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Advances on PPARγ Research in the Emerging Era of Precision Medicine.

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor superfamily that functions as a lig … layer regulations. In addition, novel classes of therapeutics modulating PPARγ and new direction of Исследование on genetic variants that affect PPARγ function and antidiabetic drug response are highlighted, which sheds light on PPARγ as a promising target for developing safer and precision medicine based therapeutic strategies.

Growth hormone therapy in children; Исследование and practice - A review.

Short stature remains the most common reason for referral to a pediatric Endocrinologist and its management remains a challenge. One of the main controversies is the diagnosis of idiopathic short stature and the role of new technologies for genetic investigation of children with inadequate growth. Complexities in management of children with short stature includes selection of who should receive interventions such as recombinant human growth hormone, and how should this agent dose be adjusted during treatment. Should anthropometrical data be the primary determinant or should biochemical and gen

Isolation and Identification of the Follicular Microbiome: Implications for Acne Research.

Our understanding of the microbiome and the role of Propionibacterium acnes in skin homeostasis and acne pathogenesis is evolving. Multiple … es not impact P. acnes-related characterization and that all may be equally useful for acne-related Исследование studies.

[Recent progress in the Исследование of Eosinophilic GastroIntestinal Diseases (EGIDs)].

Eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), which are included in eosinophilic gastrointestinal disorders (EGIDs) … number of patients with EoE is rapidly increasing in both Western and Asian countries. In Japan, a Исследование group of the Ministry of Health, Labor and Welfare has announced recommendations for the diagnosis and management of EoE and EGE in 2015. For a diagnosis of EoE, endoscopic abnormalities and histological confirmation of dense eosinophile infiltratio …

[Research status and progress of biomaterials for bone repair and reconstruction].

Artificial bone repair material is the best substitute for autologous bone transplantation. Bone repair materials are constantly being replaced and upgraded, which can be roughly divided into three generations: bioinert materials, bioactive materials, and smart materials. Research and development of bone repair materials with multiple biological activities, in vivo degradation property that perfectly fit for new bone formation, and ability of complete reconstruction of bone tissue in physiological state are the focus of future Исследование.

Words with weight: The construction of obesity in eating disorders Исследование.

In current public health discourse, obesity is conceptualized as a disease epidemic, with treatment being weight loss. The pursuit of weight loss as a treatment for the "disease" of obesity is in direct contradiction to the history of Исследование in eating disorders, which has demonstrated the risks for the development of eating disorders. In this study, we critically examined the eating disorder literature to explore this contradiction. We analyzed 30 of the top-cited articles in the eating disorder literature between 1994 and 2011, asking: how is the concept of obesity examined in eating disord…

[Development of keratophakia and new Исследование advances in lenticule transplantation].

In the 1980s, a new treatment of aphakia and keratoconus with keratophakia thrived because of its simple, effective and reversible character … tophakia principle. This review describes the history and development of keratophakia and the basic Исследование and clinical effect of refractive lenticule transplantation. (Chin J Ophthalmol, 2018, 54: 792-796).

A review of sleep Исследование in patients with spinal cord injury.

Study design: Systematic review. Objectives: Sleep disturbances are a common complaint among individuals with spinal cord injury (SCI) and were not usually present before the SCI. Their sleep disturbances, including disrupted sleep, spasms, and problems with initiating and sustaining sleep through the night, affect SCI individuals' overall quality of life due to excessive tiredness and low energy levels during the day. Despite the high prevalence of sleep complaints in this population, current knowledge about sleep in the SCI population has not been systematically assessed. Setting: Capital Re

Metabolism and mitochondria in polycystic kidney disease Исследование and therapy.

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, potentially lethal, monogenic diseases and is caused predominantly by mutations in polycystic kidney disease 1 (PKD1) and PKD2, which encode polycystin 1 (PC1) and PC2, respectively. Over the decades-long course of the disease, patients develop large fluid-filled renal cysts that impair kidney function, leading to end-stage renal disease in ~50% of patients. Despite the identification of numerous dysregulated pathways in ADPKD, the molecular mechanisms underlying the renal dysfunction from mutations in PKD genes an

Current Исследование on carbetocin and implications for prevention of postpartum haemorrhage.

BACKGROUND: Postpartum haemorrhage (PPH) is the leading cause of maternal mortality in low-income countries and is a significant contributor to severe maternal morbidity and long-term disability. Carbetocin may be an underused uterotonic for prevention of PPH. A number of studies are being conducted that may challenge the place of oxytocin as the first choice of uterotonics for prevention of PPH. This paper describes the current Исследование into carbetocin and ranking of effectiveness of uterotonics that may provide important new information to assist healthcare decision makers to ensure that wom…

Setting the Исследование agenda for induced abortion in Africa and Asia.

