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An analysis of VEP components in optic neuritis.

Various VEP parameters were analysed in 126 patients with multiple sclerosis, isolated optic neuritis or isolated myelopathy. The single most common deviation in eyes with clinical evidence of optic neuritis was a prolongation of the latency to P100. After the findings concerning P100 and N70 were combined two patterns of abnormalities emerged: 1) delayed P100 and delayed N70, 2) delayed P100 and absence of N70. In a few cases only one of the potentials was affected. Also in eyes without clinical evidence of optic neuritis the same patterns occurred but discrepancies between N70 and P100 were …

Corticosteroid therapy for the treatment of optic neuritis.

Optic neuritis is frequently the first clinical sign of multiple sclerosis (MS). Study results indicate that methylprednisolone pulse therapy reduces the rate of development of MS over a two year period. Patients also experience quicker recovery of vision. This short duration therapy presents immediate and intense nursing care challenges. Coordination of care between three departments at the University of Michigan Medical Center enables many patients to complete IV [intravenous] pulse therapy at home. Although coordination is challenging for providers, ambulatory care and home care benefit pat…

A prospective case-control study comparing optical coherence tomography characteristics in neuromyelitis optica spectrum disorder- optic neuritis and idiopathic optic neuritis.

BACKGROUND: Neuromyelitis optica spectrum disorder-optic neuritis (NMOSD-ON) can now be distinguished from other types of ON as a specific disease by the Aquaporin-4 antibody (AQP4-Ab) test. NMOSD-ON can cause severe retinal nerve fiber layer (RNFL) damage. The optical coherence tomography (OCT) characteristics between NMOSD- ON and idiopathic optic neuritis (IDON) were seldom studied in Asians. METHODS: This prospective case-control study involved 152 eyes from 143 optic neuritis (ON) patients. All the patients were divided into either the NMOSD-ON group or the IDON group based on the AQP4-A…

OCT-defined optic atrophy thresholds are associated with blunted optic nerve swelling in recurrent optic neuritis.

BACKGROUND: Acute optic neuritis (ON) can be associated with optic disc edema which can be quantified by optical coherence tomography (OCT) peripapillary retinal nerve fiber layer (RNFL) measurements. In patients with recurrent visual symptoms, objective measures can confirm a new clinical attack. Optic atrophy may preclude RNFL swelling during recurrent ON, but this has not been systematically evaluated. METHODS: Patients with recurrent ipsilateral ON with OCT within 2 weeks of symptoms were retrospectively identified from 8 international centers. RESULTS: We identified 112 patients (MOGAD,…

Experimental optic neuritis induced by the microinjection of lipopolysaccharide into the optic nerve.

Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve which leads to retinal ganglion cell (RGC) loss, and visual dysfunction. We investigated the ability of a single microinjection of bacterial lipopolysaccharide (LPS) directly into the optic nerve to induce functional and structural alterations compatible with ON. For this purpose, optic nerves from male Wistar rats remained intact or were injected with vehicle or LPS. The effect of LPS was evaluated at several time points post-injection in terms of: i) visual pathway and retin…

Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis.

Optical coherence tomography (OCT) is a non-invasive imaging technique routinely used in ophthalmology to visualize and quantify the layers of the retina. It also provides information on optic nerve head topography, peripapillary retinal nerve fiber layer thickness, and macular volume, which correlate with axonal loss. These measurements are of particular interest in optic neuropathies and in multiple sclerosis, and OCT parameters are now used as endpoints in neurologic clinical trials.

Pediatric acute bilateral optic neuritis: A case report.

With the improvement of diagnostic technology, the diagnosis of optic neuritis (ON) has become increasingly accurate. Due to the special characteristics of the pediatric population, there is currently a lack of large-scale studies and related guidelines on pediatric ON. This case report describes the complete diagnosis and treatment process of a 7-year-old male patient with bilateral acute ON, from onset to symptom relief. During the outpatient stage, the patient was suspected of having different types of ON by different departments, but the diagnosis was confirmed through antibody testing aft…

Нетипичное представление оптического неврита в мультиклерозе.

Оптический неврит (ON) — это воспаление зрительного нерва. «Типический» ON обычно ассоциируется с множественным склерозом (MS), и его классическая триада включает внезапную потерю зрения, боль в движении глаз и дишроматопсия. Обычно он имеет хороший визуальный результат независимо от лечения. Помимо этого, представление называется "нетипичным" и к числу причин относятся аутоиммунные заболевания, инфекции и оптическая нейропатия, связанная с системными расстройствами и т.д. Эти случаи требуют особого лечения в зависимости от причины. Поэтому важно проводить различие между "типичным" и "типичным

Совпадение в аннотации оригинала
Optic neuritis (ON) is the inflammation of the optic nerve. 'Typical' ON is commonly associated with multiple sclerosis (MS) and its classic triad includes sudden loss of vision, pain with eye movement and dyschromatopsia. It usually has good visual outcome irrespective of treatment. Presentation other than this is termed as 'atypical' ON and causes include …

Upregulated Retinal Neurofilament Expression in Experimental Optic Neuritis.

In optic neuritis (ON), transient thickening of the macular retinal nerve fibre layer (RNFL) can be observed. This optical coherence tomography-based observation is not understood. The axonal diameter correlates with the neurofilament (Nf) protein content, but there are no data on the retinal tissue concentration of Nfs. The myelin-oligodendrocyte-glycoprotein (MOG) induced experimental autoimmune encephalomyelitis (EAE) model was used to investigate the retinas of Brown Norway rats with (i) visual evoked potentials (VEP) confirmed ON, (ii) VEP confirmed absence of ON and (iii) control animals…

Bilateral Optic Neuritis after COVID-19 mRNA Vaccination.

We report the case of a healthy man who was diagnosed with bilateral optic neuritis after COVID-19 vaccination. A 63-year-old man presented with acute painful blurred vision in his left eye and temporal pain. Eleven days before the appearance of his symptoms, he received the first dose of COVID-19 mRNA vaccination. On examination, his best corrected visual acuity was 20/20 in his right eye and counting fingers in the left eye. Funduscopic examination showed bilateral optic disc swelling, and postcontrast magnetic resonance imaging showed left optic nerve sheath enhancement, consistent with lef…

Optic neuritis in lung adenocarcinoma: A challenging diagnosis.

Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up - including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and ritu…