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Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial.

BACKGROUND: Staphylococcus aureus remains a common cause of ventilator-associated pneumonia, with little change in incidence over the past 1 … 6 or higher; had an acute physiology and chronic health evaluation II score of 25 or higher with a Glasgow coma scale (GCS) score of more than 5, or an acute physiology and chronic health evaluation II score of at least 30 with a GCS score of 5 or less; had a Sequential Organ Failure Assessment score of 9 or higher; or had active pulmonary disease that would impair …

Malnutrition-related hyperammonemic encephalopathy presenting with burst suppression: a case report.

BACKGROUND: Hyperammonemia is a common cause of metabolic encephalopathy, mainly related to hepatic cirrhosis. Numerous nonhepatic etiologies exist but they are infrequent and not well known, thus, leading to misdiagnosis and inadequate care. Electroencephalography has a proven diagnostic and prognostic role in comatose patients. Burst suppression is a preterminal pattern found in deep coma states and is rarely associated with metabolic causes. CASE PRESENTATION: We report the case of an 81-year-old Caucasian man presenting with rapidly progressive somnolence and mutism. Soon after his arriva

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… A physical examination revealed an alteration of consciousness (Glasgow Coma Scale 4/15) without any other relevant signs. Routine laboratory values were in the normal range. A urine culture showed no bacterial growth and toxicology screening was negative. …

Preserving Continuity of Cancer Therapy in Patients with Hematologic Malignancies and Chronic Subdural Hematomas: Comparative Outcomes of Middle Meningeal Artery Embolization and Surgery.

Background/Objective: Hematologic cancer patients are at high risk of developing chronic subdural hematomas (cSDH), and traditional treatment with surgery is potentially risky in this patient population, with associated coagulopathy and thrombocytopenia. Neurointerventional endovascular middle meningeal artery embolization (MMAE) is emerging as a novel minimally invasive treatment method for cSDH, and its efficacy and complication profile has not been evaluated in patients with hematologic cancers. Methods: We conducted a retrospective cohort study of adults with hematologic malignancies and c

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… Baseline demographic characteristics, including age, sex, body mass index, Glasgow Coma Scale (GCS), and preoperative KPS, were comparable between groups. … Coma Scale BMI Body Mass Index HIV Human Immunodeficiency Virus Supplementary Materials The following supporting information can be downloaded at https://www.mdpi.com/article/10.3390/cancers18172824/s1 , Figure S1: (A) Propensity score overlap. …

N-Acetylcystine в неврологических расстройствах: систематический обзор клинических и переводческих доказательств по всему миру Seven Расстройства.

N-ацетилцистейн (NAC) — прекурсор глютатиона с установленными антиоксидантами и антивоспалительными свойствами, которые были исследованы в качестве нейрозащитного агента в различных неврологических условиях. В ходе этого систематического обзора систематически составлялся обзор клинических данных по НХД по всем странам. seven Неврологические расстройства. В библиотеке Пубмеда и Кокрана были найдены материалы, опубликованные между 1 Январь 1995 и 31 декабрь 2025. Twenty-three Были проведены следующие исследования: травма головного мозга (TBI, n = 6), болезнь Альцгеймера (AD, n = 5), болезнь Парк

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… Coma Scale; UPDRS = Unified Parkinson’s Disease Rating Scale; VAS = visual analog scale; AE = adverse event. … These results align with the findings of Gouda et al. [ 9 ], who reported significant improvement in Glasgow Coma Scale and a reduction in the length of stay in the intensive care unit in patients with moderate–severe TBI in whom high-dose IV NAC was administered. …

Nonlinear Association Between Calculated Globulin Levels and 28-Day Mortality in Patients with Sepsis: A Retrospective Cohort Study.

