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Acupuncture for treatment of irritable bowel syndrome.

BACKGROUND: Irritable bowel syndrome (IBS), a disorder of altered bowel habits associated with abdominal pain or discomfort. The pain, disco … treatment was compared to an unclearly specified combination of one or more of the drugs diazepam, perphenazine or domperidone, the difference was not statistically significant with a RR of 1.49(95% CI 0.94 to 2.34; n=48). AUTHORS' CONCLUSIONS: Most of the trials included in this review were of poor quality and were heterogeneous in terms of interventions, c …

Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments (SMART-CAT) in first-episode schizophrenia patients: Rationale and trial design.

Accumulated studies have investigated pharmacological interventions for first-episode schizophrenia (FES) patients. However, studies on subs … y assigned to one of the treatments with oral olanzapine, risperidone, amisulpride, aripiprazole or perphenazine. Subjects who fail to respond after 8 weeks will enter the phase 2 randomization. Phase 2 is an equipoise-stratified randomization trial, and patients will be randomly assigned to oral olanzapine, amisulpride or clozapine for 8 weeks. Subjects who f …

[Clozapine and pregnancy].

UNLABELLED: This article reviews the relations between clozapine and pregnancy. Six case reports are identified in the literature of pregnan … following can be recommended: 1) Increase the clozapine dosage; 2) Add a classic antipsychotic like perphenazine, trifluoperazine or haloperidol. Diabetes: obesity, glucose intolerance or a family history of diabetes are risk factors to develop gestational diabetes. The follow-up of patients, who take an atypical antipsychotic, should include constant monitori …

Окисляющий стресс как терапевтическая цель в амиотропическом боковом склерозе: возможности и ограничения.

Амиотропический боковой склероз (ALS), известный также как болезнь моторных нейронов (MND) и болезнь Лу Гехрига, характеризуется потерей нижних моторных нейронов в спинном мозге и верхних моторных нейронов в коре головного мозга. Ввиду сложного и многофакторного характера различных факторов и механизмов риска, связанных с механическим нейронным дегенерацией, патологические механизмы БАС не в полной мере понимаются. Окисляющий стресс one из известных причин патогенез АБС. Это наблюдалось у пациентов, а также у клеточных и животных моделей и, как известно, вызывало митохондриальную дисфункцию и

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… Although the genetic deletion of NOX2 did not affect survival or neurochemical markers (GFAP, Iba-1, and CD68) in SOD1 G93A mice [ 101 ], pharmacological NOX inhibitors (perphenazine and thioridazine) could reduce NOX activity and superoxide levels in the spinal cord of SOD1 G93A mice [ 101 ]. … reactive gliosis | [ 96 ] AM1241 | SOD1 G93A mice | 1 mg/kg/day, i.p. | (1) Delayed motor impairment and disease progression (paralysis score and weight loss) (2) Increased mice survival | [ 96 ] Modification of oxidative stress-related factors | NOX2 deletion | NOX2 knockout mice with SOD1 G93A mice | Perphenazine …

A Transcriptome-Based Drug Discovery Paradigm for Neurodevelopmental Disorders.

Advances in genetic discoveries have created substantial opportunities for precision medicine in neurodevelopmental disorders. Many of the genes implicated in these diseases encode proteins that regulate gene expression, such as chromatin-associated proteins, transcription factors, and RNA-binding proteins. The identification of targeted therapeutics for individuals carrying mutations in these genes remains a challenge, as the encoded proteins can theoretically regulate thousands of downstream targets in a considerable number of cell types. Here, we propose the application of a drug discovery

What Zebrafish and Nanotechnology Can Offer for Cancer Treatments in the Age of Personalized Medicine.

Cancer causes millions of deaths each year and thus urgently requires the development of new therapeutic strategies. Nanotechnology-based anticancer therapies are a promising approach, with several formulations already approved and in clinical use. The evaluation of these therapies requires efficient in vivo models to study their behavior and interaction with cancer cells, and to optimize their properties to ensure maximum efficacy and safety. In this way, zebrafish is an important candidate due to its high homology with the human genoma, its large offspring, and the ease in developing specifi

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… Perphenazine (PPZ), a drug approved for psychosis therapy, was found to be effective against T-cell acute lymphoblastic leukemia (T-ALL) in a combined screening for small molecules with toxic effect in MYC-overexpressing thymocytes in zebrafish and T-ALL cells [ 199 ]. … NDMA | N-nitrosodimethylamine NF1 | Neurofibromin 1 NK | Natural killer cells PARP | Poly ADP ribose polymerase PC | Pancreatic cancer PD-1 | Programmed cell death-1 PDAC | Pancreatic ductal adenocarcinoma PD-L1 | Programmed cell death ligand-1 PDX | Patient Derived Xenografts PlexA1 | Plexin-A1 PPZ | Perphenazine …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… hydromorphone”, “oxycodone”, “hydrocodone”, “fentanyl”, “methadone”, “morphine”, “codeine”, “butorphanol”, “nalbuphine”, “tramadol”, “tapentadol”, “meperidine”, “buprenorphine”, “oxymorphone” | Antipsychotics | “chlorpromazine”, “thioridazine”, “mesoridazine”, “levomepromazine”, “loxapine”, “molindone”, “perphenazine …

The expert consensus guideline series. Treatment of behavioral emergencies 2005.

