurate. The aim of this project was to develop technology to integrate postmortem, high-resolution, whole-brain MRI into the planning and execution of pathologic analysis through pre

Abnormalities in normal appearing tissues in early primary progressive multiple sclerosis and their relation to disability: a tissue specific magnetisation transfer study.

BACKGROUND: Patients with primary progressive multiple sclerosis (PPMS) often develop severe disability despite low levels of abnormality on conventional magnetic resonance imaging (MRI). This may relate to diffuse pathological processes occurring in normal appearing brain tissue (NABT) involving both white matter (NAWM) and grey matter (NAGM). Magnetisation transfer imaging (MTI) is capable of identifying these processes and may be particularly informative when applied to patients with early PPMS. AIM: To assess the relationship between abnormalities in NABT identified by MTI and disability …

Tuberculous involvement of the oesophagus with oesophagobroncheal fistula.

Tuberculous involvement of the oesophagus is a rare disease. Even if it is suspected, diagnosis is often difficult though dysphagia and ches … se. The patient was immunocompromised due to treatment with azathioprine that she was receiving for multiple sclerosis. The fistula was successfully treated by antituberculous chemotherapy alone.

Infectious agents and neurodegeneration.

A growing body of epidemiologic and experimental data point to chronic bacterial and viral infections as possible risk factors for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Infections of the central nervous system, especially those characterized by a chronic progressive course, may produce multiple damage in infected and neighbouring cells. The activation of inflammatory processes and host immune responses cause chronic damage resulting in alterations of neuronal function and viability, but different pathogens can also dir

[Prognostics factors of renal failure in multiple sclerosis].

INTRODUCTION: Urinary symptoms occur in 50 to 80% of patients with Multiple Sclerosis (MS). This study was conducted to determine prevalence of renal failure during MS follow-up and to investigate the correlation of these complications with disease characteristics and urodynamic findings. METHODS: One hundred and twenty-one consecutive patients have been followed for (MS) (61 men and 60 women) between 1995 and 2009 in our institution. The demographic findings of patients were documented. The history was obtained and a detailed neurological and urological physical examination was performed for…

Fingolimod inhibits brain atrophy and promotes brain-derived neurotrophic factor in an animal model of multiple sclerosis.

Longitudinal brain atrophy quantification is a critical efficacy measurement in multiple sclerosis (MS) clinical trials and the determination of No Evidence of Disease Activity (NEDA). Utilising fingolimod as a clinically validated therapy we evaluated the use of repeated brain tissue volume measures during chronic experimental autoimmune encephalomyelitis (EAE) as a new preclinical efficacy measure. Brain volume changes were quantified using magnetic resonance imaging (MRI) at 7 Tesla and correlated to treatment-induced brain derived neurotrophic factor (BDNF) measured in blood, cerebrospinal…

The autophagy-senescence-inflammasome axis: A novel triad in neurodegenerative diseases?

Chronic neuroinflammation is a defining feature of brain ageing and neurodegenerative disorders, yet the molecular mechanisms responsible fo … istic hub. Evidence across Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, stroke, and chronic neuropathic pain highlight the broad relevance of this pathological network. We further analyse current therapeutic strategies targeting autophagy, senescence, and inflammasome pathways, emphasising the limitations of single-tar …

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

BACKGROUND: Despite the relative success of immuno-modulatory disease-modifying therapy in relapsing remitting multiple sclerosis, progressive worsening of disability remains a major problem, particularly for those with secondary progressive multiple sclerosis. Various underlying mechanisms are likely to contribute, augmented by comorbidities (such as vascular risk) and ageing. In the phase 2b MS-STAT trial, simvastatin (80 mg) (Sandoz Ltd, Camberley, UK) reduced the mean annualised whole brain atrophy rate by 43% compared to placebo in patients with secondary progressive multiple sclerosis (p…

Коллаген типа I, скрытый в повреждениях белой материи, препятствует восстановлению и функциональному восстановлению.

Повреждения белой материи вызваны церебральным кровопотоком, связанным с инсультом и демиелинизирующими заболеваниями, такими, как множественный склероз. Ремилинизация происходит спонтанно после травмы белой материи, но прогрессирующий множественный склероз и инсульт белой материи обычно характеризуются провалом ремиэлации. Однако механизмы, лежащие в основе слабого воспоминания о повреждениях, вызванных обезвоживанием и инсультом, остаются неясными. В текущем исследовании мы продемонстрировали, что коллагенные волокна, накопившиеся в демиелионированных повреждениях нескольких склерозных пацие

Совпадение в аннотации оригинала
White matter injury is caused by cerebral blood flow disturbances associated with stroke and demyelinating diseases such as multiple sclerosis. Remyelination is induced spontaneously after white matter injury, but progressive multiple sclerosis and white matter stroke are usually characterised by remyelination failure. However, the mechanisms underlying impa…

Evaluation of the relationship between retinal nerve layer thickness and corpus callosum atrophy in MRI with memory impairment in patients with multiple sclerosis.

