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Study protocol for the randomized controlled trial of EMBOLDEN: a multifaceted intervention aimed at Enhancing physical and community MoBility in OLDEr adults with health inequities using commuNity co-design.

BACKGROUND: Reduced physical mobility is common in older adults and is associated with adverse outcomes, including functional decline, depression, social isolation, and poor nutritional status. Group-based programs focusing on physical activity and nutrition to support healthier lifestyles have demonstrated benefits, particularly when paired with social engagement activities. This paper presents the protocol for a randomized controlled trial (RCT) to test a lifestyle intervention called EMBOLDEN: a multifaceted intervention aimed at Enhancing physical and community MoBility in OLDEr adults wit

Outcomes of cranial nerve disorders in pharyngo-laryngeal herpes zoster: A retrospective study of 34 cases at a single institution.

OBJECTIVE: Pharyngo-laryngeal herpes zoster (HZ) is a rare but clinically important manifestation of varicella-zoster virus (VZV) reactivati … h), followed by the facial nerve (24 %). Dysphagia occurred in 22 patients (65 %), with 5 requiring nutritional support and 2 developing aspiration pneumonia. Among 25 patients with cranial nerve paralysis, only 14 (56 %) achieved complete recovery. Laryngeal paralysis resulting from the X nerve impairment demonstrated the poorest prognosis, with a recovery rate of 5 …

[Analysis of Qingkailing Injection in treatment of combined medication features of 2 147 cases of upper respiratory tract infection].

Acute upper respiratory infection is one of the common infectious diseases,especially in the elderly people. Qingkailing Injection has the e … n to use Qingkailing Injection in combination with hormones,antipyretics and analgesics,antibiotics,nutritional support agents,antitussive,expectorant and antiasthmatic drugs,as well as traditional Chinese medicine Jiebiao agents and blood management agents. The combination of potassium chloride injection and cephalosporin injection is the most commonly used in combi …

Oxidative damage impact on aging and age-related diseases: drug targeting of telomere attrition and dynamic telomerase activity flirting with imidazole-containing dipeptides.

It has been documented that telomere-associated cellular senescence may contribute to certain age-related disorders, including an increase i … individuals suggest that longer telomeres are associated with better survival and an advanced oral nutritional support with non-hydrolyzed carnosine (or carcinine and patented compositions thereof) and patented N-acetylcarnosine lubricant eye drops are useful therapeutic tools of a critical telomere length maintenance that may fundamentally be applied in the treatme …

Interrelationships of food, nutrition, diet and health: the National Association of State Universities and Land Grant Colleges White Paper.

Nutrition and food science have each enhanced the development of an abundant, nutritious, safe food supply. A healthy diet should contain all of the required nutrients and sufficient calories to balance energy expenditure and provide for growth and maintenance throughout the life cycle. Importantly, dietary factors are associated with 5 of the 10 leading causes of death, including coronary heart disease, certain types of cancer, stroke, noninsulin dependent diabetes mellitus and atherosclerosis. National health care expenditures for 1990 totaled $666 billion of which 30% are related to inappro

Targeting 7-ketocholesterol-driven metabolic dysfunction in obesity: Therapeutic potential of Bifidobacterium and dietary antioxidants.

7-Ketocholesterol (7-KC), a highly cytotoxic oxysterol generated during cholesterol oxidation, accumulates in obesity-associated dyslipidemia and plays a significant role in sustaining chronic low-grade inflammation, oxidative stress, and apoptosis. These pathogenic processes contribute to the development and progression of major obesity-related complications, including insulin resistance, cardiovascular disease, and non-alcoholic fatty liver disease. Existing pharmacological interventions offer limited efficacy in counteracting 7-KC induced cellular toxicity, highlighting the need for safe an

Associations Between Micronutrient Sufficiency, Subjective Well-Being, and Mortality Among Community-Dwelling Chinese Adults.

