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Screening for Cardiac Amyloidosis When Conducting Carpal Tunnel Surgery.

Background: Carpal tunnel syndrome (CTS) has emerged as an early indicator of cardiac amyloidosis (CA) caused by transthyretin-associated (ATTR) mutations, possibly linked to adverse cardiovascular outcomes. This case series examines the relationship between idiopathic CTS and CA imaging diagnosis. Methods: Twenty-two patients from the cross-sectional study CarPoS (NCT05409833) were included. These patients underwent physical evaluation, laboratory exams, electrocardiography, echocardiography, cardiac magnetic resonance (CMR) imaging, and scintigraphy with 99mTc-3,3-diphosphono-1,2-propanodica

Spinal brown tumors as a rare cause of spinal cord compression: Report of case series.

INTRODUCTION AND IMPORTANCE: Brown tumors (BTs) are rare benign osteolytic lesions that arise in the context of uncontrolled hyperparathyroidism. They mostly located in the large bone and rarely in the spine. Spine involvement can cause neurologic symptoms and rarely spinal cord compression. The aim of this study is to diagnose BTs of the spine in presence of spinal cord compression symptoms leading to appropriate treatment. CASE PRESENTATION: Retrospective study of 4 cases of Brown tumors revealed by spine cord compression and rapidly operated in our neurosurgery department between 2014 and

Повсеместность коморбидной мигрени в множестве склерозов: сосуществуют ли множественный склероз и мигрень?

Множественный склероз (MS) является хроническим воспалительным заболеванием, вызывающим многофукаловое демиэлирование и повреждение аксона в центральной нервной системе. Последние исследования свидетельствуют о том, что среди пациентов, страдающих НР, наблюдается более высокий уровень заболеваемости мигренью, чем среди населения в целом. В ходе этого перекрестного исследования, проведенного в одном центре, была проведена оценка распространенности мигрени среди пациентов, проходящих курс лечения с целью изменения болезней (ДМТ). МЕТОДЫ: Всего 205 Включены пациенты с сенсорным синдромом. Все уча

The preliminary opinion of Canadian spine surgeons on Medical Assistance in Dying (MAID); a cross-sectional survey of Canadian Spine Society (CSS) members.

BackgroundOn June 17, 2016, providing medical assistance in dying became legal in Canada. This controversial change has had reverberating implications for the entire medical community. This is especially true for physicians that regularly deal with end-of-life decisions, among them neurosurgical and orthopedic spine surgeons, whose patients suffer from a variety of debilitating conditions. With this study we sought to document the opinions of Canadian spine surgeons in hopes of better understanding the sentiment within the speciality towards this change and assess how it evolves over time.Meth

Взаимоотношения между Т-помощником 1 Воспаление биомаркеров и гематологический индекс реакции пациентов с множественным склерозом.

Множественный склероз - это хроническая, прогрессивная, нетрудоспособная болезнь, связанная с высоким уровнем инфицирования, свидетельствами хронического воспаления и высоким коэффициентом смертности. Ненормальные свойства сыворотки цитокины и изменения в активности провокационных клеток были связаны с повторным излучением множественных склерозов (MS-RR). Цель этого исследования состоит в том, чтобы ввести новые подстрекательские коэффициенты, полученные на основе гематологических и липидных индексов в качестве дискриминаторов Т-помощи (Th)-1/Th-2 - деятельность в ОР-МС. Методы, используемые п

Взаимосвязь между социальной поддержкой и духовным благополучием пациентов с множественным склерозом.

АИМ: Данное исследование было направлено на определение взаимосвязи между духовным благополучием и предполагаемой социальной поддержкой (ПСС) у пациентов с множественным склерозом (МС). Это было перекрестное исследование. Это исследование было проведено в Исфахане в 2021 году на 120 пациентов, имеющих MS. Участникам было больше 18 лет, и они обратились в клинику MS. МЕТОДЫ: Темы отбирались с помощью удобного отбора проб. Данные собирались с помощью вопросников Cheraghi и Davari Dolatabadi Perseiveed Social Support and Paloutzian and Ellison's Beening (SWB) и анализировались с использованием оп

Case Report: Trametinib in the treatment of patients with metastatic lung adenocarcinoma harboring NF1 mutation: a case series and literature review.

