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The Kaleidoscope of Polyautoimmunity: An Odyssey of Diagnostic Dilemmas.

Diagnostic accuracy is of the utmost importance, both in the clinical setting and for research purposes. Mixed connective tissue disease (MCTD), rheumatoid arthritis (RA), Sjogren's syndrome (SS), and overlap syndrome (OS) frequently exhibit symptoms that mimic those of other conditions. Unfortunately, there is no singular definitive test for diagnosing these connective tissue diseases (CTDs), necessitating the reliance on expert opinions. Further complicating the matter, these diseases have overlapping clinical and serological features, and some individuals with one autoimmune disease may dev…

Leveraging stories of cardiac amyloidosis patients of African ancestry or descent to support patient-derived data elements for efficient diagnosis and treatment.

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… Rheum. Dis. Clin. 48 (1), 245–258. Available at:. 10.1016/j.rdc.2021.08.004 Tran D., Li B., Heeg B., Bambri R., Stewart M., Grima D., et al. (2020). Impact of tafamidis on life expectancy and quality of life of transthyretin amyloid cardiomyopathy patients. J. …

Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia.

OBJECTIVES: This study aims to investigate dynamic thiol/disulphide homeostasis in patients with fibromyalgia syndrome (FMS). PATIENTS AND METHODS: Fifty female patients with FMS (mean age 40.5±7.2 years; range 21 to 55 years) and 40 healthy female controls (mean age 39±9.4 years, range 22 to 55 years) were included in the study. Pain visual analog scale, tender points, Fibromyalgia Impact Questionnaire, and Beck Depression Inventory were evaluated. Age, body mass index (BMI), and symptom durations were also recorded. Native thiol, disulphide and total thiol levels were measured with a novel

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… Arthritis Rheum 1990;33:160-72. 23. Burckhardt CS, Clark SR, Bennett RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol 1991;18:728-33. 24. Sarmer S, Ergin S, Yavuzer G. …

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

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Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review.

Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological

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… Arthritis Rheum. 2007;57:1473–1480. doi: 10.1002/art.23085. 183. Pileri A, Baraldi C, Broccoli A, Maglie R, Patrizi A, Zinzani P, et al. Cutaneous leukocytoclastic vasculitis in B-cell chronic lymphocytic leukemia patients. … Semin Arthritis Rheum. 2013;43:362–366. doi: 10.1016/j.semarthrit.2013.07.002. 193. Youinou P, Mackenzie LE, Lamour A, Mageed RA, Lydyard PM. Human CD5-positive B cells in lymphoid malignancy and connective tissue diseases. …

Disseminated herpes zoster encephalitis induced by low-dose corticosteroids.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Int J Rheum Dis. 2020;23(2):197–202. doi: 10.1111/1756-185X.13725. 3. Ferreira J.C., Marques H.H., Ferriani M.P., et al. Herpes zoster infection in childhood-onset systemic lupus erythematosus patients: a large multicenter study. Lupus. 2016;25(7):754–759. doi: 10.1177/0961203315627203. 4. …

Joint Pain and Arthritis as First Clinical Manifestation of Systemic Amyloidosis and Multiple Myeloma: Case Report and Brief Literature Review.

Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a d

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… Arthritis Rheum. 2013;43:405–412. doi: 10.1016/j.semarthrit.2013.07.004. 9. Pessler F., Ogdie A.R., Mayer C.T., Kretzschmar W.W., Dai L., Elsaman A.M., Einhorn E., Krenn V., Schumacher H.R. …

Disappearance of femoral head shortly after femoral neck fracture: a case report and literature review.

This case report describes a woman in her 70s who presented with a 3-month history of hip pain and inability to walk. Upon admission, she was diagnosed with the extremely rare condition of complete femoral head disappearance. A comprehensive examination was conducted to determine the cause and devise an effective treatment strategy, taking the patient's medical history into account. Through interdisciplinary discussions, occult infection and other potential causes were ruled out. The femoral head disappearance was ultimately determined to be due to wear, ischemia, and absorption following a fr

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… Ann Rheum Dis 1962 ; 21 : 23 – 30 . 18623865 10.1136/ard.21.1.23 PMC1007248 15 Wang J Zhang Y Zhao C , et al . Femoral head necrosis due to Brucella infection in China: case series and literature review . …

Acute kidney injury following CAR-T cell therapy: a nephrologist's perspective.