BackgroundSepsis remains a significant global health challenge, causing approximately 11 million deaths annually. The calculated globulin (CG) level, which is derived from total protein and albumin levels, plays crucial roles in the immune response and inflammation. However, the relationship between the CG level and sepsis mortality remains unexplored.MethodsThis retrospective cohort study analyzed sepsis patients from the eICU Collaborative Research Database. The primary outcome was 28-day ICU mortality. The relationship between the CG level and mortality was examined via generalized additive

Sinking Skin Flap Syndrome After Decompressive Hemicraniectomy in a Patient With Calvarial Multiple Myeloma Who Underwent a Lumbar Puncture: A Case Report.

Sinking skin flap syndrome (SSFS) or "syndrome of the trephined" is a rare complication that can occur after decompressive craniectomy. Disabling neurologic deficits, as well as the impairment of overall mental status with the development of a concave deformity and relaxation of the skin flap, are frequently observed. This usually develops several weeks to months after craniectomy. The pathophysiology of the syndrome includes cerebrospinal fluid (CSF) hypovolemia and the development of an atmospheric pressure gradient that can be worsened by CSF diversion, dehydration, and change in position s

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… Glasgow Coma Scale (GCS) was 15. Labs, including a complete blood count and a complete metabolic panel, were within normal limits. CT head (CTH) was done, which showed postoperative changes with right hemispheric edema in a similar pattern compared to previous studies (Figure 1 ). … Two days after the procedure patient became progressively more lethargic, arousable to sternal rub, and oriented, with Glasgow Coma Scale 12, other neurologic exams were unchanged. …

Comparative Study of Single Burr-Hole Craniostomy versus Twist-Drill Craniostomy in Patients with Chronic Subdural Hematoma.

BACKGROUND: Chronic subdural hematoma (CSDH) is predominantly a disease of the elderly. On accounting its risk-to-benefit ratio, there was a … (25.39% vs. 15.21%), seizure (1.58% vs. 4.34%), and diplopia (4.76% vs. 0%). The mean preoperative Glasgow Coma Scale (GCS) score in BHC versus TDC was 13.44 ± 2.23 SD versus 12.47 ± 2.95 SD limb weakness was noted in 52.38% BHC group and 82.60% TDC group. There was significantly decreased GCS score in TDC group. The number of the patients with limb weakness on aff …

First aid interventions by laypeople for acute oral poisoning.

BACKGROUND: Oral poisoning is a major cause of mortality and disability worldwide, with estimates of over 100,000 deaths due to unintentiona … f poisoning, providing very low-certainty evidence. Therefore we are uncertain about the effects on Glasgow Coma Scale scores (mean difference (MD) -0.15, 95% CI -0.43 to 0.13, 1 study, 34 participants) or incidence of adverse events (risk ratio (RR) 1.24, 95% CI 0.26 to 5.83, 1 study, 34 participants). No information was available concerning mortality, duration of …

Hypercalcemia of Malignancy: An Emergency Medicine Simulation.

Hypercalcemia is a poor prognostic factor associated with malignancy. The signs and symptoms of hypercalcemia that the patients present to the emergency department are vague and often overlap with the general symptoms of cancer itself or the adverse effects of the chemotherapy. Given that the development of hypercalcemia of malignancy can present with imminent danger to the patient and is a treatable condition, emergency physicians should know how to recognize and treat it. It also marks a time at which discussions regarding plans of care should be initiated with the patients. In this report,

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… Coma Scale 14, cranial nerves I-XII intact, reflexes normal in upper and lower limbs Cardiovascular system | Heart sounds normal, slow heart rate, jugular venous pressure flat (difficult to see), pain to palpation across chest wall (rib metastasis), mastectomy scar on the chest Respiratory system | … When asked for initial vitals: Temperature 37 (oral), heart rate 59 (sinus), blood pressure 85/50, respiratory rate 18 The neurological assessment is as follows: Glasgow Coma Scale 14, alert, oriented to person and place, not oriented to time. …

Prognostic Factors and Risk Stratification in Malignant Tumor Patients With Sepsis: A Retrospective Cohort Study.

