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Xenotropic murine leukemia virus-related virus is not associated with chronic fatigue syndrome in patients from different areas of the us in the 1990s.

BACKGROUND: In 2009, xenotropic murine leukemia virus-related virus (XMRV) was reported in 67% of patients with chronic fatigue syndrome (CFS) compared to 4% of controls. Since then numerous reports failed to detect XMRV in other cohorts of CFS patients, and some studies suggested that XMRV sequences in human samples might be due to contamination of these samples with mouse DNA. RESULTS: We determined the prevalence of XMRV in patients with CFS from similar areas in the United States as the original 2009 study, along with patients with chronic inflammatory disorders and healthy persons. Using…

Prolonged impact of chemotherapy on fatigue in breast cancer survivors: a longitudinal comparison with radiotherapy-treated breast cancer survivors and noncancer controls.

BACKGROUND: In this study, the authors examined the influence of prior treatment on the course of fatigue in breast cancer survivors. Patients who received chemotherapy were expected to have greater fatigue than patients who received radiotherapy and noncancer controls 6 months after the completion of treatment, but they were expected to recover to levels similar to those of the other 2 groups 3 years later. METHODS: Patients with stage 0 through II breast cancer completed the Fatigue Symptom Inventory (FSI) and the Profile of Mood States Fatigue Scale (POMS-FAT) 6 months (T1) and 42 months (…

Patient-reported outcomes in primary Sjogren's syndrome: comparison of the long and short versions of the Profile of Fatigue and Discomfort--Sicca Symptoms Inventory.

OBJECTIVES: The long-form 64-item Profile of Fatigue and Discomfort--Sicca Symptoms Inventory (PROFAD-SSI) questionnaire was developed as a patient-reported assessment tool for use in primary SS (PSS) and other rheumatic disorders. In this study, we assess whether the (shorter and more practical) 19-item PROFAD-SSI-SF (short form) gives similar results and whether a still briefer version using visual analogue scales (VASs) is feasible. METHODS: Questionnaire surveys comprising the long and short versions of the PROFAD-SSI were mailed to 43 patients with PSS and 50 patients with RA, who were a…

Patterns of objective physical functioning and perception of mood and fatigue in posttreatment breast cancer patients and healthy controls: an ambulatory psychophysiological investigation.

OBJECTIVE: To monitor objective physiological and self-report measures among apparently disease-free breast cancer patients (n = 33) in the … etry activity were measured during one day, together with multiple repeated assessments of mood and fatigue. Traditional retrospective measures of well-being were also evaluated. Our ambulatory methodology permitted estimation of physiological rhythms of cardiorespiratory and accelerometry activity. RESULTS: Patients reported lower ambulatory levels of e …

Long-term follow-up of patients from the 1989 Q fever outbreak: no evidence of excess cardiac disease in those with fatigue.

BACKGROUND: In 1989, an outbreak of Q fever (C. burnetii infection) with 147 confirmed cases occurred in Solihull, West Midlands. Three patients developed cardiomyopathy in the subsequent 10 years. The cohort has been followed up with respect to the development of fatigue and, in this instance, cardiac effects after the original infection. AIM: To determine whether persisting fatigue after Q fever represented sub-clinical cardiomyopathy. DESIGN: Prospective follow-up study. METHODS: All traceable subjects from the original outbreak, and community age-, sex- and smoking-matched controls, wer…

Стойкость энтеровиральной РНК в синдроме хронической усталости связана с аномальным производством равных количеств положительных и отрицательных нити энтеровиральной РНК.

Фрагмент субгеномного ограничения от CDNA, полученный из вируса Коксаки В2 (CVB2), был подколон в вектор реберопробы, позволяющий производить зонды РНК, характерные для данной группы, в дополнение либо к позитивной (геномической) или отрицательной (временной) нити интрозовиральной РНК. Эти рибопробы использовались для наблюдения за продуктивной инфекцией культивированных клеток CVB2; как и ожидалось, позитивная траектория RNA была синтезирована примерно в 100 раз избытком над отрицательной нитью. РНК была извлечена из мышечной биопсии у пациентов с хроническим синдромом усталости и проведена п

Совпадение в аннотации оригинала
A subgenomic restriction fragment from cDNA prepared from Coxsackie B2 virus (CVB2) RNA was subcloned into a riboprobe vector allowing the p … xcess over negative strand. RNA was extracted from muscle biopsy samples from patients with chronic fatigue syndrome and probed for the presence of enteroviral RNA. In cases where enteroviral RNA was detected the amounts of positive and negative strands of enteroviral RNA were approximately equal, in contrast to the situation in lytic infection of culture …

Acute caffeine and carbohydrate strategies for fatigue-related sport-specific performance in team-sport athletes: a systematic review and multilevel meta-analysis.

