Результаты поиска

Coagulation dysfunction in term neonatal sepsis: a prospective cohort study.

OBJECTIVE: To characterize clinical features, conventional coagulation profiles, and rotational thromboelastometry (ROTEM) parameters in ter … n tests included platelet count, prothrombin time/international normalized ratio (INR), aPTT ratio, fibrinogen, D-dimer, and selected natural anticoagulants. Viscoelastic coagulation was evaluated using ROTEM (INTEM, EXTEM, and FIBTEM assays). The primary outcome was all-cause mortality within 28 days after sepsis diagnosis. Associations between clinical, la …

[A comparative study of coagulation function and disease severity between hyperlipidemic acute pancreatitis and biliary acute pancreatitis].

OBJECTIVE: To compare coagulation function and disease severity between hyperlipidemic acute pancreatitis (HLAP) and biliary acute pancreati … tial thromboplastin time (APTT), international normalized ratio (INR), antithrombin- III (AT- III), fibrinogen degradation products (FDP), fibrinogen (Fbg), D-dimer, and disseminated intravascular coagulation (DIC) score; the severity of the disease was measured by the sequential organ failure assessment (SOFA), acute physiology and chronic health evaluation …

[Clinical characteristics of psoriatic arthritis with positive rheumatoid factor or anti-cyclic citrullinated peptide antibody].

OBJECTIVE: To analyze the clinical and laboratory features of psoriatic arthritis (PsA) patients with positive rheumatoid factor (RF) or ant … 2.43±14.34) years vs. (47.59±12.75) years old, P=0.005]. The positive rate of RF and serum level of fibrinogen in the anti-CCP antibody positive group were higher than those in the negative group. The PsA patients in the anti-CCP antibody positive group were all polyarthritis, while 68.6% patients in the negative group were polyarthritis, but there was no st …

In vitro investigations of the clot formation and resolution properties of cryopreserved platelets.

While platelets for transfusion are traditionally stored at room temperature (20-24°C), cryopreservation at -80°C is attractive, as it facilitates an extension of the shelf-life from 7 days to several years. Cryopreserved platelets display enhanced procoagulant capacity, which may distort the balance between clot formation and resolution. Platelets were frozen at -80°C using DMSO and thawed and resuspended in fresh plasma before testing. Fresh components (day 1) were tested in parallel. The supernatant of thawed platelets contained a higher concentration of fibrinogen, plasminogen, TAFI, FXIII…

From Pump to Neck: A Focused Review of Mechanical Complications in Extracorporeal Membrane Oxygenation (ECMO) Circuits.

Extracorporeal membrane oxygenation (ECMO) is a life-saving modality, yet it carries inherent risks of device-related adverse events. This m … ion of a core biomarker panel including plasma-free hemoglobin, lactate dehydrogenase, D-dimer, and fibrinogen. The review also addresses physical circuit emergencies, identifying recirculation associated with veno-venous ECMO, as well as clinical signs of oxygenator thrombosis, catastrophic pump failure, and cavitation. The hope is to equip clinicians with …

Biotactic Nanodrugs Induce Tumor-Localized and Durable Embolization via Programmatic Participation in Physiological Biochemical Reactions.

The clinical application of tumor vascular obstruction therapy (TVOT) is mainly hindered by imprecise obstruction localization and transient embolic effects. We developed a biotactic nanodrug termed PDA-A@Fib to achieve precise and sustained TVOT by programmatically participating in the physiological biochemical reactions related to the coagulation-fibrinolysis axis. Composed of a polydopamine (PDA) core loaded with aminomethylbenzoic acid (AA) and coated with fibrinogen (Fib), PDA-A@Fib was recruited to the tumor site following DMXAA-primed vascular damage via Fib-platelet interactions. Subse…

Group A Streptococcal Virulence Factors and Vaccine Development-An Update.

A Group A Streptococcus (GAS, Streptococcus pyogenes) is an exclusively human pathogen whose virulence is driven by a diverse array of surface structures, secreted toxins, and immune evasion mechanisms. Central to its pathogenicity is the M protein, a surface-anchored molecule that inhibits phagocytosis by interfering with complement deposition and binding host factors such as fibrinogen. GAS also secretes a wide range of toxins and enzymes that damage tissues and disrupt host defences. Streptolysin O and streptolysin S are potent cytolysins that lyse immune cells and contribute to tissue necr…

Purtscher-Like Retinopathy Secondary to an Appendiceal Neuroendocrine Neoplasm Complicated by a Periappendiceal Abscess.