BACKGROUND Sepsis is a life-threatening complication in cancer patients and a major contributor to ICU admission and mortality. Although tumor-related factors affect outcomes, the prognostic value of ICU-specific clinical parameters remains insufficiently explored. This study aimed to identify ICU-related predictors of mortality beyond tumor characteristics in cancer patients with sepsis. MATERIAL AND METHODS We conducted a single-center retrospective cohort study including 4301 cancer patients with sepsis. Independent predictors of 28-day mortality were identified using multivariable logistic

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… The severity of illness was assessed using validated ICU scoring systems, including the Simplified Acute Physiology Score II (SAPS II), Simplified Acute Physiology Score III (SAPS III), SOFA, Logistic Organ Dysfunction Score, Systemic Inflammatory Response Syndrome score, Glasgow Coma Scale score, Oxford … Non-survivors also had worse organ dysfunction, reflected by lower Glasgow Coma Scale scores ( P< 0.001), higher Systemic Inflammatory Response Syndrome scores ( P <0.001), and higher rates of acute kidney injury (AKI; P <0.001) and septic shock ( P <0.001). …

Epidemiologic and Clinical Characteristics of Cancer Patients Presented to the Emergency Service with COVID-19 Symptoms.

PURPOSE: The study aimed to define the clinical characteristics of coronavirus disease (COVID-19) in cancer patients admitted to the emergency service (ES) and to determine the parameters associated with mortality. PATIENTS AND METHODS: The data of patients with COVID-19 symptoms and solid or hematological malignancies under anticancer treatment, who presented to the ES between March 1, 2020, and March 31, 2021, and underwent RT-PCR (Real-Time Polymerase Chain Reaction) testing, were evaluated. Demographic, clinical, and laboratory parameters were compared between COVID-19-negative and COVID-

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… Table 3 Glasgow Coma Score, Performance Score, Vital Signs, and Laboratory Parameters of the Patients COVID-19 Positive Group (n=203) COVID-19 Negative Group (n=265) P* value Median (ÇAA) Glasgow Coma Scale 15.0 (0.0) 15.0 (0.0) 0.050 ECOG PS score 2.0 (2.0) 2.0 (2.0) 0.173 Systolic blood pressure 110 … | COVID-19 Positive Group (n=203) | COVID-19 Negative Group (n=265) | P* value Median (ÇAA) Glasgow Coma Scale | 15.0 (0.0) | 15.0 (0.0) | 0.050 ECOG PS score | 2.0 (2.0) | 2.0 (2.0) | 0.173 Systolic blood pressure | 110. 0 (20.0) | 110. 0 (20.0) | 0.992 Diastolic blood pressure | 70.0 (20.0) | 70.0 …

Can treating critically-ill haematological malignancy patients in a separate intensive care unit decrease intensive care unit mortality?

Background/aimThe aim of the study was to investigate whether treating haematological malignancy (HM) patients in a separate intensive care unit (ICU) would reduce ICU mortality.Materials and methodsHM patients treated by the same ICU team in a general medical ICU (GM-ICU) and a separate haematology ICU (H-ICU) were included in this study. Patients’ demographic characteristics and ICU data were recorded retrospectively. Differences in the ICU course and prognosis between these two groups were determined.ResultsA total of 251 patients (102 from GM-ICU, 149 from H-ICU) were included in this stud

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… coma scale - GCS etc. ) at admission, laboratory values at admission, therapeutic procedures that the patient underwent during the ICU stay (mechanical ventilation – MV, renal replacement therapy – RRT, etc.), existing infections at ICU admission, infections and complications (gastrointestinal - GI … Table 1 General characteristics of all study patients, and patients in haematology ICU and general medical ICU. * median [interquartile ranges], n: numberICU: intensive care unit, APACHE: acute physiology and chronic health evaluation, GCS: Glasgow coma scale, SOFA: sequential organ failure assessment …

Коопетин как новый кровопролитный знак дифференциального диагноза у больных Строке.

