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Concurrent macular oedema and optic neuritis in Crohn's disease with varied response to steroids.

A patient with a 10-year history of Crohn's disease presented to our ophthalmology service with symptoms of acute anterior uveitis. Previous episodes had been treated successfully with topical steroids.However, on this occasion after treatment with topical steroids, the patient developed macular oedema with concurrent optic neuritis in the affected eye.Furthermore, optic neuritis persisted despite oral steroid treatment contrary to expectations based on current literature. After 6 months of treatment, optic disc oedema had markedly improved but was replaced by sectoral disc pallor.

Acute retinal necrosis presenting as central retinal artery occlusion with cilioretinal sparing.

PURPOSE: To report a case of acute retinal necrosis presenting as central retinal artery occlusion with cilioretinal sparing. METHODS: Single interventional case report. The findings of the ophthalmic examination, MRI, blood parameters, biopsy results and clinical course are reported. RESULTS: A forty two year old gentleman reporting sudden loss of sight, ophthalmic examination revealing uveitis, central retinal artery occlusion with cilioretinal sparing and peripheral necrotizing retinitis. CONCLUSIONS: Central retinal artery occlusion can be an early feature of acute retinal necrosis (ARN…

Ocular reticulum cell sarcoma.

Although rare, ocular reticulum cell sarcoma presents a recognisable clinical pattern, as confirmed by 3 new cases. Typical patients, in their sixth and seventh decades, initially complain of gradual visual loss. Examination reveals 'uveitis' with prominent vitreous debris and/or chorioretinal infiltrative lesions. Topical steroid and mydriatic therapy is ineffective. Reticulum cell sarcoma in the central nervous or other systems may precede or accompany the ophthalmic presentation. In an increasing number of cases tissue diagnosis and effective therapy have followed vitreous aspiration.

Combined central retinal and posterior ciliary artery occlusion in a young female with primary myelofibrosis and Sweet's syndrome: A case report.

Primary myelofibrosis (PMF) is a rare myeloproliferative neoplasm that typically affects older adults but may present aggressively in younge … , and anticoagulation with apixaban, vision did not recover. One week later, she developed anterior uveitis, keratic precipitates, and elevated intraocular pressure. Fundus showed Amalric's sign of choroidal infarction and Elschnig spots, confirmed on fluorescein angiography. Inflammation responded to topical and systemic corticosteroids, with normalizati …

Presentation and management of tislelizumab induced toxic optic neuropathy.

Immune checkpoint inhibitors (ICIs) have revolutionised the management of advanced malignancies, but can cause immune-related adverse events (irAEs), including vision-threatening complications such as optic neuropathy. Ocular irAEs have been described with several programmed death-1/programmed death-ligand 1 and cytotoxic T lymphocyte-associated antigen-4 inhibitors, but ocular toxicities of tislelizumab have so far been limited to Vogt-Koyanagi-Harada (VKH)-like uveitis, panuveitis and retinal vasculitis. We describe a woman with metastatic lung adenocarcinoma who was treated with second-line…

Intraocular Inflammation After Intravitreal Faricimab Injections: A Case Series.

BACKGROUND: Intraocular inflammation (IOI) is a rare but potentially sight-threatening complication that can occur after intravitreal anti-v … red after faricimab intravitreal injections. RESULTS: All patients were diagnosed with significant uveitis with anterior vitreous involvement and 4 out of the 5 patients presented subacutely with high intraocular pressure while the remaining patient presented acutely within 4 days following IVT with normal intraocular pressure. The patients received, on …

Ocular findings in cats with feline infectious peritonitis treated with GS-441524: a preliminary prospective study of 118 cases.

ObjectivesThis study aims to characterise the presence and nature of ocular findings in cats diagnosed with feline infectious peritonitis (F … /118 (40.1%) cats had ocular abnormalities, with the most common associated findings being anterior uveitis, keratic precipitates and chorioretinitis. Throughout the course of treatment with GS-441524, significant improvements were observed in all ocular segments, with rapid improvement noted during the first 7 days of treatment in most cases. Residual ch …

Newly Diagnosed VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome in a Patient Presenting With Legionella Pneumonia.

