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A Rare Case of Oligosecretory Multiple Myeloma With Intracranial Plasmacytoma.

Multiple myeloma (MM) is a hematologic malignancy characterized by monoclonal plasma cell proliferation within the bone marrow. According to current International Myeloma Working Group (IMWG) criteria, true non-secretory multiple myeloma (NSMM) is defined by the absence of detectable monoclonal protein even on serum free light chain (FLC) assay, unlike oligosecretory multiple myeloma (OSMM), in which electrophoresis and immunofixation are negative but the FLC κ/λ ratio is pathological - making diagnosis particularly challenging by conventional techniques. The association of OSMM with an intrac

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… Clinical examination showed a good general condition (ECOG performance status 1), a Glasgow Coma Scale score of 15, hemodynamic stability, no signs of infection, and no peripheral edema. Neurological examination confirmed partial left CN III palsy without any other neurological deficits. …

A tertiary care centre experience with Elranatamab: A report of three cases.

IntroductionThe introduction of proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies has changed the treatment paradigm of multiple myeloma. With the advent of these new therapeutic options, life expectancy has substantially increased for myeloma patients which has led to an increased number of patients with triple-class refractory disease. Thus, there remains an unmet need for effective novel therapies with good tolerability and safety profile. Elranatamab, is the most widely used bispecific antibody currently in the Indian setting. However, it has only been used on a clin

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… In view of poor GCS (Glasgow coma scale) and imminent risk of aspiration pneumonitis, endotracheal intubation was performed and patient was put on mechanical ventilation. …

Твердая неэптическая гипераммония, связанная с уреаплазмой парвума и инфекциями гомини Микопласмы в двойном иммунозапугивании женщины, представляющей как предполагаемый перитональный карциноматоз.

Острая гипераммония, не связанная с гепатической гипераммонией, является редким, но потенциально опасным для жизни заболеванием у пациентов, страдающих иммунокомпромиссной болезнью. Виды Ureaplasma и Mycoplasma являются быстродействующими врожденными организмами, которые генерируют аммиак и могут вызывать распространенную культурно-отрицательную инфекцию. Мы сообщаем о случае 63-year-old Женщина, получающая двойную биологическую терапию, оклелизумаб от множественных склерозов и секукинуумаб от псориаза, которая имела историю стерильности пюрии и симптомов мочи ниже. В течение двух месяцев ее с

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… On ICU admission, she was encephalopathic with a Glasgow Coma Scale score of 9 and West Haven grade III-IV, and plasma ammonia had increased to 575 µmol/L. …

Неврологические последствия гипергликемии: сообщение о редком представлении о синдроме осмотической демиелинации.

Синдром осмотического обезвоживания (ОРД) представляет собой редкое, но потенциально опасное для жизни неврологическое расстройство. Она характеризуется невоспалительным обезвоживанием, которое, как правило, вызвано внезапными сменами сыворотки. Однако появляющиеся данные свидетельствуют о том, что резкие осмотические изменения, вызванные сильной гипергликемией, даже при отсутствии натриевого дисбаланса, могут также приводить к образованию ОРВ. ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: А 57-year-old мужского пола с плохо управляемым типом 2 Больной диабет и хроническое употребление алкоголя сопровождаются период

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… Neurologically, he was alert, with a Glasgow Coma Scale score of 15 (E4V5M6). Cranial nerve examination was unremarkable, with no focal neurological deficits noted. Muscle bulk, tone, and power were preserved across all limbs, with strength graded at 4+/5. …

Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.

Hypercalcaemia and leukocytosis are two paraneoplastic conditions associated with poor prognosis. Adenosquamous carcinoma is a rare and aggressive histological subtype of lung cancer consisting of adenocarcinoma and squamous cell components. We report the case of a 57-year-old male smoker who was admitted to the Emergency Room with skull and neck tumefactions, confusion and deteriorated general condition. The complementary study in the ER revealed severe hypercalcaemia (19.8 mg/dL), leukocytosis (18.7 × 109/L) and extensive osteolytic lesions of the skull on cranioencephalic computer tomograph

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… In the ER, he was conscious and disoriented (Glasgow Coma Scale of 13 points). He was apyretic, slightly tachycardic (101 bpm), normotensive and had a peripheral oxygen saturation of 92%. …

Регулирующие расстройства и качество жизни у пациентов с травматологической и трахеотической каннулой: обзор.