Provision of safe abortion is widely recognized as vital to addressing the health and wellbeing of populations. Research on abortion is essential to meet the UN Sustainable Development Goals. Researchers in population health from university, policy, and practitioner contexts working on two multidisciplinary projects on family planning and safe abortion in Africa and Asia were brought together for a workshop to discuss the future Исследование agenda on induced abortion. Research on care-seeking behavior, supply of abortion care services, and the global and national policy context will help improve …

Нейроиммунологические исследования. Доклад Кубинской сети нейроиммунологии.

Нейроиммунологию можно проследить еще в XIX веке с помощью описаний некоторых болезней и синдромов (например, множественный склероз и синдром Гильена Баррета). Диагностические средства основаны на анализе цереброспинной жидкости (CSF), разработанном Квинке, или на разработке нейроиммунотерапии с более ранним выражением в Pasteur’ это вакцина от бешенства. Тем не менее, эта область, которая начала определяться как независимая область исследований в 1940-х годах, превратилась в инновационное и интегрированное поле на общих краях нейрофизики, иммунологии и смежных клинических и исследовател

Совпадение в аннотации оригинала
Neuroimmunology can be traced back to the XIX century through the descriptions of some of the disease’s models (e.g., multiple scleros … ;s vaccine for rabies. Nevertheless, this field, which began to become delineated as an independent Исследование area in the 1940s, has evolved as an innovative and integrative field at the shared edges of neurosciences, immunology, and related clinical and Исследование areas, which are currently becoming a major concern for neuroscience and indeed for all of the …

In Honor of Dr. Ahmad Fayaz, A Prominent Rabies Researcher.

Dr. Ahmad Fayaz is one of the famous scientists in Iran in the field of rabies, and the most prominent person in controlling and prevention … es. This paper intends to celebrate his scientific contributions through reviewing his services and Исследованиеes.

Inclusion of pregnant and breastfeeding women in Исследование - efforts and initiatives.

Pregnant and breastfeeding women have been rendered therapeutic orphans as they have been historically excluded from clinical trials. Labell … miology of drugs used during pregnancy and lactation, and offers recommendations for regulators and Исследованиеers in academia and industry to increase the available pharmacokinetic and -dynamic understanding of medication use in pregnancy.

[Research development and thinking of clinical study of Polygonum multiflorum].

In order to offer the accordance and Исследование ideas for further Исследование of effect, indication and ensure the safety and effectiveness of clinical medication, the current states of clinical application and adverse reaction of Polygonum multiflorum were summarized. The related literatures in recent years were collated, analyzed and summed up. P. multiflorum is widely used and has variety of adverse reactions. At present, it's used to treat hyperlipidemia, white hair, hair loss, hypertension, vitiligo, etc. Adverse reactions are liver damage, allergic reactions, mental symptoms, chronic enteriti…

[Advances in basic and clinical Исследование on liver cirrhosis in 2016].

Esophageal and gastric varices are common complications of liver cirrhosis and are seen in 50% of patients with liver cirrhosis. The annual incidence rate of esophagogastric variceal bleeding is 5%-15%, and even if the recommended treatment is used, the 6-week mortality rate is still as high as 15%-20%. Spontaneous bacterial peritonitis (SBP) is a common complication of end-stage liver disease and has an incidence rate of 10%-30% in patients with severe liver damage. SBP refers to the bacterial infection of the peritoneum and/or ascites that occurs in the absence of any inflammation in adjacen

Recent progress in translational Исследование on neurovascular and neurodegenerative disorders.

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acu … advances offer the potential to overcome almost two decades of marginally successful translational Исследование on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.This review reports and summarizes some of the most interesting …

The Role of Innate Immune System Receptors in Epilepsy Research.

BACKGROUND & OBJECTIVE: Epilepsy is one of the most complex neurological disorders and its study requires a broad knowledge of neurology and neuroscience. It comprises a diverse group of neurological disorders that share the central feature of spontaneous recurrent seizures, and are often accompanied by cognitive deficits and mood disorder. This condition is one of the most common neurological disorders. Until recently, alterations of neuronal activities had been the focus of epilepsy Исследование. This neurocentric emphasis did not address issues that arise in more complex models of epileptogenes…