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The Rates of Cement Leakage Following Vertebroplasty in Osteoporotic versus Metastatic Disease.

Introduction Percutaneous vertebroplasty is used for symptomatic osteoporotic fractures and osteolytic neoplasms. We performed a retrospective study to analyze the pattern of leaks in the two cohorts. Material and Methods Vertebroplasties performed over a 7-year period at a tertiary orthopaedic center were included in the study and divided into osteoporotic and neoplastic groups. The incidence and pattern of cement leaks in each group were documented and analyzed. Results There were 75 leaks of a cohort of 211 vertebroplasties with a relatively equal proportion in osteoporotic and neoplastic g

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… Medicine (Baltimore) 2018;97(12):e0184. doi: 10.1097/MD.0000000000010184. 33. Georgy B A. Clinical experience with high-viscosity cements for percutaneous vertebral body augmentation: occurrence, degree, and location of cement leakage compared with kyphoplasty. … Medicine (Baltimore) 2019;98(08):e14317. doi: 10.1097/MD.0000000000014317. 37. Schmidt R, Cakir B, Mattes T, Wegener M, Puhl W, Richter M. Cement leakage during vertebroplasty: an underestimated problem? Eur Spine J. 2005;14(05):466–473. doi: 10.1007/s00586-004-0839-5. …

The reporting quality and transparency of orthopaedic studies using Bayesian analysis requires improvement: A systematic review.

BackgroundBayesian methods are being used more frequently in orthopaedics. To advance the use and transparent reporting of Bayesian studies, reporting guidelines have been recommended. There is currently little known about the use or applications of Bayesian analysis in orthopedics including adherence to recommended reporting guidelines. The objective is to investigate the reporting of Bayesian analysis in orthopedic surgery studies; specifically, to evaluate if these papers adhere to reporting guidelines.MethodsWe searched PUBMED to December 2nd, 2020. Two reviewers independently identified s

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… Medicine (Baltimore) 94:e510. https://doi.org/10.1097/MD.0000000000000510 Forsberg JA, Wedin R, Boland PJ, Healey JH (2017) Can We Estimate Short- and Intermediate-term Survival in Patients Undergoing Surgery for Metastatic Bone Disease? … Medicine (Baltimore) 94:e595. https://doi.org/10.1097/MD.0000000000000595 Wang L, He K, Chen Z (2016) Statistical Analyses of Femur Parameters for Designing Anatomical Plates. …

HERV-W Env вызывает нейронный пироптоз с помощью NLRP3-CASP1-GSDMD Pathway в недавней Шизофрении.

HERVs (человеческие эндогенные ретровирусы) являются остатками древних внешних ретровирусов, которые интегрировались в геном человека, особенно в микробных клетках. Среди них белковый ген HERV-Wenv (Human Internal revoiruses W семейный белок), расположенный на хромосоме 7 и выраженный главным образом в плаценте человека, тесно связан с различными нейропсихиатрическими расстройствами, включая шизофрению, а также аутоиммунные заболевания и рак. Недавние исследования выявили аномальное выражение цитокина в качестве ключевого фактора в патофизиологии шизофрении. В частности, повышенные уровни сыво

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… Cells were cultured in a 1:1 mixture of Minimal Essential Medium Eagle (MEM) (2225320, Gibco, Baltimore, MD, USA) and F-12 (2209586, Gibco, Baltimore, MD, USA), supplemented with 10% fetal bovine serum (2001003, Biological Industries, Beit HaEmek, Israel), 100mmol/L sodium pyruvate (2185865, Gibco, Baltimore … , MD, USA) and 1% penicillin/streptomycin (15140148, Gibco, Baltimore, MD, USA). …

Use of Complementary Traditional Chinese Medicines by Adult Cancer Patients in Taiwan: A Nationwide Population-Based Study.

BACKGROUND: Many patients with cancer seek complementary and alternative medicine treatments. We investigated the use of traditional Chinese medicine (TCM) by adult cancer patients in Taiwan. METHODS: We reviewed the Registry for Catastrophic Illness Patients Database of Taiwan, and included all adult patients diagnosed cancer, based on the International Classification of Diseases (ninth revision), from 2001 to 2009 and followed until 2011. This database allowed categorization of patients as TCM users (n = 74 620) or non-TCM users (n = 508 179). All demographic and clinical claims data were a

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… Medicine (Baltimore) . 2016 ; 95 : e2476 . 26765450 10.1097/MD.0000000000002476 PMC4718276 4 Chung VC Wu X Lu P et al Chinese herbal medicine for symptom management in cancer palliative care: systematic review and meta-analysis . … Medicine (Baltimore) . 2016 ; 95 : e2793 . 26886628 10.1097/MD.0000000000002793 PMC4998628 5 Hu C Zhang H Wu W et al Acupuncture for pain management in cancer: a systematic review and meta-analysis . …

Efficacy and Safety of Balloon Kyphoplasty for Pathological Vertebral Fractures in Patients with Hematological Malignancies in Our Institution.

