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Epidemiology and predictive values of risk factors for neonatal group B streptococcal sepsis.

OBJECTIVES: To determine the incidence of and factors affecting risk factors for neonatal group B streptococcal (GBS) sepsis and their predi … t 26-32 weeks gestation and at delivery, using several screening methods. Clinical risk factors for neonatal sepsis were recorded during labour. MAIN OUTCOME MEASURES: Incidence of antenatal anovaginal GBS carriage and clinical risk factors during labour, their predictive values for intra-partum GBS carriage and their relationship, if any, to demographic and obs …

Association between neonatal sepsis and lung function in school-age children born preterm.

BACKGROUND: Premature birth is associated with long-term respiratory sequelae, and impaired lung function is common in this population. Although bronchopulmonary dysplasia (BPD) is a known risk factor, the long-term impact of neonatal sepsis remains unclear. This study investigated the association between neonatal sepsis and lung function in school-aged children born preterm. METHODS: In this retrospective cohort study, clinical information including neonatal sepsis history was obtained from medical records. Standardized spirometry was performed. Multiple linear regression with sequential adj…

[Lipid metabolomics-based biomarker analysis of neonatal sepsis in serum and cerebrospinal fluid].

Neonatal sepsis remains a leading cause of morbidity and mortality among newborns worldwide. Despite advances in neonatal care， early diagnosis of sepsis remains challenging due to the lack of sensitive and specific biomarkers. While serum-based indicators have been widely studied， lipid metabolism in cerebrospinal fluid （CSF） remains relatively underexplored， limiting our understanding of central nervous system involvement （CNS） in the early stages of neonatal sepsis. This study aimed to systematically investigate lipid metabolic alterations in both serum and CSF samples from neonates with co…

A nonsurgical cecal slurry model for neonatal sepsis: Pathophysiological insights and therapeutic applications.

Neonatal sepsis remains a leading cause of morbidity and mortality worldwide. However, experimental models that accurately reflect the clinical features of neonatal sepsis in preterm infants are limited. The cecal slurry (CS) model is a nonsurgical polymicrobial sepsis model that enables the controlled induction of sepsis in neonatal mice. In this review, we describe the technical details and advantages of the model, including its reproducibility, dose dependency, and applicability to neonatal pups corresponding to term and preterm infants. We also summarize recent applications of the CS model…

Sulodexide attenuates sepsis-induced lung injury in neonatal rats via TNF-α pathway.

BACKGROUND: Neonatal sepsis is a leading cause of morbidity and mortality, often complicated by acute lung injury (ALI). Current treatments lack targeted anti-inflammatory or antioxidant strategies. Sulodexide (SDX), a glycosaminoglycan with endothelial-protective, anti-inflammatory, and antioxidant properties, may offer therapeutic benefit. METHODS: A lipopolysaccharide (LPS)-induced neonatal rat model was used to evaluate the effects of SDX. Following LPS injection, neonatal rats received SDX at different doses. Survival, lung histopathology, wet-to-dry lung weight ratios, and serum procalc…

Construction and validation of neonatal sepsis diagnostic nomograms: a single-site retrospective study.

BACKGROUND: Neonatal sepsis remains a major cause of morbidity and mortality, while blood culture, although considered the diagnostic reference standard, is limited by delayed reporting and reduced sensitivity in routine practice. This study aimed to develop and internally validate practical diagnostic nomograms for neonatal sepsis using routinely available clinical and laboratory data. METHODS: We conducted a single-center retrospective study using medical record and laboratory data from the Children's Hospital of Soochow University between October 13, 2019 and October 13, 2025. After screen…

Effect of Intrapartum Antibiotic Exposure Time on Neonatal Sepsis: A Prospective Cohort Study.

OBJECTIVE: To examine the association between the duration of intrapartum antibiotic exposure (IAE) and the risk of culture-negative early-onset neonatal sepsis (EONS) and any late-onset neonatal sepsis (LONS) in the first week. METHODS: Preterm neonates (≤ 34 weeks) were enrolled into: Group A (no IAE; n = 282), Group B (IAE < 24 h; n = 204) and Group C (IAE ≥ 24 h; n = 84). The risk factors for EONS and LONS were noted and all neonates were followed up for culture-negative EONS (primary outcome). Secondary outcomes included culture-positive EONS, culture-negative and culture-positive LONS, …

Determinants of CRP measurements and CRP dynamics during early neonatal sepsis work up.