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly described inflammatory disease characterized by recurrent autoimmune manifestations, such as chondritis and uveitis, in the setting of classic laboratory abnormalities, including elevated inflammatory markers and macrocytic anemia. It is caused by an acquired mutation in the UBA1 gene within the myeloid lineage, ultimately resulting in cell death and systemic inflammation. Timely diagnosis can help expedite treatment and encourage monitoring for complications of the disease, most notably a predilection to infe…

Outcome of Ocular Toxoplasmosis in a Paediatric Population.

ABSTRACT: PURPOSE: Toxoplasmosis is the most common cause of infectious uveitis of the posterior segment. Current literature regarding this parasitic ocular infection in children is sparse. In this study, we focused on localisation of retinal infiltration and visual outcome in children and adolescents. ABSTRACT: MATERIAL AND METHODS: Single-centre, retrospective study from 2012 to 2021. Patients were divided into three subgroups depending on foveal involvement: (1) direct foveal infiltrate, (2) with extrafoveal infiltrate, either with or (3) without fovea-involving inflammation. The primary o…

Ocular Manifestations of Biopsy-Proven B Virus Infection with Central Nervous System Involvement.

IMPORTANCE: B virus, or herpes B infection, is a rare zoonotic disease acquired through contact with macaques. Ocular involvement of B virus is rarely documented in literature, yet it may progress rapidly and result in blindness if not recognized promptly. OBJECTIVE: To present a unique case of human B virus infection with clinical features including severe central nervous system dysfunction and bilateral panuveitis in a patient with history of monkey bite. DESIGN, SETTING, AND PARTICIPANTS: This descriptive, qualitative report examined a unique case of B virus infection treated at a tertiar…

Comparative Efficacy and Safety of Biosimilar Bevacizumab (Stivant®) versus Reference Product (Avastin®) in Prethreshold Type I Retinopathy of Prematurity.

PURPOSE: To compare the efficacy and safety of Stivant® (biosimilar bevacizumab, CinnaGen, Iran) to Avastin® (innovator bevacizumab, Genente … plete retinal vascularization. Safety was assessed through the monitoring of adverse events such as uveitis and endophthalmitis. RESULTS: Forty-four infants were included in the study. The mean age at IVB injection was 34.5 weeks. Complete retinal vascularization occurred at a mean age of 60.02 weeks for Stivant® and 59.93 weeks for Avastin® (P = 0.59). …

Isolated Anterior Segment Relapse in a Child With B-Cell Precursor Acute Lymphoblastic Leukemia: A Rare Case Report.

Ocular relapse in pediatric acute lymphoblastic leukemia (ALL) is rare and typically associated with central nervous system or bone marrow involvement. Anterior segment infiltration as the sole manifestation of relapse is exceptionally uncommon and may mimic noninfectious uveitis, leading to diagnostic delay. We report the case of a 4-year-old boy with a history of B-cell precursor ALL, diagnosed at age 2 and treated according to the ALL IC BFM 2009 protocol. The patient remained in remission until presenting with persistent redness and irritation of the left eye, unresponsive to topical corti…

Liver X Receptor-Growth Differentiation Factor 15 Activation Drives Profibrotic Changes in the Aqueous Outflow Tract of Uveitic Glaucoma.

Cytomegalovirus (CMV)-induced anterior uveitis is linked to increased intraocular pressure, suggesting profibrotic changes in the eye's drainage system. Previous studies on the aqueous humor (AH) of patients with CMV uveitic glaucoma (UG) highlighted the activation of the liver X receptor (LXR) pathway, yet a potential that it has a role in increased intraocular pressure remained unelucidated. Herein, the LXR pathway's role in AH outflow in UG was explored. Global transcriptional analysis revealed that LXR activation primarily induces transforming growth factor-β signaling, with growth differe…

Diagnostic riddle- case report of ocular syphilis.

Syphilis is one of sexually transmitted infections (STIs). The incidence of Treponema pallidum infection has increased in the last 20 years. … ye (OS). The left eye presented high intraocular pressure (IOP) of 31 mmHg and symptoms of anterior uveitis with a linear branching corneal erosion. A B-scan ultrasound of the left eye revealed no vitritis. The preliminary diagnosis of herpetic infection was made, and antiviral therapy was introduced. Despite the initial improvement, symptoms of active an …

Clinical Patterns and Factors Contributing to Ophthalmic and Otologic Events Associated With Immune Checkpoint Inhibitors: A Narrative Review.