Objective Patients with hematological malignancies, particularly those with multiple myeloma, often suffer from pathological vertebral compression fractures (VCFs). Consequent and significant spinal pain and paralysis impair the activities of daily living and quality of life and delay subsequent chemotherapy. Balloon kyphoplasty (BKP), which is less invasive than conventional therapies, is a type of percutaneous vertebroplasty in which cement is injected into the broken vertebrae to stabilize the spinal column. The present study assessed the effect of BKP on hematological tumors. Methods We re

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… Medicine (Baltimore) 98: e14793, 2019. 11. Wang B, Zhao CP, Song LX, Zhu L. Balloon kyphoplasty versus percutaneous vertebroplasty for osteoporotic vertebral compression fracture: a meta-analysis and systematic review. J Orthop Surg Res 13: 1-8, 2018. 12. … Medicine (Baltimore) 98: e17810, 2019. 15. Beall DP, Chambers MR, Thomas S, et al. Prospective and multicenter evaluation of outcomes for quality of life and activities of daily living for balloon kyphoplasty in the treatment of vertebral compression fractures: the EVOLVE trial. …

PROMIS® Health Organization (PHO) 2021 Conference Abstracts.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… O10 Developing a multimedia patient-reported outcomes measure for low literacy patients Chao Long 1,2,3 , Laura Beres 3 , Albert Wu 3 , Aviram Giladi 2 1 Johns Hopkins Medicine, Baltimore, MD, USA. 2 The Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, MD, USA. 3 Johns Hopkins … , Baltimore, MD, USA. 3 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA Correspondence: Chao Long chaolong@jhu.edu. …

NF-κB: master regulator of cellular responses in health and disease.

The NF-κB transcription control proteins play widespread roles in cellular behavior, regulating immune responses, inflammation, cell survival, proliferation, and development. Here, we attempt to comprehensively review these diverse functions and underlying mechanisms, leading readers to relevant references of both historic and topical importance. Because of the huge number of NF-κB control mechanisms and functions, and the vast literature that describes these, being comprehensive is a daunting task but we hope that readers will find clues to lead them to whatever understanding they may seek. A

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… Introduction The transcription factor NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) was first identified in 1986 by Ranjan Sen and David Baltimore as a nuclear protein that binds to the enhancer element of the immunoglobulin κ light chain gene in B cells, thereby regulating …

Respiratory Tract Infections: Sinusitis, Bronchitis, and Pneumonia

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… Medicine (Baltimore) 2006;85:278–287. doi: 10.1097/01.md.0000232560.22098.4e. 43. Renaud C, Campbell AP. Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients. … Medicine (Baltimore) 2000;79:250–260. doi: 10.1097/00005792-200007000-00006. 66. Junghanss C, Marr KA, Carter RA, Sandmaier BM, Maris MB, Maloney DG, et al. …

Managing emotional and physical stress in sickle cell anemia: a review of effective strategies and approaches.

Sickle cell anemia (SCA) is a genetic blood disorder characterized by recurrent pain episodes, chronic complications, and significant emotional and physical stress. This review article explores effective strategies for managing both the emotional and physical aspects of stress in SCA patients. A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, and Google Scholar, using keywords such as "sickle cell anemia", "stress management", "psychological support", and "pain management". Emotional stress in SCA arises from chronic pain, frequent hospitaliza

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… Medicine (Baltimore) 2024 ; 103 : e36898 . 38215146 10.1097/MD.0000000000036898 PMC10783340 [2] Obeagu EI . Maximizing longevity: erythropoietin’s impact on sickle cell anaemia survival rates . … Medicine (Baltimore) 2024 ; 103 : e38075 . 38701274 10.1097/MD.0000000000038075 PMC11062666 [14] Obeagu EI Obeagu GU . Implications of climatic change on sickle cell anemia: a review . Medicine (Baltimore) 2024 ; 103 : e37127 . 38335412 10.1097/MD.0000000000037127 PMC10860944 [15] Obeagu EI . …

Defibrotide for prophylaxis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in pediatric high-risk patients: consensus guidelines from the European Society for Blood and Marrow Transplantation (EBMT).