Диагноз у пациентов, страдающих инсультом, основывается главным образом на клинических и радиологических результатах; поэтому существует потребность в серологических маркерах, которые могут ориентировать клинического врача. Коопетин — новый маркер крови для диагностики и прогнозирования в нескольких неврологических условиях, таких, как ишемический инсульт, геморрагический инсульт, аневризмальное кровоизлияние субарахноида и множественный склероз. Цель нашего исследования состояла в том, чтобы подчеркнуть диагностическую ценность сентептина при проведении различия между подтипами инсульта и ими

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… A negative correlation between the copeptin level and Glasgow Coma Scale (GCS) was also identified. …

Characteristics and predictors of mortality of patients with hematologic malignancies requiring invasive mechanical ventilation.

RationaleAcute respiratory failure (ARF) may complicate the course of hematologic malignancies (HMs). Our objective was to study the characteristics, outcomes and predictors of mortality of patients with HMs who required intubation for ARF.MethodsThis retrospective cohort study evaluated all patients with HMs who were admitted to the Intensive Care Unit (ICU) of King Abdul-Aziz Medical City-Riyadh between 2008 and 2013 and required invasive mechanical ventilation. We noted their baseline characteristics, treatments and different outcomes. Multivariable logistic regression analysis was performe

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… Coma Scale score, and baseline levels of the partial pressure of oxygen to the fraction of inspired oxygen ratio (PaO 2 :FiO 2 ), platelet count, creatinine, lactate, bilirubin and International Normalized Ratio (INR). … The Glasgow Coma Scale was 12.2 ± 3.9 for the NIV patients compared with 10.2 ± 4.4 ( P = 0.06) for the other patients. Most patients (96.6%) had central venous catheter and required vasopressors (77.0%). New renal replacement therapy was provided to 18 patients (14.8%) for acute kidney injury. …

Is severe hypocalcemia immediately life threatening?

ObjectiveSevere hypocalcemia (Ca MethodsA retrospective observational study was carried out over a 2-year period in the Adult Emergency Department (ED) of Nantes University Hospital. All patients who had a protein-corrected calcium concentration measure were eligible for inclusion. Patients with multiple myeloma were excluded. The primary outcome was the number of life-threatening cardiac arrhythmias and/or neurological complications during the stay in the ED.ResultsA total of 41,823 patients had protein-corrected calcium (pcCa) concentrations measured, 155 had severe hypocalcemia, 22 were exc

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… A neurological complication was defined by the presence of seizures (before admission or during ED stay) or a coma with a Glasgow Coma Scale of less than 9/15 ( 17 ). …

37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017

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… The Glasgow coma scale was used to score awakening, with a motor score of 6 with an eye score of 3 or 4 defined as awakening. The patients with good neurologic outcome were divided in an early and late awakening group. Good neurologic outcome was defined as a GOS score of 4 or 5 after six months. … Awakening was defined as Glasgow Coma Scale motor score (GCS-M) 6 in the ICU. Neurological outcome was assessed using the cerebral performance category scale (CPC) at 180 days. …

Quality of Life as a Non-mortality Patient-centred Outcome in the Critically Ill: A Retrospective Analysis.

ObjectivesMortality is a common gauged endpoint in critically ill patients. Reduced quality of life is an aligned repercussion of protracted critical illness. Baseline status, severity of illness and its trajectory influence the outcomes. Patient-oriented outcomes are those that matter the most to a patient. However, quite often, family approves of trade-offs with survivorship in the Indian context. We looked at non-mortality outcomes in patients on high-intensity life-sustaining interventions admitted to the intensive care unit (ICU) despite poor prognosis and died on full support or survived

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… coma scale) in first 4 weeks and last week pre-death or discharge; any pressure sores and extremity contractures and self-pay versus insurance/third party. … Table 3: Neurological status during ICU stay. e: Eye, m: Motor, v: Verbal [Glasgow coma scale]. …

Predictive value of the prothrombin time-to-albumin ratio for 28- and 90-day mortality in lung cancer patients admitted to the intensive care unit: A retrospective cohort study.