Micronutrient sufficiency is essential for health, yet many Chinese adults fall short of recommended intake levels. Using data from 12 382 adults in the China Health and Nutrition Survey, this study examined the prevalence of micronutrient sufficiency-defined by 2023 Dietary Reference Intakes for six vitamins and seven minerals-and its associations with subjective well-being (SWB), health care costs, and mortality. Only 10% of adults met sufficiency criteria. Sufficient intake was associated with higher odds of life satisfaction (OR = 1.12, 95% CI [1.02, 1.24], P < .05), with stronger effects

Amaranth (Amaranthus caudatus L.): Nutritional Composition, Bioactive Compounds, Processing Technologies, Food Applications, and Future Perspectives.

Amaranth (Amaranthus caudatus L.) is an Andean pseudocereal with a nutritional profile characterized by its protein, dietary fiber, and bioactive compound content, adequate balance of essential amino acids, and the presence of bioactive compounds with antioxidant, anti-inflammatory, and cardiometabolic properties. This review analyzes the main processing methods applied to amaranth, including milling, roasting, popping, rolling, extrusion, germination, fermentation, encapsulation, and component isolation, describing how these technologies modify its nutritional, functional, and technological p

Nutritional Factors Affecting Uremic Toxin Production.

Chronic kidney disease (CKD) is characterized by persistent exposure to uremic toxins (UTs), many of which originate from gut microbial metabolism and contribute to renal, cardiovascular, and metabolic complications. Current evidence indicates that CKD is associated with dysbiosis and the enrichment of microbial taxa carrying genes involved in UT precursor production. Diet is a major modulator of the gut microbiota and therefore represents a promising lever to reduce UT generation in synergy with current nephroprotective therapies. Beyond simple protein restriction, more specific dietary appro

Advancements in research on feeding intolerance to enteral nutrition in neurocritical patients undergoing sedation and analgesia.

In the Neurocritical Care Unit (NICU), deep sedation and analgesia are essential for managing critically ill patients to control intracrania … of FI in the context of sedation and analgesia is vital for developing standardized, individualized nutritional support plans for neurocritical patients. This review systematically elaborates the "neuro-sedation-gut" triad mechanism, stratifies population-specific risk factors graded by the GRADE system, integrates precise multimodal assessment tools, and proposes an …

Best Practices for Communicating Nutrition and Brain Health Science.

The state of the science of nutrition and its relationship to brain health is complex, making dissemination of research findings difficult. One contributing factor is the lack of a consensus on defining brain health. Some organizations emphasize cognitive function (eg, memory, perception, judgment, decline, impairment) and/or the presence of dementia, whereas others use a broader conceptualization to include mood and stress. Regarding nutrition, some studies support specific dietary patterns, such as the MIND (Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenera

Non-Alcoholic Fatty Liver Disease in Poultry: Risk Factors, Mechanism of Development, and Emerging Strategies.

Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant metabolic disorder in modern poultry production, particularly affecting high-yielding laying hens. This condition compromises bird welfare, productivity, and economic sustainability within commercial farming systems. This narrative review provides a comprehensive overview of the underlying mechanisms through which hepatic lipid accumulation, metabolic dysfunctions, hormonal imbalances, genetic susceptibilities, and environmental stress contribute to the development of NAFLD. The multifactorial nature of NAFLD is explored th

Enteral versus parenteral nutrition in auto-HCT: a randomized controlled trial on clinical outcomes and gut microbiome dynamics.

Disruption of the gut microbiome is a common consequence of chemotherapy, linked with detrimental treatment outcomes (e.g. sepsis), especially in haematopoietic stem cell transplant (HCT) recipients. Preclinical data suggest that enteral nutrition (EN) is superior to parenteral nutrition (TPN), minimising gut atrophy and promoting eubiosis; yet, TPN continues to be used. Here, we evaluated the clinical effects of EN and TPN in autologous HCT recipients and their influence on gut microbiome dynamics. Despite efforts to optimise delivery, EN was poorly tolerated and ultimately proved unfeasible.