SOS/VOD is a life-threatening complication of hematopoietic stem cell transplantation, especially in children, with incidences reaching up to 15-20%. Despite efforts, SOS/VOD remains unpredictable with significant morbidity and mortality. High-risk criteria are clearly defined, and the pediatric EBMT diagnostic criteria have improved sensitivity, reducing treatment delays and enhancing outcomes. A meta-analysis combining retrospective and prospective studies found a risk ratio of 0.30 for SOS/VOD with defibrotide (DF) prophylaxis. Additionally, two prospective trials were conducted: the pediat

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… Eighty percent of children and half of the adult patients presented with anicteric SOS/VOD within the 21-day limit of the Baltimore criteria and would have been missed. … Obligatory hyperbilirubinemia (>2 mg/dL) is the hallmark of the Baltimore criteria. …

From post-war reconstruction to the twenty-first century - ophthalmic pathology in Freiburg 1945-2015. Part 2: review of 43,169 histological diagnoses from 39,256 specimens collected over 71 years at a large German tertiary eye care centre.

BACKGROUND: Ophthalmic pathology is essential for diagnosing ocular diseases, correlating clinical and histopathological findings, and advancing research. The Eye Center at the University of Freiburg, Germany, has archived histopathological specimens since 1945, offering a unique resource to analyse long-term diagnostic trends. This study examines 43,169 diagnoses from 39,256 specimens over 71 years (1945–2015), providing insights into the evolution of ophthalmic pathology at a major tertiary care centre. METHODS: We performed a retrospective analysis of all archived ophthalmic pathology repor

Exploring the ethical decision-making experience of caregivers of end stage cancer patients in Iran: a phenomenological study.

BackgroundEthical decision making is a complex issue because it strongly depends on the religion, beliefs, traditional laws and moral views of each society. The purpose of this study was to explore the experience of Iranian family caregivers of end stage cancer patients about ethical decision making.MethodsThis qualitative study is based on van Manen's method of hermeneutic phenomenology. In-depth interviews were carried out to collect data. Participants were 12 caregiver. Audiotapes were transcribed and analyzed for common themes that represented the participants' experiences. Trustworthiness

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… Quill T Battin M Physician-assisted dying: the case for palliative care and patient choice 2004 Baltimore Johns Hopkins University Quill T, Battin M. Physician-assisted dying: the case for palliative care and patient choice. Baltimore: Johns Hopkins University; 2004. 29. … Foley K Hendin H The case against assisted suicide: for the right to end-of-life care 2002 Baltimore Johns Hopkins University Foley K, Hendin H. The case against assisted suicide: for the right to end-of-life care. Baltimore: Johns Hopkins University; 2002. 30. …

Regulatory T cells and immune escape in HCC: understanding the tumor microenvironment and advancing CAR-T cell therapy.

Liver cancer, which most commonly manifests as hepatocellular carcinoma (HCC), is the sixth most common cancer in the world. In HCC, the immune system plays a crucial role in the growth and proliferation of tumor cells. HCC achieve immune escape through the tumor microenvironment, which significantly promotes the development of this cancer. Here, this article introduces and summarizes the functions and effects of regulatory T cells (Tregs) in the tumor microenvironment, highlighting how Tregs inhibit and regulate the functions of immune and tumor cells, cytokines, ligands and receptors, etc, t

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… J Immunol (Baltimore Md 1950). (1997) 158:551–9. doi: 10.4049/jimmunol.158.2.551 115. Cannons JL, Choi Y, Watts TH. Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response. … J Immunol (Baltimore Md 1950). (2016) 196:484–92. doi: 10.4049/jimmunol.1403039 119. Suryadevara CM, Desai R, Farber SH, Choi BD, Swartz AM, Shen SH, et al. …

Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations.

Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was 12 days (IQR, 9-15); 59% were treated for >10 days. There was marked variability in treatment durations across hospitals.

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… Jae Hyoung Lee, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Karen Howard, Department of Pharmacy, University of Utah Health, Salt Lake City, Utah, USA. … Pranita D Tamma, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. …

Take the reins: a study protocol of a randomized controlled trial testing the effects of time-restricted eating vs. nutrition control on cancer-related fatigue among survivors of hematological malignancies.