Chimeric antigen receptor T (CAR-T) cell therapy, an emerging personalized immunotherapy for various haematologic malignancies, autoimmune diseases and other conditions, involves the modification of patients' T cells to express a chimeric antigen receptor that recognizes tumour or autoimmune cell antigens, allowing CAR-T cells to destroy cancerous and other target cells selectively. Despite remarkable clinical improvements in patients, multiple adverse effects have been associated with CAR-T cell therapy. Among the most recognized adverse effects are cytokine release syndrome, immune effector

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… Ann Rheum Dis 2023;82:93–4. 44. Taubmann J, Knitza J, Müller F et al. Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies. Rheumatology (Oxford) 2024;63:e12–4. 10.1093/rheumatology/kead330 45. … Ann Rheum Dis 2023;82:1117–20. 10.1136/ard-2023-223952 46. Müller F, Boeltz S, Knitza J et al. CD19-targeted CAR T cells in refractory antisynthetase syndrome. Lancet 2023;401:815–8. 10.1016/S0140-6736(23)00023-5 47. Melilli E, Mussetti A, Linares GS et al. …

Реальная эффективность вакцины против рекомбинантного зостера ≥50- Взрослые, страдающие аутоиммунными заболеваниями.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Данные реального мира об эффективности вакцины (ВЭ) прилегающей рекомбинантной вакцины от зостера (ВЗВ) для предотвращения герпеса зостера (ВЗ) у лиц с аутоиммунными заболеваниями (АИД) ограничены. Для устранения этого пробела в знаниях мы намеревались провести оценку VE 2 Дозы RZV против HZ в ≥50- взрослые в возрасте от одного года с отобранными АИД (ремуматоидный артрит, воспалительный кишечник, системный волшебный эритематос, множественный склероз (MS), псориаз (PsO) и псориатический артрит). Мы провели ретроспективное когортное исследование с использованием деидентиф

Совпадение в аннотации оригинала
BACKGROUND: Real-world data on the vaccine effectiveness (VE) of the adjuvanted recombinant zoster vaccine (RZV) to prevent herpes zoster (HZ) among individuals with autoimmune diseases (AIDs) are limited. To address this knowledge gap, we aimed to evaluate the VE of 2 RZV doses against HZ in ≥50-year-old adults with selected AIDs (rheumatoid arthritis, infl…

Current advancements in cellular immunotherapy for autoimmune disease.

The management of autoimmune diseases is currently limited by therapies that largely suppress the immune system, often resulting in partial and temporary remissions. Cellular immunotherapies offer a targeted approach by redirecting immune cells to correct the underlying autoimmunity. This review explores the latest advances in cellular immunotherapies for autoimmune diseases, focusing on various strategies, such as the use of chimeric antigen receptor (CAR) T cells, chimeric auto-antibody receptor (CAAR) T cells, regulatory T cells (Tregs), and tolerogenic dendritic cells (TolDCs). We review r

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… Ann Rheum Dis 82(8):1117–1120 54. … Ann Rheum Dis 83(4):543–546 55. Kasperkiewicz M, Ellebrecht CT, Takahashi H, Yamagami J, Zillikens D, Payne AS, Amagai M (2017) Pemphigus Nat Rev Dis Primers 3:17026 56. …

Etodolac improves collagen induced rheumatoid arthritis in rats by inhibiting synovial inflammation, fibrosis and hyperplasia.

Synovial hyperplasia is the main cause of chronic rheumatoid arthritis (RA), but the mechanism of synovial hyperplasia is still unclear. Etodolac (ETD) is a selective COX-2 inhibitor for relieving pain and stiffness in RA, but the disease modifying effect is still lack of evidence. Proteomics method was used to study the differential proteome of synovial tissue in collagen induced arthritis (CIA) in rats. With the help of STRING analysis, the upregulated proteins enriched in the cluster of complement and coagulation cascades and platelet degranulation were highlighted, these proteins with fibr…

Diagnostic imaging for spinal disorders in the elderly: a narrative review.