INTRODUCTION: Multiple sclerosis (MS) is a chronic neurological disease in which demyelination and loss of axons lead to disruption of communication between neurons in the central nervous system. Cognitive impairment occurs in a significant proportion of patients with MS. Therefore, the aim of this study was to investigate the relationship between retinal nerve fiber layer (RNFL) thickness and corpus callosum atrophy in magnetic resonance imaging with memory disorders in patients with MS. METHODS: This descriptive analytical study was performed on patients with a diagnosis of relapsing-remitt…

Beta7 integrins contribute to demyelinating disease of the central nervous system.

A role for alpha4 integrins in different forms of the multiple sclerosis-like disease experimental autoimmune encephalomyelitis (EAE) has been demonstrated, but the individual contributions of alpha4beta1, alpha4beta7, and the related alphaEbeta7 integrin have not been determined. The P7 integrins alpha4beta7 and alphaEbeta7 play a central role in chronic inflammation, mediating the trafficking, entry, and/or adhesion of lymphocytes in the inflamed pancreas and gut, and their ligands MAdCAM-1, VCAM-1 and E-cadherin are expressed on brain endothelial cells and/or on microvessels in the inflamed…

The evolution of criteria for assessing disease activity and progression in multiple sclerosis (or the "saga of acronyms").

Therapeutic advances in multiple sclerosis have led to the evolution of criteria used to assess disease activity and progression. The concept of NEDA aims for the complete absence of clinical and radiological activity but is very strict and difficult to sustain. MEDA was proposed as a more realistic goal, allowing minimal disease activity. Disability progression can no longer be assessed using the EDSS alone, leading to the development of composite measures such as NEP and NEPAD. Studies have shown that most disability worsening occurs independently of relapses, giving rise to the key concept …

Свободный свет о взаимодействии между неврологическими симптомами и психиатрическими эпзодами в множестве склерозов: Новел Гипотез и терапевтические авеню.

Множественный склероз — это хроническое нервно-воспалительное расстройство, при этом различные повреждения центральной нервной системы вызываются в разные моменты времени. Тревожные расстройства и серьезные депрессивные расстройства являются обычным коморбидом множественного склероза. В таких случаях очевидна корреляция между остротой психиатрических приступов и неврологическими симптомами, однако детализированная причинно-следственная связь является неясной. Данные свидетельствуют о том, что дисрегулированные и/или миелин антигенно-реактивные лимфоциты проникают в мозговую ткань, стимулируя п

Совпадение в аннотации оригинала
Multiple sclerosis is a chronic neuroinflammatory disorder, with different central nervous system lesions being induced at distinct time points. Anxiety disorders and major depressive disorder are common comorbidities of multiple sclerosis. In such cases, a correlation between psychiatric episode severity and neurological symptom progression is evident; howe…

HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.

BACKGROUND: The association between multiple sclerosis and class II alleles of the major histocompatibility complex, in particular the DRB1*1501-DQB1*0602 haplotype, is well established but their role in determining specific features of this clinically heterogeneous disease is unknown as few studies involving large sample sizes have been performed. METHODS: 729 patients with multiple sclerosis were typed for the HLA DR15 phenotype. All patients underwent clinical assessment and a detailed evaluation of their clinical records was undertaken. RESULTS: The presence of DR15 was associated with y…

CAR T-клетки сталкиваются с аутоиммунными неврологическими заболеваниями: новый рассвет для терапии.

Аутоиммунный иммунитет и аутоиммунные заболевания возникают тогда, когда иммунная система ошибочно нацеливается на самоантигены, ведущие к повреждению тканей. Следовательно, иммуноводство и в основном иммунно-прессивные препараты представляют собой обычное лечение в таких условиях, как системная волчанка эритематосус, ревматоидный артрит и множественный склероз. Однако многие из этих агентов зачастую не обеспечивают лекарство и имеют предел в лечении симптомов. Это подчеркивает настоятельную необходимость еще более продвинутого лечения пациентов, с тем чтобы ограничить прогрессирующую инвалидн

Совпадение в аннотации оригинала
Autoimmunity and autoimmune diseases arise when the immune system erroneously targets self-antigens leading to tissue damage. Consequently, immunomodulatory and mainly immunosuppressive drugs comprise the conventional treatment in conditions such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, many of these agents often…