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The combinatorial action of hyphal growth and candidalysin is critical for promoting Candida albicans oropharyngeal infection.

Candida albicans is one of the most common fungal pathogens, yet much remains unknown about how its virulence factors cooperate to promote p … p, candidalysin, hyphal growth, and Sap2p) in vitro and in an in vivo murine model of oropharyngeal candidiasis. Increasing the number of C. albicans gene deletions correlated with reduced oral fungal burden, with hyphal growth and candidalysin together being critical for infection, inflammation, and mortality during oropharyngeal infection. These findings de …