BACKGROUND: Cancer-related fatigue is one of the most common and debilitating side effects of cancer and its treatments. Fatigue may stem from disruptions in circadian rhythms and dysregulation of glucose metabolism, which can be improved through time-restricted eating. Time-restricted eating is a daily eating pattern that entails consuming food within a defined, consistent window (e.g., 10 h) every day. When the eating window aligns with the daylight hours, it can entrain circadian processes and modulate physiological regulation of whole-body metabolism. It is hypothesized that time-restricte

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… The consent document was developed using the template from the University of Maryland Baltimore’s Research Compliance Office. … All confidential information will be locked in a cabinet in a secured location at the University of Maryland School of Nursing or in a database hosted on University of Maryland Baltimore-hosted HIPAA-compliant servers accessible only with a personal password. …

A human self-stimulatory CD4+ T cell antigen-presenting cell subset presents and recognizes agonistic self-antigens to sustain exponential autologous clonal expansion.

A new human xeno-free T cell expansion strategy enabled T cell receptor α/β (TCRα/β)-driven autologous reactivity and continuous long-term IL-2-dependent expansion of an unconventional professional T cell antigen-presenting cell (T-APC) subset. Autologous T-APC cultures were obtained from small peripheral blood mononuclear cell samples that yielded over 1020-fold expansions by an approach that did not require cell purification or genetic manipulation. Primary T-APCs constitutively expressed major histocompatibility complex class II glycoproteins, costimulatory B7 molecules, and FOXP3 in long-t

Long-term Nlrp3 gain-of-function mutation promotes cardiac dysfunction independent of inflammasome in mice.

Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in human nucleotide-binding domain, leucine-rich repeat-containing protein 3 (NLRP3), which lead to constitutive inflammasome activation and excessive IL-1β secretion. Long-term IL-1 blockade has markedly improved patient outcomes by preventing systemic inflammation and amyloidosis. However, whether chronic NLRP3 mutation exerts inflammasome-independent effects on the cardiac function remains unknown. We generated Nlrp3C257Y/WT knock-in mice as a novel CAPS model. Long-term surviva

CTLA4 rs3087243-A-linked haplotype is associated with increased CTLA-4 expression and suppressive function in human regulatory T cells.

CTLA-4 is an inhibitory receptor on T cells that limits immune activation by competing with the co-stimulatory receptor CD28 for binding to CD80 and CD86 on antigen-presenting cells. Regulatory T cells (Tregs) employ CTLA-4-mediated transendocytosis as a key suppressive mechanism. Several CTLA4 polymorphisms are associated with autoimmune disease risk and may modulate CTLA-4 expression and function. Here, we analyzed samples from 155 genotyped subjects using flow cytometry and functional assays to determine how haplotypes formed by 3 CTLA4 single-nucleotide polymorphisms shape T-cell phenotype

TCRαβ repertoire plasticity defines universal CD8+ T cell responses directed at influenza-specific HLA-A*02:01-PB1413-421 epitope.

HLA-A*02:01-restricted PB1413+CD8+ T cells provide the broadest reported cross-reactive immunity against influenza A, B, and C viruses. Here, we investigated T cell receptor (TCR) clonotypic signatures within these universal A2/PB1413+CD8+ T cell pools, compared with immunodominant influenza A-specific M158+CD8+ T cells and codominant influenza B-specific A2/HA543+CD8+ memory T cells. Using single-cell reverse transcriptase polymerase chain reaction and RNA sequencing methodologies, we defined TCRαβ repertoire composition and diversity. Our study shows that CD8+ T cells responding to these 3 e

TNFα promotes brain-predominant EAE independent of IFNγ and IL-17A in HLA-DR3 transgenic mice.

Multiple sclerosis (MS) is thought to be mediated by human leukocyte antigen (HLA) class II-restricted autoreactive CD4 T cells producing interleukin (IL)-17A and/or interferon γ (IFNγ), but the necessity of these cytokines for disease pathogenesis is unclear. Utilizing HLA-DR3 (DRβ1*0301) transgenic mice lacking IFNγ or IL-17A in experimental autoimmune encephalomyelitis (EAE), a model of MS, we found that neither cytokine is essential for disease induction, although both have distinct roles. The absence of IFNγ caused atypical, brain-predominant EAE characterized by high levels of IL-17A, wh