OBJECTIVES: Due to inherent dangers and barriers to research in emergency settings, few data are available to guide clinicians about how bes … tial treatment with olanzapine or quetiapine is unsuccessful, increasing the dosage is recommended. Perphenazine was consistently rated second line and droperidol and chlorpromazine received third-line ratings throughout. CONCLUSIONS: Within the limits of expert opinion and with the expectation that future research data will take precedence, these guidelines …

The Future of Oncology in Psychiatric Medications.

Recent years have provided numerous reports on the mechanisms of action of psychiatric medications (antidepressants, antipsychotics, mood stabilizers, and antidementia drugs) that directly inhibit the growth of cancer cells, as well as on their indirect effects on the psyche and immune system, and their supportive effects on chemotherapeutic agents. The mechanisms of the anticancer activity of psychiatric drugs include inhibition of dopamine and N-methyl-D-aspartate receptors that work via signaling pathways (PI3K/AKT/mTOR/NF-κB, ERK, Wnt/ß-catenin, and bcl2), metabolic pathways (ornithine dec

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… sarcoma iloperidone | - breast, colorectal cancer, glioblastoma olanzapine | - breast, lung, pancreatic cancer, glioblastoma, glioma, lymphoblastoma penfluridol | - breast, colorectal, esophageal, gallbladder, liver, lung, pancreatic, prostate, renal cancer, glioblastoma, glioma, leukemia, melanoma perphenazine …

Emerging therapeutic strategies in glioblastsoma: drug repurposing, mechanisms of resistance, precision medicine, and technological innovations.

Glioblastoma (GBM) is an aggressive Grade IV brain tumor with a poor prognosis. It results from genetic mutations, epigenetic changes, and factors within the tumor microenvironment (TME). Traditional treatments like surgery, radiotherapy, and chemotherapy provide limited survival benefits due to the tumor's heterogeneity and resistance mechanisms. This review examines novel approaches for treating GBM, focusing on repurposing existing medications such as antipsychotics, antidepressants, and statins for their potential anti-GBM effects. Advances in molecular profiling, including next-generation

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… Drug repurposing candidates Typical antipsychotics (APs) Antipsychotic drugs (Aps), such as haloperidol, trifluoperazine, fluphenazine, thioridazine, perphenazine, and chlorpromazine, are primarily used to treat psychosis, schizophrenia, bipolar disorder, and Tourette syndrome. … Preclinical studies show that fluoxetine effectively reduces GBM growth, comparable to TMZ, and enhances the effects of imatinib when combined with sertraline and perphenazine [ 119 ]. These findings suggest its potential for combination therapies in GBM treatment. …

Targeting Reactive Oxygen Species Capacity of Tumor Cells with Repurposed Drug as an Anticancer Therapy.

Accumulating evidence shows that elevated levels of reactive oxygen species (ROS) are associated with cancer initiation, growth, and response to therapies. As concentrations increase, ROS influence cancer development in a paradoxical way, either triggering tumorigenesis and supporting the proliferation of cancer cells at moderate levels of ROS or causing cancer cell death at high levels of ROS. Thus, ROS can be considered an attractive target for therapy of cancer and two apparently contradictory but virtually complementary therapeutic strategies for the regulation of ROS to treat cancer. Desp

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… In vitroanticancer activity of fluphenazine, perphenazine and prochlorperazine. A review Journal of Applied Toxicology 2021 41 1 82 94 10.1002/jat.4046 32852120 162 Xu F. Xia Y. Feng Z. …

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps.

Leishmaniasis is a neglected tropical disease endemic primarily to low- and middle-income countries, for which there has been inadequate development of affordable, safe, and efficacious therapies. Clinical manifestations of leishmaniasis range from self-healing skin lesions to lethal visceral infection with chances of relapse. Although treatments are available, secondary effects limit their use outside the clinic and negatively impact the quality of life of patients in endemic areas. Other non-medicinal treatments, such as thermotherapies, are limited to use in patients with cutaneous leishman

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… Biological Impact in Leishmaniasis | Beneficial to | State of Testing for Leishmaniases | Refs Rifabutin | HIV+ Tuberculosis | FDA Approved | RNA Polymerase inhibitor for Gram + bacteria, Leishmanicidal | Leishmanicidal effect | CL/MCL ( L. braziliensis, L. panamensis) | in silico, in vitro | [ 79 ] Perphenazine …

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.

BACKGROUND: Postoperative nausea and vomiting (PONV) is a common adverse effect of anaesthesia and surgery. Up to 80% of patients may be aff … granisetron, haloperidol, meclizine, methylprednisolone, metoclopramide, ondansetron, palonosetron, perphenazine, promethazine, ramosetron, rolapitant, scopolamine, and tropisetron) compared to placebo (inactive control). We performed network meta-analyses (NMAs) to estimate the relative effects and ranking (with placebo as reference) of all available single d …

The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction.

PURPOSE: Erectile dysfunction (ED) is one of the most prevalent male sexual dysfunctions. ED has been in the past mistakenly considered a purely psycho-sexological symptom by patients and doctors. However, an ever-growing body of evidence supporting the role of several organic factors in the pathophysiological mechanisms underlying ED has been recognized. METHODS: The Italian Society of Andrology and Sexual Medicine (SIAMS) commissioned an expert task force involving several other National Societies to provide an updated guideline on the diagnosis and management of ED. Derived recommendations

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… Among anti-psychotics, quetiapine, ziprasidone, perphenazine, aripiprazole and brexpiprazole (with the last two associated with the lowest impact on sexual life) have been related to lower rates of sexual dysfunction (16–27%), when compared to olanzapine, risperidone, haloperidol, and clozapine (40–60% …

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