ВВЕДЕНИЕ: Операция по Трахеостомии (TCT) и последующее включение трахеиальной каннулы (TC) сопряжены с рядом физических, коммуникативных и психологических изменений для пациента. В этих клинических ситуациях часто наблюдаются такие расстройства настроения и расстройства, как болезненное беспокойство, депрессия и стресс, что сказывается на качестве жизни (QoL) и процессе реабилитации. Цель этого обзора состоит в изучении исследований, содержащихся в литературе по расстройствам регулирования (АЖД) у пациентов с ТХТ или ТЦ, и того, как это влияет на их QOL в ходе процесса реабилитации. МЕТОДЫ: Ис

Развитие энцефалита рецептора против NMDA у пациента с множественным склерозом.

Энцефалит рецептора против N-метил-D (антиNMDA) является редким подтипом аутоиммунного энцефалита, который часто вызывает симптомы, характерные для ранней стадии заболевания. В данном случае речь идет о пациентке с повторным излучением множественных склерозов (RRMS), у которой появился энцефалит рецептора против NMDA, при этом она прошла курс лечения, позволяющий нейтрализовать болезни. У нее были нейрокогнитивные симптомы и нетипичные магнитные резонансные открытия. Клинические и лабораторные исследования, включая поясничные проколы, подтвердили наличие антител IgG против подблока GluN1 рецеп

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… On day 9 of hospitalisation, the patient’s level of consciousness became stuporous, with a Glasgow Coma Scale score of 6 despite receiving first-line treatment. Generalised hypotonia and roving eye movements were observed. …

ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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… Methods Adult patients with a moderate-severe TBI (Glasgow Coma Scale 3–12) consecutively admitted to the intensive care unit (ICU) at a single trauma referral centre over 12 months were eligible following informed consent. …

Group-Based Trajectory Modeling of Platelet in Patients with Aplastic Anemia: A Study Based on the MIMIC Database.

BackgroundPlatelets are the main components supporting coagulation and hemostasis. Nevertheless, no sufficient research has been done on how variations in platelet counts during hospital stays affect aplastic anemia (AA) patients' prognoses.ObjectiveThis study proposes to evaluate the association between alterations in platelet levels and illness risk in patients with AA using group-based trajectory modeling (GBTM).MethodsGBTM was used to group AA patients based on changes in platelet levels. Cox regression models were used to evaluate the relationship between platelet levels and patients' 30-

Proceedings of Reanimation 2021, the French Intensive Care Society International Congress.

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Cancer Therapy-Induced Encephalitis.

Encephalitis associated with cancer therapies is a rare but serious complication that can significantly impact patients' quality of life and it requires prompt identification and management. Over the past two decades, immunotherapy-particularly immune checkpoint inhibitors-has become a cornerstone of cancer treatment, with up to half of metastatic cancer patients in economically developed countries now receiving these therapies. The widespread adoption of immunotherapy has led to improved survival rates and long-term remissions, even in patients with advanced metastatic disease. However, as im

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… However, most patients with encephalitis will not present a severely depressed Glasgow coma scale (GCS) score on admission and may even perform well on basic cognitive assessments such as mini-mental-status (MMS), or Montreal Cognitive Assessment (MoCA) tests, and might, especially in autoimmune or paraneoplastic …

Missed Until Critical: Unravelling the Mystery of Persistent Hemolysis With a Definitive Diagnosis of Babesiosis.

Babesiosis is a parasitic protozoan infection caused primarily by Babesia microti in the United States. Its presentation can imitate that of malaria, which often leads to misdiagnosis. We present here a case of a 54-year-old female with multiple comorbidities, such as hypertension and hyperlipidemia, who was initially diagnosed with malaria but, with further investigation, was found to have babesiosis. The patient initially presented with anemia and thrombocytopenia, prompting an extensive and meticulous workup including a peripheral blood smear and autoimmune studies. From these tests, we wer

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… She had a Glasgow coma scale (GCS) score of 15 on initial arrival and was sedated and intubated for respiratory failure, but no documented serial GCS score could be obtained during chart review. Liver function tests (LFTs) were normal despite AMA and ANA being positive. …

Outcome Prediction of Hematologic Malignancy in Critically Sick People.