BackgroundThe neurofibromin 1 (NF1) protein regulates the downstream RAS/RAF/MEK/ERK pathway and functions as a tumor suppressor. Somatic pathogenic mutations in NF1 are found in approximately 4.7%-10% of NSCLC, with a higher frequency in lung adenocarcinomas, reaching up to 15% in certain cohorts. Trametinib, a MEK inhibitor, has demonstrated activity in tumors with NF1 alteration in preclinical models, and clinical activity in low-grade glioma and plexiform neurofibromas in neurofibromatosis type 1. Trametinib had only limited clinical efficacy in other tumor types with NF1 mutations in the

Missed Until Critical: Unravelling the Mystery of Persistent Hemolysis With a Definitive Diagnosis of Babesiosis.

Babesiosis is a parasitic protozoan infection caused primarily by Babesia microti in the United States. Its presentation can imitate that of malaria, which often leads to misdiagnosis. We present here a case of a 54-year-old female with multiple comorbidities, such as hypertension and hyperlipidemia, who was initially diagnosed with malaria but, with further investigation, was found to have babesiosis. The patient initially presented with anemia and thrombocytopenia, prompting an extensive and meticulous workup including a peripheral blood smear and autoimmune studies. From these tests, we wer

Prevention of oxaliplatin-related neurotoxicity by ω-3 PUFAs: A double-blind randomized study of patients receiving oxaliplatin combined with capecitabine for colon cancer.

BackgroundPeripheral neurotoxicity (PN) is a frequent side effect of oxaliplatin treatment, and also is its dose-limiting toxicity. Studies have confirmed that ω-3 polyunsaturated fatty acids (ω-3 PUFAs) had a neuroprotective effect. However, the efficacy of ω-3 PUFAs on the prevention of oxaliplatin-related neurotoxicity remains unclear. We assessed the effect of ω-3 PUFAs on the neurotoxicity in colon cancer patients treated by oxaliplatin combined with capecitabine.MethodsIn a randomized, double-blind, placebo-controlled study, 179 patients with colon cancer receiving oxaliplatin combined w

A Qualitative Study to Assess Collusion and Psychological Distress in Cancer Patients.

IntroductionCollusion is frequently encountered but least studied entity in palliative care services in India. Impact of collusion is manifold and identifying it requires good communication skills. Once identified, it gives an indication for existing healthy versus developing unhealthy collusion to be dealt within families.ObjectiveThe objective of this study was to identify the prevalence of collusion and its clinical and psychological correlates among patients and caregivers in a palliative cancer care.Materials and methodsWe describe systematic identification and unraveling of collusion acr

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… After all, unraveling of the collusion can also help us to divert focus from body to soul and fits well in definition of healing in the Indian context.[ 1 ] Reading patient's needs at particular stage of serious illnesses is a key to deal with treatment refusal and treating noncompliance. …

FASTINA - protocol for a randomised feasibility trial of time-restricted eating to improve response to multiple myeloma therapy.

Multiple myeloma (MM) is an incurable plasma cell malignancy with relapses and diminishing response durations. Preclinical studies suggest that time-restricted eating (TRE)-related metabolic changes may enhance chemosensitivity by exploiting cancer cell vulnerabilities to nutrient deprivation. Clinical data in solid tumours remain limited and heterogeneous, mainly supporting feasibility and possible toxicity reduction rather than definitive efficacy. While efficacy has been explored in breast cancer patients, there is a lack of data for haematological patients, including MM. FASTINA (Fasting i

Is it feasible to conduct a randomised controlled trial of pretransplant exercise (prehabilitation) for patients with multiple myeloma awaiting autologous haematopoietic stem cell transplantation? Protocol for the PREeMPT study.

INTRODUCTION: While myeloma is an incurable malignancy, developments in disease management have led to increased life expectancy in recent years. Treatment typically involves stem-cell transplantation. Increased survival rates equate to more patients living with the burden of both the disease and its treatment for increasing number of years, rendering myeloma a long-term condition.Evidence exists to demonstrate the benefits of exercise for patients recovering from stem-cell transplantation, and prehabilitation-exercise before treatment-has been shown to be effective in other disease areas. To

Substrate reduction therapy with miglustat for type 1 Gaucher disease: a retrospective analysis from a single institution.

IntroductionGaucher disease (GD) is an infrequent progressive multisystem lysosomal storage disorder caused by the deficient activity of the lysosomal enzyme, glucocerebrosidase. A retrospective, single-center analysis of the clinical experience concerning the use of miglustat (N-butyldeoxynojirimycin), an oral inhibitor of glucosylceramide synthase, in type 1 Gaucher disease (GD1) was conducted to evaluate the efficacy, adverse events (AE), and outcome of miglustat therapy.Patients and methodsSix adult Caucasian patients with GD1 (two women and four men), aged 21-81 years (median age 59 years

Is lack of suitable housing a barrier to home-based dialysis therapy for patients with end-stage renal disease? A cohort study.