C-reactive protein (CRP) is a well-established marker of inflammation in neonates. Recent studies have shown the potential of CRP velocity a … le infants exhibited even higher CRPv values (p = 0.018). Only two cases of blood culture-confirmed neonatal sepsis were identified, with CRPv values of 3.22 and 0.02 mg/L/h., Neither case required NICU admission. Regression analyses revealed that higher gestational age was significantly associated with elevated CRPv levels (p = 0.004) whereas hypothermia was lin …

Bioinformatics-based identification and validation of mitochondria-related genes associated with neonatal sepsis.

BACKGROUND: While mitochondrial involvement in sepsis has been widely studied, its role in neonatal sepsis (NESE) remains unclear. This study aimed to explore the molecular mechanisms of mitochondrial-related genes (MRGs) in NESE using bioinformatics analysis. METHODS: This study utilized neonatal sepsis-related datasets GSE69686 and GSE95233. Differentially expressed genes (DEGs) were identified by comparing NESE and control groups. Subsequently, candidate genes were then selected by intersecting DEGs with MRGs. These candidate genes were further refined using least absolute shrinkage and se…

Corynebacterium amycolatum: an underestimated pathogen in early-onset neonatal sepsis-a case report.

BACKGROUND: Early-onset neonatal sepsis (EOS) is a critical condition primarily caused by maternal-fetal transmission of bacterial pathogens during delivery, with Escherichia coli and Group B Streptococcus being the most prevalent. However, neonatal sepsis can also involve other rare bacteria, including Corynebacterium amycolatum, which was first described in 1988 and is widely recognized as an emerging pathogen in infectious diseases. CASE PRESENTATION: A male infant was admitted to the neonatal intensive care unit (NICU) due to premature birth and tachypnea. His mother had experienced prema…

A 10-Year Study of Neonatal Sepsis from Tuen Mun Hospital, Hong Kong.

BACKGROUND: Neonatal sepsis is a major cause of infant mortality, and it accounts for a significant consumption of antimicrobials in paediatrics. This is the first comprehensive study on neonatal sepsis in Hong Kong. METHODS: From 2014 to 2023, all neonates admitted to a single institution with culture-proven infections from the blood and/or cerebrospinal fluid were selected and reviewed retrospectively. The infecting organisms, their antibiotic nonsusceptibility pattern, and the concordance of empirical antimicrobial therapy with the microbiological profiles were described and were further c…

Utility of doppler ultrasound in early-onset neonatal sepsis: A case-control study.

BACKGROUND: Early-onset sepsis is one of the leading causes of neonatal morbidity and mortality worldwide and timely diagnosis is, therefore, of paramount importance. As there is a lack of literature regarding early alteration of the cerebral blood flow (CBF) in neonatal sepsis, our study aimed to appraise changes in the CBF velocities and Doppler indices in neonates with early-onset neonatal sepsis (EONS) and to assess its diagnostic accuracy. METHODS: A total of 99 neonates were recruited in the study; 56 neonates with EONS, and the age-matched 43 neonates without any manifestations of seps…

Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis.

In adults, liver-resident macrophages, or Kupffer cells (KCs), reside in the sinusoids and sterilize circulating blood by capturing rapidly flowing microbes. We developed quantitative intravital imaging of 1-day-old mice combined with transcriptomics, genetic manipulation, and in vivo infection assays to interrogate increased susceptibility of newborns to bloodstream infections. Whereas 1-day-old KCs were better at catching Escherichia coli in vitro, we uncovered a critical 1-week window postpartum when KCs have limited access to blood and must translocate from liver parenchyma into the sinuso

Epidemiology of late-onset sepsis in Malaysian neonatal intensive care units, 2015-2020.