Immune checkpoint inhibitors, which are a type of cancer immunotherapy, have been associated with the development of adverse events related to an overactive immune system caused by the effect of this type of therapy. It affects a wide range of organs, including the ear and eye. Ophthalmic toxicity related to immune checkpoint inhibitors usually occurs bilaterally. Corneal toxicity (mainly dry eye disease) and uveitis are the most commonly reported patterns of toxicity. Other patterns of involvement include optic neuritis, serous retinal detachment, keratitis, ophthalmoplegia, and ocular myasth…

Нейро-Бехсет маскирует себя как эпилептик и менингоэнцефалит в отделе экстренной помощи.

Болезнь Бекета (BD) — редкий маленький васкулит, который обычно проявляется в повторяющихся болезненных оральных или половых язвах, увеитах и кожных повреждениях. У некоторых пациентов с Б.Д. возникают неврологические симптомы, называемые нейро-бехетной болезнью. В аварийном отделении эти симптомы могут быть ошибочно восприняты в связи с другими общими острыми проблемами, включая инсульт, инфекцию, эпилепсию, множественный склероз, токсиновое поглощение или психические заболевания. Мы представим случай с 28-летним мужчиной с нейро-БД, имитирующим эпилептику и менингоэнцефалит. Он активно захва

Совпадение в аннотации оригинала
BACKGROUND: Behcet disease (BD) is a rare small vessel vasculitis that commonly manifests as recurrent painful oral or genital ulcerations, uveitis, and skin lesions. Some patients with BD develop neurological symptoms termed neuro-Behcet's disease. In the emergency department setting, these symptoms can be mistaken for other common acute issues including st…

MELAS syndrome with rare manifestations misdiagnosed as vasculitis in the absence of lactic acidosis: A case report.

INTRODUCTION: The syndrome of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is one of the most common inherited mitochondrial disorders. PRESENTATION OF CASE: A 33- year-old male was admitted due to edema, urinary retention, and reduce urinary output. The medical history included a pigmentary retinopathy (PR) at age of 22 and uveitis at age of 30, which were both treated with prednisolone. At age of 32, unapparent bilateral sensorineural hearing loss (SNHL) and symmetric basal ganglia calcifications were observed in neurologic study, and received predni…

A United States expert consensus to standardise definitions, follow-up, and treatment targets for extra-intestinal manifestations in inflammatory bowel disease.

BACKGROUND AND AIMS: Extra-intestinal manifestations (EIMs) are a common complication of inflammatory bowel diseases (IBD), affecting up to … ture review and expert opinion focusing on five major EIMs (erythema nodosum, pyoderma gangrenosum, uveitis, peripheral arthritis, and axial arthritis) were rated in three voting rounds. RESULTS: For use in a clinical practice setting and as part of the creation of a prospective registry of patients with EIMs, the panel developed definitions for erythema …

[SOLVING A MEDICAL MYSTERY THROUGH THE EYES OF A YOUNG PATIENT WITH BUDD-CHIARI SYNDROME AND A NEW VISION LOSS].

INTRODUCTION: Budd-Chiari syndrome is a heterogeneous group of disorders characterized by venous drainage obstruction of the liver and is ex … ndrome, who was examined due to acute vision loss in his left eye. Left eye examination revealed panuveitis presenting with anterior uveitis, intermediate uveitis and an occlusive retinal vasculitis. The ocular examination raised suspicion that the diagnosis was Behcet's disease. Actually, Budd-Chiari syndrome was part of the presentation of Behcet's dise …

Unilateral Endogenous Bacterial Endophthalmitis Post-Coronavirus Disease-19 in an Healthy Asian Indian Male.

Coronavirus disease 2019 (COVID-19) is associated with ocular involvement either during or after the infection. These include conjunctivitis, conjunctival hyperemia, chemosis, epiphora, reactivation of anterior uveitis, or presenting as anterior sclero-uveitis, cotton wool spots, retinal hemorrhages, retinal artery/vein occlusion, ophthalmic artery occlusion, panuveitis, papillophlebitis, central serous retinopathy, presumed fungal endophthalmitis, and multifocal chorioretinitis. A 47-year-old Asian Indian male was diagnosed with COVID-19 and had no other systemic history of note at the time o…