The high prevalence of neck and low back pain in the rapidly aging population is associated with significant increases in health care expenditure. While spinal imaging can be useful to identify less common causes of neck and back pain, overuse and misuse of imaging services has been widely reported. This narrative review aims to provide primary care providers with an overview of available imaging studies with associated potential benefits, adverse effects, and costs for the evaluation of neck and back pain disorders in the elderly population. While the prevalence of arthritis and degenerative

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… Arthritis Rheum. 2008;58:15–25. doi: 10.1002/art.23177. Aebi M. The adult scoliosis. Eur Spine J. 2005;14:925–948. doi: 10.1007/s00586-005-1053-9. Moxon J, Parr A, Emeto T, Walker P, Norman P, Golledge J. Diagnosis and monitoring of abdominal aortic aneurysm: Current status and future prospects. … Arthritis Rheum. 2009;60:3072–3080. doi: 10.1002/art.24853. Simmons ED, Guyer RD, Graham-Smith A, Herzog R. Radiograph assessment for patients with low back pain. Spine J. 2003;3:3–5. doi: 10.1016/S1529-9430(02)00454-0. Savigny P, Watson P, Underwood M. …

Neutrophil extracellular traps in homeostasis and disease.

Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the

Применение периферального магнитного стимула в процессе реабилитации: обзор.

Перпериферийная магнитная стимуляция все чаще используется для лечения дисфункций, связанных с различными расстройствами. Однако в настоящее время отсутствует консенсус в отношении его эффективности применительно к конкретным группам населения, болезням, условиям вмешательства, продолжительности лечения или результатам. Цель этого аналитического обзора заключалась в выявлении, обобщении и составлении карт соответствующей литературы по периферической магнитной стимуляции с уточнением ее применения в разбивке по типам заболеваний, участку лечения, функциональным дефектам, результатам и условиям

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… Int J Rheum Dis 2016 ; 19 : 287 – 293 . 10.1111/1756-185X.12565 25955771 43 Bölükbaş N , Vural M , Karan A , Yalçin O , Eskiyurt N : Effectiveness of functional magnetic versus electrical stimulation in women with urinary incontinence . …

Emerging therapeutics in the management of COVID-19.

The severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) pandemic has placed a tremendous burden on healthcare systems globally. Therapeutics for treatment of the virus are extremely inconsistent due to the lack of time evaluating drug efficacy in clinical trials. Currently, there is a deficiency of published literature that comprehensively discusses all therapeutics being considered for the treatment of COVID-19. A review of the literature was performed for articles related to therapeutics and clinical trials in the context of the current COVID-19 pandemic. We

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… Radin AR van Adelsberg J Fiore S Huang X Yancopoulos GD Stahl N Genovese MC Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial Ann Rheum …

BCMA/CD19 CAR T cell therapy for refractory myasthenia gravis: Proteomic signatures and single-cell transcriptomics of disease flares.

Myasthenia gravis (MG) is an autoimmune disorder characterized by B cell dysfunction. Here, we designed B cell maturation antigen (BCMA)/CD19 chimeric antigen receptor T cell (CAR T cell) therapy for six refractory MGs, demonstrating favorable safety with grade 1 cytokine release syndrome observed. CAR T cell expansion induced profound B cell depletion, a sustained reduction in acetylcholine receptor (AChR) antibody titers, and symptom improvement. Five patients achieved drug-free remission with minimal manifestations by month 6, persisting through the 12-month follow-up despite B cell reconst

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… Rheum. Dis. 83 , 1409 – 1420 ( 2024 ). 38777374 10.1136/ard-2024-225727 19 D. B. Sanders , G. I. Wolfe , M. Benatar , A. Evoli , N. E. Gilhus , I. Illa , N. Kuntz , J. M. Massey , A. Melms , H. Murai , M. Nicolle , J. Palace , D. P. Richman , J. Verschuuren , P. … Rheum. Dis. 83 , 1304 – 1314 ( 2024 ). 38777376 10.1136/ard-2024-225785 29 M. Shi , J. Wang , H. Huang , D. Liu , H. Cheng , X. Wang , W. Chen , Z. Yan , W. Sang , K. Qi , D. Li , F. Zhu , Z. Li , J. Qiao , Q. Wu , L. Zeng , X. Fei , W. Gu , Y. Miao , K. Xu , J. Zheng , J. …

Autoimmune Diseases and Plasma Cells Dyscrasias: Pathogenetic, Molecular and Prognostic Correlations.