Purtscher-like retinopathy (PLR) is a rare retinal microvasculopathy that is induced by non-traumatic systemic illnesses. We describe the ca … optical coherence tomography (OCT). Systemic evaluation revealed elevated D-dimer levels: 547 ng/mL fibrinogen equivalent units (FEU) (normal <500 ng/mL FEU), and subsequent imaging identified a periappendiceal infiltrate. Laparoscopic appendectomy confirmed the presence of a well-differentiated grade 3 ANEN. Postoperative follow-up demonstrated regression o …

Advancing treatment strategies against MRSA: unveiling the potency of tubuloside A in targeting sortase A and mitigating pathogenicity.

In addressing the formidable challenge posed by methicillin-resistant Staphylococcus aureus (MRSA), this investigation elucidates a novel th … compared to traditional antibiotics. TnA significantly impedes Staphylococcus aureus' adherence to fibrinogen, notably disrupting biofilm development and the integration of staphylococcal protein A (SpA) into the cell wall. Enhanced survival in MRSA-infected A549 cells treated with TnA was demonstrated by live-dead cell assays, confirming its efficacy. The …

Cryoproteins in Non-HCV-Related Autoimmune Disorders: A Serious Cold-Induced Problem.

The precipitation of cryoglobulins, serum immunoglobulins, below 37 °C defines the clinical cryoglobulinemic syndrome, a systemic vasculitis … infections, autoimmune diseases, and B-cell lymphoproliferative disorders. The cryoprecipitation of fibrinogen has been described as a rare disorder, perhaps underestimated and not fully understood, causing thrombotic occlusion and ischemia in different rheumatic disorders. Cold temperature plays a pathogenetic role in autoimmune hemolytic anemias, in which …

The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch-Schönlein Purpura: A Five-Year Retrospective Study.

Background/Objectives: Immunoglobulin A (IgA) vasculitis (IgAV), classically known as Henoch-Schönlein purpura (HSP), is a type of nonthromb … ization. Measurements of immunological panels (IgA, IgM, IgG, and IgE), C3, C4, C-reactive protein, fibrinogen, and hematite sedimentation rate (VSH) determined using blood samples revealed that there is a strong correlation between the elements of the immunological panel and the HSP manifestations. Results: Additionally, elevated IgG and normal IgA serum le …

Red Blood Cell-Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell-Depleted Thrombi, Restoring Severe Bacteremia in Rats.

Extracorporeal hemoadsorption for treating bacteremia has exhibited limited success due to the lack of a clear strategy for effectively brin … bacterial margination, facilitating their effective capture on the CDT surface on the channel wall. Fibrinogen and fibronectin in CDT are found to primarily contribute to capturing various bacteria. The extracorporeal CDT filters (eCDTF), which integrate all these principles, demonstrate significant depletion of major antibiotic-resistant and human fecal bac …

Воспаление и коагулирование нервных и психиатрических расстройств.

Коагулирующие факторы по сути выражаются в различных клетках мозга, включая астроциты и микроглию. Их взаимодействие с воспалительной системой имеет важное значение для благополучия мозга, но они также имеют решающее значение для развития многих заболеваний мозга, таких, как инсульт и травматическое повреждение мозга. Воздействие коагуляции на клеточную клетку происходит главным образом с помощью рецепторов с протезиной. В этом обзоре мы подытоживаем роль каскада коагуляции в развитии различных заболеваний, включая психические расстройства. В таких подстрекательских болезнях, как множественный

Совпадение в аннотации оригинала
Coagulation factors are intrinsically expressed in various brain cells, including astrocytes and microglia. Their interaction with the infla … rent diseases including psychiatric disorders. In inflammatory diseases such as multiple sclerosis, fibrinogen activates microglia and suppresses the differentiation of oligodendrocytes, leading to axonal damage and suppression of remyelination. In ischemic stroke, thrombin activity is associated with the size of infarction, and the inhibition of either thro …

RNA therapeutics to control fibrinolysis: review on applications in biology and medicine.

Regulation of fibrinolysis, the process that degrades blood clots, is pivotal in maintaining hemostasis. Dysregulation leads to thrombosis or excessive bleeding. Proteins in the fibrinolysis system include fibrinogen, coagulation factor XIII, plasminogen, tissue plasminogen activator, urokinase plasminogen activator, α2-antiplasmin, thrombin-activatable fibrinolysis inhibitor, plasminogen activator inhibitor-1, α2-macroglobulin, and others. While each of these is a potential therapeutic target for diseases, they lack effective or long-acting inhibitors. Rapid advances in RNA-based technologies…