This retrospective observational study assesses the prognostic utility of the prothrombin time/albumin ratio (PAR) for 28- and 90-day mortality in patients with lung cancer. A total of 959 patients with lung cancer were included from the Medical Information Mart for Intensive Care IV v2.2 database (USA). The time origin was defined as intensive care unit (ICU) admission, and patients were censored at 28 and 90 days post-admission for the respective outcome analyses. The main variables were the PAR index, 28-day mortality, and 90-day mortality. Relevant clinical data were extracted, and Cox reg

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… Disease severity scores included Logistic Organ Dysfunction System (LODS), Oxford Acute Severity of Illness Score (OASIS), SAPS II, SOFA, Glasgow Coma Scale, and Acute Physiology Score III (APS III). … APS III = Acute Physiology Score III, AIDS = acquired immune deficiency syndrome, ALP = alkaline phosphatase, ALT = alanine aminotransferase, APTT = activated partial thromboplastin time, AST = aspartate aminotransferase, GCS = Glasgow Coma Scale, ICU = intensive care unit, INR = international normalized …

Performance of six severity-of-illness scores in cancer patients requiring admission to the intensive care unit: a prospective observational study.

IntroductionThe aim of this study was to evaluate the performance of five general severity-of-illness scores (Acute Physiology and Chronic Health Evaluation II and III-J, the Simplified Acute Physiology Score II, and the Mortality Probability Models at admission and at 24 hours of intensive care unit [ICU] stay), and to validate a specific score - the ICU Cancer Mortality Model (CMM) - in cancer patients requiring admission to the ICU.MethodsA prospective observational cohort study was performed in an oncological medical/surgical ICU in a Brazilian cancer centre. Data were collected over the f

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… For sedated patients, Glasgow Coma Scale score before sedation was used [ 18 ]. Zero points or normal values were inserted where data were missing [ 19 ]. There were no missing variables for physiological data. … Glasgow Coma Scale in the evaluation of outcome in the intensive care unit: findings from the Acute Physiology and Chronic Health Evaluation III study. Crit Care Med. 1993;21:1459–1465. doi: 10.1097/00003246-199310000-00012. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. …

Читинас-3-подобный-1: многообразный игрок в нейроинфламмации и дегенеративной патологии с терапевтическими последствиями.

Читинас-3-подобный-1 (CHI3L1) — эволюционно сохранившийся белок, содержащийся в ключевых биологических процессах, включая реконструирование тканей, ангиогенез и нейроинфламмацию. Она стала важным игроком в различных нейродегенеративных заболеваниях и расстройствах мозга. Повышенные уровни CHI3L1 наблюдались в таких неврологических условиях, как травматическое повреждение мозга (TBI), болезнь Альцгеймера (AD), болезнь Паркинсона (PD), амиотропический боковой склероз (ALS), болезнь Креуцфельда-Якоба (CJD), множественный склероз (MS), оптика нейромиелита (NMO), вызванная ВИЧ деменция (HAD), цереб

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… [ 81 ] CSF cerebrospinal fluid, YKL-40 tyrosine, lysine, and leucine with a molecular weight of 40, GCS Glasgow Coma Scale, TBI traumatic brain injury, CIS cerebral ischemic stroke, TIA transient ischemic attack, MCI mild cognitive impairment, PPMS primary progressive multiple sclerosis … [ 81 ] CSF cerebrospinal fluid, YKL-40 tyrosine, lysine, and leucine with a molecular weight of 40, GCS Glasgow Coma Scale, TBI traumatic brain injury, CIS cerebral ischemic stroke, TIA transient ischemic attack, MCI mild cognitive impairment, PPMS primary progressive multiple sclerosis …