Multiple myeloma and monoclonal gammopathy of undetermined significance are plasma cell dyscrasias characterized by monoclonal proliferation of pathological plasma cells with uncontrolled production of immunoglobulins. Autoimmune pathologies are conditions in which T and B lymphocytes develop a tendency to activate towards self-antigens in the absence of exogenous triggers. The aim of our review is to show the possible correlations between the two pathological aspects. Molecular studies have shown how different cytokines that either cause inflammation or control the immune system play a part i

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… Rheum. Dis. 2014;17:635–639. doi: 10.1111/1756-185X.12267. 10. Kyle R.A., Durie B.G., Rajkumar S.V., Landgren O., Blade J., Merlini G., Kröger N., Einsele H., Vesole D.H., Dimopoulos M., et al. … Rheum. Dis. 1992;51:951–954. doi: 10.1136/ard.51.8.951. 94. Ardalan M.R., Shoja M.M. Multiple myeloma presented as acute interstitial nephritis and rheumatoid arthritis-like polyarthritis. Am. J. Hematol. 2007;82:309–313. doi: 10.1002/ajh.20796. 95. …

Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis.

Osteoarthritis (OA) is a degenerative joint disease and an important cause of incapacitation. There is a lack of drugs and effective treatments that stop or slow the OA progression. Modern pharmacological treatments, such as analgesics, have analgesic effects but do not affect the course of OA. Long-term use of these drugs can lead to serious side effects. Given the OA nature, it is likely that lifelong treatment will be required to stop or slow its progression. Therefore, there is an urgent need for disease-modifying OA treatments that are also safe for clinical use over long periods. Phytonu

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… Arthritis Rheum. 2008;58:26–35. doi: 10.1002/art.23176. 2. Suri P., Morgenroth D.C., Hunter D.J. Epidemiology of osteoarthritis and associated comorbidities. PM&R. 2012;4:S10–S19. doi: 10.1016/j.pmrj.2012.01.007. 3. Loeser R.F., Goldring S.R., Scanzello C.R., Goldring M.B. … Rheum. Dis. 1995;54:289–297. doi: 10.1136/ard.54.4.289. 76. Burrage P.S., Mix K.S., Brinckerhoff C.E. Matrix metalloproteinases: Role in arthritis. Front. Biosci. 2006;11:529–543. doi: 10.2741/1817. 77. Feng Z., Lian K. …

Emerging strategies and therapies for treatment of Paget's disease of bone.

Paget's disease of bone (PDB) is a progressive monostotic or polyostotic metabolic bone disease characterized by focal abnormal bone remodeling, with increased bone resorption and excessive, disorganized, new bone formation. PDB rarely occurs before middle age, and it is the second most frequent metabolic bone disorder after osteoporosis, affecting up to 3% of adults over 55 years of age. One of the most striking and intriguing clinical features is the focal nature of the disorder, in that once the disease is established within a bone, there is only local spread within that bone and no systemi

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… Arthritis Rheum. 1980;23(10):1095–1103. doi: 10.1002/art.1780231005. 6. Eekhoff ME, van der Klift M, Kroon HM, et al. Paget’s disease of bone in The Netherlands: A population-based radiological and biochemical survey – the Rotterdam Study. … Semin Arthritis Rheum. 1994;23(4):273–275. doi: 10.1016/0049-0172(94)90061-2. 127. Siris E, Weinstein RS, Altman R, et al. Comparative study of alendronate versus etidronate for the treatment of Paget’s disease of bone. …