Совпадение в полном тексте источника
… Nutritional support (either TPN or EN) was discontinued when the total oral intake was sufficient as determined by the dietician. For further details on EN and TPN provision, please see Supplementary Methods . … This may simply be a matter of providing EN to patients that are willing and therefore likely to tolerate NGT, and optimising the timing of nutritional support. …

The role of diet and nutrition in glaucoma.

PURPOSE OF REVIEW: This review aims to explore the connection between diet and nutritional intake with optic nerve health for patients with glaucoma. RECENT FINDINGS: Using the AAO Grading Criteria to determine level of evidence, Level 1 and Level 2 studies reviewed here examine associations between nutritional intake and glaucoma. Increasing consumption of dietary nitrates and retinols, incorporating the Mediterranean diet, and reducing intake of ultra-processed foods to lower glaucoma risk are supported by Level 1 evidence. Level 2 evidence suggests that dietary niacin, antioxidants, fruits

Decrypting the messages in the matrix: The proceedings of a symposium on dairy food matrix science and public health opportunities.

Although food matrix research is still in its infancy, there is an emerging understanding of the important role of the food matrix on human nutrition and physiology, as well as for public health. This understanding has largely been propelled forward by research involving different milk and dairy food matrices which has revealed that in addition to their distinct array of nutrients and bioactive compounds, milk and dairy foods also contain complex food matrix microstructures that act as nutrient and bioactive delivery systems that set them apart from the other food groups. Due to these distinct

Hyperhomocysteinemia in Adult Patients: A Treatable Metabolic Condition.

Hyperhomocysteinemia (HHcy) is recognized as an independent risk factor for various significant medical conditions, yet controversy persists around its assessment and management. The diagnosis of disorders afffecting homocysteine (Hcy) metabolism faces delays due to insufficient awareness of its clinical presentation and unique biochemical characteristics. In cases of arterial or venous thrombotic vascular events, particularly with other comorbidities, it is crucial to consider moderate to severe HHcy. A nutritional approach to HHcy management involves implementing dietary strategies and targe

Malnutrition in Spinal Muscular Atrophy Type I: Case Report of a Novel Nutritional Intervention With Improved Growth and Function While Receiving Parallel Gene Splicing Therapies.

Children with spinal muscular atrophy (SMA) frequently experience feeding intolerance and diminished growth. Although splicing modulators to prevent symptoms are available worldwide, adequate nutrition to support growth, development, and improved quality of life remains essential. We present a case study of a one-year-old malnourished male with SMA type I who achieved improved growth and feeding tolerance with a human milk (HM)-derived nutrition intervention. Despite feeding with appropriately balanced semielemental formula, he remained severely malnourished after two months of hospitalization

Healthy Food Pyramid as Well as Physical and Mental Activity in the Prevention of Alzheimer's Disease.

The ageing of the population is resulting in neurodegenerative diseases, including Alzheimer's disease (AD), which are an increasing social, economic and medical problem. Diet and physical activity are now considered as important modifiable factors that help prevent or delay the development of AD and other dementia-related diseases. The pyramid of healthy nutrition and lifestyle is a way of presenting the principles, the implementation of which gives a chance for proper development and a long healthy life. The basis of the pyramid, in the first place, is physical activity. Our review of the li

Subclinical thiamine deficiency identified by pretreatment evaluation in an esophageal cancer patient.

Despite the fact that both thiamine deficiency (TD) and Wernicke encephalopathy (WE) have been observed to some degree in cancer patients, such cases of TD and/or WE reported to date have all been diagnosed after the initiation of treatment. We here report a case of TD that presented without the commonly accepted triad of WE symptoms based on a total nutritional evaluation prior to the onset of treatment for cancer. The patient was a 71-year-old man with esophageal cancer who was referred to the oncology outpatient clinic for evaluation to determine the treatment plan. Although he did not pres

Effects of Drugs and Excipients on Hydration Status.

Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal (i.e., a lack of thirst sensation) or external (e.g., polypharmacy or chronic consumption of certain drugs). However, to date, research on the interaction between hydration status and drugs/excipients has been scarce. Drugs may trigger the appearance of hypohydration by means of the increase of water