People with hematologic malignancies (HM) frequently postulate intensive care unit (ICU) hospitalization due to organ damage caused by the disease process or treatment-related consequences. This study is aimed at looking at mortality and sign factors in adult patients with hematologic malignancy (HM) who have been hospitalized in the ICU. Death was one quality indicator; researchers used a machine learning approach to find determinants of death. As per the study, there have been 206 patients hospitalized in the ICU (mean age: 51.3 ± 13.6 years; 60% male). The average length of stay was three d

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… The lack of arousal and consciousness was classified as coma, measured using the Glasgow Coma Scale (GCS). Uncertainty, behavioral problems, changed level of awareness, and indications of emergency department or widespread neurologic noticeable symptoms were all used to characterize encephalopathy. …

Primary care referrals of patients with potentially serious diseases to the emergency department or a quick diagnosis unit: a cross-sectional retrospective study.

BackgroundIn Spain, primary healthcare (PHC) referrals for diagnostic procedures are subject to long waiting-times, and physicians and patients often use the emergency department (ED) as a shortcut. We aimed to determine whether patients evaluated at a hospital outpatient quick diagnosis unit (QDU) who were referred to ED from 12 PHC centers could have been directly referred to QDU, thus avoiding ED visits. As a secondary objective, we determined the proportion of QDU patients who might have been evaluated in a less rapid, non-QDU setting.MethodsWe carried out a cross-sectional retrospective c

Abstracts - IANCON 2024

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… Mean systolic blood pressure, diastolic blood pressure, Glasgow Coma Scale (GCS), NIHSS at presentation, Computed tomography - Alberta Stroke Program Early CT Score (CT-ASPECTS), collateral score, time to hospital arrival, time to thrombolysis, and time to thrombectomy were 147 mmHg (±28.58), 86 mmHg …

Neutropenic sepsis and septic shock in ICU patients: A single-center experience over the last decade.

PURPOSE: Sepsis and septic shock in patients with neutropenia are associated with high mortality. We investigated the features and outcome predictors of neutropenic sepsis in the last decade. METHODS: Consecutive patients who were admitted to the intensive care unit (ICU) of a French university-affiliated hospital in 2012-2022, met criteria for sepsis or septic shock, and had neutropenia were included retrospectively. Patient features were collected and compared for 2012-2017 and 2018-2022. Factors associated with hospital mortality were sought by univariate and multivariate analyses. RESULT

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… CAR, chimeric antigen receptor; ECOG, eastern cooperative oncology group; GCS, glasgow coma scale; HSCT, hematopoietic stem-cell transplantation; IQR, interquartile range; SAPS II, simplified acute physiology score version II; SOFA, sepsis-related organ failure assessment. …

Long-Term Outcome of Patients With a Hematologic Malignancy and Multiple Organ Failure Admitted at the Intensive Care.

ObjectivesHistorically, patients with a hematologic malignancy have one of the highest mortality rates among cancer patients admitted to the ICU. Therefore, physicians are often reluctant to admit these patients to the ICU. The aim of our study was to examine the survival of patients who have a hematologic malignancy and multiple organ failure admitted to the ICU.DesignThis retrospective cohort study, part of the HEMA-ICU study group, was designed to study the survival of patients with a hematologic malignancy and organ failure after admission to the ICU. Patients were followed for at least 1

PROCEEDINGS 32nd Symposium ESVN-ECVN WROCLAW, POLAND 12th-14th September 2019. Selected research communications of the 32nd Symposium of the ESVN-ECVN Wroclaw, Poland 12th to 14th September 2019.

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… [O22] The prognostic value of modified Glasgow Coma SCALE and CT imaging findings of cats after traumatic brain injury L. Poad 1 , S. Cortellini 1 , E. … Beltran 1 1 Department of Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA UK The modified Glasgow Coma Scale (MGCS) has been shown to be a useful predictor of short‐term prognosis in dogs following traumatic brain injury (TBI). …

ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes.

BackgroundThe usefulness of non-invasive mechanical ventilation (NIMV) in oncohematological patients is still a matter of debate.AimTo analyze the rate of noninvasive ventilation failure and the main characteristics associated with this endpoint in oncohematological patients with acute respiratory failure (ARF).MethodsA ventilatory support protocol was developed and implemented before the onset of the study. According to the PaO2/FiO2 (P/F) ratio and clinical judgment, patients received supplementary oxygen therapy, NIMV, or invasive mechanical ventilation (IMV).ResultsEighty-two patients were

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… The following contraindications for NIMV were considered in the tested protocol: presence of hemodynamic instability with noradrenaline requirement in dose > 0.25 μg/kg/min, or in rapid ascension; Glasgow coma scale (GCS) < 14; recent upper digestive tract surgery (last 7 days) involving the esophagus …