BACKGROUND: Although caffeine and carbohydrate are established ergogenic strategies for physical performance, it remains unclear whether these benefits translate to the decision-making and sport-specific skills that determine team-sport performance under fatigue. METHODS: PubMed, Web of Science Core Collection, and SPORTDiscus were searched on 28 July 2026. Thirty-one reports were retained; their reported analyzed sample sizes summed to 441 athletes. Twenty-three independent quantitative study clusters, with reported analyzed sample sizes summing to 341 athletes, contributed 67 effects. Multi…

Associations of psychological resilience and change fatigue with innovative behavior among hemodialysis nurses in Chinese public hospitals: a cross-sectional mediation analysis.

BACKGROUND: Against the backdrop of continuously rising demand for healthcare services and an increasingly scarce nursing workforce, innovat … ent sector. OBJECTIVE: This study examined the associations of psychological resilience and change fatigue with innovative behavior among hemodialysis nurses in Chinese public hospitals, and explored whether change fatigue was statistically indirectly associated with the relationship between psychological resilience and innovative behavior, aiming to pro …

Sustaining presence under depletion: A grounded theory study of family-centered care, compassion fatigue, and nursing-sensitive quality outcomes in pediatric settings.

BACKGROUND: Pediatric nurses face challenges delivering family-centered care while managing compassion fatigue, with potential consequences for care quality and patient safety. AIM: This study explored the social processes through which pediatric nurses navigate family-centered care and compassion fatigue, and how these were perceived to shape nursing-sensitive quality outcomes. METHOD: A constructivist grounded theory design was employed. Twenty-two pediatric and neonatal intensive care nurses participated in semi-structured interviews. Data collection and constant comparative analysis occu…

Effects of demineralization around orthodontic brackets bonded with different adhesive agents on fatigue-based shear bond strength: an in vitro comparative study.

BACKGROUND AND AIM: There is limited evidence regarding the effect of demineralization around orthodontic brackets on shear bond strength (SBS). The aim of this in vitro fatigue study was to evaluate the effect of demineralization developing around orthodontic brackets bonded with different adhesive agents on fatigue-based SBS under laboratory conditions. METHODS: A total of 60 extracted human maxillary premolars bonded with Gemini metal brackets were randomly allocated into three groups (n = 20). Bracket bonding was performed using Transbond™ XT (acid etching + primer + adhesive) in Group 1,…

Compassion Fatigue as a Mediator Between Emotional Intelligence and Marital Anxiety Among Unmarried Mental Health Professionals Working in Family and Social Services.

Professionals working in family and social services are frequently exposed to emotionally demanding interpersonal experiences, which may influence both their occupational well-being and their perceptions of close relationships. This study was conducted to examine the mediating role of compassion fatigue in the relationship between emotional intelligence and marital anxiety among unmarried mental health professionals in Türkiye. The sample consisted of 311 unmarried mental health workers, including psychologists, social workers, and psychological counselors employed in provincial directorates o…

Dynamic Cyclic Fatigue Resistance and Bending Stiffness of Blue-Treated NiTi Rotary Instruments at Simulated Intracanal Temperature: A Comparative In Vitro Study.

BACKGROUND: To compare the dynamic cyclic fatigue resistance, bending stiffness and phase transformation characteristics of blue heat-treated instruments, VDW Rotate (VR) and Azur Blue (AzB), at a simulated intracanal temperature of 34 ± 1°C. METHODS: Fifty-eight new instruments (n=29 per group) were allocated as follows: dynamic cyclic fatigue testing (n=12), bending stiffness evaluation (n=12), differential scanning calorimetry (DSC) (n=1), X-ray diffraction (XRD) (n=2) and energy-dispersive X-ray fluorescence (EDXRF) (n=2). Dynamic cyclic fatigue testing was conducted in an artificial cana…

Hyperbaric oxygen therapy for fatigue recovery: Experimental evidence and optimal regimen from a mouse model established by a chronic multi-stressor paradigm.