ObjectiveTo determine whether inadequate housing is the main barrier to the provision of home dialysis treatment.DesignProspective observational study.ParticipantsAll patients attending a predialysis clinic between 2006 and 2009 deemed medically suitable for home dialysis and not active on the preemptive transplant list.SettingA predialysis clinic in a London teaching hospital.Main outcome measureAssessment of patient's accommodation for suitability for home-based dialysis using departmental guidelines and the Government's Housing Health and Safety Rating System regulations 2005.ResultsA lack

Developing a pan-cancer research autopsy programme.

AimsRapid procurement of a wide variety of metastatic and primary cancers and normal tissues after death through rapid autopsy opens largely unexplored avenues in cancer research. We describe a high-volume rapid research autopsy programme at a large academic medical centre.MethodsAdvanced-stage cancer patients, most commonly inpatients in palliative care facilities, were approached to participate in a cancer research autopsy programme with the goal of acquiring multidimensionally annotated tissue for cancer research. On death of an enrolled patient, a predetermined notification plan was enacte

Indications and contraindications of dental implants in medically compromised patients: update.

OBJECTIVES: People with systemic sclerosis (SSc) are vulnerable in COVID-19 and face challenges related to shifting COVID-19 risk and protective restrictions. We evaluated mental health symptom trajectories in people with SSc through March 2022. METHODS: The longitudinal Scleroderma Patient-centred Intervention Network (SPIN) COVID-19 cohort was launched in April 2020 and included participants from the ongoing SPIN Cohort and external enrolees. Analyses included estimated means with 95% CIs for anxiety and depression symptoms pre-COVID-19 for ongoing SPIN Cohort participants and anxiety, depr

Expression of Cysteine-Rich Secreted Acidic Protein in Multiple Myeloma and Its Effect on the Biological Behavior of Cancer Cells.

The multiple myeloma is a malignant clonal tumor of bone marrow plasma cells that is incurable and inevitably recurrent. The mechanisms of progression include tumor cell metastasis, immune escape, resistance to apoptosis, and malignant proliferation. The cysteine-rich secreted acidic protein is closely related to the growth, development, remodeling, and repair of cells and tissues. In our study, we divided myeloma patients and patients with other blood diseases into groups and measured the cysteine-rich secreted acidic protein (SPARC) content in the serum of different groups of patients as wel

Характеристики самоидентифицированных сексуальных азартных игроков в клинике азартных заболеваний.

Фон и цели Исследования сексуального зависимости процветали в последний десятилетний период, стимулированные развитием большого количества онлайн-сексуальных активностей. Несмотря на накопление исследований, однако, доказательства, собранные в клинических образцах людей, ищущих лечение, остаются редкими. Целью этого исследования было описать характеристики (социodemографические, сексуальные привычки и сопутствующие заболевания) самоназначенных «сексуальных зависимых». Методы Образец составлял 72 пациента, обратившихся в поликлинический центр лечения по поводу своих сексуальных поведений. Данны

Psychiatric morbidity and poor follow-up underlie suboptimal functional and survival outcomes in Huntington's disease.

BackgroundHuntington's disease (HD), an inherited, often late-onset, neurodegenerative disorder, is considered to be a rare, orphan disease. Research into its genetic correlates and services for those affected are inadequate in most low-middle income countries, including India. The apparent 'incurability' often deters symptomatic and rehabilitative care, resulting in poor quality of life and sub-optimal outcomes. There are no studies assessing disease burden and outcomes from India.MethodsWe attempted to evaluate individuals diagnosed to have HD at our tertiary-care center between 2013 and 201

A Prospective Evaluation of Percutaneous Vertebroplasty in Osteoporotic Vertebral Compression Fracture Patients.

Background Osteoporotic vertebral compression fracture (OVCF) is a common problem in old age, which causes incapacitating pain and leads to significant disability, morbidity, and mortality. Percutaneous vertebroplasty (PVP), a minimally invasive procedure, results in immediate pain relief with decreased morbidity. The primary aim of this study was to evaluate the quality of life (QOL), as denoted by the Roland-Morris Disability Questionnaire (RMDQ) score. In contrast, the secondary aims were determining pain relief using the 11-point Numeric Pain Rating Scale (NPRS) and vertebral height restor