INTRODUCTION: To determine the epidemiology of blood culture-positive late-onset sepsis (LOS, >72 hours of age) in 44 Malaysian neonatal intensive care units (NICUs). MATERIALS AND METHODS: Study Design: Multicentre retrospective observational study using data from the Malaysian National Neonatal Registry. PARTICIPANTS: 739486 neonates (birthweight ≥500g, gestation ≥22 weeks) born and admitted in 2015-2020. RESULTS: LOS developed in 2707 (0.4%) neonates. Median annual incidence (per 100 admissions) was 12.0 (range: 8.1-13.8) in extremely preterm (EPT, gestation <28 weeks), 5.3 (range: 5.0-6

Association between vancomycin therapeutic drug monitoring and clinical outcomes in treating neonatal sepsis.

BACKGROUND: Neonatal sepsis is commonly treated with vancomycin in the neonatal intensive care unit. Therapeutic drug monitoring of vancomycin is routinely used to personalise dosing to optimise effectiveness and avoid toxicity. OBJECTIVES: This study aimed to define a target range by evaluating associations between vancomycin trough concentrations or area under the concentration time curve over 24 hours (AUC24h) and clinical outcomes in neonates. METHODS: Neonates, who were admitted to the neonatal intensive care unit and received intravenous vancomycin, were included in this retrospective …

Nonfermenting, Gram-Negative Bacilli Causing Neonatal Sepsis in Odisha, India: Four-Year Surveillance.

Introduction In India, blood culture-positive sepsis results in mortality in 33%-35% of affected neonates. Nonfermenting Gram-negative bacilli (NFGNB), particularly Acinetobacter baumannii  and Burkholderia   cepacia commonly cause hospital-acquired infection. Materials and methods We performed a subgroup analysis as part of a prospective study conducted in a neonatal intensive care unit in a tertiary care hospital in Odisha, India, between January 2017 and December 2020. Neonates with blood culture-positive sepsis caused by NFGNB were enrolled in this study. Demographic characteristics of the

Неонатальный сепсис из-за Коксакивируса В3, осложненный печенью и легочным кровоизлиянием.

ЦЕЛИ: Coxsackievirus B3 (CVB3) — однострунная РНК, включенная в категорию "Human Enterovirus B", связанная с многочисленными, даже серьезными проблемами здоровья человека. В связи с инфекциями в организме новорождённых существует угроза для жизни. У новорожденных инфекция может передаваться вертикально, внутриутробно или после родов, а также, возможно, через грудное молоко. Неонатальный сепсис может привести к серьезным осложнениям, таким, как отказ печени и кровоизлияние в лёгкие, с последующей смертью.В отделение скорой помощи был доставлен новорожденный мужского пола с лихорадкой, общей гип

Совпадение в аннотации оригинала
OBJECTIVES: Coxsackievirus B3 (CVB3) is a single-stranded RNA included in the "Human Enterovirus B" category associated with multiple, even … tion can be transmitted vertically, intrapartum or postpartum, and potentially through breast milk. Neonatal sepsis may result in severe complications, such as liver failure and pulmonary hemorrhage, with subsequent death. CASE PRESENTATION: A male newborn was admitted to the emergency department with fever, generalized hypotonia, hypo-reactivity to external sti …

Candida albicans-associated sepsis in a pre-term neonatal rhesus macaque (Macaca mulatta).

Invasive Candida infections (ICI) have been associated with neurodevelopmental impairment or death in human pre-term neonates. Candidiasis in nonhuman primates is seen mostly in immunosuppressed animals, and ICI is not commonly reported. Here, we report a case of Candida albicans-associated ICI in a pre-term neonatal rhesus macaque.

Determinants and Outcome of Community-Acquired Late-Onset Neonatal Sepsis in Rural Bangladesh.

Background. This study examined the sociodemographic as well as other determinants and outcome of community-acquired late-onset neonatal sepsis (LONS) in rural Bangladesh at Matlab. Methods. In this retrospective chart review, we used an unmatched case-control design (1:2 ratio) to evaluate the factors associated with LONS and their outcomes among babies admitted to the neonatal ward of Matlab Hospital of icddr,b, from January 2012 to December 2014. Neonates presenting with any of the clinical signs of serious bacterial infection during 3 to 28 days of life constituted the cases (LONS), and th…