AIMS: Fatigue in safety-critical occupations is multifactorial and often overlaps with chronic stress-related neurobehavioral impairment. Hyperbaric oxygen therapy (HBOT) may accelerate fatigue recovery, but its efficacy and optimal regimen are unclear. We evaluated HBOT and identified the optimal number of sessions in a mouse chronic multi-stressor-induced fatigue-like phenotype. MATERIALS AND METHODS: C57BL/6 J mice subjected to a multi-stressor paradigm (restraint, noise, forced running, and overcrowding for 15 days) underwent different post-fatigue interventions: natural recovery, normoba…

Associations between heart rate and physical activity in people with post-COVID-19 condition accounting for myalgic encephalomyelitis/chronic fatigue syndrome symptoms.

BACKGROUND: Tachycardia after mild activity or during rest is a common complaint among people with post-COVID-19 condition (PCC). Understanding the relationships between heart rate (HR) and physical activity (PA) in this population is crucial for developing appropriate rehabilitation protocols. OBJECTIVE: To investigate the associations between HR and PA in individuals with PCC, accounting for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) symptoms. DESIGN: Observational study. SUBJECTS: Sixteen adults with PCC (81% females, mean age 51 ± 12 years). METHODS: Participants were …

Acute Post-Match Fatigue and Recovery Kinetics of Neuromuscular Performance and Muscle Damage After a Friendly Match in Elite Youth Football Players.

Background and Objectives: The purpose of this study was to investigate the acute fatigue response to a standardized friendly football match in elite adolescent players and to describe the subsequent recovery of neuromuscular performance, biochemical markers, and subjective perceptions over a 72-h period. Methods: Thirty-seven elite male youth football players (16.3 ± 0.7 years) participated in this repeated-measures study. Neuromuscular function was assessed using the countermovement jump (CMJ) and repeated sprint ability (RSA) tests. Muscle damage was evaluated by measuring blood creatine ki…

Confidence-driven adaptive time window for real-time driver fatigue detection in Level 2-3 autonomous vehicles: a multi-dataset validation study.

Driver fatigue constitutes a critical safety hazard in Level 2-3 (L2-3) conditionally automated vehicles, where the paradoxical demand for sustained supervisory vigilance despite minimal active engagement accelerates cognitive underload and impairs timely takeover readiness. Existing vision-based driver monitoring systems are constrained by fixed temporal analysis windows and binary classifiers that neither quantify prediction uncertainty nor adapt to the heterogeneity of real-world fatigue dynamics, resulting in elevated false alarm rates and poor cross-domain generalization. This study intro…

Trazodone, melatonin, and combination therapy for insomnia, fatigue, and daytime sleepiness following traumatic brain injury: study protocol for a randomized clinical trial.

BACKGROUND: Sleep problems are common and disabling after traumatic brain injury (TBI). They negatively affect cognitive recovery, emotions, and overall quality of life. Fatigue and excessive daytime sleepiness are also frequent and significantly impair daily functioning. Although trazodone and melatonin are used off-label, we still do not know which works better or if they are more effective together for improving sleep quality, fatigue, and daytime sleepiness in TBI patients. This randomized, double-blind clinical trial aims to compare the effectiveness of trazodone, melatonin, and their com…

Effects of Repeated Contrast Therapy on Forearm Microcirculatory and Neuromechanical Recovery After Climbing-Specific Fatigue in Amateur Climbers: A Randomized Controlled Trial.

Objective: To determine whether contrast therapy improves recovery after climbing-specific forearm fatigue in amateur climbers. Methods: In a randomized repeated-measures trial, 40 climbers were allocated to passive recovery (n = 20) or Game Ready contrast therapy (n = 20). Both groups completed a fixed-task intermittent fingerboard protocol on a 20 mm edge using a half-crimp grip, with 7 s of work and 3 s of rest for five sets; the load was not individualized to climbing-specific maximal finger-flexor force. The intervention group received bilateral forearm treatment consisting of alternating…

Effect of exercise-induced muscle fatigue on reaction times under postural perturbation conditions in individuals with and without chronic low back pain.

BACKGROUND: Total reaction time (TRT), composed of premotor time (PMT) and electromechanical delay (EMD), is susceptible to muscle fatigue and can be affected by pain. Limited evidence is available regarding the postural control capacity of patients with chronic low back pain(cLBP) following muscle fatigue-induced postural perturbation. This study aimed to examine the impact of pain and muscle fatigue on reaction time, so as to gain insights into the neuromuscular control strategy changes associated with muscle fatigue effect of cLBP. METHODS: Twenty-four subjects with cLBP (cLBP group) and t…